LOCUS       NM_001127376            1418 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus cellular communication network factor 6 (Ccn6), mRNA.
ACCESSION   NM_001127376
VERSION     NM_001127376.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1418)
  AUTHORS   Lester WC, Johnson T, Hale B, Serra N, Elgart B, Wang R, Geyer CB
            and Sperry AO.
  TITLE     Aurora A Kinase (AURKA) is required for male germline maintenance
            and regulates sperm motility in the mouse
  JOURNAL   Biol Reprod 105 (6), 1603-1616 (2021)
   PUBMED   34518881
REFERENCE   2  (bases 1 to 1418)
  AUTHORS   Wei S, Wang K, Zhao Z, Huang X, Tang W and Zhao Z.
  TITLE     WISP-3/CCN6 inhibits apoptosis by regulating caspase pathway after
            hyperoxia in lung epithelial cells
  JOURNAL   Gene 673, 82-87 (2018)
   PUBMED   29920361
  REMARK    GeneRIF: WISP-3/CCN6 has a role in inhibiting apoptosis by
            regulating caspase pathway after hyperoxia in lung epithelial cells
REFERENCE   3  (bases 1 to 1418)
  AUTHORS   Martin EE, Huang W, Anwar T, Arellano-Garcia C, Burman B, Guan JL,
            Gonzalez ME and Kleer CG.
  TITLE     MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human
            metaplastic breast carcinomas
  JOURNAL   Oncogene 36 (16), 2275-2285 (2017)
   PUBMED   27819674
REFERENCE   4  (bases 1 to 1418)
  AUTHORS   Hann S, Kvenvold L, Newby BN, Hong M and Warman ML.
  TITLE     A Wisp3 Cre-knockin allele produces efficient recombination in
            spermatocytes during early prophase of meiosis I
  JOURNAL   PLoS One 8 (9), e75116 (2013)
   PUBMED   24040393
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1418)
  AUTHORS   Batmunkh R, Nishioka Y, Aono Y, Azuma M, Kinoshita K, Kishi J,
            Makino H, Kishi M, Takezaki A and Sone S.
  TITLE     CCN6 as a profibrotic mediator that stimulates the proliferation of
            lung fibroblasts via the integrin beta1/focal adhesion kinase
            pathway
  JOURNAL   J Med Invest 58 (3-4), 188-196 (2011)
   PUBMED   21921419
  REMARK    GeneRIF: demonstrated that CCN6 induced the proliferation of lung
            fibroblasts by binding to integrin beta1, leading to the
            phosphorylation of FAK(Y397).
REFERENCE   6  (bases 1 to 1418)
  AUTHORS   Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M,
            Haltiwanger RS and Holdener BC.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   7  (bases 1 to 1418)
  AUTHORS   Witte F, Dokas J, Neuendorf F, Mundlos S and Stricker S.
  TITLE     Comprehensive expression analysis of all Wnt genes and their major
            secreted antagonists during mouse limb development and cartilage
            differentiation
  JOURNAL   Gene Expr Patterns 9 (4), 215-223 (2009)
   PUBMED   19185060
REFERENCE   8  (bases 1 to 1418)
  AUTHORS   Kawaki H, Kubota S, Suzuki A, Lazar N, Yamada T, Matsumura T,
            Ohgawara T, Maeda T, Perbal B, Lyons KM and Takigawa M.
  TITLE     Cooperative regulation of chondrocyte differentiation by CCN2 and
            CCN3 shown by a comprehensive analysis of the CCN family proteins
            in cartilage
  JOURNAL   J Bone Miner Res 23 (11), 1751-1764 (2008)
   PUBMED   18597638
REFERENCE   9  (bases 1 to 1418)
  AUTHORS   Kutz WE, Gong Y and Warman ML.
