LOCUS       NP_035468                122 aa            linear   ROD 28-APR-2025
DEFINITION  C-C motif chemokine 9 precursor [Mus musculus].
ACCESSION   NP_035468
VERSION     NP_035468.1
DBSOURCE    REFSEQ: accession NM_011338.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 122)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 122)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 122)
  AUTHORS   Ikuta,K., Fukuda,A., Ogawa,S., Masuo,K., Goto,N., Hiramatsu,Y.,
            Tsuda,M., Kimura,Y., Matsumoto,Y., Kimura,Y., Maruno,T., Kanda,K.,
            Nishi,K., Takaori,K., Uemoto,S., Takaishi,S., Chiba,T., Nishi,E.
            and Seno,H.
  TITLE     Nardilysin inhibits pancreatitis and suppresses pancreatic ductal
            adenocarcinoma initiation in mice
  JOURNAL   Gut 68 (5), 882-892 (2019)
   PUBMED   29798841
REFERENCE   4  (residues 1 to 122)
  AUTHORS   Li,B., Zhang,S., Huang,N., Chen,H., Wang,P., Yang,J. and Li,Z.
  TITLE     CCL9/CCR1 induces myeloid-derived suppressor cell recruitment to
            the spleen in a murine H22 orthotopic hepatoma model
  JOURNAL   Oncol Rep 41 (1), 608-618 (2019)
   PUBMED   30365155
  REMARK    GeneRIF: CCL9 secreted by splenic macrophages induces a
            CCR1dependent accumulation of MDSCs.
REFERENCE   5  (residues 1 to 122)
  AUTHORS   Sakuma,Y., Kodama,Y., Eguchi,T., Uza,N., Tsuji,Y., Shiokawa,M.,
            Maruno,T., Kuriyama,K., Nishikawa,Y., Yamauchi,Y., Tsuda,M.,
            Ueda,T., Matsumori,T., Morita,T., Tomono,T., Kakiuchi,N., Mima,A.,
            Sogabe,Y., Marui,S., Kuwada,T., Okada,A., Watanabe,T., Nakase,H.,
            Chiba,T. and Seno,H.
  TITLE     Chemokine CXCL16 mediates acinar cell necrosis in cerulein induced
            acute pancreatitis in mice
  JOURNAL   Sci Rep 8 (1), 8829 (2018)
   PUBMED   29891873
  REMARK    GeneRIF: In conclusion, Cxcl16 expressed in pancreatic acini
            contributes to the development of acinar cell necrosis through the
            induction of Ccl9 and subsequent neutrophil infiltration.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 122)
  AUTHORS   Fukuda,S., Hanano,Y., Iio,M., Miura,R., Yoshie,O. and Nomiyama,H.
  TITLE     Genomic organization of the genes for human and mouse CC chemokine
            LEC
  JOURNAL   DNA Cell Biol 18 (4), 275-283 (1999)
   PUBMED   10235110
REFERENCE   7  (residues 1 to 122)
  AUTHORS   Krulova,M., Havelkova,H., Kosarova,M., Holan,V., Hart,A.A.,
            Demant,P. and Lipoldova,M.
  TITLE     IL-2-induced proliferative response is controlled by loci Cinda1
            and Cinda2 on mouse chromosomes 11 and 12: a distinct control of
            the response induced by different IL-2 concentrations
  JOURNAL   Genomics 42 (1), 11-15 (1997)
   PUBMED   9177770
REFERENCE   8  (residues 1 to 122)
  AUTHORS   Hara,T., Bacon,K.B., Cho,L.C., Yoshimura,A., Morikawa,Y.,
            Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Schall,T.J. and
            Miyajima,A.
  TITLE     Molecular cloning and functional characterization of a novel member
            of the C-C chemokine family
  JOURNAL   J Immunol 155 (11), 5352-5358 (1995)
   PUBMED   7594550
REFERENCE   9  (residues 1 to 122)
  AUTHORS   Youn,B.S., Jang,I.K., Broxmeyer,H.E., Cooper,S., Jenkins,N.A.,
            Gilbert,D.J., Copeland,N.G., Elick,T.A., Fraser,M.J. Jr. and
            Kwon,B.S.
  TITLE     A novel chemokine, macrophage inflammatory protein-related
            protein-2, inhibits colony formation of bone marrow myeloid
            progenitors
  JOURNAL   J Immunol 155 (5), 2661-2667 (1995)
   PUBMED   7650394
REFERENCE   10 (residues 1 to 122)
  AUTHORS   Poltorak,A.N., Bazzoni,F., Smirnova,I.I., Alejos,E., Thompson,P.,
            Luheshi,G., Rothwell,N. and Beutler,B.
