LOCUS       NM_011338               3008 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 9 (Ccl9), mRNA.
ACCESSION   NM_011338
VERSION     NM_011338.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3008)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3008)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3008)
  AUTHORS   Ikuta,K., Fukuda,A., Ogawa,S., Masuo,K., Goto,N., Hiramatsu,Y.,
            Tsuda,M., Kimura,Y., Matsumoto,Y., Kimura,Y., Maruno,T., Kanda,K.,
            Nishi,K., Takaori,K., Uemoto,S., Takaishi,S., Chiba,T., Nishi,E.
            and Seno,H.
  TITLE     Nardilysin inhibits pancreatitis and suppresses pancreatic ductal
            adenocarcinoma initiation in mice
  JOURNAL   Gut 68 (5), 882-892 (2019)
   PUBMED   29798841
REFERENCE   4  (bases 1 to 3008)
  AUTHORS   Li,B., Zhang,S., Huang,N., Chen,H., Wang,P., Yang,J. and Li,Z.
  TITLE     CCL9/CCR1 induces myeloid-derived suppressor cell recruitment to
            the spleen in a murine H22 orthotopic hepatoma model
  JOURNAL   Oncol Rep 41 (1), 608-618 (2019)
   PUBMED   30365155
  REMARK    GeneRIF: CCL9 secreted by splenic macrophages induces a
            CCR1dependent accumulation of MDSCs.
REFERENCE   5  (bases 1 to 3008)
  AUTHORS   Sakuma,Y., Kodama,Y., Eguchi,T., Uza,N., Tsuji,Y., Shiokawa,M.,
            Maruno,T., Kuriyama,K., Nishikawa,Y., Yamauchi,Y., Tsuda,M.,
            Ueda,T., Matsumori,T., Morita,T., Tomono,T., Kakiuchi,N., Mima,A.,
            Sogabe,Y., Marui,S., Kuwada,T., Okada,A., Watanabe,T., Nakase,H.,
            Chiba,T. and Seno,H.
  TITLE     Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced
            acute pancreatitis in mice
  JOURNAL   Sci Rep 8 (1), 8829 (2018)
   PUBMED   29891873
  REMARK    GeneRIF: In conclusion, Cxcl16 expressed in pancreatic acini
            contributes to the development of acinar cell necrosis through the
            induction of Ccl9 and subsequent neutrophil infiltration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3008)
  AUTHORS   Fukuda,S., Hanano,Y., Iio,M., Miura,R., Yoshie,O. and Nomiyama,H.
  TITLE     Genomic organization of the genes for human and mouse CC chemokine
            LEC
  JOURNAL   DNA Cell Biol 18 (4), 275-283 (1999)
   PUBMED   10235110
REFERENCE   7  (bases 1 to 3008)
  AUTHORS   Krulova,M., Havelkova,H., Kosarova,M., Holan,V., Hart,A.A.,
            Demant,P. and Lipoldova,M.
  TITLE     IL-2-induced proliferative response is controlled by loci Cinda1
            and Cinda2 on mouse chromosomes 11 and 12: a distinct control of
            the response induced by different IL-2 concentrations
  JOURNAL   Genomics 42 (1), 11-15 (1997)
   PUBMED   9177770
REFERENCE   8  (bases 1 to 3008)
  AUTHORS   Hara,T., Bacon,K.B., Cho,L.C., Yoshimura,A., Morikawa,Y.,
            Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Schall,T.J. and
            Miyajima,A.
  TITLE     Molecular cloning and functional characterization of a novel member
            of the C-C chemokine family
  JOURNAL   J Immunol 155 (11), 5352-5358 (1995)
   PUBMED   7594550
REFERENCE   9  (bases 1 to 3008)
  AUTHORS   Youn,B.S., Jang,I.K., Broxmeyer,H.E., Cooper,S., Jenkins,N.A.,
            Gilbert,D.J., Copeland,N.G., Elick,T.A., Fraser,M.J. Jr. and
            Kwon,B.S.
  TITLE     A novel chemokine, macrophage inflammatory protein-related
            protein-2, inhibits colony formation of bone marrow myeloid
            progenitors
  JOURNAL   J Immunol 155 (5), 2661-2667 (1995)
   PUBMED   7650394
REFERENCE   10 (bases 1 to 3008)
  AUTHORS   Poltorak,A.N., Bazzoni,F., Smirnova,I.I., Alejos,E., Thompson,P.,
            Luheshi,G., Rothwell,N. and Beutler,B.
