LOCUS       NM_020279               3753 bp    mRNA    linear   ROD 20-AUG-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 28 (Ccl28), mRNA.
ACCESSION   NM_020279
VERSION     NM_020279.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3753)
  AUTHORS   Li,J.H., Zhao,S.J., Guo,Y., Chen,F., Traub,R.J., Wei,F. and
            Cao,D.Y.
  TITLE     Chronic stress induces wide-spread hyperalgesia: The involvement of
            spinal CCK1 receptors
  JOURNAL   Neuropharmacology 258, 110067 (2024)
   PUBMED   38992792
  REMARK    GeneRIF: Chronic stress induces wide-spread hyperalgesia: The
            involvement of spinal CCK1 receptors.
REFERENCE   2  (bases 1 to 3753)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3753)
  AUTHORS   Dhanushkodi,N.R., Prakash,S., Quadiri,A., Zayou,L., Srivastava,R.,
            Tran,J., Dang,V., Shaik,A.M., Chilukurri,A., Suzer,B., Vera,P.,
            Sun,M., Nguyen,P., Lee,A., Salem,A., Loi,J., Singer,M.,
            Nakayama,T., Vahed,H., Nesburn,A.B. and BenMohamed,L.
  TITLE     Mucosal CCL28 Chemokine Improves Protection against Genital Herpes
            through Mobilization of Antiviral Effector Memory CCR10+CD44+
            CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the
            Infected Vaginal Mucosa
  JOURNAL   J Immunol 211 (1), 118-129 (2023)
   PUBMED   37222480
  REMARK    GeneRIF: Mucosal CCL28 Chemokine Improves Protection against
            Genital Herpes through Mobilization of Antiviral Effector Memory
            CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells
            into the Infected Vaginal Mucosa.
REFERENCE   4  (bases 1 to 3753)
  AUTHORS   Yan,Y., Hu,K., Fu,M., Deng,X., Luo,S., Tong,L., Guan,X., He,S.,
            Li,C., Jin,W., Du,T., Zheng,Z., Zhang,M., Liu,Y. and Hu,Q.
  TITLE     CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein D To
            Induce Protective Systemic Immunity against Genital Viral Challenge
  JOURNAL   mSphere 6 (2), e00058-21 (2021)
   PUBMED   33910988
  REMARK    GeneRIF: CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein
            D To Induce Protective Systemic Immunity against Genital Viral
            Challenge.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3753)
  AUTHORS   Yan,J., Yuan,P., Gui,L., Wang,Z., Yin,P., Gao,W.Q. and Ma,B.
  TITLE     CCL28 Downregulation Attenuates Pancreatic Cancer Progression
            Through Tumor Cell-Intrinsic and -Extrinsic Mechanisms
  JOURNAL   Technol Cancer Res Treat 20, 15330338211068958 (2021)
   PUBMED   34939465
  REMARK    GeneRIF: CCL28 Downregulation Attenuates Pancreatic Cancer
            Progression Through Tumor Cell-Intrinsic and -Extrinsic Mechanisms.
REFERENCE   6  (bases 1 to 3753)
  AUTHORS   Hieshima,K., Ohtani,H., Shibano,M., Izawa,D., Nakayama,T.,
            Kawasaki,Y., Shiba,F., Shiota,M., Katou,F., Saito,T. and Yoshie,O.
  TITLE     CCL28 has dual roles in mucosal immunity as a chemokine with
            broad-spectrum antimicrobial activity
  JOURNAL   J Immunol 170 (3), 1452-1461 (2003)
   PUBMED   12538707
  REMARK    GeneRIF: CCL28 has dual functions in mucosal immunity as a
            chemokine attracting cells expressing CCR10 and/or CCR3 and also as
            an apically secreted molecule with a potent antimicrobial activity
            against a broad spectrum of microbes.
REFERENCE   7  (bases 1 to 3753)
  AUTHORS   Basu,S., Schaefer,T.M., Ghosh,M., Fuller,C.L. and Reinhart,T.A.
  TITLE     Molecular cloning and sequencing of 25 different rhesus macaque
            chemokine cDNAs reveals evolutionary conservation among C, CC, CXC,
            AND CX3C families of chemokines
  JOURNAL   Cytokine 18 (3), 140-148 (2002)
   PUBMED   12126650
REFERENCE   8  (bases 1 to 3753)
  CONSRTM   IUIS/WHO Subcommittee on Chemokine Nomenclature
  TITLE     Chemokine/chemokine receptor nomenclature
  JOURNAL   J Immunol Methods 262 (1-2), 1-3 (2002)
   PUBMED   12080938
REFERENCE   9  (bases 1 to 3753)
  AUTHORS   Pan,J., Kunkel,E.J., Gosslar,U., Lazarus,N., Langdon,P.,
            Broadwell,K., Vierra,M.A., Genovese,M.C., Butcher,E.C. and Soler,D.
