LOCUS       NM_009138               1073 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 25 (Ccl25), transcript
            variant 1, mRNA.
ACCESSION   NM_009138
VERSION     NM_009138.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1073)
  AUTHORS   Xie,D., Ma,Y., Gao,C. and Pan,S.
  TITLE     Piezo1 activation on microglial cells exacerbates demyelination in
            sepsis by influencing the CCL25/GRP78 pathway
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113045 (2024)
   PUBMED   39236454
  REMARK    GeneRIF: Piezo1 activation on microglial cells exacerbates
            demyelination in sepsis by influencing the CCL25/GRP78 pathway.
REFERENCE   2  (bases 1 to 1073)
  AUTHORS   Grammer,C., Komorowska,J.A. and Swann,J.B.
  TITLE     Vhl safeguards thymic epithelial cell identity and thymopoietic
            capacity by constraining Hif1a activity during development
  JOURNAL   iScience 27 (7), 110258 (2024)
   PUBMED   39040069
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1073)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1073)
  AUTHORS   Li,J., Zhao,C., Wang,D., Wang,S., Dong,H., Wang,D., Yang,Y., Li,J.,
            Cui,F., He,X. and Qin,J.
  TITLE     ZIM3 activation of CCL25 expression in pulmonary metastatic nodules
            of osteosarcoma recruits M2 macrophages to promote metastatic
            growth
  JOURNAL   Cancer Immunol Immunother 72 (4), 903-916 (2023)
   PUBMED   36161509
  REMARK    GeneRIF: ZIM3 activation of CCL25 expression in pulmonary
            metastatic nodules of osteosarcoma recruits M2 macrophages to
            promote metastatic growth.
REFERENCE   5  (bases 1 to 1073)
  AUTHORS   Tereshchenko,V., Bulygin,A., Zavodskii,R., Maksyutov,A.,
            Kurilin,V., Fisher,M., Semenyuk,N., Aladev,S. and Sennikov,S.
  TITLE     The murine DCs transfected with DNA-plasmid encoding CCR9
            demonstrate the increased migration to CCL25 and thymic cells in
            vitro and to the thymus in vivo
  JOURNAL   Cytokine 142, 155473 (2021)
   PUBMED   33647585
  REMARK    GeneRIF: The murine DCs transfected with DNA-plasmid encoding CCR9
            demonstrate the increased migration to CCL25 and thymic cells in
            vitro and to the thymus in vivo.
REFERENCE   6  (bases 1 to 1073)
  AUTHORS   Townson,J.R. and Nibbs,R.J.
  TITLE     Characterization of mouse CCX-CKR, a receptor for the
            lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and
            MIP-3beta/mCCL19: comparison to human CCX-CKR
  JOURNAL   Eur J Immunol 32 (5), 1230-1241 (2002)
   PUBMED   11981810
  REMARK    GeneRIF: Characterization of mouse CCX-CKR, a receptor for the
            lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and
            MIP-3beta/mCCL19: comparison to human CCX-CKR.  (CCX-CKR)
REFERENCE   7  (bases 1 to 1073)
  AUTHORS   Bleul,C.C. and Boehm,T.
  TITLE     Chemokines define distinct microenvironments in the developing
            thymus
  JOURNAL   Eur J Immunol 30 (12), 3371-3379 (2000)
   PUBMED   11093154
  REMARK    Erratum:[Eur J Immunol 2001 Feb;31(2):675]
REFERENCE   8  (bases 1 to 1073)
  AUTHORS   Norment,A.M., Bogatzki,L.Y., Gantner,B.N. and Bevan,M.J.
  TITLE     Murine CCR9, a chemokine receptor for thymus-expressed chemokine
            that is up-regulated following pre-TCR signaling
  JOURNAL   J Immunol 164 (2), 639-648 (2000)
   PUBMED   10623805
REFERENCE   9  (bases 1 to 1073)
  AUTHORS   Wurbel,M.A., Philippe,J.M., Nguyen,C., Victorero,G., Freeman,T.,
            Wooding,P., Miazek,A., Mattei,M.G., Malissen,M., Jordan,B.R.,
            Malissen,B., Carrier,A. and Naquet,P.
  TITLE     The chemokine TECK is expressed by thymic and intestinal epithelial
            cells and attracts double- and single-positive thymocytes
            expressing the TECK receptor CCR9
  JOURNAL   Eur J Immunol 30 (1), 262-271 (2000)
   PUBMED   10602049
REFERENCE   10 (bases 1 to 1073)
  AUTHORS   Vicari,A.P., Figueroa,D.J., Hedrick,J.A., Foster,J.S., Singh,K.P.,
            Menon,S., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Bacon,K.B. and
            Zlotnik,A.
  TITLE     TECK: a novel CC chemokine specifically expressed by thymic
            dendritic cells and potentially involved in T cell development
  JOURNAL   Immunity 7 (2), 291-301 (1997)
   PUBMED   9285413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK131875.1, AK134138.1 and DQ158256.1.
