LOCUS       NM_001164044             370 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 27A (Ccl27a), transcript
            variant 3, mRNA.
ACCESSION   NM_001164044
VERSION     NM_001164044.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 370)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 370)
  AUTHORS   Davila,M.L., Xu,M., Huang,C., Gaddes,E.R., Winter,L.,
            Cantorna,M.T., Wang,Y. and Xiong,N.
  TITLE     CCL27 is a crucial regulator of immune homeostasis of the skin and
            mucosal tissues
  JOURNAL   iScience 25 (6), 104426 (2022)
   PUBMED   35663027
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 370)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 370)
  AUTHORS   Xiao,C., Zhou,Q., Li,X., Li,H., Zhong,Y., Meng,T., Zhu,M., Sun,H.,
            Liu,S., Tang,R., Pu,J., Xu,Y. and Xiao,P.
  TITLE     Losartan and Dexamethasone may inhibit chemotaxis to reduce the
            infiltration of Th22 cells in IgA nephropathy
  JOURNAL   Int Immunopharmacol 42, 203-208 (2017)
   PUBMED   27930971
  REMARK    GeneRIF: this study shows that losartan and dexamethasone may
            suppress inflammatory responses in IgA nephropathy by inhibiting
            CCL27 expression in Th22 cells
REFERENCE   5  (bases 1 to 370)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 370)
  AUTHORS   Morales,J., Homey,B., Vicari,A.P., Hudak,S., Oldham,E., Hedrick,J.,
            Orozco,R., Copeland,N.G., Jenkins,N.A., McEvoy,L.M. and Zlotnik,A.
  TITLE     CTACK, a skin-associated chemokine that preferentially attracts
            skin-homing memory T cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14470-14475 (1999)
   PUBMED   10588729
REFERENCE   7  (bases 1 to 370)
  AUTHORS   Baird,J.W., Nibbs,R.J., Komai-Koma,M., Connolly,J.A.,
            Ottersbach,K., Clark-Lewis,I., Liew,F.Y. and Graham,G.J.
  TITLE     ESkine, a novel beta-chemokine, is differentially spliced to
            produce secretable and nuclear targeted isoforms
  JOURNAL   J Biol Chem 274 (47), 33496-33503 (1999)
   PUBMED   10559234
REFERENCE   8  (bases 1 to 370)
  AUTHORS   Ishikawa-Mochizuki,I., Kitaura,M., Baba,M., Nakayama,T., Izawa,D.,
            Imai,T., Yamada,H., Hieshima,K., Suzuki,R., Nomiyama,H. and
            Yoshie,O.
  TITLE     Molecular cloning of a novel CC chemokine, interleukin-11 receptor
            alpha-locus chemokine (ILC), which is located on chromosome 9p13
            and a potential homologue of a CC chemokine encoded by molluscum
            contagiosum virus
  JOURNAL   FEBS Lett 460 (3), 544-548 (1999)
   PUBMED   10556532
REFERENCE   9  (bases 1 to 370)
  AUTHORS   Hromas,R., Broxmeyer,H.E., Kim,C., Christopherson,K. 2nd and
            Hou,Y.H.
  TITLE     Isolation of ALP, a novel divergent murine CC chemokine with a
            unique carboxy terminal extension
  JOURNAL   Biochem Biophys Res Commun 258 (3), 737-740 (1999)
   PUBMED   10329455
REFERENCE   10 (bases 1 to 370)
  AUTHORS   Forger,J.M. 3rd, Bronson,R.T., Huang,A.S. and Reiss,C.S.
  TITLE     Murine infection by vesicular stomatitis virus: initial
            characterization of the H-2d system
  JOURNAL   J Virol 65 (9), 4950-4958 (1991)
   PUBMED   1651414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807796.17 and AK005753.1.
            
            On Mar 13, 2018 this sequence version replaced NM_001164044.1.
            
            Transcript Variant: This variant (3) differs in the 3' UTR and
            coding region, compared to variant 1. The encoded isoform (3) is
            shorter and has a distinct C-terminus, compared to isoform 1.
            Variants 3 and 4 encode the same isoform (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF104370.1, BU530998.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AL807796.17        130712-130762       c
            52-366              AK005753.1         5-319
            367-370             AL807796.17        129772-129775       c
FEATURES             Location/Qualifiers
     source          1..370
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 22.08 cM"
     gene            1..370
                     /gene="Ccl27a"
                     /gene_synonym="ALP; Ccl27; CTACK; CTAK; ESkine; ILC;
                     PESKY; Scya27; Scya27a"
                     /note="C-C motif chemokine ligand 27A"
                     /db_xref="GeneID:20301"
                     /db_xref="MGI:MGI:1343459"
     exon            1..77
                     /gene="Ccl27a"
                     /gene_synonym="ALP; Ccl27; CTACK; CTAK; ESkine; ILC;
                     PESKY; Scya27; Scya27a"
                     /inference="alignment:Splign:2.1.0"
     exon            78..145
                     /gene="Ccl27a"
                     /gene_synonym="ALP; Ccl27; CTACK; CTAK; ESkine; ILC;
                     PESKY; Scya27; Scya27a"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..362
                     /gene="Ccl27a"
                     /gene_synonym="ALP; Ccl27; CTACK; CTAK; ESkine; ILC;
                     PESKY; Scya27; Scya27a"
                     /note="isoform 3 is encoded by transcript variant 3; C-C
                     motif chemokine 27; small inducible cytokine A27a;
                     skinkine; skinskine; CC chemokine ILC; IL-11 R-alpha-locus
                     chemokine; cutaneous T-cell-attracting chemokine;
                     chemokine (C-C motif) ligand 27A"
                     /codon_start=1
                     /product="C-C motif chemokine 27 isoform 3"
                     /protein_id="NP_001157516.1"
                     /db_xref="CCDS:CCDS51144.1"
                     /db_xref="GeneID:20301"
                     /db_xref="MGI:MGI:1343459"
                     /translation="MSRLRRYEVALEAEEEIYWGCFYFFPWLRMWRRERSSAHPREQK
                     LEPLRGLMSCLSSGLRPAPQRSGRGLLCRTPTAAAQTAGALKI"
     exon            146..205
                     /gene="Ccl27a"
                     /gene_synonym="ALP; Ccl27; CTACK; CTAK; ESkine; ILC;
                     PESKY; Scya27; Scya27a"
                     /inference="alignment:Splign:2.1.0"
     exon            206..370
                     /gene="Ccl27a"
                     /gene_synonym="ALP; Ccl27; CTACK; CTAK; ESkine; ILC;
                     PESKY; Scya27; Scya27a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttaacggtc cgtttccggg gcggagccag ggagggcggg gagtttaggc tgtgccgacc
       61 cctgagcccc ccttcaggaa ccgttcggag ccccggacat gtcgcgattg aggagatacg
      121 aggtggcgct ggaagcggag gaggagatct actggggctg cttctacttt tttccttggc
      181 tgcgaatgtg gcgcagggag cggagctcgg cgcacccccg ggagcagaag ctggagcctc
      241 tgcggggcct aatgagctgt ttgtcgagcg gcctgaggcc tgctccccag cgctcgggtc
      301 gtggtctcct ctgtcgcacc cccaccgctg ctgcacagac agccggtgca ttaaagattt
      361 aaagtcacgc
//
