LOCUS       NM_010516               2028 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus cellular communication network factor 1 (Ccn1), mRNA.
ACCESSION   NM_010516
VERSION     NM_010516.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2028)
  AUTHORS   Arriagada,C., Lin,E., Schonning,M. and Astrof,S.
  TITLE     Mesodermal fibronectin controls cell shape, polarity, and
            mechanotransduction in the second heart field during cardiac
            outflow tract development
  JOURNAL   Dev Cell 60 (1), 62-84 (2025)
   PUBMED   39413783
REFERENCE   2  (bases 1 to 2028)
  AUTHORS   Moldovan,G.E., Massri,N., Vegter,E.L., Pauneto-Delgado,I.N.,
            Burns,G.W., Joshi,N., Gu,B., Arora,R. and Fazleabas,A.T.
  TITLE     YAP1 and WWTR1 are required for murine pregnancy initiation
  JOURNAL   Reproduction 169 (1), e240355 (2025)
   PUBMED   39503541
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2028)
  AUTHORS   Fischer,A.G., Elliott,E.M., Brittian,K.R., Garrett,L., Sadri,G.,
            Aebersold,J., Singhal,R.A., Nong,Y., Leask,A., Jones,S.P. and Moore
            Iv,J.B.
  TITLE     Matricellular protein CCN1 promotes collagen alignment and scar
            integrity after myocardial infarction
  JOURNAL   Matrix Biol 133, 14-32 (2024)
   PUBMED   39098433
  REMARK    GeneRIF: Matricellular protein CCN1 promotes collagen alignment and
            scar integrity after myocardial infarction.
REFERENCE   4  (bases 1 to 2028)
  AUTHORS   Li,T., Qian,Y., Li,H., Wang,T., Jiang,Q., Wang,Y., Zhu,Y., Li,S.,
            He,X., Shi,G., Su,W., Lu,Y. and Chen,Y.
  TITLE     Cellular communication network factor 1 promotes retinal leakage in
            diabetic retinopathy via inducing neutrophil stasis and neutrophil
            extracellular traps extrusion
  JOURNAL   Cell Commun Signal 22 (1), 275 (2024)
   PUBMED   38755602
  REMARK    GeneRIF: Cellular communication network factor 1 promotes retinal
            leakage in diabetic retinopathy via inducing neutrophil stasis and
            neutrophil extracellular traps extrusion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2028)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   6  (bases 1 to 2028)
  AUTHORS   Smith,J.B. and Herschman,H.R.
  TITLE     Glucocorticoid-attenuated response genes encode intercellular
            mediators, including a new C-X-C chemokine
  JOURNAL   J Biol Chem 270 (28), 16756-16765 (1995)
   PUBMED   7622488
REFERENCE   7  (bases 1 to 2028)
  AUTHORS   Bork,P.
  TITLE     The modular architecture of a new family of growth regulators
            related to connective tissue growth factor
  JOURNAL   FEBS Lett 327 (2), 125-130 (1993)
   PUBMED   7687569
  REMARK    Review article
REFERENCE   8  (bases 1 to 2028)
  AUTHORS   O'Brien,T.P. and Lau,L.F.
  TITLE     Expression of the growth factor-inducible immediate early gene
            cyr61 correlates with chondrogenesis during mouse embryonic
            development
  JOURNAL   Cell Growth Differ 3 (9), 645-654 (1992)
   PUBMED   1419914
REFERENCE   9  (bases 1 to 2028)
  AUTHORS   Latinkic,B.V., O'Brien,T.P. and Lau,L.F.
  TITLE     Promoter function and structure of the growth factor-inducible
            immediate early gene cyr61
  JOURNAL   Nucleic Acids Res 19 (12), 3261-3267 (1991)
   PUBMED   2062642
REFERENCE   10 (bases 1 to 2028)
  AUTHORS   O'Brien,T.P., Yang,G.P., Sanders,L. and Lau,L.F.
  TITLE     Expression of cyr61, a growth factor-inducible immediate-early gene
  JOURNAL   Mol Cell Biol 10 (7), 3569-3577 (1990)
   PUBMED   2355916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136729.7 and AK159452.1.