  TITLE     A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial
            cells in mucosal tissues
  JOURNAL   J Immunol 165 (6), 2943-2949 (2000)
   PUBMED   10975800
REFERENCE   10 (bases 1 to 3753)
  AUTHORS   Wang,W., Soto,H., Oldham,E.R., Buchanan,M.E., Homey,B., Catron,D.,
            Jenkins,N., Copeland,N.G., Gilbert,D.J., Nguyen,N., Abrams,J.,
            Kershenovich,D., Smith,K., McClanahan,T., Vicari,A.P. and
            Zlotnik,A.
  TITLE     Identification of a novel chemokine (CCL28), which binds CCR10
            (GPR2)
  JOURNAL   J Biol Chem 275 (29), 22313-22323 (2000)
   PUBMED   10781587
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC040510.1.
            
            On Apr 6, 2007 this sequence version replaced NM_020279.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040510.1, BC055864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3753              BC040510.1         13-3765
FEATURES             Location/Qualifiers
     source          1..3753
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13"
     gene            1..3753
                     /gene="Ccl28"
                     /gene_synonym="CCK1; MEC; Scya28"
                     /note="C-C motif chemokine ligand 28"
                     /db_xref="GeneID:56838"
                     /db_xref="MGI:MGI:1861731"
     exon            1..118
                     /gene="Ccl28"
                     /gene_synonym="CCK1; MEC; Scya28"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..447
                     /gene="Ccl28"
                     /gene_synonym="CCK1; MEC; Scya28"
                     /note="C-C motif chemokine 28; small-inducible cytokine
                     A28; chemokine (C-C motif) ligand 28"
                     /codon_start=1
                     /product="C-C motif chemokine 28 precursor"
                     /protein_id="NP_064675.1"
                     /db_xref="CCDS:CCDS56900.1"
                     /db_xref="GeneID:56838"
                     /db_xref="MGI:MGI:1861731"
                     /translation="MQQAGLTLMAVAVCVAFQTSEAILPMASSCCTEVSHHVSGRLLE
                     RVSSCSIQRADGDCDLAAVILHVKRRRICISPHNRTLKQWMRASEVKKNGRENVCSGK
                     KQPSRKDRKGHTTRKHRTRGTHRHEASR"
     exon            119..245
                     /gene="Ccl28"
                     /gene_synonym="CCK1; MEC; Scya28"
                     /inference="alignment:Splign:2.1.0"
     exon            246..3740
                     /gene="Ccl28"
                     /gene_synonym="CCK1; MEC; Scya28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      502..507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl28"
                     /gene_synonym="CCK1; MEC; Scya28"
                     /note="hexamer: TATAAA"
     polyA_site      540
                     /gene="Ccl28"
                     /gene_synonym="CCK1; MEC; Scya28"
                     /note="major polyA site"
     regulatory      696..701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl28"
                     /gene_synonym="CCK1; MEC; Scya28"
                     /note="hexamer: TATAAA"
     polyA_site      726
                     /gene="Ccl28"
                     /gene_synonym="CCK1; MEC; Scya28"
     regulatory      3714..3719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl28"
                     /gene_synonym="CCK1; MEC; Scya28"
                     /note="hexamer: ATTAAA"
     polyA_site      3740
                     /gene="Ccl28"
                     /gene_synonym="CCK1; MEC; Scya28"
ORIGIN      
        1 cctgatccca cagcctcacc tgagtcattg ccagactcag tgggtcaggc gggaatgcag
       61 caagcagggc tcacactcat ggctgtggct gtgtgtgtgg cttttcaaac ctcagaagcc
      121 atacttccca tggcctccag ctgttgcact gaggtgtctc atcatgtttc cggaagactt
      181 ctggaaagag tgagttcatg cagcatccag agagctgacg gggactgcga cctggctgct
      241 gtcatccttc atgttaaacg tagaagaatc tgcatcagcc cgcacaatcg tactttgaag
      301 cagtggatga gagcctcaga ggtaaagaag aatggcagag aaaacgtatg ttctgggaaa
      361 aaacaaccca gcaggaagga cagaaaaggg cacactacga gaaagcacag aacacgtgga
      421 acacacaggc acgaagcctc tcgttagaac agacatgtga acctacagtg aactcctcaa
