LOCUS       NM_021443                517 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus C-C motif chemokine ligand 8 (Ccl8), mRNA.
ACCESSION   NM_021443 XM_001480890
VERSION     NM_021443.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Sun,Z., Sen,H., Zhu,X. and Islam,S.A.
  TITLE     Cutting Edge: CCR8 Signaling Regulates IL-25- and IL-33-Responsive
            Skin Group 2 Innate Lymphoid Cell Migration and Function
  JOURNAL   J Immunol 211 (12), 1751-1755 (2023)
   PUBMED   37921466
REFERENCE   3  (bases 1 to 517)
  AUTHORS   Kim,H.S., Lee,H.K., Kim,K., Ahn,G.B., Kim,M.S., Lee,T.Y., Son,D.J.,
            Kim,Y., Hong,J.T. and Han,S.B.
  TITLE     Mesenchymal stem cells enhance CCL8 expression by podocytes in
            lupus-prone MRL.Faslpr mice
  JOURNAL   Sci Rep 13 (1), 13074 (2023)
   PUBMED   37567910
  REMARK    GeneRIF: Mesenchymal stem cells enhance CCL8 expression by
            podocytes in lupus-prone MRL.Fas[lpr] mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 517)
  AUTHORS   Lee,Y., Lee,J., Park,M., Seo,A., Kim,K.H., Kim,S., Kang,M.,
            Kang,E., Yoo,K.D., Lee,S., Kim,D.K., Oh,K.H., Kim,Y.S., Joo,K.W.
            and Yang,S.H.
  TITLE     Inflammatory chemokine (C-C motif) ligand 8 inhibition ameliorates
            peritoneal fibrosis
  JOURNAL   FASEB J 37 (1), e22632 (2023)
   PUBMED   36468785
  REMARK    GeneRIF: Inflammatory chemokine (C-C motif) ligand 8 inhibition
            ameliorates peritoneal fibrosis.
REFERENCE   5  (bases 1 to 517)
  AUTHORS   Naderi,A., Farmaki,E., Chavez,B., Cai,C., Kaza,V., Zhang,Y.,
            Soltanmohammadi,E., Daneshvar,N., Chatzistamou,I. and Kiaris,H.
  TITLE     Beneficial effects of CCL8 inhibition at lipopolysaccharide-induced
            lung injury
  JOURNAL   iScience 25 (12), 105520 (2022)
   PUBMED   36404927
REFERENCE   6  (bases 1 to 517)
  AUTHORS   Tsou,C.L., Peters,W., Si,Y., Slaymaker,S., Aslanian,A.M.,
            Weisberg,S.P., Mack,M. and Charo,I.F.
  TITLE     Critical roles for CCR2 and MCP-3 in monocyte mobilization from
            bone marrow and recruitment to inflammatory sites
  JOURNAL   J Clin Invest 117 (4), 902-909 (2007)
   PUBMED   17364026
REFERENCE   7  (bases 1 to 517)
  CONSRTM   IUIS/WHO Subcommittee on Chemokine Nomenclature
  TITLE     Chemokine/chemokine receptor nomenclature
  JOURNAL   J Immunol Methods 262 (1-2), 1-3 (2002)
   PUBMED   12080938
REFERENCE   8  (bases 1 to 517)
  AUTHORS   Wagner,K., Dendorfer,U., Chilla,S., Schlondorff,D. and Luckow,B.
  TITLE     Identification of new regulatory sequences far upstream of the
            mouse monocyte chemoattractant protein-1 gene
  JOURNAL   Genomics 78 (3), 113-123 (2001)
   PUBMED   11735217
REFERENCE   9  (bases 1 to 517)
  AUTHORS   Cohen-Tannoudji,M., Vandormael-Pournin,S., Le Bras,S.,
            Coumailleau,F., Babinet,C. and Baldacci,P.
  TITLE     A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus
            region on mouse chromosome 11
  JOURNAL   Genomics 68 (3), 273-282 (2000)
   PUBMED   10995569
REFERENCE   10 (bases 1 to 517)
  AUTHORS   Van Damme,J., Proost,P., Lenaerts,J.P. and Opdenakker,G.
  TITLE     Structural and functional identification of two human,
            tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3)
            belonging to the chemokine family
  JOURNAL   J Exp Med 176 (1), 59-65 (1992)
   PUBMED   1613466
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY707942.1, BC117101.1, BX639248.1 and AI449326.1.
            
            On Aug 11, 2009 this sequence version replaced NM_021443.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK793037.1, CJ137042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BY707942.1         2-9
            9-455               BC117101.1         7-453
            456-502             BX639248.1         12-58               c
            503-517             AI449326.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 49.91 cM"
     gene            1..517
                     /gene="Ccl8"
                     /gene_synonym="1810063B20Rik; HC14; MCP-2; Mcp2; Scya8"
                     /note="C-C motif chemokine ligand 8"
                     /db_xref="GeneID:20307"
                     /db_xref="MGI:MGI:101878"
     exon            1..128
                     /gene="Ccl8"
                     /gene_synonym="1810063B20Rik; HC14; MCP-2; Mcp2; Scya8"
                     /inference="alignment:Splign:2.1.0"
     exon            129..240
                     /gene="Ccl8"
                     /gene_synonym="1810063B20Rik; HC14; MCP-2; Mcp2; Scya8"
                     /inference="alignment:Splign:2.1.0"
     exon            241..511
                     /gene="Ccl8"
                     /gene_synonym="1810063B20Rik; HC14; MCP-2; Mcp2; Scya8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      481..486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl8"
                     /gene_synonym="1810063B20Rik; HC14; MCP-2; Mcp2; Scya8"
                     /note="hexamer: AATAAA"
     polyA_site      511
                     /gene="Ccl8"
                     /gene_synonym="1810063B20Rik; HC14; MCP-2; Mcp2; Scya8"
                     /note="major polyA site"
ORIGIN      
        1 agagttagat tgagaggacg ctagccttca ctccaaaatc tttgccttca acatgaagat
       61 ctacgcagtg cttctttgcc tgctgctcat agctgtccct gtcagcccag agaagctgac
      121 tgggccagat aaggctccag tcacctgctg ctttcatgta ctaaagctga agatccccct
      181 tcgggtgctg aaaagctacg agagaatcaa caatatccag tgccccatgg aagctgtggt
      241 tttccagacc aagcagggta tgtctctctg tgtagacccc acacagaagt gggtcagtga
      301 gtacatggag atccttgacc agaagtctca aattctgcag ccttgaacct tcacacctga
      361 gttaagagac agccaaagct ggaagttctc ccctaatctt ctccaggcag agagatgtta
      421 caagcagatg gtgcctgggc tgcgtgtttt ctcatccttg tctgttatat gaacaactga
      481 aataaaagct tacactgatt tgcaaatgta aaaaaaa
//
