LOCUS       NM_013653                579 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 5 (Ccl5), mRNA.
ACCESSION   NM_013653
VERSION     NM_013653.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 579)
  AUTHORS   Yu,W., Yao,Y., Ye,N., Zhao,Y., Ye,Z., Wei,W., Zhang,L. and Chen,J.
  TITLE     The myokine CCL5 recruits subcutaneous preadipocytes and promotes
            intramuscular fat deposition in obese mice
  JOURNAL   Am J Physiol Cell Physiol 326 (5), C1320-C1333 (2024)
   PUBMED   38497114
  REMARK    GeneRIF: The myokine CCL5 recruits subcutaneous preadipocytes and
            promotes intramuscular fat deposition in obese mice.
REFERENCE   2  (bases 1 to 579)
  AUTHORS   Costa,R.M., Cerqueira,D.M., Bruder-Nascimento,A., Alves,J.V.,
            Awata,W.M.C., Singh,S., Kufner,A., Prado,D.S., Johny,E.,
            Cifuentes-Pagano,E., Hawse,W.F., Dutta,P., Pagano,P.J., Ho,J. and
            Bruder-Nascimento,T.
  TITLE     Role of the CCL5 and Its Receptor, CCR5, in the Genesis of
            Aldosterone-Induced Hypertension, Vascular Dysfunction, and
            End-Organ Damage
  JOURNAL   Hypertension 81 (4), 776-786 (2024)
   PUBMED   38240165
  REMARK    GeneRIF: Role of the CCL5 and Its Receptor, CCR5, in the Genesis of
            Aldosterone-Induced Hypertension, Vascular Dysfunction, and
            End-Organ Damage.
REFERENCE   3  (bases 1 to 579)
  AUTHORS   Liao,X., Zeng,Q., Xie,L., Zhang,H., Hu,W., Xiao,L., Zhou,H.,
            Wang,F., Xie,W., Song,J., Sun,X., Wang,D., Ding,Y., Jiao,Y.,
            Mai,W., Aini,W., Hui,X., Liu,W., Hsueh,W.A. and Deng,T.
  TITLE     Adipose stem cells control obesity-induced T cell infiltration into
            adipose tissue
  JOURNAL   Cell Rep 43 (3), 113963 (2024)
   PUBMED   38492218
REFERENCE   4  (bases 1 to 579)
  AUTHORS   Zhao,F., Zhu,G., He,J., Xu,X., Zhu,W., Jiang,W. and He,G.
  TITLE     CircMAPK1 promoted CD8 + T cell infiltration in LUAD by improving
            the IGF2BP1 dependent CCL5 upregulation
  JOURNAL   Int Immunopharmacol 127, 111267 (2024)
   PUBMED   38091827
  REMARK    GeneRIF: CircMAPK1 promoted CD8 + T cell infiltration in LUAD by
            improving the IGF2BP1 dependent CCL5 upregulation.
REFERENCE   5  (bases 1 to 579)
  AUTHORS   Wang,J., Zhao,F., Xu,L., Wang,J., Zhai,J., Ren,L. and Zhu,G.
  TITLE     C-C Motif Chemokine Ligand 5 (CCL5) Promotes Irradiation-Evoked
            Osteoclastogenesis
  JOURNAL   Int J Mol Sci 24 (22), 16168 (2023)
   PUBMED   38003358
  REMARK    GeneRIF: C-C Motif Chemokine Ligand 5 (CCL5) Promotes
            Irradiation-Evoked Osteoclastogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 579)
  AUTHORS   Shin,H.S., Drysdale,B.E., Shin,M.L., Noble,P.W., Fisher,S.N. and
            Paznekas,W.A.
  TITLE     Definition of a lipopolysaccharide-responsive element in the
            5'-flanking regions of MuRantes and crg-2
  JOURNAL   Mol Cell Biol 14 (5), 2914-2925 (1994)
   PUBMED   7513046
REFERENCE   7  (bases 1 to 579)
  AUTHORS   Danoff,T.M., Lalley,P.A., Chang,Y.S., Heeger,P.S. and Neilson,E.G.
  TITLE     Cloning, genomic organization, and chromosomal localization of the
            Scya5 gene encoding the murine chemokine RANTES
  JOURNAL   J Immunol 152 (3), 1182-1189 (1994)
   PUBMED   7507961
REFERENCE   8  (bases 1 to 579)
  AUTHORS   Schall,T.J., Simpson,N.J. and Mak,J.Y.
