LOCUS       NM_010217               2418 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus cellular communication network factor 2 (Ccn2), mRNA.
ACCESSION   NM_010217
VERSION     NM_010217.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2418)
  AUTHORS   Eibach,Y., Kreher,S., Poetsch,M.S., Kho,A.L., Gaertner,U.,
            Clemen,C.S., Schroder,R., Guo,K., Milting,H., Meder,B., Potente,M.,
            Richter,M., Schneider,A., Meiners,S., Gautel,M. and Braun,T.
  TITLE     The deubiquitinase USP5 prevents accumulation of protein aggregates
            in cardiomyocytes
  JOURNAL   Sci Adv 11 (4), eado3852 (2025)
   PUBMED   39841822
REFERENCE   2  (bases 1 to 2418)
  AUTHORS   Arriagada,C., Lin,E., Schonning,M. and Astrof,S.
  TITLE     Mesodermal fibronectin controls cell shape, polarity, and
            mechanotransduction in the second heart field during cardiac
            outflow tract development
  JOURNAL   Dev Cell 60 (1), 62-84 (2025)
   PUBMED   39413783
REFERENCE   3  (bases 1 to 2418)
  AUTHORS   Moldovan,G.E., Massri,N., Vegter,E.L., Pauneto-Delgado,I.N.,
            Burns,G.W., Joshi,N., Gu,B., Arora,R. and Fazleabas,A.T.
  TITLE     YAP1 and WWTR1 are required for murine pregnancy initiation
  JOURNAL   Reproduction 169 (1), e240355 (2025)
   PUBMED   39503541
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2418)
  AUTHORS   Yang,G., Xiang,J., Yang,X., Liu,X., Li,Y., Li,L., Kang,L., Liang,Z.
            and Yang,S.
  TITLE     Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to
            modulate renal fibrosis through alternative splicing-mediated
            upregulation of CCN2
  JOURNAL   Elife 13, 98524 (2024)
   PUBMED   39495216
  REMARK    GeneRIF: Nuclear translocation of SIRT4 mediates deacetylation of
            U2AF2 to modulate renal fibrosis through alternative
            splicing-mediated upregulation of CCN2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2418)
  AUTHORS   Sun,C., Fan,W., Basha,S., Tian,T., Jin-Smith,B., Barkin,J., Xie,H.,
            Zhou,J., Yin,X.M., Ling,C., Sun,B., Petersen,B. and Pi,L.
  TITLE     Extracellular matrix protein 1 binds to connective tissue growth
            factor against liver fibrosis and ductular reaction
  JOURNAL   Hepatol Commun 8 (11), e0564 (2024)
   PUBMED   39470347
  REMARK    GeneRIF: Extracellular matrix protein 1 binds to connective tissue
            growth factor against liver fibrosis and ductular reaction.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2418)
  AUTHORS   Jay,P., Berge-Lefranc,J.L., Marsollier,C., Mejean,C., Taviaux,S.
            and Berta,P.
  TITLE     The human growth factor-inducible immediate early gene, CYR61, maps
            to chromosome 1p
  JOURNAL   Oncogene 14 (14), 1753-1757 (1997)
   PUBMED   9135077
REFERENCE   7  (bases 1 to 2418)
  AUTHORS   Bork,P.
  TITLE     The modular architecture of a new family of growth regulators
            related to connective tissue growth factor
  JOURNAL   FEBS Lett 327 (2), 125-130 (1993)
   PUBMED   7687569
  REMARK    Review article
REFERENCE   8  (bases 1 to 2418)
  AUTHORS   O'Brien,T.P. and Lau,L.F.
  TITLE     Expression of the growth factor-inducible immediate early gene
            cyr61 correlates with chondrogenesis during mouse embryonic
            development
  JOURNAL   Cell Growth Differ 3 (9), 645-654 (1992)
   PUBMED   1419914
REFERENCE   9  (bases 1 to 2418)
  AUTHORS   Brunner,A., Chinn,J., Neubauer,M. and Purchio,A.F.
