LOCUS       NM_009828               3376 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus cyclin A2 (Ccna2), mRNA.
ACCESSION   NM_009828 XM_017319444
VERSION     NM_009828.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3376)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3376)
  AUTHORS   Tscherner,A.K., McClatchie,T., Macaulay,A.D. and Baltz,J.M.
  TITLE     Relationship of quantitative reverse transcription polymerase chain
            reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome
            identifies mouse preimplantation embryo reference genesdagger
  JOURNAL   Biol Reprod 109 (5), 601-617 (2023)
   PUBMED   37669129
REFERENCE   3  (bases 1 to 3376)
  AUTHORS   Ciemerych,M.A. and Sicinski,P.
  TITLE     Cell cycle in mouse development
  JOURNAL   Oncogene 24 (17), 2877-2898 (2005)
   PUBMED   15838522
  REMARK    Review article
REFERENCE   4  (bases 1 to 3376)
  AUTHORS   Wolgemuth,D.J., Lele,K.M., Jobanputra,V. and Salazar,G.
  TITLE     The A-type cyclins and the meiotic cell cycle in mammalian male
            germ cells
  JOURNAL   Int J Androl 27 (4), 192-199 (2004)
   PUBMED   15271198
  REMARK    Review article
REFERENCE   5  (bases 1 to 3376)
  AUTHORS   Winston,N.
  TITLE     Regulation of early embryo development: functional redundancy
            between cyclin subtypes
  JOURNAL   Reprod Fertil Dev 13 (1), 59-67 (2001)
   PUBMED   11545166
  REMARK    Review article
REFERENCE   6  (bases 1 to 3376)
  AUTHORS   Blanchard,J.M.
  TITLE     Cyclin A2 transcriptional regulation: modulation of cell cycle
            control at the G1/S transition by peripheral cues
  JOURNAL   Biochem Pharmacol 60 (8), 1179-1184 (2000)
   PUBMED   11007956
  REMARK    Review article
REFERENCE   7  (bases 1 to 3376)
  AUTHORS   Sweeney,C., Murphy,M., Kubelka,M., Ravnik,S.E., Hawkins,C.F.,
            Wolgemuth,D.J. and Carrington,M.
  TITLE     A distinct cyclin A is expressed in germ cells in the mouse
  JOURNAL   Development 122 (1), 53-64 (1996)
   PUBMED   8565853
REFERENCE   8  (bases 1 to 3376)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
REFERENCE   9  (bases 1 to 3376)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   10 (bases 1 to 3376)
  AUTHORS   Pagano,M., Pepperkok,R., Verde,F., Ansorge,W. and Draetta,G.
  TITLE     Cyclin A is required at two points in the human cell cycle
  JOURNAL   EMBO J 11 (3), 961-971 (1992)
   PUBMED   1312467
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117584.11, BC052730.1 and AK044924.1.