  TITLE     WISP3, the gene responsible for the human skeletal disease
            progressive pseudorheumatoid dysplasia, is not essential for
            skeletal function in mice
  JOURNAL   Mol Cell Biol 25 (1), 414-421 (2005)
   PUBMED   15601861
  REMARK    GeneRIF: the WISP3 gene is essential to skeletal growth or
            homeostasis in humans but not in mice [WISP3]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153958.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164141
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AC153958.2         153522-153723       c
            203-500             AC153958.2         148188-148485       c
            501-743             AC153958.2         144866-145108       c
            744-937             AC153958.2         143077-143270       c
            938-1418            AC153958.2         140900-141380       c
FEATURES             Location/Qualifiers
     source          1..1418
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 20.19 cM"
     gene            1..1418
                     /gene="Ccn6"
                     /gene_synonym="Gm735; WISP-3; Wisp3"
                     /note="cellular communication network factor 6"
                     /db_xref="GeneID:327743"
                     /db_xref="MGI:MGI:2685581"
     exon            1..202
                     /gene="Ccn6"
                     /gene_synonym="Gm735; WISP-3; Wisp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1219
                     /gene="Ccn6"
                     /gene_synonym="Gm735; WISP-3; Wisp3"
                     /note="CCN family member 6; WNT1 inducible signaling
                     pathway protein 3"
                     /codon_start=1
                     /product="cellular communication network factor 6
                     precursor"
                     /protein_id="NP_001120848.1"
                     /db_xref="CCDS:CCDS48537.1"
                     /db_xref="GeneID:327743"
                     /db_xref="MGI:MGI:2685581"
                     /translation="MRRLLFCTLLMTGLTQLCCRTQGSAPQDSTPGGRPGAALEVYQR
                     TEVCRWPCRCPPQRPTCPPGVSLVRDGCGCCKVCAKQPGDTCNEAEICDPHKGLYCDY
                     SGDTPRYETGVCAYLVAVGCEFNRVYYQNGQVFQPHPLFSCLCVSGAIGCTPLFIPKL
                     AGSNCSAAKGRRKTDPPNCGRGTLQQQNSASYKTMSAYRNLPLTWRKKCLVQATKWTP
                     CSRTCGMGISNRVTNDNANCEMRKERRLCYIQPCSRNTSQAVKIPRGETCQPTFQLPK
                     AEKFVFSGCSSTQSYRPTFCGICLDKRCCVPNKSKMITVRFDCPSEGSFKWQMLWVTS
                     CVCQRDCREPGDIFSELRIL"
     exon            203..500
                     /gene="Ccn6"
                     /gene_synonym="Gm735; WISP-3; Wisp3"
                     /inference="alignment:Splign:2.1.0"
     exon            501..743
                     /gene="Ccn6"
                     /gene_synonym="Gm735; WISP-3; Wisp3"
                     /inference="alignment:Splign:2.1.0"
     exon            744..937
                     /gene="Ccn6"
                     /gene_synonym="Gm735; WISP-3; Wisp3"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1418
                     /gene="Ccn6"
                     /gene_synonym="Gm735; WISP-3; Wisp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccagtgaa atccgcaggg cactgggaca gatcctcaga cggaaagtgc aacccgggag
       61 tctgaagccc aggaggtgga gacgtggttc cttgtgcagg agacagggga gctttgtgcc
      121 tggcgcttct ccatctctcc atcctcccgg catcatgcgt aggctcctct tttgcactct
      181 gctcatgact gggctgacac agctctgctg caggacacag ggcagtgcac cacaagactc
      241 gacccctgga gggcggcctg gagcagcatt ggaggtgtat cagcgtacag aggtctgccg
      301 ctggccctgc agatgccccc cgcagaggcc cacttgtcct cctggggtga gtttggtgag
      361 ggacggctgt ggatgctgca aagtctgtgc caagcaacca ggggacacct gtaacgaagc
      421 cgagatctgc gacccccaca aaggcctgta ctgtgactac tccggggaca cgcctaggta
      481 cgagacaggc gtgtgcgcat atcttgtggc agttggatgt gagttcaaca gggtctatta
      541 ccagaatggc caagtatttc agccccaccc actgttcagc tgcctctgtg tgagtggggc
      601 cattggatgc acgcccctct tcatccccaa gctggctggc agcaactgtt ctgcagctaa
      661 aggaagaagg aagactgatc ccccaaactg tggccgggga accctgcagc agcagaactc
      721 agcaagctac aagacaatgt cagcttatag gaatctccca cttacttgga ggaaaaaatg
      781 tctcgtgcaa gcaaccaagt ggactccctg ctccagaacg tgcggaatgg gaatttctaa
      841 ccgggtaacc aacgataacg ccaactgtga aatgagaaag gagaggaggc tgtgctacat
      901 ccagccctgc agcaggaaca catcacaggc agtgaagatc cccagaggag aaacatgtca
      961 acccactttc caactcccca aagctgaaaa atttgttttt tctggatgct caagcactca
     1021 gagttacaga cccactttct gtggaatatg cctggacaag agatgctgtg tccccaacaa
     1081 atctaaaatg attactgtta ggtttgactg ccccagtgaa gggtcattta agtggcagat
     1141 gctgtgggtc acatcttgtg tgtgtcagag ggactgcaga gaaccaggag atatattttc
     1201 tgagctcagg attctataga gccaaacagg gaggcaaggt taaggctaag tcattcatgc
     1261 cataaggaaa accctgacgt agctacacaa gggcgaaaag cttacttaag ggacttaaca
     1321 cagagatagt gaccattctt agcttgctat atttgtgaca agagaagatt ctaaaacata
     1381 tactaataaa acaaaaacga atgcttgaag aattttaa
//
