LOCUS       NM_016873               1784 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus cellular communication network factor 5 (Ccn5), mRNA.
ACCESSION   NM_016873 XM_980874
VERSION     NM_016873.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1784)
  AUTHORS   Song,M.H., Yoo,J., Kwon,D.A., Chepurko,E., Cho,S., Fargnoli,A.,
            Hajjar,R.J., Park,W.J., Zangi,L. and Jeong,D.
  TITLE     Modified mRNA-Mediated CCN5 Gene Transfer Ameliorates Cardiac
            Dysfunction and Fibrosis without Adverse Structural Remodeling
  JOURNAL   Int J Mol Sci 25 (11), 6262 (2024)
   PUBMED   38892449
  REMARK    GeneRIF: Modified mRNA-Mediated CCN5 Gene Transfer Ameliorates
            Cardiac Dysfunction and Fibrosis without Adverse Structural
            Remodeling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1784)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1784)
  AUTHORS   Lee,M.A., Raad,N., Song,M.H., Yoo,J., Lee,M., Jang,S.P., Kwak,T.H.,
            Kook,H., Choi,E.K., Cha,T.J., Hajjar,R.J., Jeong,D. and Park,W.J.
  TITLE     The matricellular protein CCN5 prevents adverse atrial structural
            and electrical remodelling
  JOURNAL   J Cell Mol Med 24 (20), 11768-11778 (2020)
   PUBMED   32885578
  REMARK    GeneRIF: The matricellular protein CCN5 prevents adverse atrial
            structural and electrical remodelling.
REFERENCE   4  (bases 1 to 1784)
  AUTHORS   Yoon,A., Im,S., Lee,J., Park,D., Jo,D.H., Kim,J.H., Kim,J.H. and
            Park,W.J.
  TITLE     The matricellular protein CCN5 inhibits fibrotic deformation of
            retinal pigment epithelium
  JOURNAL   PLoS One 13 (12), e0208897 (2018)
   PUBMED   30571728
  REMARK    GeneRIF: these data suggest that down-regulation of CCN5 is
            associated with fibrotic deformation of Retinal pigment epithelium
            (RPE) under pathological conditions and that restoration of the
            CCN5 level effectively promotes recovery of deformed RPE.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1784)
  AUTHORS   Kim,J., Joo,S., Eom,G.H., Lee,S.H., Lee,M.A., Lee,M., Kim,K.W.,
            Kim,D.H., Kook,H., Kwak,T.H. and Park,W.J.
  TITLE     CCN5 knockout mice exhibit lipotoxic cardiomyopathy with mild
            obesity and diabetes
  JOURNAL   PLoS One 13 (11), e0207228 (2018)
   PUBMED   30485307
  REMARK    GeneRIF: Knockout (KO) of CCN5, which encodes a matricellular
            protein, caused mild obesity. The CCN5 KO mice also exhibited mild
            diabetes characterized by high fasting glucose levels and impaired
            insulin and glucose tolerances. Cardiac hypertrophy, ectopic lipid
            accumulation, and impaired lipid metabolism in hearts were observed
            in CCN5 KO.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1784)
  AUTHORS   Bayle,J., Fitch,J., Jacobsen,K., Kumar,R., Lafyatis,R. and
            Lemaire,R.
  TITLE     Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of
            Wnt signaling in altered dermal fibrillin deposition and systemic
            sclerosis
  JOURNAL   J Invest Dermatol 128 (4), 871-881 (2008)
   PUBMED   17943183
REFERENCE   7  (bases 1 to 1784)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   8  (bases 1 to 1784)
  AUTHORS   Kumar,S., Hand,A.T., Connor,J.R., Dodds,R.A., Ryan,P.J.,
            Trill,J.J., Fisher,S.M., Nuttall,M.E., Lipshutz,D.B., Zou,C.,
            Hwang,S.M., Votta,B.J., James,I.E., Rieman,D.J., Gowen,M. and
            Lee,J.C.