      481 gtgaactggc ccatatctgg ttataaattt ctcagctgaa tcttccttat tgacacctaa
      541 tgctttgtct tgtttcattt cgttttgttt tgttaatgaa taactgcagc taaggatgta
      601 agcacttggg ttgtacatgt aggttcaatc ccagcaccaa aagcaaaaca aacaaaactg
      661 tgcacaagta accaatatag ttaacttaaa aactatataa aatccatctt tatatataaa
      721 ttctaactat atagaattcc tccaactttt ttttattcaa gttttccagc tctacagagg
      781 agttgaaaga atggaacatg ggctatatac atacctgcca cctacattat tagtcactat
      841 taatctctct gtgtgtctct gtctctttct ctgtgtgtgt gtgtgtgtgt gtacatacat
      901 ataagaactt cttcactaaa tcatttgaaa agttgcaaac aacatgacct atatcttaat
      961 ccatttcttg ttattaaaag aacatttatg attaagtaac ccctaaagaa tgcaacttta
     1021 tttagttcag gttcctgagg tgagaacacc taagaccttg gcacttatat ctggttagca
     1081 tctagtgaag accttctcac tgggccttag tgtgacagct gcatatgacg agaatcctct
     1141 tccttttctt ataaagccac tagcatccgg gagaccacac ccatgtagcc tagtttaaca
     1201 ccaactacac tcaatgcccc atctccaaat gccaacatat ggatttaagg atacataaat
     1261 atctggagaa cacatagcaa cacttcagtc ctaatttcta gaatttcgct tgctatccct
     1321 caagaataaa cacgttttcc taaataatta cactagcagt tttataccgg gaaagcaaac
     1381 aattccatat tgtctatatt caaatttctt tatttccaga tcactttata taattctttt
     1441 caatctagct cacctattgc ctttttttgt gctttagtgt tttcaatata aaatcatctc
     1501 tcaggtgttc tctttcctgt cttccttctc ttacttcata gcacagactt ttagaaagag
     1561 taaagattag agctagctct acatcccagg tttgtctgac tggtcctggt ggtcagactt
     1621 ttccatttca agcttcctag gaagatttgt acacttcttg tctcctttgt ggctctataa
     1681 catcattttc taagtaggag ggtataagcc aagtaagtgg tgcttagagg tttgagtagc
     1741 tatgaccctg ttgtaaactc tagcactgag aaacctggcc tcactgtcca gaaacttctc
     1801 tcttctgttg tggttctcag agcaatggct gtattataaa tacagggatc agtcctggat
     1861 tggtgggtaa ttttgtattg ttcttaacaa gaatcaatca atcaatctct ctctctctcg
     1921 ctctcgctct ctctctctcc cctttctatc tcccctctgt ctctctctct ctgtgtgtgg
     1981 ggtgtgttgt gtgtgttgag taaagctcga gtctgctcct ggcttccttt ggatgaagat
     2041 gtagaactct cagctcctcc agcacaatgg gtgttgctgg gcttcctgcc aacaattaaa
     2101 tattgacttt tataagaaag aacagagaga gagagagaga gagagagaga gagagagaga
     2161 gagagagaga gagaagcgca tggagctctg actggcccag aaccagctaa gcagaccagg
     2221 ctggtcccaa actcacagag atccacctag cttcctaaat gctaggatca aaggcatgca
     2281 ccaccgcact tgactctaga agcccatttt tttaaaactc ccaatcgatc tcctccctgt
     2341 tttctgagtt gattcacttt ggagaagttt agacacatgg taaaagctca ttttccagga
     2401 gagccattag agcaggggca ggttttcagg gtgtgaggtg tccttgatgc cttgggcagt
     2461 tccaggtggt ggattatagg attacctgga ggtacaaata gcacacaaag aagtgtcccc
     2521 attcctggac tcttacaggt tctccttgca ggccccacag tgcgctgagt tatgtggaca
     2581 tggagatggg aagggaactc tgtcacttgt gttcccaaag ggcaagggga ctcatgctgg
     2641 tttatagcat gaacacatct gccaccagca ctgtgggtga tgattcttgg caaaagccac
     2701 attcatagac caagatgggc ctcaacctga ctcaatgcac ttaaccacat accctcaaag
     2761 cagaggaaac tgcgaaatgc ttcagttttt ggtttgtgac agcttttcat caggtcagtc
     2821 ttagaaacta tcattaagtt ttgtccggaa gtatagcatt tttctgttcg actctggcat
     2881 gactttgaga ggcatcacca aagtgcaggc ctaaatgcca aagaaagcaa cactggattt
     2941 aaaattgtag taaatacaat aaataagatc aaagcaagtc acagatttta aatttgtcct
     3001 gatggtcatg ctgaaaagtt aaaaggaaaa ccaaaacatt gatctttgag cattttaatt
     3061 gatcatttga atcagataaa tgtttttgtt ttatttctgc ttataacaca tcatccataa
     3121 tttgatacaa tttggagttg atataattga cagaattttg tacgctatat tttaaaaact
     3181 ggctgctatg gtttgggtaa gtgtcctcaa cggcctgtgt attgaaggtt tgcttgttct
     3241 tcatcctgtg gtgctcctgg gaagcaggga aaaactggaa tgtggagtct tcccttcagg
     3301 gtgtgtcctg tctttgtttc acaccaccaa gaagcaagca gcttccttgg tctcatattt
     3361 ccaccacaaa atattctgtc tgccacaggc ccagtggtaa tggatcacag gctgaaactt
     3421 ctaaaatcga gagccaaaat aaacctttct gctttttaag ttgatttgtc tcaagtactt
     3481 gttacagaaa cggaggatga atgcaaagat tttattgtaa tgtaaatagc taatgagatt
     3541 atcaaaataa aaaagctctt agagactacc atatgtgctt agtaaaatat gttttattat
     3601 aataaataca atattgtgct gtaagtactg ttactatacc acaagttact taaagtacta
     3661 agtcacccag gttaatgtgt aagccttttt tttttaatgt attctcattc tttattaaaa
     3721 actatacaat ttattataaa aaaaaaaaaa aaa
//
