LOCUS       NM_010930               2384 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus cellular communication network factor 3 (Ccn3), mRNA.
ACCESSION   NM_010930
VERSION     NM_010930.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2384)
  AUTHORS   Wang,K., Mitoh,Y., Horie,K. and Yoshida,R.
  TITLE     Exploring the Role of Ccn3 in Type III Cell of Mice Taste Buds
  JOURNAL   J Neurochem 169 (1), e16291 (2025)
   PUBMED   39709613
REFERENCE   2  (bases 1 to 2384)
  AUTHORS   Babey,M.E., Krause,W.C., Chen,K., Herber,C.B., Torok,Z.,
            Nikkanen,J., Rodriguez,R., Zhang,X., Castro-Navarro,F., Wang,Y.,
            Wheeler,E.E., Villeda,S., Leach,J.K., Lane,N.E., Scheller,E.L.,
            Chan,C.K.F., Ambrosi,T.H. and Ingraham,H.A.
  TITLE     A maternal brain hormone that builds bone
  JOURNAL   Nature 632 (8024), 357-365 (2024)
   PUBMED   38987585
  REMARK    GeneRIF: A maternal brain hormone that builds bone.
REFERENCE   3  (bases 1 to 2384)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2384)
  AUTHORS   Rose,K.P., Manilla,G., Milon,B., Zalzman,O., Song,Y., Coate,T.M.
            and Hertzano,R.
  TITLE     Spatially distinct otic mesenchyme cells show molecular and
            functional heterogeneity patterns before hearing onset
  JOURNAL   iScience 26 (10), 107769 (2023)
   PUBMED   37720106
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2384)
  AUTHORS   Luan,Y., Zhang,H., Ma,K., Liu,Y., Lu,H., Chen,X., Liu,Y. and
            Zhang,Z.
  TITLE     CCN3/NOV Regulates Proliferation and Neuronal Differentiation in
            Mouse Hippocampal Neural Stem Cells via the Activation of the
            Notch/PTEN/AKT Pathway
  JOURNAL   Int J Mol Sci 24 (12), 10324 (2023)
   PUBMED   37373471
  REMARK    GeneRIF: CCN3/NOV Regulates Proliferation and Neuronal
            Differentiation in Mouse Hippocampal Neural Stem Cells via the
            Activation of the Notch/PTEN/AKT Pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2384)
  AUTHORS   Lafont,J., Jacques,C., Le Dreau,G., Calhabeu,F., Thibout,H.,
            Dubois,C., Berenbaum,F., Laurent,M. and Martinerie,C.
  TITLE     New target genes for NOV/CCN3 in chondrocytes: TGF-beta2 and type X
            collagen
  JOURNAL   J Bone Miner Res 20 (12), 2213-2223 (2005)
   PUBMED   16294274
  REMARK    GeneRIF: Study indicates that NOV is a positive modulator of
            chondrogenesis.
            Erratum:[J Bone Miner Res. 2006 Feb;21(2):352]
REFERENCE   7  (bases 1 to 2384)
  AUTHORS   Fu,C.T., Bechberger,J.F., Ozog,M.A., Perbal,B. and Naus,C.C.
  TITLE     CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible
            mechanism of connexin-mediated growth suppression
  JOURNAL   J Biol Chem 279 (35), 36943-36950 (2004)
   PUBMED   15213231
  REMARK    GeneRIF: CCN3 binds to the C terminus of Cx43 and has a role in
            mediating growth control induced by specific gap junction proteins
REFERENCE   8  (bases 1 to 2384)
  AUTHORS   Natarajan,D., Andermarcher,E., Schofield,P.N. and Boulter,C.A.
  TITLE     Mouse Nov gene is expressed in hypaxial musculature and cranial
            structures derived from neural crest cells and placodes
  JOURNAL   Dev Dyn 219 (3), 417-425 (2000)
   PUBMED   11066097
REFERENCE   9  (bases 1 to 2384)
  AUTHORS   Snaith,M.R., Natarajan,D., Taylor,L.B., Choi,C.P., Martinerie,C.,
            Perbal,B., Schofield,P.N. and Boulter,C.A.
