LOCUS       NM_013652                674 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 4 (Ccl4), mRNA.
ACCESSION   NM_013652
VERSION     NM_013652.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 674)
  AUTHORS   Schorn,F., Werthenbach,J.P., Hoffmann,M., Daoud,M.,
            Stachelscheid,J., Schiffmann,L.M., Hildebrandt,X., Lyu,S.I.,
            Peltzer,N., Quaas,A., Vucic,D., Silke,J., Pasparakis,M. and
            Kashkar,H.
  TITLE     cIAPs control RIPK1 kinase activity-dependent and -independent cell
            death and tissue inflammation
  JOURNAL   EMBO J 42 (22), e113614 (2023)
   PUBMED   37789765
REFERENCE   2  (bases 1 to 674)
  AUTHORS   Nazarov,K., Perik-Zavodskii,R., Perik-Zavodskaia,O., Alrhmoun,S.,
            Volynets,M., Shevchenko,J. and Sennikov,S.
  TITLE     Murine Placental Erythroid Cells Are Mainly Represented by CD45+
            Immunosuppressive Erythroid Cells and Secrete CXCL1, CCL2, CCL3 and
            CCL4 Chemokines
  JOURNAL   Int J Mol Sci 24 (9), 8130 (2023)
   PUBMED   37175837
  REMARK    GeneRIF: Murine Placental Erythroid Cells Are Mainly Represented by
            CD45[+] Immunosuppressive Erythroid Cells and Secrete CXCL1, CCL2,
            CCL3 and CCL4 Chemokines.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 674)
  AUTHORS   Chang,T.T., Li,S.Y., Lin,L.Y., Chen,C. and Chen,J.W.
  TITLE     Macrophage inflammatory protein-1beta as a novel therapeutic target
            for renal protection in diabetic kidney disease
  JOURNAL   Biomed Pharmacother 161, 114450 (2023)
   PUBMED   36863097
  REMARK    GeneRIF: Macrophage inflammatory protein-1beta as a novel
            therapeutic target for renal protection in diabetic kidney disease.
REFERENCE   4  (bases 1 to 674)
  AUTHORS   Rosin,J.M., Tretiakov,N., Hanniman,E., Hampton,K. and Kurrasch,D.M.
  TITLE     Gestational Bisphenol A Exposure Impacts Embryonic Hypothalamic
            Microglia Numbers, Ramification, and Phagocytic Cups
  JOURNAL   Front Neurosci 16, 830399 (2022)
   PUBMED   35250464
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 674)
  AUTHORS   Gonzalez-Rodriguez,S., Lorenzo-Herrero,S., Sordo-Bahamonde,C.,
            Hidalgo,A., Gonzalez,S., Menendez,L. and Baamonde,A.
  TITLE     Involvement of CD4+ and CD8+ T-lymphocytes in the modulation of
            nociceptive processing evoked by CCL4 in mice
  JOURNAL   Life Sci 291, 120302 (2022)
   PUBMED   34999112
  REMARK    GeneRIF: Involvement of CD4(+) and CD8(+) T-lymphocytes in the
            modulation of nociceptive processing evoked by CCL4 in mice.
REFERENCE   6  (bases 1 to 674)
  AUTHORS   Post,T.W., Bozic,C.R., Rothenberg,M.E., Luster,A.D., Gerard,N. and
            Gerard,C.
  TITLE     Molecular characterization of two murine eosinophil beta chemokine
            receptors
  JOURNAL   J Immunol 155 (11), 5299-5305 (1995)
   PUBMED   7594543
REFERENCE   7  (bases 1 to 674)
  AUTHORS   Irving,S.G., Zipfel,P.F., Balke,J., McBride,O.W., Morton,C.C.,
            Burd,P.R., Siebenlist,U. and Kelly,K.
  TITLE     Two inflammatory mediator cytokine genes are closely linked and
            variably amplified on chromosome 17q
  JOURNAL   Nucleic Acids Res 18 (11), 3261-3270 (1990)
   PUBMED   1972563
REFERENCE   8  (bases 1 to 674)
  AUTHORS   Wilson,S.D., Billings,P.R., D'Eustachio,P., Fournier,R.E.,
            Geissler,E., Lalley,P.A., Burd,P.R., Housman,D.E., Taylor,B.A. and
            Dorf,M.E.
  TITLE     Clustering of cytokine genes on mouse chromosome 11
  JOURNAL   J Exp Med 171 (4), 1301-1314 (1990)
   PUBMED   1969921
REFERENCE   9  (bases 1 to 674)
  AUTHORS   Brown,K.D., Zurawski,S.M., Mosmann,T.R. and Zurawski,G.