            
            On or before Sep 20, 2017 this sequence version replaced
            XM_017319444.1, NM_009828.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.267436.1,
                                           SRR1660813.153836.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AC117584.11        117372-117629
            259-617             AC117584.11        118107-118465
            618-3201            BC052730.1         1-2584
            3202-3304           AK044924.1         2640-2742
            3305-3376           AC117584.11        125474-125545
FEATURES             Location/Qualifiers
     source          1..3376
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 17.67 cM"
     gene            1..3376
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /note="cyclin A2"
                     /db_xref="GeneID:12428"
                     /db_xref="MGI:MGI:108069"
     exon            1..258
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /inference="alignment:Splign:2.1.0"
     exon            259..924
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             739..2007
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /note="cyclin-A; Cyclin A2 (Cyclin A)"
                     /codon_start=1
                     /product="cyclin-A2"
                     /protein_id="NP_033958.2"
                     /db_xref="CCDS:CCDS17313.1"
                     /db_xref="GeneID:12428"
                     /db_xref="MGI:MGI:108069"
                     /translation="MPGTSRHSGRDAGSALLSLHQEDQENVNPEKLAPAQQPRAQAVL
                     KAGNVRGPAPQQKLKTRRVAPLKDLPINDEHVTAGPSWKAVSKQPAFTIHVDEAEETQ
                     KRPAELKETECEDALAFNAAVSLPGARKPLTPLDYPMDGSFESPHAMDMSIVLEDKPV
                     NVNEVPDYQEDIHTYLREMEVKCKPKVGYMKRQPDITNSMRAILVDWLVEVGEEYKLQ
                     NETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTY
                     SKKQVLRMEHLVLKVLAFDLAAPTVNQFLTQYFLHLQPANCKVESLAMFLGELSLIDA
                     DPYLKYLPSLIAGAAFHLALYTVTGQSWPESLAQQTGYTLESLKPCLVDLHQTYLKAP
                     QHAQQSIREKYKHSKYHSVSLLNPPETLSV"
     exon            925..1168
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1278
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1502
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1710
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1824
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1958
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..3376
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2242..2247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /note="hexamer: AATAAA"
     polyA_site      2263
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /note="major polyA site"
     regulatory      3351..3356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /note="hexamer: AATAAA"
     polyA_site      3376
                     /gene="Ccna2"
                     /gene_synonym="Ccn-1; Ccn1; Ccna; Cyca; CycA2"
                     /note="major polyA site"
ORIGIN      
        1 gtttttcgag acagggtttc tcaagacagg atttctttgt gtagctgacc tggaactaac
       61 tctgcagtcc aggctggcct tgcactcaag agatccacct gcctctgcct cctgagatgc
      121 ccggaaaagg cttggccatc gcctcctggc tgcccggttt tcttatgaac actttttttc
      181 tacttttgag acatcatctc actacatagc tgacttggac taacttgaat tcagagatct
      241 gaaactctgg gattaaaggc gccacccagc gaccaggaga aggcgcttca ccccttagct
      301 gaggcgaagg ccgacacctc gaggccccga gggcttgtct ggaccgccca gcggctccgg
      361 caggatccta tgaggctaca gatccactga gcagcagaga tcggccgaaa gcggccgccc
      421 gccccgccct cctctgcgca ggcgcgtcct caggctcccg ccctgtaaga ttcccgtcgg