  TITLE     Genomic structure and chromosomal mapping of the mouse nov gene
  JOURNAL   Genomics 38 (3), 425-428 (1996)
   PUBMED   8975721
REFERENCE   10 (bases 1 to 2384)
  AUTHORS   Martinerie,C., Chevalier,G., Rauscher,F.J. 3rd and Perbal,B.
  TITLE     Regulation of nov by WT1: a potential role for nov in nephrogenesis
  JOURNAL   Oncogene 12 (7), 1479-1492 (1996)
   PUBMED   8622864
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129583.15.
            
            On Jul 6, 2018 this sequence version replaced NM_010930.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y09257.1, X96585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC129583.15        28580-28707         c
            129-354             AC129583.15        28220-28445         c
            355-615             AC129583.15        26594-26854         c
            616-830             AC129583.15        25253-25467         c
            831-2384            AC129583.15        20855-22408         c
FEATURES             Location/Qualifiers
     source          1..2384
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 21.49 cM"
     gene            1..2384
                     /gene="Ccn3"
                     /gene_synonym="C130088N23Rik; Nov"
                     /note="cellular communication network factor 3"
                     /db_xref="GeneID:18133"
                     /db_xref="MGI:MGI:109185"
     exon            1..128
                     /gene="Ccn3"
                     /gene_synonym="C130088N23Rik; Nov"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1127
                     /gene="Ccn3"
                     /gene_synonym="C130088N23Rik; Nov"
                     /note="protein NOV homolog; novH; CCN family member 3;
                     nephroblastoma overexpressed; nephroblastoma-overexpressed
                     gene protein homolog"
                     /codon_start=1
                     /product="CCN family member 3 precursor"
                     /protein_id="NP_035060.1"
                     /db_xref="CCDS:CCDS27471.1"
                     /db_xref="GeneID:18133"
                     /db_xref="MGI:MGI:109185"
                     /translation="MSLFLRKRCLCLGFLLFHLLSQVSASLRCPSRCPPKCPSISPTC
                     APGVRSVLDGCSCCPVCARQRGESCSEMRPCDQSSGLYCDRSADPNNQTGICMVPEGD
                     NCVFDGVIYRNGEKFEPNCQYFCTCRDGQIGCLPRCQLDVLLPGPDCPAPRKVAVPGE
                     CCEKWTCGSDEQGTQGTLGGLALPAYRPEATVGVEVSDSSINCIEQTTEWSACSKSCG
                     MGVSTRVTNRNRQCEMVKQTRLCIVRPCEQEPEEVTDKKGKKCLRTKKSLKAIHLQFE
                     NCTSLYTYKPRFCGVCSDGRCCTPHNTKTIQVEFQCLPGEIIKKPVMVIGTCTCYSNC
                     PQNNEAFLQDLELKTSRGEI"
     exon            129..354
                     /gene="Ccn3"
                     /gene_synonym="C130088N23Rik; Nov"
                     /inference="alignment:Splign:2.1.0"
     exon            355..615
                     /gene="Ccn3"
                     /gene_synonym="C130088N23Rik; Nov"
                     /inference="alignment:Splign:2.1.0"
     exon            616..830
                     /gene="Ccn3"
                     /gene_synonym="C130088N23Rik; Nov"
                     /inference="alignment:Splign:2.1.0"
     exon            831..2384
                     /gene="Ccn3"
                     /gene_synonym="C130088N23Rik; Nov"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2141..2146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccn3"
                     /gene_synonym="C130088N23Rik; Nov"
                     /note="hexamer: AATAAA"