  TITLE     Identification and cloning of a connective tissue growth
            factor-like cDNA from human osteoblasts encoding a novel regulator
            of osteoblast functions
  JOURNAL   J Biol Chem 274 (24), 17123-17131 (1999)
   PUBMED   10358067
REFERENCE   9  (bases 1 to 1784)
  AUTHORS   Pennica,D., Swanson,T.A., Welsh,J.W., Roy,M.A., Lawrence,D.A.,
            Lee,J., Brush,J., Taneyhill,L.A., Deuel,B., Lew,M., Watanabe,C.,
            Cohen,R.L., Melhem,M.F., Finley,G.G., Quirke,P., Goddard,A.D.,
            Hillan,K.J., Gurney,A.L., Botstein,D. and Levine,A.J.
  TITLE     WISP genes are members of the connective tissue growth factor
            family that are up-regulated in wnt-1-transformed cells and
            aberrantly expressed in human colon tumors
  JOURNAL   Proc Natl Acad Sci U S A 95 (25), 14717-14722 (1998)
   PUBMED   9843955
REFERENCE   10 (bases 1 to 1784)
  AUTHORS   Zhang,R., Averboukh,L., Zhu,W., Zhang,H., Jo,H., Dempsey,P.J.,
            Coffey,R.J., Pardee,A.B. and Liang,P.
  TITLE     Identification of rCop-1, a new member of the CCN protein family,
            as a negative regulator for cell transformation
  JOURNAL   Mol Cell Biol 18 (10), 6131-6141 (1998)
   PUBMED   9742130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ560868.1, AL731698.10 and BC032877.1.
            
            On Aug 8, 2009 this sequence version replaced NM_016873.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032877.1, AF100778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BQ560868.1         1-29
            30-30               AL731698.10        5650-5650
            31-179              BQ560868.1         31-179
            180-180             AL731698.10        5800-5800
            181-519             BC032877.1         106-444
            520-575             AL731698.10        10078-10133
            576-617             BC032877.1         501-542
            618-618             AL731698.10        13670-13670
            619-1784            BC032877.1         544-1709
FEATURES             Location/Qualifiers
     source          1..1784
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.49 cM"
     gene            1..1784
                     /gene="Ccn5"
                     /gene_synonym="Crgr4; Ctgfl; Rcop1; Wisp2"
                     /note="cellular communication network factor 5"
                     /db_xref="GeneID:22403"
                     /db_xref="MGI:MGI:1328326"
     exon            1..276
                     /gene="Ccn5"
                     /gene_synonym="Crgr4; Ctgfl; Rcop1; Wisp2"
                     /inference="alignment:Splign:2.1.0"
     exon            277..369
                     /gene="Ccn5"
                     /gene_synonym="Crgr4; Ctgfl; Rcop1; Wisp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..1065
                     /gene="Ccn5"
                     /gene_synonym="Crgr4; Ctgfl; Rcop1; Wisp2"
                     /note="connective tissue growth factor-like protein;
                     CTGF-L; WISP-2; CCN family member 5; WNT1 inducible
                     signaling pathway protein 2"
                     /codon_start=1
                     /product="CCN family member 5 precursor"
                     /protein_id="NP_058569.2"
                     /db_xref="CCDS:CCDS17016.1"
                     /db_xref="GeneID:22403"
                     /db_xref="MGI:MGI:1328326"
                     /translation="MRGNPLIHLLAISFLCILSMVYAQLCPAPCACPWTPPQCPPGVP