      481 gccttcgctc gcggcgaccg gcgcttctgg tgacgtcacg gactccggac gccctcattg
      541 gtttatttca atagtcgcgg gctacttgaa ctacaagacc agcagccggc gggcggcgcg
      601 cagctcgcgg ctcctgggct ctacgctcct cccgcctgca gcctctgctc cgcgggtcgg
      661 ccgccagggt cccgcgctgc tccggagcgg cgggcgctgt gcacgctctg ccgccgacag
      721 aaccggaccg gagccgcgat gccgggcacc tcgaggcatt cgggtcgcga tgcgggctca
      781 gccctgctct cgctgcatca ggaagaccaa gagaatgtca accccgaaaa actggcgcca
      841 gcccagcagc cgcgggcgca ggcggtgctg aaggccggga acgtgcgtgg acccgcgccg
      901 cagcagaagc tcaagactcg acgggttgct cctcttaagg accttcctat aaacgatgag
      961 catgtcactg ctggtccttc atggaaagca gtcagtaaac agcctgcctt caccattcat
     1021 gtggatgaag cagaagagac tcagaagagg ccagctgagc ttaaagaaac agagtgtgaa
     1081 gatgccctgg cttttaatgc agctgtctct ttacccggag caagaaaacc actgacacct
     1141 cttgactatc caatggatgg cagttttgaa tcaccacatg ctatggatat gtctattgtc
     1201 ttagaagaca agccagtgaa cgttaatgaa gtacctgact atcaagaaga cattcacacg
     1261 taccttaggg aaatggaggt taaatgtaaa cctaaagtgg gttacatgaa gaggcagcca
     1321 gacatcacta acagcatgag ggccatcctt gtggactggc tggttgaggt gggagaagaa
     1381 tataaactac agaatgagac cctgcatttg gctgtgaact acattgatag attcctctcc
     1441 tccatgtctg tgttaagagg gaagcttcag cttgtaggca cggctgctat gctgctagct
     1501 tcgaagtttg aagaaatata ccccccagaa gtagcagagt ttgtgtatat tacagacgat
     1561 acctattcca agaagcaggt tctgagaatg gagcacctag tattgaaagt ccttgctttt
     1621 gacttggctg caccaacagt aaatcagttc cttacccagt acttcctgca cctgcagcct
     1681 gcaaactgta aggttgaaag cttagcaatg tttttgggag aactgagttt gatagatgct
     1741 gacccgtacc ttaagtacct gccttcactc attgctggag ctgccttcca cttggctctc
     1801 tacacagtca caggacagag ctggcctgag tcattggcac aacagactgg atataccctg
     1861 gagagtctta agccttgtct tgtggacctt caccagacct acctcaaagc gccacaacat
     1921 gcccaacagt caatacggga aaagtacaag cattcaaaat atcacagtgt ttctcttctc
     1981 aacccaccag agacactaag tgtgtgagtg aaagactgcc ggctttgttt gaaacaggag
     2041 tcgctcggag tccatgctgt acagttttta tgtcgggttt tagtttcaca atcacttctg
     2101 aatgtagatg gtatagccac agacaaatta tggtatccat tgcttttaaa atggttttaa
     2161 tttgtatatc ttttgtacat gtgtctattt ggataatttt aattggttaa cattggtgct
     2221 gccaactgtc aagatattga gaataaactg atttggaaat ctttgcaagt caaagttaat
     2281 ctgagataaa aatatgaatg atgtcgttta gaaactaact tgatttgttt tattgtacag
     2341 tggggagtag gaaaagattt tataaaacta aaatatttca gggaaaaaga ccttcaaatt
     2401 ctggcattga ttgattattc taagcaacca aaccaaactg ctgacttgtt cataaataac
     2461 caaaagtaga caaactgttt tcaatgtagc agaactcatt cggctctcag atgttacagt
     2521 agtttatgga gacattttat ttatcaactt taacaaataa ggtcttacat gagttgggaa
     2581 gcttgtgcaa cagaaaagtt ttccagaaag tttattcaaa gcataatgtt aaagacaaac
     2641 agtgtatcaa gaagttcagc ttgtaagata cccagagctg ttagcactga gtatgtatac
     2701 acacacacac acacagagat ccaccacttt agcttagtta gcagttctct tcttcttctt
     2761 ccttttccct tggcctttac ttggtgcctt ctggtttgca ctggtctgag ctctgtgaat
     2821 gaagtaatat aacagctcac tgtatcccat ctgtcctgga ttgggtcact gggactctga
     2881 aaggtgcccc attttataga accagctttt aatgtatatt tgaaagaggc cagaaatttg
     2941 ttaccttatt ttctttgggt tcttctctgg ctccaaaata atcatttctt cttcttcact
     3001 atctgatagc actatagggg cacctttgga aaagtccaaa aaaggagttt actgcttaag
     3061 cacatcagag gtcctaacgc tcccatctcc aggctaaggg agctcccaag ctctactgcc
     3121 cggaggctga cactctttcc gaatcttacc ctgttctaag taagtagctc cttgcagctc
     3181 tgaaaatttg taaaaattga tgttttctat aaactctttc tttccttttt ccccagagga
     3241 catgtaggcc agaatgctct aattcttgct accaggactg cccatgaaaa atgtagaaaa
     3301 ctgctttgtt tgcccatttt tctcttgaac agtaattata tatgtgtgta aataaagcat
     3361 gcaaattaac ccttta
//
