LOCUS       NM_019577               1297 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 24 (Ccl24), transcript
            variant 1, mRNA.
ACCESSION   NM_019577
VERSION     NM_019577.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1297)
  AUTHORS   Greenman,R., Segal-Salto,M., Barashi,N., Hay,O., Katav,A., Levi,O.,
            Vaknin,I., Aricha,R., Aharoni,S., Snir,T., Mishalian,I., Olam,D.,
            Amer,J., Salhab,A., Safadi,R., Maor,Y., Trivedi,P., Weston,C.J.,
            Saffioti,F., Hall,A., Pinzani,M., Thorburn,D., Peled,A. and Mor,A.
  TITLE     CCL24 regulates biliary inflammation and fibrosis in primary
            sclerosing cholangitis
  JOURNAL   JCI Insight 8 (12), e162270 (2023)
   PUBMED   37345655
  REMARK    GeneRIF: CCL24 regulates biliary inflammation and fibrosis in
            primary sclerosing cholangitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1297)
  AUTHORS   Wang,Y., Wu,X., Geng,M., Ding,J., Lv,K., Du,H., Ding,J., Pei,W.,
            Hu,X., Gu,J., Wang,L., Zhang,Y. and Gao,J.
  TITLE     CCL24 Protects Renal Function by Controlling Inflammation in
            Podocytes
  JOURNAL   Dis Markers 2021, 8837825 (2021)
   PUBMED   34221188
  REMARK    GeneRIF: CCL24 Protects Renal Function by Controlling Inflammation
            in Podocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1297)
  AUTHORS   Lee,S.H., Chaves,M.M., Kamenyeva,O., Gazzinelli-Guimaraes,P.H.,
            Kang,B., Pessenda,G., Passelli,K., Tacchini-Cottier,F., Kabat,J.,
            Jacobsen,E.A., Nutman,T.B. and Sacks,D.L.
  TITLE     M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated
            cooperative interaction with eosinophils in cutaneous leishmaniasis
  JOURNAL   Sci Immunol 5 (46) (2020)
   PUBMED   32276966
  REMARK    GeneRIF: M2-like, dermal macrophages are maintained via
            IL-4/CCL24-mediated cooperative interaction with eosinophils in
            cutaneous leishmaniasis.
REFERENCE   4  (bases 1 to 1297)
  AUTHORS   Kannan,Y., Entwistle,L.J., Pelly,V.S., Perez-Lloret,J.,
            Walker,A.W., Ley,S.C. and Wilson,M.S.
  TITLE     TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides
            polygyrus
  JOURNAL   PLoS Pathog 13 (7), e1006536 (2017)
   PUBMED   28759611
  REMARK    GeneRIF: TPL-2-regulated Ccl24 in CD11c+CD11b+ cells prevents
            accelerated type-2 mediated immunity to H. polygyrus.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1297)
  AUTHORS   Wilson,G.J., Hewit,K.D., Pallas,K.J., Cairney,C.J., Lee,K.M.,
            Hansell,C.A., Stein,T. and Graham,G.J.
  TITLE     Atypical chemokine receptor ACKR2 controls branching morphogenesis
            in the developing mammary gland
  JOURNAL   Development 144 (1), 74-82 (2017)
   PUBMED   27888192
REFERENCE   6  (bases 1 to 1297)
  AUTHORS   Duchesnes,C.E., Murphy,P.M., Williams,T.J. and Pease,J.E.
  TITLE     Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals
            distinct extracellular residues involved in recognition of the
            eotaxin family of chemokines
  JOURNAL   Mol Immunol 43 (8), 1221-1231 (2006)
   PUBMED   16102831
  REMARK    GeneRIF: Distinct acidic and basic residues within CCR3 determine
            both receptor expression and activation by the eotaxins.
REFERENCE   7  (bases 1 to 1297)
  AUTHORS   Pope,S.M., Zimmermann,N., Stringer,K.F., Karow,M.L. and
            Rothenberg,M.E.
  TITLE     The eotaxin chemokines and CCR3 are fundamental regulators of
            allergen-induced pulmonary eosinophilia
  JOURNAL   J Immunol 175 (8), 5341-5350 (2005)
   PUBMED   16210640
  REMARK    GeneRIF: The eotaxin-2 pathway plays a fundamental role in
            eosinophil recruitment during ovalbumin-induced experimental
            asthma.
REFERENCE   8  (bases 1 to 1297)
  AUTHORS   Pope,S.M., Fulkerson,P.C., Blanchard,C., Akei,H.S.,
            Nikolaidis,N.M., Zimmermann,N., Molkentin,J.D. and Rothenberg,M.E.
  TITLE     Identification of a cooperative mechanism involving interleukin-13
            and eotaxin-2 in experimental allergic lung inflammation
  JOURNAL   J Biol Chem 280 (14), 13952-13961 (2005)
   PUBMED   15647285
  REMARK    GeneRIF: Results demonstrate a cooperative mechanism between
            interleukin-13 and eotaxin-2, where IL-13 mediates allergen-induced
            eotaxin-2 expression, and eotaxin-2 mediates IL-13-induced airway
            eosinophilia.
REFERENCE   9  (bases 1 to 1297)
  CONSRTM   IUIS/WHO Subcommittee on Chemokine Nomenclature
  TITLE     Chemokine/chemokine receptor nomenclature
  JOURNAL   J Immunol Methods 262 (1-2), 1-3 (2002)
   PUBMED   12080938
REFERENCE   10 (bases 1 to 1297)
  AUTHORS   Zimmermann,N., Hogan,S.P., Mishra,A., Brandt,E.B., Bodette,T.R.,
            Pope,S.M., Finkelman,F.D. and Rothenberg,M.E.
