LOCUS       NM_009137               1815 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 22 (Ccl22), mRNA.
ACCESSION   NM_009137
VERSION     NM_009137.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1815)
  AUTHORS   Yuan,Y., Hu,R., Park,J., Xiong,S., Wang,Z., Qian,Y., Shi,Z., Wu,R.,
            Han,Z., Ong,S.G., Lin,S., Varady,K.A., Xu,P., Berry,D.C., Shu,G.
            and Jiang,Y.
  TITLE     Macrophage-derived chemokine CCL22 establishes local LN-mediated
            adaptive thermogenesis and energy expenditure
  JOURNAL   Sci Adv 10 (26), eadn5229 (2024)
   PUBMED   38924414
  REMARK    GeneRIF: Macrophage-derived chemokine CCL22 establishes local
            LN-mediated adaptive thermogenesis and energy expenditure.
REFERENCE   2  (bases 1 to 1815)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1815)
  AUTHORS   Qi,Z., Zhong,W., Jiao,B., Chen,K., Yang,X., Wang,L., Zeng,W.,
            Huang,J. and Xie,J.
  TITLE     Activation of G-protein-coupled receptor 183 initiates inflammatory
            pain via macrophage CCL22 secretion
  JOURNAL   Eur J Pharmacol 954, 175872 (2023)
   PUBMED   37353188
  REMARK    GeneRIF: Activation of G-protein-coupled receptor 183 initiates
            inflammatory pain via macrophage CCL22 secretion.
REFERENCE   4  (bases 1 to 1815)
  AUTHORS   Baer,C., Kimura,S., Rana,M.S., Kleist,A.B., Flerlage,T.,
            Feith,D.J., Chockley,P., Walter,W., Meggendorfer,M., Olson,T.L.,
            Cheon,H., Olson,K.C., Ratan,A., Mueller,M.L., Foran,J.M.,
            Janke,L.J., Qu,C., Porter,S.N., Pruett-Miller,S.M., Kalathur,R.C.,
            Haferlach,C., Kern,W., Paietta,E., Thomas,P.G., Babu,M.M.,
            Loughran,T.P. Jr., Iacobucci,I., Haferlach,T. and Mullighan,C.G.
  TITLE     CCL22 mutations drive natural killer cell lymphoproliferative
            disease by deregulating microenvironmental crosstalk
  JOURNAL   Nat Genet 54 (5), 637-648 (2022)
   PUBMED   35513723
  REMARK    GeneRIF: CCL22 mutations drive natural killer cell
            lymphoproliferative disease by deregulating microenvironmental
            crosstalk.
REFERENCE   5  (bases 1 to 1815)
  AUTHORS   Rudzki,E.N., Ander,S.E., Coombs,R.S., Alrubaye,H.S., Cabo,L.F.,
            Blank,M.L., Gutierrez-Melo,N., Dubey,J.P., Coyne,C.B. and
            Boyle,J.P.
  TITLE     Toxoplasma gondii GRA28 Is Required for Placenta-Specific Induction
            of the Regulatory Chemokine CCL22 in Human and Mouse
  JOURNAL   mBio 12 (6), e0159121 (2021)
   PUBMED   34781732
  REMARK    GeneRIF: Toxoplasma gondii GRA28 Is Required for Placenta-Specific
            Induction of the Regulatory Chemokine CCL22 in Human and Mouse.
REFERENCE   6  (bases 1 to 1815)
  AUTHORS   Ross,R., Ross,X.L., Ghadially,H., Lahr,T., Schwing,J., Knop,J. and
            Reske-Kunz,A.B.
  TITLE     Mouse langerhans cells differentially express an activated T
            cell-attracting CC chemokine
  JOURNAL   J Invest Dermatol 113 (6), 991-998 (1999)
   PUBMED   10594742
REFERENCE   7  (bases 1 to 1815)
  AUTHORS   Chantry,D., Romagnani,P., Raport,C.J., Wood,C.L., Epp,A.,
            Romagnani,S. and Gray,P.W.
