LOCUS       NM_011337                804 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 3 (Ccl3), mRNA.
ACCESSION   NM_011337
VERSION     NM_011337.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 804)
  AUTHORS   Ross,J.L., Puigdelloses-Vallcorba,M., Pinero,G., Soni,N.,
            Thomason,W., DeSisto,J., Angione,A., Tsankova,N.M., Castro,M.G.,
            Schniederjan,M., Wadhwani,N.R., Raju,G.P., Morgenstern,P.,
            Becher,O.J., Green,A.L., Tsankov,A.M. and Hambardzumyan,D.
  TITLE     Microglia and monocyte-derived macrophages drive progression of
            pediatric high-grade gliomas and are transcriptionally shaped by
            histone mutations
  JOURNAL   Immunity 57 (11), 2669-2687 (2024)
   PUBMED   39395421
REFERENCE   2  (bases 1 to 804)
  AUTHORS   Nazarov,K., Perik-Zavodskii,R., Perik-Zavodskaia,O., Alrhmoun,S.,
            Volynets,M., Shevchenko,J. and Sennikov,S.
  TITLE     Acute blood loss in mice forces differentiation of both
            CD45-positive and CD45-negative erythroid cells and leads to a
            decreased CCL3 chemokine production by bone marrow erythroid cells
  JOURNAL   PLoS One 19 (9), e0309455 (2024)
   PUBMED   39231178
  REMARK    GeneRIF: Acute blood loss in mice forces differentiation of both
            CD45-positive and CD45-negative erythroid cells and leads to a
            decreased CCL3 chemokine production by bone marrow erythroid cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 804)
  AUTHORS   Rodrigo,M.B., De Min,A., Jorch,S.K., Martin-Higueras,C.,
            Baumgart,A.K., Goldyn,B., Becker,S., Garbi,N., Lemmermann,N.A. and
            Kurts,C.
  TITLE     Dual fluorescence reporter mice for Ccl3 transcription,
            translation, and intercellular communication
  JOURNAL   J Exp Med 221 (7) (2024)
   PUBMED   38661718
REFERENCE   4  (bases 1 to 804)
  AUTHORS   Li,H., Tang,Y., Liu,Z., Chen,K., Zhang,K., Hu,S., Pan,C., Yang,H.,
            Li,B. and Chen,H.
  TITLE     Lumbar instability remodels cartilage endplate to induce
            intervertebral disc degeneration by recruiting osteoclasts via
            Hippo-CCL3 signaling
  JOURNAL   Bone Res 12 (1), 34 (2024)
   PUBMED   38816384
  REMARK    GeneRIF: Lumbar instability remodels cartilage endplate to induce
            intervertebral disc degeneration by recruiting osteoclasts via
            Hippo-CCL3 signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 804)
  AUTHORS   Wang,X., Zhang,L., Zhou,Y., Wang,Y., Wang,X., Zhang,Y., Quan,A.,
            Mao,Y., Zhang,Y., Qi,J., Ren,Z., Gu,L., Yu,R. and Zhou,X.
  TITLE     Chronic Stress Exacerbates the Immunosuppressive Microenvironment
            and Progression of Gliomas by Reducing Secretion of CCL3
  JOURNAL   Cancer Immunol Res 12 (5), 516-529 (2024)
   PUBMED   38437646
  REMARK    GeneRIF: Chronic Stress Exacerbates the Immunosuppressive
            Microenvironment and Progression of Gliomas by Reducing Secretion
            of CCL3.
REFERENCE   6  (bases 1 to 804)
  AUTHORS   Matsue,H., Cruz,P.D. Jr., Bergstresser,P.R. and Takashima,A.
  TITLE     Langerhans cells are the major source of mRNA for IL-1 beta and
            MIP-1 alpha among unstimulated mouse epidermal cells
  JOURNAL   J Invest Dermatol 99 (5), 537-541 (1992)
   PUBMED   1385544
REFERENCE   7  (bases 1 to 804)
  AUTHORS   Heufler,C., Topar,G., Koch,F., Trockenbacher,B., Kampgen,E.,
            Romani,N. and Schuler,G.
  TITLE     Cytokine gene expression in murine epidermal cell suspensions:
            interleukin 1 beta and macrophage inflammatory protein 1 alpha are
            selectively expressed in Langerhans cells but are differentially
            regulated in culture
  JOURNAL   J Exp Med 176 (4), 1221-1226 (1992)
   PUBMED   1402664
REFERENCE   8  (bases 1 to 804)
  AUTHORS   Blackshear,P.J., Verghese,G.M., Johnson,J.D., Haupt,D.M. and
            Stumpo,D.J.
  TITLE     Characteristics of the F52 protein, a MARCKS homologue
  JOURNAL   J Biol Chem 267 (19), 13540-13546 (1992)
   PUBMED   1618855
REFERENCE   9  (bases 1 to 804)
  AUTHORS   Irving,S.G., Zipfel,P.F., Balke,J., McBride,O.W., Morton,C.C.,
            Burd,P.R., Siebenlist,U. and Kelly,K.