  TITLE     A family of small inducible proteins secreted by leukocytes are
            members of a new superfamily that includes leukocyte and
            fibroblast-derived inflammatory agents, growth factors, and
            indicators of various activation processes
  JOURNAL   J Immunol 142 (2), 679-687 (1989)
   PUBMED   2521353
REFERENCE   10 (bases 1 to 674)
  AUTHORS   Sherry,B., Tekamp-Olson,P., Gallegos,C., Bauer,D., Davatelis,G.,
            Wolpe,S.D., Masiarz,F., Coit,D. and Cerami,A.
  TITLE     Resolution of the two components of macrophage inflammatory protein
            1, and cloning and characterization of one of those components,
            macrophage inflammatory protein 1 beta
  JOURNAL   J Exp Med 168 (6), 2251-2259 (1988)
   PUBMED   3058856
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY163868.1, AL596122.14 and BY157376.1.
            
            On Mar 1, 2007 this sequence version replaced NM_013652.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY752114.1, M23503.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-367               BY163868.1         2-368
            368-624             AL596122.14        175734-175990
            625-674             BY157376.1         282-331
FEATURES             Location/Qualifiers
     source          1..674
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.09 cM"
     gene            1..674
                     /gene="Ccl4"
                     /gene_synonym="Act-2; AT744.1; MIP-1B; Mip1b; Scya4"
                     /note="C-C motif chemokine ligand 4"
                     /db_xref="GeneID:20303"
                     /db_xref="MGI:MGI:98261"
     exon            1..155
                     /gene="Ccl4"
                     /gene_synonym="Act-2; AT744.1; MIP-1B; Mip1b; Scya4"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..358
                     /gene="Ccl4"
                     /gene_synonym="Act-2; AT744.1; MIP-1B; Mip1b; Scya4"
                     /note="C-C motif chemokine 4; ACT2; SIS-gamma; MIP-1-beta;
                     immune activation protein 2; small-inducible cytokine A4;
                     macrophage inflammatory protein 1-beta; chemokine (C-C
                     motif) ligand 4"
                     /codon_start=1
                     /product="C-C motif chemokine 4 precursor"
                     /protein_id="NP_038680.1"
                     /db_xref="CCDS:CCDS36256.1"
                     /db_xref="GeneID:20303"
                     /db_xref="MGI:MGI:98261"
                     /translation="MKLCVSALSLLLLVAAFCAPGFSAPMGSDPPTSCCFSYTSRQLH
                     RSFVMDYYETSSLCSKPAVVFLTKRGRQICANPSEPWVTEYMSDLELN"
     exon            156..270
                     /gene="Ccl4"
                     /gene_synonym="Act-2; AT744.1; MIP-1B; Mip1b; Scya4"
                     /inference="alignment:Splign:2.1.0"
     exon            271..660
                     /gene="Ccl4"
                     /gene_synonym="Act-2; AT744.1; MIP-1B; Mip1b; Scya4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      638..643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl4"
                     /gene_synonym="Act-2; AT744.1; MIP-1B; Mip1b; Scya4"
                     /note="hexamer: AATAAA"
     polyA_site      656
                     /gene="Ccl4"
                     /gene_synonym="Act-2; AT744.1; MIP-1B; Mip1b; Scya4"
                     /note="major polyA site"
ORIGIN      
        1 agcacagcac tcggccagct tctgaagctt ctgggccctg cagtcccagc tctgtgcaaa
       61 cctaaccccg agcaacacca tgaagctctg cgtgtctgcc ctctctctcc tcttgctcgt
      121 ggctgccttc tgtgctccag ggttctcagc accaatgggc tctgaccctc ccacttcctg
      181 ctgtttctct tacacctccc ggcagcttca cagaagcttt gtgatggatt actatgagac
      241 cagcagtctt tgctccaagc cagctgtggt attcctgacc aaaagaggca gacagatctg
      301 tgctaacccc agtgagccct gggtcactga gtacatgagt gacttggagt tgaactgagc
      361 agctccagcg gcagggcagg aggagccact tcaggagagg cctcctcagc cctgatgctt
      421 ctcactgaga agcgtccttg ctcctcacgt tcagatttcc tgcccctctt cttaatttaa
      481 atctctgtgt agactttgtt ttgttttttt gggggagtat tatttctatt atttatgttt
      541 tagttatagg acgcgtgtct cccatggaga tggtccacca ttgctgtttc tctgctattg
      601 tggatatgac tgtgaaattg atttcatgca ttttcataat aaatctttct ttaagatata
      661 aaaaaaaaaa aaaa
//