  TITLE     Macrophage-derived chemokine is localized to thymic medullary
            epithelial cells and is a chemoattractant for CD3(+), CD4(+),
            CD8(low) thymocytes
  JOURNAL   Blood 94 (6), 1890-1898 (1999)
   PUBMED   10477717
REFERENCE   8  (bases 1 to 1815)
  AUTHORS   Gonzalo,J.A., Pan,Y., Lloyd,C.M., Jia,G.Q., Yu,G., Dussault,B.,
            Powers,C.A., Proudfoot,A.E., Coyle,A.J., Gearing,D. and
            Gutierrez-Ramos,J.C.
  TITLE     Mouse monocyte-derived chemokine is involved in airway
            hyperreactivity and lung inflammation
  JOURNAL   J Immunol 163 (1), 403-411 (1999)
   PUBMED   10384142
REFERENCE   9  (bases 1 to 1815)
  AUTHORS   Kanazawa,N., Nakamura,T., Tashiro,K., Muramatsu,M., Morita,K.,
            Yoneda,K., Inaba,K., Imamura,S. and Honjo,T.
  TITLE     Fractalkine and macrophage-derived chemokine: T cell-attracting
            chemokines expressed in T cell area dendritic cells
  JOURNAL   Eur J Immunol 29 (6), 1925-1932 (1999)
   PUBMED   10382755
REFERENCE   10 (bases 1 to 1815)
  AUTHORS   Schaniel,C., Pardali,E., Sallusto,F., Speletas,M., Ruedl,C.,
            Shimizu,T., Seidl,T., Andersson,J., Melchers,F., Rolink,A.G. and
            Sideras,P.
  TITLE     Activated murine B lymphocytes and dendritic cells produce a novel
            CC chemokine which acts selectively on activated T cells
  JOURNAL   J Exp Med 188 (3), 451-463 (1998)
   PUBMED   9687523
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY198556.1, AK155764.1 and BF661256.1.
            
            On Jul 31, 2007 this sequence version replaced NM_009137.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF076596.1, AK155083.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BY198556.1         2-4
            4-1804              AK155764.1         2-1802
            1805-1815           BF661256.1         1-11                c
FEATURES             Location/Qualifiers
     source          1..1815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.75 cM"
     gene            1..1815
                     /gene="Ccl22"
                     /gene_synonym="ABCD-1; DCBCK; MDC; Scya22"
                     /note="C-C motif chemokine ligand 22"
                     /db_xref="GeneID:20299"
                     /db_xref="MGI:MGI:1306779"
     exon            1..103
                     /gene="Ccl22"
                     /gene_synonym="ABCD-1; DCBCK; MDC; Scya22"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..309
                     /gene="Ccl22"
                     /gene_synonym="ABCD-1; DCBCK; MDC; Scya22"
                     /note="small inducible cytokine subfamily A22; C-C motif
                     chemokine 22; dendritic cell and B cell derived chemokine;
                     CC chemokine ABCD-1; small-inducible cytokine A22;
                     activated B and dendritic cell-derived; small inducible
                     cytokine subfamily A, member 22; SMALL INDUCIBLE CYTOKINE
                     A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND
                     DENDRITIC CELL-DERIVED); chemokine (C-C motif) ligand 22"
                     /codon_start=1
