LOCUS       NM_172301               2316 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus cyclin B1 (Ccnb1), mRNA.
ACCESSION   NM_172301 NM_007629
VERSION     NM_172301.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2316)
  AUTHORS   Fan,L.H., Qi,S.T., Wang,Z.B., Ouyang,Y.C., Lei,W.L., Wang,Y.,
            Li,A., Wang,F., Li,J., Li,L., Li,Y.Y., Hou,Y., Schatten,H.,
            Wang,W.H., Sun,Q.Y. and Ou,X.H.
  TITLE     MEIKIN expression and its C-terminal phosphorylation by PLK1 is
            closely related the metaphase-anaphase transition by affecting
            cyclin B1 and Securin stabilization in meiotic oocyte
  JOURNAL   Histochem Cell Biol 162 (6), 447-464 (2024)
   PUBMED   39093409
  REMARK    GeneRIF: MEIKIN expression and its C-terminal phosphorylation by
            PLK1 is closely related the metaphase-anaphase transition by
            affecting cyclin B1 and Securin stabilization in meiotic oocyte.
REFERENCE   2  (bases 1 to 2316)
  AUTHORS   Feng,J., Xie,L., Lu,W., Yu,X., Dong,H., Ma,Y. and Kong,R.
  TITLE     Hyperactivation of p53 contributes to mitotic catastrophe in
            podocytes through regulation of the Wee1/CDK1/cyclin B1 axis
  JOURNAL   Ren Fail 46 (2), 2365408 (2024)
   PUBMED   38874119
  REMARK    GeneRIF: Hyperactivation of p53 contributes to mitotic catastrophe
            in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis.
REFERENCE   3  (bases 1 to 2316)
  AUTHORS   Wen,C., Cao,L., Wang,S., Xu,W., Yu,Y., Zhao,S., Yang,F., Chen,Z.J.,
            Zhao,S., Yang,Y. and Qin,Y.
  TITLE     MCM8 interacts with DDX5 to promote R-loop resolution
  JOURNAL   EMBO J 43 (14), 3044-3071 (2024)
   PUBMED   38858601
REFERENCE   4  (bases 1 to 2316)
  AUTHORS   Xu,Y., Zheng,Z., Pan,H., Zhao,M., Zhang,J., Peng,S., Liu,J.,
            Pan,W., Yin,Z., Xu,S., Wei,C., Qin,J.J., Lin,Y., Wan,J. and Wang,M.
  TITLE     Kielin/chordin-like protein deficiency aggravates pressure
            overload-induced cardiac dysfunction and remodeling via
            P53/P21/CCNB1 signaling in mice
  JOURNAL   FASEB J 38 (5), e23513 (2024)
   PUBMED   38421300
  REMARK    GeneRIF: Kielin/chordin-like protein deficiency aggravates pressure
            overload-induced cardiac dysfunction and remodeling via
            P53/P21/CCNB1 signaling in mice.
REFERENCE   5  (bases 1 to 2316)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2316)
  AUTHORS   Chapman,D.L. and Wolgemuth,D.J.
  TITLE     Identification of a mouse B-type cyclin which exhibits
            developmentally regulated expression in the germ line
  JOURNAL   Mol Reprod Dev 33 (3), 259-269 (1992)
   PUBMED   1280449
REFERENCE   7  (bases 1 to 2316)
  AUTHORS   Hanley-Hyde,J., Mushinski,J.F., Sadofsky,M., Huppi,K., Krall,M.,
            Kozak,C.A. and Mock,B.
  TITLE     Expression of murine cyclin B1 mRNAs and genetic mapping of related
            genomic sequences
  JOURNAL   Genomics 13 (4), 1018-1030 (1992)
   PUBMED   1387105
REFERENCE   8  (bases 1 to 2316)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   9  (bases 1 to 2316)
  AUTHORS   Milatovich,A. and Francke,U.
