LOCUS       NM_001372363            2269 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus cerebral cavernous malformation 2-like (Ccm2l),
            transcript variant 1, mRNA.
ACCESSION   NM_001372363 XM_006499325
VERSION     NM_001372363.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Choi,J.P., Yang,X., He,S., Song,R., Xu,Z.R., Foley,M., Wong,J.J.,
            Xu,C.R. and Zheng,X.
  TITLE     CCM2L (Cerebral Cavernous Malformation 2 Like) Deletion Aggravates
            Cerebral Cavernous Malformation Through Map3k3-KLF Signaling
            Pathway
  JOURNAL   Stroke 52 (4), 1428-1436 (2021)
   PUBMED   33657857
  REMARK    GeneRIF: CCM2L (Cerebral Cavernous Malformation 2 Like) Deletion
            Aggravates Cerebral Cavernous Malformation Through Map3k3-KLF
            Signaling Pathway.
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Rosen,J.N., Sogah,V.M., Ye,L.Y. and Mably,J.D.
  TITLE     ccm2-like is required for cardiovascular development as a novel
            component of the Heg-CCM pathway
  JOURNAL   Dev Biol 376 (1), 74-85 (2013)
   PUBMED   23328253
  REMARK    GeneRIF: ccm2-like is required for cardiovascular development as a
            novel component of the Heg-CCM pathway.
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Zheng,X., Xu,C., Smith,A.O., Stratman,A.N., Zou,Z., Kleaveland,B.,
            Yuan,L., Didiku,C., Sen,A., Liu,X., Skuli,N., Zaslavsky,A.,
            Chen,M., Cheng,L., Davis,G.E. and Kahn,M.L.
  TITLE     Dynamic regulation of the cerebral cavernous malformation pathway
            controls vascular stability and growth
  JOURNAL   Dev Cell 23 (2), 342-355 (2012)
   PUBMED   22898778
  REMARK    GeneRIF: Loss of CCM2L reduces endocardial growth factor expression
            and impairs tumor growth and wound healing
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928862.13.
            
            On Aug 30, 2019 this sequence version replaced XM_006499325.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3655466.1,
                                           SRR13422600.1940190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AL928862.13        69748-69829
            83-250              AL928862.13        71553-71720
            251-334             AL928862.13        74434-74517
            335-518             AL928862.13        74615-74798
            519-973             AL928862.13        75551-76005
            974-1109            AL928862.13        78565-78700
            1110-1173           AL928862.13        80194-80257
            1174-1303           AL928862.13        82275-82404
            1304-1442           AL928862.13        83186-83324
            1443-2269           AL928862.13        84702-85528
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 75.41 cM"
     gene            1..2269
                     /gene="Ccm2l"
                     /note="cerebral cavernous malformation 2-like"
                     /db_xref="GeneID:228788"
                     /db_xref="MGI:MGI:2385159"
     exon            1..82
                     /gene="Ccm2l"
                     /inference="alignment:Splign:2.1.0"
     exon            83..250
                     /gene="Ccm2l"
                     /inference="alignment:Splign:2.1.0"
     exon            251..334
                     /gene="Ccm2l"
                     /inference="alignment:Splign:2.1.0"
     exon            335..518
                     /gene="Ccm2l"
                     /inference="alignment:Splign:2.1.0"
     exon            519..973
                     /gene="Ccm2l"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1109