                     /product="C-C motif chemokine 22 precursor"
                     /protein_id="NP_033163.1"
                     /db_xref="CCDS:CCDS40441.1"
                     /db_xref="GeneID:20299"
                     /db_xref="MGI:MGI:1306779"
                     /translation="MATLRVPLLVALVLLAVAIQTSDAGPYGANVEDSICCQDYIRHP
                     LPSRLVKEFFWTSKSCRKPGVVLITVKNRDICADPRQVWVKKLLHKLS"
     exon            104..227
                     /gene="Ccl22"
                     /gene_synonym="ABCD-1; DCBCK; MDC; Scya22"
                     /inference="alignment:Splign:2.1.0"
     exon            228..1811
                     /gene="Ccl22"
                     /gene_synonym="ABCD-1; DCBCK; MDC; Scya22"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1806
                     /gene="Ccl22"
                     /gene_synonym="ABCD-1; DCBCK; MDC; Scya22"
ORIGIN      
        1 attagacacc tgacgaggac acataacatc atggctaccc tgcgtgtccc actcctggtg
       61 gctctcgtcc ttcttgctgt ggcaattcag acctctgatg caggtcccta tggtgccaat
      121 gtggaagaca gtatctgctg ccaggactac atccgtcacc ctctgccatc acgtttagtg
      181 aaggagttct tctggacctc aaaatcctgc cgcaagcctg gcgttgtttt gataaccgtc
      241 aagaaccgag atatctgtgc cgatcccagg caggtctggg tgaagaagct actccataaa
      301 ctgtcctagg gaggaggacc tgatgaccat gggtctggtg tggtccaggg aggctcagca
      361 agccctattc ttctgccatt ccagcaagag ccttgccaac gacgccacct ttactcacct
      421 ccatcccctg ggctgtcact ctgtgaggct ctggtccctc tacctcccct ctatcccttc
      481 cagcttatcc cccttcaatg tggcagctgg gaaacacatt caggccagcc ttacccaatg
      541 cctactcccc actgctttag atgagaccag cgtccttgtt ttgatgccct gatcctatga
      601 tgccttcccc atccccagcc ttggccccct tctcttcttg catgtaggga aggcccatag
      661 gtttcaaata tgtgctacct agttcccttt ctggggggtt ctaataccca gcatgttttt
      721 cctgctgcag gcacctatcc agtgccacac acctcccaag tttctatcag tcccagtggg
      781 catccaccaa gccccaaact tcagacttcc ttggcctcca cctactctca gtagaattct
      841 gggagtttca ggctggtcca ccaggccccc cagggttagg ccaaggtccc caccagagct
      901 cctcctgttt cttggtctgc agcacggggc agggagcaag gagcaggctc agaatcagat
      961 ttcttaaagg agctgcagac tccatcagta aaaggaatct ttctcccatc cctgaatata
     1021 aggcagtttt ctgtcaacac agagactcag gttgttagaa atggccacat agatcaactg
     1081 tgaaacccta aatttaccaa gaatcaactt ccacccctct tcaaccacat gctagggtct
     1141 tttactttct ctgccccaca cctttgactc cttgcctgtg tagctgatag tcgaagttat
     1201 gctatggtgt cagtgactgc cacagtttgt ttggtattat aagctatagt tatatttata
     1261 taggaaagag gataaatata tgtgaggcca aatagacgaa ctggagagtt ttaggatctg
     1321 ggggcaggaa gggccataca aagtgatacc tcagaaaata gatggttgtg ggagctgctg
     1381 ccagtggcag agttaactta aagaacttaa ttgaaattat tcttgagtgg ctgaggccaa
     1441 gacaagaata tagaacccat tcttgcttcc ctggagacaa cagtggtccc aggggaagga
     1501 ataaaccttc ttgctcctct ggagggagca tggcctggct tagccgagtg actggactgt
     1561 gtgagattgg gggcatcgct tttcctctct gagcctcagc tgacagcata tgggaccaca
     1621 aagggcttga tccaaaccac agggattgac agtgccagcc acagctgtgt ccagggctcg
     1681 tgttctgcca gaaggagcac ctggacgacc agggccacca ctagtgctac tttgctcact
     1741 gcccatgcat gtcctgaagg tccctccccc tcctctccta cttctgggaa aataaatgct
     1801 cgccaataat aaaaa
//