  TITLE     Human cyclin B1 gene (CCNB1) assigned to chromosome 5 (q13-qter)
  JOURNAL   Somat Cell Mol Genet 18 (3), 303-307 (1992)
   PUBMED   1386686
REFERENCE   10 (bases 1 to 2316)
  AUTHORS   Bothwell,A.L., Ballard,D.W., Philbrick,W.M., Lindwall,G.,
            Maher,S.E., Bridgett,M.M., Jamison,S.F. and Garcia-Blanco,M.A.
  TITLE     Murine polypyrimidine tract binding protein. Purification, cloning,
            and mapping of the RNA binding domain
  JOURNAL   J Biol Chem 266 (36), 24657-24663 (1991)
   PUBMED   1722210
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC112701.6.
            
            On Nov 17, 2006 this sequence version replaced NM_172301.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011478.1, AK166686.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC112701.6         55629-55733
            106-276             AC112701.6         56212-56382
            277-438             AC112701.6         56497-56658
            439-621             AC112701.6         58468-58650
            622-780             AC112701.6         60332-60490
            781-1017            AC112701.6         60721-60957
            1018-1158           AC112701.6         61199-61339
            1159-1269           AC112701.6         61983-62093
            1270-2316           AC112701.6         62330-63376
FEATURES             Location/Qualifiers
     source          1..2316
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 53.23 cM"
     gene            1..2316
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /note="cyclin B1"
                     /db_xref="GeneID:268697"
                     /db_xref="MGI:MGI:88302"
     exon            1..105
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1377
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /note="cyclin B1, related sequence 13"
                     /codon_start=1
                     /product="G2/mitotic-specific cyclin-B1"
                     /protein_id="NP_758505.2"
                     /db_xref="CCDS:CCDS36768.1"
                     /db_xref="GeneID:268697"
                     /db_xref="MGI:MGI:88302"
                     /translation="MALRVTRNTKINAENKAKVSMAGAKRVPVTVTAASKPGLRPRTA
                     LGDIGNKVSEELQARVPLKREAKTLGTGKGTVKALPKPVEKVPVCEPEVELAEPEPEP
                     ELEHVREEKLSPEPILVDNPSPSPMETSGCAPAEEYLCQAFSDVILAVSDVDADDGAD
                     PNLCSEYVKDIYAYLRQLEEEQSVRPKYLQGREVTGNMRAILIDWLIQVQMKFRLLQE
                     TMYMTVSIIDRFMQNSCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTNNTYTK
                     HQIRQMEMKILRVLNFSLGRPLPLHFLRRASKVGEVDVEQHTLAKYLMELSMLDYDMV
                     HFAPSQIAAGAFCLALKILDNGEWTPTLQHYLSYSEDSLLPVMQHLAKNVVMVNCGLT
                     KHMTVKNKYAASKHAKISTLAQLNCTLVQNLSKAVTKA"
     exon            106..276
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            277..438
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..621
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            622..780
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1017
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1158
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1269
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..2316
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1463..1468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /note="hexamer: AATAAA"