  TITLE     Identification of a gene family regulated by transforming growth
            factor-beta
  JOURNAL   DNA Cell Biol 10 (4), 293-300 (1991)
   PUBMED   2029337
REFERENCE   10 (bases 1 to 2418)
  AUTHORS   Ryseck,R.P., Macdonald-Bravo,H., Mattei,M.G. and Bravo,R.
  TITLE     Structure, mapping, and expression of fisp-12, a growth
            factor-inducible gene encoding a secreted cysteine-rich protein
  JOURNAL   Cell Growth Differ 2 (5), 225-233 (1991)
   PUBMED   1888698
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ159336.1, BQ917383.1, CJ055589.1, BQ892143.1, CB317714.1 and
            BQ031485.1.
            
            On Apr 2, 2008 this sequence version replaced NM_010217.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006783.1, SRR1660813.164314.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               CJ159336.1         2-440
            440-782             BQ917383.1         379-721
            783-1034            CJ055589.1         162-413
            1035-1656           BQ892143.1         172-793
            1657-2015           CB317714.1         271-629
            2016-2418           BQ031485.1         1-403               c
FEATURES             Location/Qualifiers
     source          1..2418
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 11.84 cM"
     gene            1..2418
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; fisp-12; Fisp12; Hcs24"
                     /note="cellular communication network factor 2"
                     /db_xref="GeneID:14219"
                     /db_xref="MGI:MGI:95537"
     exon            1..347
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; fisp-12; Fisp12; Hcs24"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..1331
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; fisp-12; Fisp12; Hcs24"
                     /note="fibroblast inducible secreated protein; CCN family
                     member 2; hypertrophic chondrocyte-specific protein 24;
                     fibroblast inducible secreted protein; hypertrophic
                     chondrocyte-specific gene product 24; Connective tissue
                     growth factor precursor (CTGF) (FISP-12 protein)
                     (Hypertrophic chondrocyte-specific protein 24); cellular
                     communication network factor 1"
                     /codon_start=1
                     /product="CCN family member 2 precursor"
                     /protein_id="NP_034347.2"
                     /db_xref="CCDS:CCDS23751.1"
                     /db_xref="GeneID:14219"
                     /db_xref="MGI:MGI:95537"
                     /translation="MLASVAGPISLALVLLALCTRPAMGQDCSAQCQCAAEAAPHCPA
                     GVSLVLDGCGCCRVCAKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPC
                     VFGGSVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCC
                     EEWVCDEPKDRTAVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGIST
                     RVTNDNTFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKIAKPVKFELSGCTSVK
                     TYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEIMKKNMMFIKTCACHYNCPGDNDI
                     FESLYYRKMYGDMA"
     exon            348..570
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; fisp-12; Fisp12; Hcs24"
                     /inference="alignment:Splign:2.1.0"
     exon            571..822
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; fisp-12; Fisp12; Hcs24"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1034