  TITLE     MIP-1 gamma: molecular cloning, expression, and biological
            activities of a novel CC chemokine that is constitutively secreted
            in vivo
  JOURNAL   J Inflamm 45 (3), 207-219 (1995)
   PUBMED   8597875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB950873.1, BE626870.1, AK151649.1 and AL596122.14.
            
            On Jan 20, 2006 this sequence version replaced NM_011338.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155032.1, AK151649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-427               CB950873.1         4-430
            428-688             BE626870.1         276-536
            689-1646            AK151649.1         557-1514
            1647-3008           AL596122.14        84260-85621         c
FEATURES             Location/Qualifiers
     source          1..3008
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.81 cM"
     gene            1..3008
                     /gene="Ccl9"
                     /gene_synonym="CCF18; MRP-2; Scya10; Scya9"
                     /note="C-C motif chemokine ligand 9"
                     /db_xref="GeneID:20308"
                     /db_xref="MGI:MGI:104533"
     exon            1..248
                     /gene="Ccl9"
                     /gene_synonym="CCF18; MRP-2; Scya10; Scya9"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..541
                     /gene="Ccl9"
                     /gene_synonym="CCF18; MRP-2; Scya10; Scya9"
                     /note="C-C motif chemokine 9; macrophage inflammatory
                     protein 1-gamma; macrophage inflammatory protein-related
                     protein 2; small inducible cytokine A10; small inducible
                     cytokine A9; MIP-1 gamma; chemokine (C-C motif) ligand 9"
                     /codon_start=1
                     /product="C-C motif chemokine 9 precursor"
                     /protein_id="NP_035468.1"
                     /db_xref="CCDS:CCDS25170.1"
                     /db_xref="GeneID:20308"
                     /db_xref="MGI:MGI:104533"
                     /translation="MKPFHTALSFLILTTALGIWAQITHATETKEVQSSLKAQQGLEI
                     EMFHMGFQDSSDCCLSYNSRIQCSRFIGYFPTSGGCTRPGIIFISKRGFQVCANPSDR
                     RVQRCIERLEQNSQPRTYKQ"
     exon            249..320
                     /gene="Ccl9"
                     /gene_synonym="CCF18; MRP-2; Scya10; Scya9"
                     /inference="alignment:Splign:2.1.0"
     exon            321..429
                     /gene="Ccl9"
                     /gene_synonym="CCF18; MRP-2; Scya10; Scya9"
                     /inference="alignment:Splign:2.1.0"
     exon            430..3008
                     /gene="Ccl9"
                     /gene_synonym="CCF18; MRP-2; Scya10; Scya9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1243..1248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl9"
                     /gene_synonym="CCF18; MRP-2; Scya10; Scya9"
                     /note="hexamer: AATAAA"
     polyA_site      1265
                     /gene="Ccl9"
                     /gene_synonym="CCF18; MRP-2; Scya10; Scya9"
                     /note="major polyA site"
     regulatory      2009..2014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl9"
                     /gene_synonym="CCF18; MRP-2; Scya10; Scya9"
                     /note="hexamer: ATTAAA"
     polyA_site      2030
                     /gene="Ccl9"
                     /gene_synonym="CCF18; MRP-2; Scya10; Scya9"
     regulatory      2987..2992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl9"
                     /gene_synonym="CCF18; MRP-2; Scya10; Scya9"
                     /note="hexamer: AGTAAA"
     polyA_site      3007
                     /gene="Ccl9"
                     /gene_synonym="CCF18; MRP-2; Scya10; Scya9"
ORIGIN      