     polyA_site      1488
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /note="major polyA site"
     regulatory      2291..2296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
                     /note="hexamer: AATAAA"
     polyA_site      2316
                     /gene="Ccnb1"
                     /gene_synonym="Ccnb1-rs1; Ccnb1-rs13; Cycb-4; Cycb-5;
                     CycB1; Cycb1-rs1"
ORIGIN      
        1 ggaacggctg ttagtgttta gctgtggata gccagaggtt agggtgtctt ctcgaatcgg
       61 ggaacctctg attttggagg agccatggcg ctcagggtca ctaggaacac gaaaattaac
      121 gcagaaaata aggccaaggt cagtatggca ggcgccaagc gtgtgcctgt gacagttact
      181 gctgcttcca agcccgggct gagaccgaga actgctcttg gagacattgg taataaagtc
      241 agcgaagagc tacaggcaag agtgcctctg aaaagggaag caaaaacgct aggtactgga
      301 aaaggtactg ttaaagccct accaaaacct gtagagaagg tgcctgtgtg tgaaccagag
      361 gtggaacttg ctgagcctga gcctgaacct gaacttgaac atgttagaga agagaagctt
      421 tctcctgaac ctattttggt tgataatccc tctccaagcc cgatggaaac atctggatgt
      481 gcgcctgcag aagagtatct gtgtcaggct ttctctgatg taatccttgc agtgagtgac
      541 gtagacgcag atgatggggc tgacccaaac ctctgtagtg aatatgtgaa agatatctat
      601 gcttatctcc gacaactgga ggaagagcag tcagttagac caaaatacct acagggtcgt
      661 gaagtgactg gaaacatgag agctatcctc attgactggc taatacaggt tcagatgaaa
      721 tttaggctgc ttcaggagac catgtacatg actgtgtcca ttattgatcg gttcatgcag
      781 aacagttgtg tgcccaagaa gatgctacag ctggtcggtg taacggccat gtttattgca
      841 agcaaatatg aggagatgta ccctccagaa ataggtgact tcgcctttgt gactaacaac
      901 acgtacacta agcaccagat cagacagatg gagatgaaga ttctcagagt tctgaacttc
      961 agcctgggtc gccctctgcc tctgcacttc ctccgtagag catctaaagt cggagaggtt
     1021 gacgtcgagc agcacacttt ggccaaatac ctcatggagc tctccatgct ggactacgac
     1081 atggtgcatt ttgctccttc tcaaattgca gctggggctt tctgcttagc gctgaaaatt
     1141 cttgacaacg gtgaatggac accaactctg cagcactacc tatcctacag tgaagactcc
     1201 ctgcttcctg ttatgcagca cctggctaag aatgtagtca tggtgaactg tggcctcaca
     1261 aagcacatga ctgtcaagaa caagtatgca gcatctaagc atgctaagat cagcacgctg
     1321 gcacagctga actgtacact agttcagaat ttgtctaagg ccgtgacaaa ggcataactc
     1381 caatagactg ctacatctgc agatgcagtt ggcaccatgt gccgcctgta cataggatac
     1441 ctaccgtgtt tacttgctct tcaataaagg ttgtgacttc tcattttaca tagcttaact
     1501 catttgaatg ttgttgcttc tgagtttagg ctaacggaag ttgtcgaatt taggagtata
     1561 ttaaaaactg catctagttt taacagtgga tccaactaat gtatatatct gtagcctata
     1621 tgtctatata catccttcac tgtgtgtcct tatatcatca tgtcttctgc ctcactctag
     1681 tttaaactct aaatctacca gctagtcctt tgttccattt tccagtggtt gccaccttta
     1741 accactgtct cttggtttgt caactttcag atctgaaacc aagtatcttt ttttatgtaa
     1801 ttatttattt gttcttaatt ggaaaatagg atgttcaaaa ttaaaggtgt gttttaaaaa
     1861 gaatttgccc ccaagtctca ctatcaacag ataagggtgt attcttgtat atcctgtata
     1921 gatataatca tgcatatact cccaaggaga tatttttata tgggttcatt ttatcaacag
     1981 tattcctatc agcattcctt tcaatgccta tattgcattt cctagtgtga acaaactgtg
     2041 tgtaacatag tcattccctc ggtgggattc aagtgcattc tctcagtgcc ctccacagtg
     2101 ttcttaaatg atgtttaatg tcttgcttgg cttcattcat agtagctctt ccaggggtgt
     2161 gctttgaatt ctgacagcca gatgggtgtg gctgccacca taccaaggcg ccactcctgt
     2221 cttgtaatgc cacctggaaa agaatcctgt ctcatttgct gttttaattt atacatctga
     2281 tatcaagttg aataaaattt attggtggaa agcttt
//