  TITLE     Molecular cloning and expression of the murine RANTES cytokine:
            structural and functional conservation between mouse and man
  JOURNAL   Eur J Immunol 22 (6), 1477-1481 (1992)
   PUBMED   1376260
REFERENCE   9  (bases 1 to 579)
  AUTHORS   Heeger,P., Wolf,G., Meyers,C., Sun,M.J., O'Farrell,S.C.,
            Krensky,A.M. and Neilson,E.G.
  TITLE     Isolation and characterization of cDNA from renal tubular
            epithelium encoding murine Rantes
  JOURNAL   Kidney Int 41 (1), 220-225 (1992)
   PUBMED   1375672
REFERENCE   10 (bases 1 to 579)
  AUTHORS   Schall,T.J., Jongstra,J., Dyer,B.J., Jorgensen,J., Clayberger,C.,
            Davis,M.M. and Krensky,A.M.
  TITLE     A human T cell-specific molecule is a member of a new gene family
  JOURNAL   J Immunol 141 (3), 1018-1025 (1988)
   PUBMED   2456327
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003101.1 and BE333205.1.
            
            On Jan 15, 2008 this sequence version replaced NM_013653.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033508.1, AK003101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-509               AK003101.1         2-510
            510-579             BE333205.1         279-348
FEATURES             Location/Qualifiers
     source          1..579
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.66 cM"
     gene            1..579
                     /gene="Ccl5"
                     /gene_synonym="MuRantes; RANTES; Scya5; SISd; TCP228"
                     /note="C-C motif chemokine ligand 5"
                     /db_xref="GeneID:20304"
                     /db_xref="MGI:MGI:98262"
     exon            1..133
                     /gene="Ccl5"
                     /gene_synonym="MuRantes; RANTES; Scya5; SISd; TCP228"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..333
                     /gene="Ccl5"
                     /gene_synonym="MuRantes; RANTES; Scya5; SISd; TCP228"
                     /note="C-C motif chemokine 5; SIS-delta; small-inducible
                     cytokine A5; T-cell-specific protein RANTES; chemokine
                     (C-C motif) ligand 5"
                     /codon_start=1
                     /product="C-C motif chemokine 5 precursor"
                     /protein_id="NP_038681.2"
                     /db_xref="CCDS:CCDS36254.1"
                     /db_xref="GeneID:20304"
                     /db_xref="MGI:MGI:98262"
                     /translation="MKISAAALTIILTAAALCTPAPASPYGSDTTPCCFAYLSLALPR
                     AHVKEYFYTSSKCSNLAVVFVTRRNRQVCANPEKKWVQEYINYLEMS"
     exon            134..245
                     /gene="Ccl5"
                     /gene_synonym="MuRantes; RANTES; Scya5; SISd; TCP228"
                     /inference="alignment:Splign:2.1.0"
     exon            246..532
                     /gene="Ccl5"
                     /gene_synonym="MuRantes; RANTES; Scya5; SISd; TCP228"
                     /inference="alignment:Splign:2.1.0"
     regulatory      507..512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl5"
                     /gene_synonym="MuRantes; RANTES; Scya5; SISd; TCP228"
                     /note="hexamer: ATTAAA"
     polyA_site      532
                     /gene="Ccl5"
                     /gene_synonym="MuRantes; RANTES; Scya5; SISd; TCP228"
                     /note="major polyA site"
ORIGIN      
        1 cttgcagagg actctgagac agcacatgca tctcccacag cctctgccgc gggtaccatg
       61 aagatctctg cagctgccct caccatcatc ctcactgcag ccgccctctg cacccccgca
      121 cctgcctcac catatggctc ggacaccact ccctgctgct ttgcctacct ctccctcgcg
      181 ctgcctcgtg cccacgtcaa ggagtatttc tacaccagca gcaagtgctc caatcttgca
      241 gtcgtgtttg tcactcgaag gaaccgccaa gtgtgtgcca acccagagaa gaagtgggtt
      301 caagaataca tcaactattt ggagatgagc taggatagag ggtttcttga ttctgaccct
      361 gtatagcttc cctgtcattg cttgctctag tcctagccag cttggggatg ccactcagta
      421 atcccctact cccactcggt cctgggaaaa tgggcatctc agctgctccg aggctctgca
      481 cagcaaaccc aagaaatcag catttcatta aaatttcaga tgcaaggaca aaaaaaaaaa
      541 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