        1 actgcacact gttccctctc ttagaactag catgttgggt gttatgtagt caaaggaggg
       61 cattatgagc tgtaccccag ggacttcctg atcctcttac atgtataaat agcaagaccg
      121 ggccaggaac agcaagcagt ctgaaggcca gctgggtctg cccactaaga agatgaagcc
      181 ttttcatact gccctctcct tcctcattct tacaactgct cttggaatct gggcccagat
      241 cacacatgca acagagacaa aagaagtcca gagcagtctg aaggcacagc aagggcttga
      301 aattgaaatg tttcacatgg gctttcaaga ctcttcagat tgctgcctgt cctataactc
      361 acggattcag tgttcaagat ttataggtta ttttcccacc agtggtgggt gtaccaggcc
      421 gggcatcatc tttatcagca agagggggtt ccaggtctgt gccaacccca gtgatcggag
      481 agttcagaga tgcattgaaa gattggagca aaactcacaa ccacggacct acaaacaata
      541 acatttgctt gaagagaagg gtgtgaactg ccagctactt tctttggtct tccccagtga
      601 ccacctaagt ggctctaagt gtttattttt ataggtatat aaacattttt tttttctgtt
      661 ccactttaaa gtggcatatc tggctttgtc acagagggga aacttgtctg tgccaacccc
      721 agtcatctga aaactcagat gcctggaagg tctgaagctg acctcaatga ctacacataa
      781 tatttgattg agataaatgg gcaaggtctg gagagatggc ttggtggtta agagcacctg
      841 ctgctcttcc agaggacctg ggttcaattc ccacttagat ggcagctcaa actatctata
      901 attccaattc caaagaaaac tgatgcccta ttttgccctt tagttagtag tatttacagt
      961 attctttata aattcacctt gacatgacca tcttgagcta cagccatcct aactgcctca
     1021 gaatcactca agttcttcca ctcggtttcc cagcggattt taagtggata aactgtgaga
     1081 gtggtctgtg ggactttgga atgtgtctgg ttctgatagt cacttatggc aacccaggta
     1141 cattcaacta ggatgaaata aattctgcct tagcccagta gtatgtctgt gtttgtaagg
     1201 acccagctga ttttcccacc acccctccat cagtaagcca ctaataaagt gcatctatgc
     1261 agccacaggt ctgtctgcct cttttgcttc agtttcctag gactatgggc tgaaattggg
     1321 ctgttaggga gaaagcatct cactcgcttt tattgaatct gcagtggaaa agaaacagag
     1381 ggagtcaggt aactttgaat attttcttca aaacaaaaga tatcatggta caattttttt
     1441 ttaatttttt gtttgtttgt ttttgttttt cgagacaggg tttctctgtg tagccctggc
     1501 tgtcctggaa ctcactctgt agaccaggtt ggcctccaac tcagaaatcc gcctgcctct
     1561 gcctcccgag tgctgggatt aaaggcgtgc gccaccacca cccggcccat ggtacaattt
     1621 ttaaatttcc agaaatatag tttattccaa tgtagacttc atatcaagga tgtattttac
     1681 ccactataga gagaatcatt aaagtgatct acaaatcttt ggaagttctc cctgttcgat
     1741 aagatcctca attctattcg aggatctcaa cttggtcagc ttgtttttat accagtctca
     1801 tgctgttttt ttactgtggc tctgtatgat aatcccttca gcagtgtctc tattgttcag
     1861 gggtgtttgg gttacctaag atcttttgtg tttccatatg aattttaaga ttgttatttt
     1921 caaaatctgt gaagaattgc attggaattt tgatgggaat tgcaatgaat ctataaattt
     1981 tttttgataa gctgaccatt gtcaaaatat taaactagac catgagcata ggtggtcttt
     2041 ccatcttctg ggtcttcttt gattgtttta gagttttcat tgtataggcc ttttgcttta
     2101 ttcattaggt ttattccaag atattatttt gcaggtattg agagtgggat tttcctccca
     2161 atttcttcct cagtatgttt gtcatttgct tataggaaga ctattggttt ttttgtatgt
     2221 gcagatcgtg tcctgacact tggctgaaag tgtttatcag ctctacgagt tttctagtgt
     2281 agcatttagg gccttttata gagagagaaa gaatgatatc atctgccaat gaatattgct
     2341 tgacttcttc ctttcctgtt tgaatccatc ttgtctcctt ctcttgcctt actgctgtag
     2401 caaaaacttc aagtactcag ctgaaaagaa gtactgagag aaagtatcca tgtccctttc
     2461 ctgattttta gcagaaatgc ttccagtttt tctccggtta gcattccgtt ggctacaggc
     2521 ttgttgtata tttcctttat tgtattgaaa tacgttcctt gtatttctgt tgtcttcagg
     2581 gctttaataa tgaagagctg ttggttttca ccacaggcat tttctgaatc tactttctgc
     2641 tttcttgaat tgagtccatt tatacagtgg atctcattta ctgatttatg tatgttgaac
     2701 atccctgcaa gtctggaatg aagctcttta tgatttcaga aaacagattt ttcttagtcc
     2761 tcatttgtaa cctctccccc tagcctgaaa cctggctgct caggtttcac tgttagcagg
     2821 aagagagcgt ggggtggacc taccgcccta tcgttctgcc actcccactg cggctgcctg
     2881 ccacctagct gttcctgagc caacacgtgg tcacctgcaa ctggactcct aggatgattt
     2941 ggcgggaatg ggcccctccc cctttttata acccagtgtc tggaatagta aaattgaacc
     3001 ttggtcag
//