            
            On Jun 16, 2009 this sequence version replaced NM_010516.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159452.1, AK156723.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC136729.7         76016-76024
            10-2021             AK159452.1         2-2013
            2022-2028           AC136729.7         79024-79030
FEATURES             Location/Qualifiers
     source          1..2028
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 70.18 cM"
     gene            1..2028
                     /gene="Ccn1"
                     /gene_synonym="Cyr61; Igfbp10"
                     /note="cellular communication network factor 1"
                     /db_xref="GeneID:16007"
                     /db_xref="MGI:MGI:88613"
     exon            1..256
                     /gene="Ccn1"
                     /gene_synonym="Cyr61; Igfbp10"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1333
                     /gene="Ccn1"
                     /gene_synonym="Cyr61; Igfbp10"
                     /note="protein CYR61; 3CH61; IBP-10; IGFBP-10; CCN family
                     member 1; IGF-binding protein 10; cysteine-rich angiogenic
                     inducer 61; insulin-like growth factor-binding protein 10;
                     intermediate early; cysteine rich protein 61"
                     /codon_start=1
                     /product="CCN family member 1 precursor"
                     /protein_id="NP_034646.1"
                     /db_xref="CCDS:CCDS17895.1"
                     /db_xref="GeneID:16007"
                     /db_xref="MGI:MGI:88613"
                     /translation="MSSSTFRTLAVAVTLLHLTRLALSTCPAACHCPLEAPKCAPGVG
                     LVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEY
                     NSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVSGQCCEE
                     WVCDEDSIKDSLDDQDDLLGLDASEVELTRNNELIAIGKGSSLKRLPVFGTEPRVLFN
                     PLHAHGQKCIVQTTSWSQCSKSCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYS
                     SLKKGKKCSKTKKSPEPVRFTYAGCSSVKKYRPKYCGSCVDGRCCTPLQTRTVKMRFR
                     CEDGEMFSKNVMMIQSCKCNYNCPHPNEASFRLYSLFNDIHKFRD"
     exon            257..470
                     /gene="Ccn1"
                     /gene_synonym="Cyr61; Igfbp10"
                     /inference="alignment:Splign:2.1.0"
     exon            471..815
                     /gene="Ccn1"
                     /gene_synonym="Cyr61; Igfbp10"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1030
                     /gene="Ccn1"
                     /gene_synonym="Cyr61; Igfbp10"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..2028
                     /gene="Ccn1"
                     /gene_synonym="Cyr61; Igfbp10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2007..2012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccn1"
                     /gene_synonym="Cyr61; Igfbp10"
                     /note="hexamer: AAGAAA"
     polyA_site      2023
                     /gene="Ccn1"
                     /gene_synonym="Cyr61; Igfbp10"
                     /note="major polyA site"
ORIGIN      
        1 gggcagaccg tgagcgagag cgccccagag aagcgcctgc aatctctgcg cctcctccgc
       61 cagcacctcg agagaaggac acccgccgcc tcggccctcg cctcaccgca ctccgggcgc
      121 atttgatccc gctgctcgcc ggcttgttgg ttctgtgtcg ccgcgctcgc cccggttcct
      181 cctgcgcgcc acaatgagct ccagcacctt caggacgctc gctgtcgccg tcacccttct
      241 ccacttgacc agactggcgc tctccacctg ccccgccgcc tgccactgcc ctctggaggc
      301 acccaagtgc gccccgggag tcgggttggt ccgggacggc tgcggctgct gtaaggtctg
      361 cgctaaacaa ctcaacgagg actgcagcaa aactcagccc tgcgaccaca ccaaggggtt
      421 ggaatgcaat ttcggcgcca gctccaccgc tctgaaaggg atctgcagag ctcagtcaga
      481 aggcagaccc tgtgaatata actccagaat ctaccaaaac ggggaaagct tccagcccaa
      541 ctgtaaacac cagtgcacat gtattgatgg cgccgtgggc tgcattcctc tgtgtcccca
      601 agaactgtct ctccccaatc tgggctgtcc caacccccgg ctggtgaaag tcagcgggca
      661 gtgctgtgaa gagtgggttt gtgatgaaga cagcattaag gactccctgg acgaccagga
      721 tgacctcctc ggactcgatg cctcggaggt ggagttaacg agaaacaatg agttaatcgc
      781 aattggaaaa ggcagctcac tgaagaggct tcctgtcttt ggcaccgaac cgcgagttct
      841 tttcaaccct ctgcacgccc atggccagaa atgcatcgtt cagaccacgt cttggtccca
      901 gtgctccaag agctgcggaa ctggcatctc cacacgagtt accaatgaca acccagagtg
      961 ccgcctggtg aaagagaccc ggatctgtga agtgcgtcct tgtggacaac cagtgtacag
     1021 cagcctaaaa aagggcaaga aatgcagcaa gaccaagaaa tccccagaac cagtcagatt
     1081 tacttatgca ggatgctcca gtgtcaagaa ataccggccc aaatactgcg gctcctgcgt
     1141 agatggccgg tgctgcacac ctctgcagac cagaactgtg aagatgcggt tccgatgcga
     1201 agatggagag atgttttcca agaatgtcat gatgatccag tcctgcaaat gtaactacaa
     1261 ctgcccgcat cccaacgagg catcgttccg actgtacagc ctattcaatg acatccacaa
     1321 gttcagggac taagtgcctc cagggttcct agtgtgggct ggacagagga gaagcgcaag
     1381 catcatggag acgtgggtgg gcggaggatg aatggtgcct tgctcattct tgagtagcat
     1441 tagggtattt caaaactgcc aaggggctga tgtggacgga cagcagcgca gccgcagttg
     1501 gagaatgcca aggggctgat gtggacggac agcagcgcag ccgcagttgg agaagacttc
     1561 gcttcatagt actggagcgg gcattattgc tccatattgg agcatgttta cggatgacgt
     1621 tctgttttct gtttgtaaat tatttgctaa gtgtattttt ttgctccaga cccccccccc
     1681 cctttcttgg ttctacaatt gtaatagaga caaaataaga ttagttgggc caagtgaaag
     1741 ccctgcttgt cctttgacag aagtaaatga aagcgcctct cattccttcc cgagcggagg
     1801 ggggacactc tgtgagtgtc cttggggcag ctacctgcac tctaaaactg caaacagaaa
     1861 ccaggtgttt taagattgaa tgttttttta tttatcaaag tgtagctttt ggggagggag
     1921 gggaaatgta atactggaat aatttgtaaa tgattttaat tttatatcag tgaagagaat
     1981 ttatttataa aattaatcat ttaataaaga aatatttacc taatatct
//
