LOCUS       NM_007628               1581 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus cyclin A1 (Ccna1), transcript variant 2, mRNA.
ACCESSION   NM_007628
VERSION     NM_007628.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1581)
  AUTHORS   Chong,D., Gu,Y., Zhang,T., Xu,Y., Bu,D., Chen,Z., Xu,N., Li,L.,
            Zhu,X., Wang,H., Li,Y., Zheng,F., Wang,D., Li,P., Xu,L., Hu,Z. and
            Li,C.
  TITLE     Neonatal ketone body elevation regulates postnatal heart
            development by promoting cardiomyocyte mitochondrial maturation and
            metabolic reprogramming
  JOURNAL   Cell Discov 8 (1), 106 (2022)
   PUBMED   36220812
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1581)
  AUTHORS   Gindi,N., Grossman,H., Bar-Joseph,H., Miller,I., Nemerovsky,L.,
            Hadas,R., Nevo,N., Galiani,D., Dekel,N. and Shalgi,R.
  TITLE     Fyn and argonaute 2 participate in maternal-mRNA degradation during
            mouse oocyte maturation
  JOURNAL   Cell Cycle 21 (8), 792-804 (2022)
   PUBMED   35104175
REFERENCE   3  (bases 1 to 1581)
  AUTHORS   Yadav,V.K., Berger,J.M., Singh,P., Nagarajan,P. and Karsenty,G.
  TITLE     Embryonic osteocalcin signaling determines lifelong adrenal
            steroidogenesis and homeostasis in the mouse
  JOURNAL   J Clin Invest 132 (4) (2022)
   PUBMED   34905510
REFERENCE   4  (bases 1 to 1581)
  AUTHORS   Ciemerych,M.A. and Sicinski,P.
  TITLE     Cell cycle in mouse development
  JOURNAL   Oncogene 24 (17), 2877-2898 (2005)
   PUBMED   15838522
  REMARK    Review article
REFERENCE   5  (bases 1 to 1581)
  AUTHORS   Wolgemuth,D.J., Lele,K.M., Jobanputra,V. and Salazar,G.
  TITLE     The A-type cyclins and the meiotic cell cycle in mammalian male
            germ cells
  JOURNAL   Int J Androl 27 (4), 192-199 (2004)
   PUBMED   15271198
  REMARK    Review article
REFERENCE   6  (bases 1 to 1581)
  AUTHORS   Winston,N.
  TITLE     Regulation of early embryo development: functional redundancy
            between cyclin subtypes
  JOURNAL   Reprod Fertil Dev 13 (1), 59-67 (2001)
   PUBMED   11545166
  REMARK    Review article
REFERENCE   7  (bases 1 to 1581)
  AUTHORS   Zeichner-David,M., Vo,H., Tan,H., Diekwisch,T., Berman,B.,
            Thiemann,F., Alcocer,M.D., Hsu,P., Wang,T., Eyna,J., Caton,J.,
            Slavkin,H.C. and MacDougall,M.
  TITLE     Timing of the expression of enamel gene products during mouse tooth
            development
  JOURNAL   Int J Dev Biol 41 (1), 27-38 (1997)
   PUBMED   9074935
REFERENCE   8  (bases 1 to 1581)
  AUTHORS   Fromm,L. and Overbeek,P.A.
  TITLE     Regulation of cyclin and cyclin-dependent kinase gene expression
            during lens differentiation requires the retinoblastoma protein
  JOURNAL   Oncogene 12 (1), 69-75 (1996)
   PUBMED   8552401
REFERENCE   9  (bases 1 to 1581)
  AUTHORS   Sweeney,C., Murphy,M., Kubelka,M., Ravnik,S.E., Hawkins,C.F.,
            Wolgemuth,D.J. and Carrington,M.
  TITLE     A distinct cyclin A is expressed in germ cells in the mouse
  JOURNAL   Development 122 (1), 53-64 (1996)
   PUBMED   8565853
REFERENCE   10 (bases 1 to 1581)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127334.3, BB573804.1, AK077114.1 and BB610316.1.
            
            [WARNING] On Mar 11, 2024 this sequence was replaced by
            NM_007628.4.
            
            On Nov 30, 2007 this sequence version replaced NM_007628.2.
            