                     LVLDGCGCCRVCARRLGESCDHLHVCDPSQGLVCQPGAGPSGRGAVCLFEEDDGSCEV
                     NGRRYLDGETFKPNCRVLCRCDDGGFTCLPLCSEDVRLPSWDCPRPRRIQVPGRCCPE
                     WVCDQAVMQPAIQPSSAQGHQLSALVTPASADGPCPNWSTAWGPCSTTCGLGIATRVS
                     NQNRFCQLEIQRRLCLSRPCLASRSHGSWNSAF"
     exon            370..586
                     /gene="Ccn5"
                     /gene_synonym="Crgr4; Ctgfl; Rcop1; Wisp2"
                     /inference="alignment:Splign:2.1.0"
     exon            587..844
                     /gene="Ccn5"
                     /gene_synonym="Crgr4; Ctgfl; Rcop1; Wisp2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1774
                     /gene="Ccn5"
                     /gene_synonym="Crgr4; Ctgfl; Rcop1; Wisp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1749..1754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccn5"
                     /gene_synonym="Crgr4; Ctgfl; Rcop1; Wisp2"
                     /note="hexamer: AATAAA"
     polyA_site      1774
                     /gene="Ccn5"
                     /gene_synonym="Crgr4; Ctgfl; Rcop1; Wisp2"
                     /note="major polyA site"
ORIGIN      
        1 ctgcccagag cttgagcttc agggctcagg acaccgtggg tcagatctgc agagcatttg
       61 acagacgctc ctgatctcca gaggaccccg ggctgggaca ggggccttgg cgaggctgca
      121 gctgctgtgg cagtagcttg ggatggaggt ctttcttgct gggaactgag gagctgagag
      181 gctcctgtca ggctcctgtc ctaaactctt ggcacttgcg gtggcttggg cttcacacac
      241 tgtcagacac cttcttggtg gcctcctcgg cctcaggttt gaagctggct ccacaaggga
      301 cacggtgaca tgaggggcaa cccactgatc catcttctgg ccatttcctt cctctgcatt
      361 ctctcaatgg tgtatgccca gctgtgccca gcaccctgtg cctgtccttg gacaccaccc
      421 cagtgcccac cgggggtacc cctggtgctg gatggctgtg gctgctgtcg agtgtgtgca
      481 cggaggctgg gggagtcctg cgaccacctg catgtctgcg accccagcca gggcctggtt
      541 tgtcagcctg gggcaggccc cagtggccgt ggtgctgtgt gcctcttcga agaggatgac
      601 gggagctgtg aggtgaatgg ccgcaggtac ctggatgggg agacctttaa acccaattgc
      661 agggttttgt gccgctgtga tgacggtggt ttcacctgcc tgccgctgtg cagtgaggat
      721 gtgcggctgc ccagctggga ctgcccacgc cccaggagaa tacaggtgcc aggaaggtgc
      781 tgccccgagt gggtgtgtga ccaggcagtg atgcagccgg caatccagcc ctcctcagcc
      841 caaggacacc aactttctgc ccttgtcact cctgcatctg ccgatggccc ctgtccaaac
      901 tggagcacag cctggggccc ctgctcaacc acctgtgggt tgggcatagc cacccgagta
      961 tccaaccaga accgattctg ccaactggag atccagcgtc gcctgtgtct gtccagaccc
     1021 tgcctggcat ccaggagcca cggctcatgg aacagtgcct tctagagcca ttgcggggat
     1081 gtggatacag ggcctgccat tctcagcaaa tgtccctagg accaggccct ggactgatgg
     1141 tagatgcccc tctccatgct cttggctgca gttaactgtc ctgggtggat tcagtgtcca
     1201 gagcctctga gcgatccctg ctctgtctga ggtgggggaa gcaggtgacc agctccattt
     1261 ctctggattc tgacccaggc ttctgggttc tcctggctag ttcctcaaaa cttccctgta
     1321 tgaaaaggac aaccaaaagg acctttaaag ctaagctgta ctgggcaagc ctggccacca
     1381 tgctggggat agtgacagta ataggtacca ggcagcagat tgcctgaaac atccaggtcc
     1441 cttcttggac ttctatgtgc ttgtcccaaa gattatgggt gaccttgtaa gtgtgccttt
     1501 cctgatctga gaacaccctg cccggctggg aagaattttc tgggaacatg aagagatgga
     1561 atcacactat tcttaagagc gtttgccaag tccaggaact tgacctttgt atttgtaaaa
     1621 atacacatct cttaaatgct cacaaagcaa gaggctccac acttctggca ggccagggcc
     1681 tttctcttca gcatgagaga gacaaggaac agtagagtac cctcctctgg aggactggcc
     1741 cggtctggaa taaacaccca aatcaagtgt ggaaaaaaaa aaaa
//