  TITLE     MIP-1 gamma: molecular cloning, expression, and biological
            activities of a novel CC chemokine that is constitutively secreted
            in vivo
  JOURNAL   J Inflamm 45 (3), 207-219 (1995)
   PUBMED   8597875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB950873.1, BE626870.1, AK151649.1 and AL596122.14.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155032.1, AK151649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..122
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.81 cM"
     Protein         1..122
                     /product="C-C motif chemokine 9 precursor"
                     /note="C-C motif chemokine 9; macrophage inflammatory
                     protein 1-gamma; macrophage inflammatory protein-related
                     protein 2; small inducible cytokine A10; small inducible
                     cytokine A9; MIP-1 gamma; chemokine (C-C motif) ligand 9"
                     /calculated_mol_wt=11557
     sig_peptide     1..21
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P51670.1)"
                     /calculated_mol_wt=2332
     mat_peptide     22..122
                     /product="C-C motif chemokine 9. /id=PRO_0000005192"
                     /note="propagated from UniProtKB/Swiss-Prot (P51670.1)"
                     /calculated_mol_wt=11557
     mat_peptide     50..122
                     /product="CCL9(29-101).
                     /evidence=ECO:0000269|PubMed:15905581. /id=PRO_0000041865"
                     /note="propagated from UniProtKB/Swiss-Prot (P51670.1)"
                     /calculated_mol_wt=8359
     mat_peptide     51..122
                     /product="CCL9(30-101).
                     /evidence=ECO:0000269|PubMed:15905581. /id=PRO_0000041866"
                     /note="propagated from UniProtKB/Swiss-Prot (P51670.1)"
                     /calculated_mol_wt=8302
     mat_peptide     52..122
                     /product="CCL9(31-101).
                     /evidence=ECO:0000269|PubMed:15905581. /id=PRO_0000041867"
                     /note="propagated from UniProtKB/Swiss-Prot (P51670.1)"
                     /calculated_mol_wt=8155
     Region          54..111
                     /region_name="SCY"
                     /note="Intercrine alpha family (small cytokine C-X-C)
                     (chemokine CXC); smart00199"
                     /db_xref="CDD:197570"
     Site            order(57..61,62..69,79..80,102..112)
                     /site_type="active"
                     /note="putative receptor binding site [active]"
                     /db_xref="CDD:238170"
     Site            order(59,61,73,75,80,85..87,95..97,103..104,107..108,
                     111..112)
                     /site_type="other"
                     /note="tetramer interface [polypeptide binding]"
                     /db_xref="CDD:238170"
     Site            order(59,61,77,79..80,86,94,96)
                     /site_type="other"
                     /note="dimer interface (P form) [polypeptide binding]"
                     /db_xref="CDD:238170"
     Site            order(59,86,95)
                     /site_type="active"
                     /note="putative receptor binding cleft [active]"
                     /db_xref="CDD:238170"
     Site            order(59..61,62..69)
                     /site_type="active"
                     /note="N-loop [active]"
                     /db_xref="CDD:238170"
     Site            order(61,73,75,85,87,95,97,103..104,107..108,111..112)
                     /site_type="other"
                     /note="dimer interface (I form) [polypeptide binding]"
                     /db_xref="CDD:238170"
     Site            order(62..64,67..69,91,93)
                     /site_type="other"
                     /note="putative glycosaminoglycan (GAG) binding site
                     [chemical binding]"
                     /db_xref="CDD:238170"
     Site            order(75,82,100,102,105..106,109)
                     /site_type="other"
                     /note="putative glycosaminoglycan (GAG) binding site
                     [chemical binding]"
                     /db_xref="CDD:238170"
     Site            79..80
                     /site_type="other"
                     /note="30s-loop"
                     /db_xref="CDD:238170"
     Site            order(89,91)
                     /site_type="other"
                     /note="40s-loop"
                     /db_xref="CDD:238170"
     CDS             1..122
                     /gene="Ccl9"
                     /gene_synonym="CCF18; MRP-2; Scya10; Scya9"
                     /coded_by="NM_011338.2:173..541"
                     /db_xref="CCDS:CCDS25170.1"
                     /db_xref="GeneID:20308"
                     /db_xref="MGI:MGI:104533"
ORIGIN      
        1 mkpfhtalsf lilttalgiw aqithatetk evqsslkaqq gleiemfhmg fqdssdccls
       61 ynsriqcsrf igyfptsggc trpgiifisk rgfqvcanps drrvqrcier leqnsqprty
      121 kq
//