            Transcript Variant: This variant (2) uses an alternate splice donor
            site in the 5' UTR compared to variant 1. Variants 1 and 2 encode
            the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X84311.1, SRR7345562.535556.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC127334.3         119604-119680       c
            78-125              BB573804.1         48-95
            126-1558            AK077114.1         132-1564
            1559-1581           BB610316.1         550-572
FEATURES             Location/Qualifiers
     source          1..1581
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 26.52 cM"
     gene            1..1581
                     /gene="Ccna1"
                     /note="cyclin A1"
                     /db_xref="GeneID:12427"
                     /db_xref="MGI:MGI:108042"
     exon            1..91
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            92..277
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1378
                     /gene="Ccna1"
                     /codon_start=1
                     /product="cyclin-A1"
                     /protein_id="NP_031654.2"
                     /db_xref="CCDS:CCDS17356.1"
                     /db_xref="GeneID:12427"
                     /db_xref="MGI:MGI:108042"
                     /translation="MHRQSSKSGVALPPVGQGPDACQMLSRAQLGQDPPQRTVLGVLT
                     ENEQYRRTCGQEITAIRCFSGSENVFPAAGKKVLSDHGVNEPAKRGFDIYMDDPEQGD
                     RDTCSGKEGIIFEDVYEVDTSMLKSDLHFLLDFNTVSPMLVDPTTHAQSEEATDFGSD
                     VINVTEYAEEIHRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRT
                     ETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPDVDEFVYITDDTYT
                     KRQLLRMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCIRTENLAKYVAELSLLEADP
                     FLKYLPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVPCLSELHKACLSIPHR
                     PQQAIREKYKASKYLHVSLMEPPVVLPLQ"
     exon            278..524
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            525..649
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..873
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1078
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1192
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1326
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1566
                     /gene="Ccna1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1541..1546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccna1"
                     /note="putative"
ORIGIN      
        1 ccctccgcgc acggccccgc ccgcccggcc ccggccgggg tgcgcttgct aatcgcccag
       61 acagagaaga acctgagaag cagggcctgc tcaggctgtg gcttactagg caatgcatcg
      121 ccagagctcc aagagtggag tcgctctgcc tccagtgggc caaggtcctg atgcttgtca
      181 aatgctcagc agagctcagc ttggccagga tcccccacag agaaccgtgc taggggtgtt
      241 gactgaaaat gagcagtaca ggaggacctg tggccaggag atcacagcaa tcagatgttt
      301 ttctggatca gaaaatgtct tccctgcggc tggaaagaaa gtgctctctg accatggggt
      361 caatgaacca gccaaacgtg ggtttgatat ctatatggat gatcctgaac agggggacag
      421 agatacctgc tcggggaaag agggcatcat atttgaggat gtgtatgaag tcgacaccag
      481 catgctcaag tcagatctcc acttcctgct ggatttcaac acagtttccc caatgctggt
      541 tgaccccacc acccatgccc agtcagagga agcaacggat tttggttcag atgtgattaa
      601 cgtaacggag tatgcagagg agattcatcg ctaccttcga gaagctgaag taagacacag
      661 acccaaggct cactacatga ggaagcagcc ggacatcacg gagggcatgc gcgccatcct
      721 ggtggactgg ctggtggagg ttggggaaga atataaactt cgcacagaga ccctgtactt
      781 ggctgtcaac ttcctggaca ggtttctctc ctgcatgtct gttctgagag ggaaattgca
      841 gcttgtcggg acagcagcta ttctcctggc ttcgaaatat gaagagatat atccgcccga
      901 cgtggatgag tttgtctaca tcaccgacga tacgtacaca aagcgacagc tactgaggat
      961 ggagcatctg ctactcaaag tcctggcatt tgatctgacc gttccaacca ccaaccaatt
     1021 cctccttcag tacctaaggc gtcaaggagt gtgcatcagg actgagaatt tggccaagta
     1081 tgttgcagaa ctgagccttc tggaagctga cccattcttg aagtatcttc cttccttggt
     1141 tgctgcagca gcttactgcc tggcaaacta tattgtgaac agacacttct ggccagaaac
     1201 acttgctgca tttacgggct attcattaaa tgagattgtg ccttgcctga gtgagctgca
     1261 taaagcatgc ctcagtatcc cccatcgacc gcagcaagca atcagggaga agtacaaggc
     1321 ttcgaagtac ctgcacgtgt ccctcatgga gccgcctgta gttcttcccc tgcagtgaat
     1381 ggcaaagctc attggccaca tcagcaggct tgctctgagg tttctgcgag tggggccaac
     1441 taacgtcagt tgtacataac accttcaaca tgagaatgtt aggttctctt agatttcagt
     1501 agtttataat ttatatagat atagacaggt attttaaaag aataaacaac ttgctgtttg
     1561 gctgtgaaaa aaaaaaaaaa a
//