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; fisp-12; Fisp12; Hcs24"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..2403
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; fisp-12; Fisp12; Hcs24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2373..2378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; fisp-12; Fisp12; Hcs24"
                     /note="hexamer: AATAAA"
     polyA_site      2403
                     /gene="Ccn2"
                     /gene_synonym="Ctgf; fisp-12; Fisp12; Hcs24"
                     /note="major polyA site"
ORIGIN      
        1 agttctttgg cgagccggct cccgggagcg tataaaagcc agcgccgccc gcctagtctc
       61 acacagctct tctctccaag aagactcagc cagatccact ccagctccga ccccaggaga
      121 ccgacctcct ccagacggca gcagccccag cccagccgac aaccccagac gccaccgcct
      181 ggagcgtcca gacaccaacc tccgcccctg tccgaatcca ggctccggcc gcgcctctcg
      241 tcgcctctgc accctgctgt gcatcctcct accgcgtccc gatcatgctc gcctccgtcg
      301 caggtcccat cagcctcgcc ttggtgctcc tcgctctctg cacccggcct gctatgggcc
      361 aggactgcag cgcgcaatgt cagtgcgcag ccgaagcagc gccgcactgc cccgccggcg
      421 tgagcctggt gctggacggc tgcggctgct gccgcgtctg cgccaagcag ctgggagaac
      481 tgtgtacgga gcgtgacccc tgcgacccac acaagggcct cttctgcgat ttcggctccc
      541 ccgccaaccg caagatcgga gtgtgcactg ccaaagatgg tgcaccctgt gtcttcggtg
      601 ggtcggtgta ccgcagcggt gagtccttcc aaagcagctg caaataccaa tgcacttgcc
      661 tggatggggc cgtgggctgc gtgcccctgt gcagcatgga cgtgcgcctg cccagccctg
      721 actgcccctt cccgagaagg gtcaagctgc ctgggaaatg ctgcgaggag tgggtgtgtg
      781 acgagcccaa ggaccgcaca gcagttggcc ctgccctagc tgcctaccga ctggaagaca
      841 catttggccc agacccaact atgatgcgag ccaactgcct ggtccagacc acagagtgga
      901 gcgcctgttc taagacctgt gggatgggca tctccacccg agttaccaat gacaatacct
      961 tctgcagact ggagaagcag agccgcctct gcatggtcag gccctgcgaa gctgacctgg
     1021 aggaaaacat taagaagggc aaaaagtgca tccggacacc taaaatcgcc aagcctgtca
     1081 agtttgagct ttctggctgc accagtgtga agacatacag ggctaagttc tgcggggtgt
     1141 gcacagacgg ccgctgctgc acaccgcaca gaaccaccac tctgccagtg gagttcaaat
     1201 gccccgatgg cgagatcatg aaaaagaata tgatgttcat caagacctgt gcctgccatt
     1261 acaactgtcc tggggacaat gacatctttg agtccctgta ctacaggaag atgtacggag
     1321 acatggcgta aagccaggaa gtaagggaca cgaactcatt agactataac ttgaactgag
     1381 ttgcatctca ttttcttctg taaaaacaat tacagtagca cattaattta aatctgtgtt
     1441 tttaactacc gtgggaggaa ctatcccacc aaagtgagaa cgttatgtca tggccataca
     1501 agtagtctgt caacctcaga cactggtttc gagacagttt acacttgaca gttgttcatt
     1561 agcgcacagt gccagaatgc acactgaggt gagtctcctg gaacagtgga gatgccagga
     1621 gaaagaaaga caggtactag ctgaggttat tttaaaagca gcagtgtgcc tactttttgg
     1681 agtgtaaccg gggagggaaa ttatagcatg cttgcagaca gacctgctct agcgagagct
     1741 gagcatgtgt cctccactag atgaggctga gtccagctgt tctttaagaa cagcagtttc
     1801 agctctgacc attctgattc cagtgacact tgtcaggagt cagagccttg tctgttagac
     1861 tggacagctt gtggcaagta agtttgcctg taacaagcca gatttttatt gatattgtaa
     1921 atattgtgga tatatatata tatatatata tatatatttg tacagttatc taagttaatt
     1981 taaagtcatt tgtttttgtt ttaagtgctt ttgggatttt aaactgatag cctcaaactc
     2041 caaacaccat aggtaggaca cgaagcttat ctgtgattca aaacaaagga gatactgcag
     2101 tgggaattgt gacctgagtg actctctgtc agaacaaatg ctgtgcaggt gataaagcta
     2161 tgtattggaa gtcagatttc tagtaggaaa tgtggtcaaa tccctgttgg tgaacaaatg
     2221 gcctttatta agaaatggct ggctcagggt aaggtccgat tcctaccagg aagtgcttgc
     2281 tgcttctttg attatgactg gtttggggtg gggggcagtt tatttgttga gagtgtgacc
     2341 aaaagttaca tgtttgcacc tttctagttg aaaataaagt atatatatat tttttatatg
     2401 aaaaaaaaaa aaaaaaaa
//