                     /gene="Ccm2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1173
                     /gene="Ccm2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1303
                     /gene="Ccm2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1442
                     /gene="Ccm2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..2269
                     /gene="Ccm2l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2242..2247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccm2l"
                     /note="hexamer: AATAAA"
     polyA_site      2269
                     /gene="Ccm2l"
                     /note="major polyA site"
ORIGIN      
        1 gggggtctgg agggggagag gagggtggca ggacaagagg agcagtttca ccatggaata
       61 tgaagccaag aaagggaaga agggctttgt gtcccccatc cgaagactgg tgttcccgaa
      121 ggctgcacgc caggctgcct tcagaagcag tgtcagtcgc aggcccctgc actctatgcc
      181 tctttatccc cctgactacc tcatcgaccc ccacatcctg ctgtgtgact acctggagaa
      241 agaggtcaag ttcctgggtc acctcacctg ggtgacttcc tcactgaacc cctccagccg
      301 agacgagctc ctgcagcttc tggacactgc caggcagctg aaggagttgc ctctgaagac
      361 cacgccagag caggacagca tcctgagcct gtccgcacgc tgcctgctgc tcacctggcg
      421 cgacaatgag gagctcatcc tgcgcatccc gacgcacgag attgctgctg cctcctacct
      481 gcaggacgac gctctgcatc tgctagtgct taagactggt ctgggggtgg accctgtgcc
      541 cgcgggcatg gatggcagcc cgggaggttc gggtcgcgat cccggccctc cgggcgccgc
      601 gcccgagaaa cgacgggtag gcacagccga gcgacgccac accatctgca gcctggactg
      661 gcgcgtggcg tggggcgggg gcgcgggcgc cgaggcccgg gcggcgggag gcggcggcag
      721 cctggagcgg cagcgcgcgg gagcgagggc gtcgggcagc tgggagcggc gacagacgtt
      781 cagtggcagc tgggagcgac ggcacgcggg cggaggtgcg ggcaagccgg gtggcagctg
      841 ggagcggcgg caggcgagtg gcggcgtcgg cggcagctgg gagcgacgcc acccgggccc
      901 caacccgctg gatccccaga accacagccc cgacgcctac tgcaacctgg tcattctggc
      961 tgtggcaaac agggatgccg ctgaggaatc ctgtgcgctc atctgtcaag tcttccagat
     1021 catctacggg gaccagagca tcgagtgtgt agaccgggcc ggctaccact acagatccac
     1081 accaaagcgg ccatggctct ccagctgcag tgagagctgt cgtacggacg ggacgtttgc
     1141 ctatgatgcc gacttgagct gctgcagctc cttcaatggc tcccaggaca catttgaagc
     1201 gtgctacagt ggcgcatcca caccgtcttt ccacggctcc cactgcagca gtatcgacca
     1261 cagcagctgg gccttcgagc agctacagga ttacatggtc acgctgcgga gtaagctggg
     1321 tcctcctgag atccagcagt ttgcattgct gctacgagac tatcgtctgg ggctgcctat
     1381 ccaggactac tgtgcaggtc tgcagaaact ctatggggac cgacggaagt tccttctcat
     1441 tggaatgcgg cccttcatcc cagatcagga catcggctac ttcgagggct tcctggagag
     1501 tatgggtatc cgcgagggcg gaatcctcac tgacagcttt ggccgcatca agcgcagcat
     1561 gagctccacg tctgcctctg ctgtgcgcag ttacgacggg gcggcccaga ggcccgaggt
     1621 gcagaccttc caccagctgc tagccgacat cactcatgac attgaggcgc tggcccctga
     1681 cgacgacgac gtctatgagg atgtctcccc aagcgggggc gaccaggttg aagacaacta
     1741 cctgtagctc tgcggcacac ttacccatac gacatcatcc ccagtatgcc tagactcctg
     1801 ggttcccatc tgtaccttct gggcttcttt ccttgcaaat gggttccctt gcaaatgggt
     1861 tcctagggct tcagtcctgc aataccgaga agatcctgca gagggcggga tagtcagtgt
     1921 tcttcaagat aaagaatcgc tccacctact ggcggacaga aaagatttcc aattcacgcc
     1981 ccactttctg caaacctgcc caaccccaaa ccagaaacat ttccagaacc tagagacctc
     2041 tcttcaattt tacaggctaa gaaactgaag agactttggg gggagttgtt tgtttgtttt
     2101 taagggaatg gatttgaggg aacaccaggt tcccatttcc acatctctac gataatttca
     2161 gctccaccca cctcacaggt ggtcattgga gtgaatggag ggcaagagct tagtgttggg
     2221 cctagcatgc tgtaggtgct caataaatgc tgtttctctc cgcttggaa
//