  TITLE     Two inflammatory mediator cytokine genes are closely linked and
            variably amplified on chromosome 17q
  JOURNAL   Nucleic Acids Res 18 (11), 3261-3270 (1990)
   PUBMED   1972563
REFERENCE   10 (bases 1 to 804)
  AUTHORS   Wilson,S.D., Billings,P.R., D'Eustachio,P., Fournier,R.E.,
            Geissler,E., Lalley,P.A., Burd,P.R., Housman,D.E., Taylor,B.A. and
            Dorf,M.E.
  TITLE     Clustering of cytokine genes on mouse chromosome 11
  JOURNAL   J Exp Med 171 (4), 1301-1314 (1990)
   PUBMED   1969921
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA895994.1, AK150634.1 and BX524012.1.
            
            On Mar 1, 2007 this sequence version replaced NM_011337.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA895994.1, AK150634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143, SAMN02415128
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AA895994.1         1-41
            42-789              AK150634.1         22-769
            790-804             BX524012.1         504-518
FEATURES             Location/Qualifiers
     source          1..804
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.04 cM"
     gene            1..804
                     /gene="Ccl3"
                     /gene_synonym="G0S19-1; LD78alpha; MIP-1alpha; MIP1-(a);
                     MIP1-alpha; Mip1a; Scya3"
                     /note="C-C motif chemokine ligand 3"
                     /db_xref="GeneID:20302"
                     /db_xref="MGI:MGI:98260"
     exon            1..177
                     /gene="Ccl3"
                     /gene_synonym="G0S19-1; LD78alpha; MIP-1alpha; MIP1-(a);
                     MIP1-alpha; Mip1a; Scya3"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..380
                     /gene="Ccl3"
                     /gene_synonym="G0S19-1; LD78alpha; MIP-1alpha; MIP1-(a);
                     MIP1-alpha; Mip1a; Scya3"
                     /note="C-C motif chemokine 3; TY-5; L2G25B; SIS-alpha;
                     MIP-1-alpha; small-inducible cytokine A3; heparin-binding
                     chemotaxis protein; macrophage inflammatory protein
                     1-alpha; MIP1 (a); macrophage inflammatory protein-1alpha;
                     chemokine (C-C motif) ligand 3"
                     /codon_start=1
                     /product="C-C motif chemokine 3 precursor"
                     /protein_id="NP_035467.1"
                     /db_xref="CCDS:CCDS36255.1"
                     /db_xref="GeneID:20302"
                     /db_xref="MGI:MGI:98260"
                     /translation="MKVSTTALAVLLCTMTLCNQVFSAPYGADTPTACCFSYSRKIPR
                     QFIVDYFETSSLCSQPGVIFLTKRNRQICADSKETWVQEYITDLELNA"
     exon            178..289
                     /gene="Ccl3"
                     /gene_synonym="G0S19-1; LD78alpha; MIP-1alpha; MIP1-(a);
                     MIP1-alpha; Mip1a; Scya3"
                     /inference="alignment:Splign:2.1.0"
     exon            290..790
                     /gene="Ccl3"
                     /gene_synonym="G0S19-1; LD78alpha; MIP-1alpha; MIP1-(a);
                     MIP1-alpha; Mip1a; Scya3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      766..771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl3"
                     /gene_synonym="G0S19-1; LD78alpha; MIP-1alpha; MIP1-(a);
                     MIP1-alpha; Mip1a; Scya3"
                     /note="hexamer: AATAAA"
     polyA_site      790
                     /gene="Ccl3"
                     /gene_synonym="G0S19-1; LD78alpha; MIP-1alpha; MIP1-(a);
                     MIP1-alpha; Mip1a; Scya3"
                     /note="major polyA site"
ORIGIN      
        1 gggcatatgg cttcagacac cagaaggata caagcagcag cgagtaccag tcccttttct
       61 gttctgctga caagctcacc ctctgtcacc tgctcaacat catgaaggtc tccaccactg
      121 cccttgctgt tcttctctgt accatgacac tctgcaacca agtcttctca gcgccatatg
      181 gagctgacac cccgactgcc tgctgcttct cctacagccg gaagattcca cgccaattca
      241 tcgttgacta ttttgaaacc agcagccttt gctcccagcc aggtgtcatt ttcctgacta
      301 agagaaaccg gcagatctgc gctgactcca aagagacctg ggtccaagaa tacatcactg
      361 acctggaact gaatgcctga gagtcttgga ggcagcgagg aaccccccaa acctccatgg
      421 gtcccgtgta gagcaggggc ttgagccccg gaacattcct gccacctgca tagctccatc
      481 tcctataagc tgtttgctgc caagtagcca catcgaggga ctcttcactt gaaattttat
      541 ttaatttaat cctattggtt taatactatt taattttgta atttatttta ttgtcatact
      601 tgtatttgtg actatttatt ctgaaagact tcaggacacg ttcctcaacc cccatctccc
      661 tcccagttgg tcacactgtt tggtgacagc tattctaggt agacatgatg acaaagtcat
      721 gaactgacaa atgtacaata gatgctttgt ttataccaga gaagtaataa atatgccctt
      781 taacaagtga aaaaaaaaaa aaaa
//