  TITLE     Murine eotaxin-2: a constitutive eosinophil chemokine induced by
            allergen challenge and IL-4 overexpression
  JOURNAL   J Immunol 165 (10), 5839-5846 (2000)
   PUBMED   11067944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC065389.1, BX524006.1, AK009718.1 and AC083858.3.
            
            On Oct 12, 2017 this sequence version replaced NM_019577.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157068.1, BF019620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BC065389.1         1-24
            25-546              BX524006.1         2-523
            547-634             AK009718.1         513-600
            635-1297            AC083858.3         25718-26380         c
FEATURES             Location/Qualifiers
     source          1..1297
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.28 cM"
     gene            1..1297
                     /gene="Ccl24"
                     /gene_synonym="CKb-6; MPIF-2; Scya24"
                     /note="C-C motif chemokine ligand 24"
                     /db_xref="GeneID:56221"
                     /db_xref="MGI:MGI:1928953"
     exon            1..150
                     /gene="Ccl24"
                     /gene_synonym="CKb-6; MPIF-2; Scya24"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..437
                     /gene="Ccl24"
                     /gene_synonym="CKb-6; MPIF-2; Scya24"
                     /note="eotaxin-2; CC chemokine CCL24; C-C motif chemokine
                     24; small-inducible cytokine A24; eosinophil chemotactic
                     protein 2; chemokine (C-C motif) ligand 24"
                     /codon_start=1
                     /product="C-C motif chemokine 24 precursor"
                     /protein_id="NP_062523.1"
                     /db_xref="CCDS:CCDS19742.1"
                     /db_xref="GeneID:56221"
                     /db_xref="MGI:MGI:1928953"
                     /translation="MAGSATIVAGLLLLVACACCIFPIDSVTIPSSCCTSFISKKIPE
                     NRVVSYQLANGSICPKAGVIFITKKGHKICTDPKLLWVQRHIQKLDAKKNQPSKGAKA
                     VRTKFAVQRRRGNSTEV"
     exon            151..268
                     /gene="Ccl24"
                     /gene_synonym="CKb-6; MPIF-2; Scya24"
                     /inference="alignment:Splign:2.1.0"
     exon            269..1297
                     /gene="Ccl24"
                     /gene_synonym="CKb-6; MPIF-2; Scya24"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      652
                     /gene="Ccl24"
                     /gene_synonym="CKb-6; MPIF-2; Scya24"
                     /note="major polyA site"
     regulatory      894..899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl24"
                     /gene_synonym="CKb-6; MPIF-2; Scya24"
                     /note="hexamer: GATAAA"
     polyA_site      914
                     /gene="Ccl24"
                     /gene_synonym="CKb-6; MPIF-2; Scya24"
ORIGIN      
        1 cggggtgtcc tcatatctcc aggatctctt ttctgcaccc cagctttgaa ctctgagctg
       61 tgcctgacct ccagaacatg gcgggctctg ctacgatcgt tgccggcctc cttctcctgg
      121 tagcctgcgc gtgttgcatc ttccccatag attctgtgac catcccctca tcttgctgca
      181 cgtcctttat ttccaagaaa attccagaaa accgagtggt tagctaccag ttggccaacg
      241 gcagcatctg tcccaaggca ggggtcatct tcatcaccaa gaagggccat aagatctgta
      301 ctgaccccaa gctgctgtgg gttcagaggc acatacaaaa actggatgcc aagaaaaacc
      361 agccttctaa aggggccaag gcagtgagaa ccaagtttgc tgtccagaga cgccgtggca
      421 atagcaccga ggtttagccg cctctcctct gtccctgaac ttggacatag gtattgacgc
      481 tttaccaggc tgctttgggg tttgacagac cagctgggat gaggtctaag ttcatttccc
      541 cattctcagc atttctttta ggggatgtgt ttattctgtg agaacctgag tgagctgcaa
      601 gcatgccaga gttctggtgt ctcctgtgct gagtgaaaag attccagaag aatatcagtt
      661 gtcctgtgtt atctcttgtg tggctcaaag gcttcatcag agcccaggtg catgagcccc
      721 gagtctctgc aggcggacct tgcttgcagc tggcttccat agggttcttg tcttagggtg
      781 gggcctgagg gctgtctgtc tgtccatctc tgggtgaaga tctgtcaaca gcagtaactc
      841 ccaaacatgc tgatgggtat accaggctgg tcccatcccc agaacttgga acagataaaa
      901 aaagttggca gaaacggagg atttcaacag cagcattttt aaacccatca gtctttgtaa
      961 agccggaggt gtaactcaga tggtggtgtg cttgcctggc atgcatgggg cattgggttt
     1021 caaccacagc accgcaaaaa ctaggcatga tggtgcatgc ctaagaagat cagaatttca
     1081 agcttagcca gacatcccag aaggcagagg caagaggatc tctgtgagtt caatgccacc
     1141 ctggtctaca tagcgagctc caggacagcc agggctacat agagagacca tttctcaaac
     1201 acccttccct aaaaataagt tcaaggctac atagccacac agaaaatttg aggccagcct
     1261 ggcccagggt ctgcctcctc ttgctgccag gatgtag
//