            
            On Apr 21, 2010 this sequence version replaced NM_009138.2.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ158256.1, AK134138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AK131875.1         2-17
            17-1036             AK134138.1         2-1021
            1037-1073           DQ158256.1         1022-1058
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 2.01 cM"
     gene            1..1073
                     /gene="Ccl25"
                     /gene_synonym="A130072A22Rik; CKb15; Scya25; TECK"
                     /note="C-C motif chemokine ligand 25"
                     /db_xref="GeneID:20300"
                     /db_xref="MGI:MGI:1099448"
     exon            1..68
                     /gene="Ccl25"
                     /gene_synonym="A130072A22Rik; CKb15; Scya25; TECK"
                     /inference="alignment:Splign:2.1.0"
     exon            69..191
                     /gene="Ccl25"
                     /gene_synonym="A130072A22Rik; CKb15; Scya25; TECK"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..553
                     /gene="Ccl25"
                     /gene_synonym="A130072A22Rik; CKb15; Scya25; TECK"
                     /note="C-C motif chemokine 25; chemokine (C-C motif)
                     ligand 25; small inducible chemokine 25; thymus-expressed
                     chemokine; small inducible cytokine A25"
                     /codon_start=1
                     /product="C-C motif chemokine 25 precursor"
                     /protein_id="NP_033164.1"
                     /db_xref="CCDS:CCDS22085.1"
                     /db_xref="GeneID:20300"
                     /db_xref="MGI:MGI:1099448"
                     /translation="MKLWLFACLVACFVGAWMPVVHAQGAFEDCCLGYQHRIKWNVLR
                     HARNYHQQEVSGSCNLRAVRFYFRQKVVCGNPEDMNVKRAMRILTARKRLVHWKSASD
                     SQTERKKSNHMKSKVENPNSTSVRSATLGHPRMVMMPRKTNN"
     exon            192..309
                     /gene="Ccl25"
                     /gene_synonym="A130072A22Rik; CKb15; Scya25; TECK"
                     /inference="alignment:Splign:2.1.0"
     exon            310..422
                     /gene="Ccl25"
                     /gene_synonym="A130072A22Rik; CKb15; Scya25; TECK"
                     /inference="alignment:Splign:2.1.0"
     exon            423..519
                     /gene="Ccl25"
                     /gene_synonym="A130072A22Rik; CKb15; Scya25; TECK"
                     /inference="alignment:Splign:2.1.0"
     exon            520..1058
                     /gene="Ccl25"
                     /gene_synonym="A130072A22Rik; CKb15; Scya25; TECK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1019..1024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl25"
                     /gene_synonym="A130072A22Rik; CKb15; Scya25; TECK"
                     /note="hexamer: AATAAA"
     polyA_site      1038
                     /gene="Ccl25"
                     /gene_synonym="A130072A22Rik; CKb15; Scya25; TECK"
                     /note="major polyA site"
ORIGIN      
        1 agttcactga tcccataggc aatacacgct acaagcaggc accagctctc aggaccagaa
       61 aggcattggt ggccccctta aaccttcagg tatctggaga ggagatctaa ccttcactat
      121 gaaactgtgg ctttttgcct gcctggttgc ctgttttgtt ggggcctgga tgccggttgt
      181 ccatgcccaa ggtgcctttg aagactgctg cctgggttac cagcacagga tcaaatggaa
      241 tgttctccgg catgctagga attatcacca gcaggaagtg agtggaagct gcaacctacg
      301 tgctgtgaga ttctacttcc gccagaaagt agtgtgtggg aatccagagg acatgaatgt
      361 gaagagggcg atgagaatct tgacagctag gaaaaggcta gtccactgga agagcgcctc
      421 agactctcag actgaaagga agaagtcaaa ccatatgaag tccaaggtgg agaaccccaa
      481 cagtacaagc gtgaggagtg ccaccctagg tcatcccagg atggtgatga tgcccagaaa
      541 gaccaacaat taagttaatt actcagagta agcaccagct ggaggatggg aggagtctgc
      601 tgaagtgccg tcttctaggc atgccagtgc caatgaactc actgaagcta cagtttcctg
      661 tacaagacca gacccaccaa cgtctcagca tgtatgagga aggaactact gcgctaaagg
      721 ccctcccact caccaaggag ctattggcta ttgatgattg ctgagggaag ggagtaattt
      781 tttttctctt tctgaagtgt gacttgagta aattgcccat agttcagtat ataatcccca
      841 acctgtgctc aggcaagcaa ccctaattaa atgcaatagc cacatacaaa agaaaaggat
      901 atgaatagtt tggtaggagg ggcttgttag gaagaagaca ttaacaggag agagaggaac
      961 gagaggatag tgagtgtgtg agagtgccta cacatgtgaa atggtcaaag aattaaaaaa
     1021 taaaaactta aaaagctatt aaaaagtaat gactgacaaa aaaaaaaaaa aaa
//