     polyA_site      2160
                     /gene="Ccn3"
                     /gene_synonym="C130088N23Rik; Nov"
     regulatory      2364..2369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccn3"
                     /gene_synonym="C130088N23Rik; Nov"
                     /note="hexamer: AATAAA"
     polyA_site      2384
                     /gene="Ccn3"
                     /gene_synonym="C130088N23Rik; Nov"
                     /note="major polyA site"
ORIGIN      
        1 agccagacct gggtgaaggg gcagtcccat ctccagcctg taacagccct agcaggcaga
       61 acatgagcct cttcctgcga aagcgatgcc tctgcctagg cttcctgctc ttccatctct
      121 taagtcaagt ctctgcatct ctgcgctgcc cttctcggtg cccacccaag tgccccagta
      181 tatcaccgac ctgcgccccc ggggtgcgct cggtgctgga cggctgctcc tgctgtccgg
      241 tgtgcgcccg ccagcgcggg gagagttgtt ctgagatgag accctgtgac cagagcagtg
      301 gtctctactg tgaccgcagc gcagacccca acaaccagac tggcatttgc atggttccag
      361 agggagacaa ctgtgtgttc gatggggtca tttaccgcaa cggagagaag tttgagccga
      421 actgtcagta cttctgcacc tgcagagatg ggcagattgg ctgtctgccc cgctgccagc
      481 tagacgtgct actgccgggt cctgactgcc cagctccgag aaaagtcgca gtgccagggg
      541 agtgctgcga aaagtggacc tgtggctcag acgagcaggg gacgcagggg acgctgggag
      601 gcttggccct tccagcctat agaccggaag ccaccgtagg agttgaagtc tctgactcca
      661 gcattaactg cattgagcag acgacggagt ggagcgcatg ttccaagagc tgtggaatgg
      721 gcgtgtccac ccgggtcacc aacaggaatc gccagtgtga gatggtaaaa cagactcgtc
      781 tctgcatcgt tcggccttgt gaacaagagc ccgaggaagt aacagacaag aaaggtaaaa
      841 agtgtctccg caccaagaaa tccctgaaag ccatccacct acagttcgag aattgcacta
      901 gcttgtacac ctataagccc cggttctgtg gggtctgcag tgatggccgc tgctgtaccc
      961 cccacaacac caaaaccatc caggtggagt ttcagtgtct cccgggggaa atcatcaaga
     1021 aaccagtcat ggtcattgga acctgtacct gctactccaa ctgccctcag aacaatgagg
     1081 ccttcctcca agatctggag ctgaagacaa gcagaggaga aatttaacag gtgctcaggg
     1141 aagcatattg gttgaggcaa atggttgctg cggcatggcc caccatctgt atataggaaa
     1201 cataatgaag ttgtcccacg tatgttgctg tgatcatatg aggccattta tatttgtctt
     1261 tttttttttt aatgaaagat gttccgaatg taaacttaga atcaaggtaa gctcaggata
     1321 tggcttaaag gtgacttcct ttcctgtgct gtttattaca agagcaaatt tatataaatt
     1381 taagtcacat aaatgatcta gttagtagaa tgtggtcaca tcacattcat tttctgtgca
     1441 ctagttaaat cccaataaat gttacagaaa tgattgacac agtgaaatct aagatcatgt
     1501 tgaatatata tatatatata tatatatata tatatatata tgtatatata tatatatata
     1561 tatatatata tatatatata tatataatac caaggttgac ttgagggatc tctactgagt
     1621 tccttgttgg ggtaggtcaa cttgtgcttc caagtgtaag atcaaagaaa acatacatct
     1681 cttgaacatg aagttcagag actgattttc tacttagtgc accaggaaat atgctatagt
     1741 tacagcagta gagtgtctct taattacgtg ggctagtgtc atgaactttc tccattatag
     1801 acaaaccgac tcctttccaa tagaaagaag ctgaaccaaa aactcccaat gcagagatga
     1861 cggggcctct cagctcatgg tttgtacccc ggaggctgct gaggcccact tcttcaaaat
     1921 taaacaggga ctctttcata gttaaagtac actgaagacc aagccaccta atttacaatc
     1981 tctgatgatt ttcaaatgtg cttttagtgc aattttgaaa aggaagagca gaatctacaa
     2041 aattttatga aagtttaaag tagctgaaga cctgctcaaa atacatcttt tggtcatagt
     2101 tatgaaaaca caagttatac atgtgtacct atgtatgctt aataaacaaa gttcacaaaa
     2161 tgtgctagaa aatacaattt gtacatcacc atacacatcc cacttttctt tttaaagtat
     2221 ttatgaaaat ataaattata cattttgtaa aatattctct ttaatttccc tagttgttac
     2281 aaacaacttt taaaaagtat gatgttatca gtgagtgact ctggtattag ttttgtgtta
     2341 tcagtttaat gctgtttact gaaaataaaa atccatgaat taaa
//
