LOCUS       NM_001270360             887 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 21D (Ccl21d), mRNA.
ACCESSION   NM_001270360 NM_001374239 NM_001378661 NM_023052 XM_001473258
            XM_003688791
VERSION     NM_001270360.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 887)
  AUTHORS   Wurm,S., Steege,A., Rom-Jurek,E.M., van Roeyen,C.R., Kurtz,A.,
            Banas,B. and Banas,M.C.
  TITLE     CCR7 Is Important for Mesangial Cell Physiology and Repair
  JOURNAL   J Histochem Cytochem 66 (1), 7-22 (2018)
   PUBMED   29077526
REFERENCE   2  (bases 1 to 887)
  AUTHORS   Onder,L., Morbe,U., Pikor,N., Novkovic,M., Cheng,H.W., Hehlgans,T.,
            Pfeffer,K., Becher,B., Waisman,A., Rulicke,T., Gommerman,J.,
            Mueller,C.G., Sawa,S., Scandella,E. and Ludewig,B.
  TITLE     Lymphatic Endothelial Cells Control Initiation of Lymph Node
            Organogenesis
  JOURNAL   Immunity 47 (1), 80-92 (2017)
   PUBMED   28709801
REFERENCE   3  (bases 1 to 887)
  AUTHORS   Finsen,A.V., Ueland,T., Sjaastad,I., Ranheim,T., Ahmed,M.S.,
            Dahl,C.P., Askevold,E.T., Aakhus,S., Husberg,C., Fiane,A.E.,
            Lipp,M., Gullestad,L., Christensen,G., Aukrust,P. and Yndestad,A.
  TITLE     The homeostatic chemokine CCL21 predicts mortality in aortic
            stenosis patients and modulates left ventricular remodeling
  JOURNAL   PLoS One 9 (11), e112172 (2014)
   PUBMED   25398010
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 887)
  AUTHORS   Montresor,A., Bolomini-Vittori,M., Toffali,L., Rossi,B.,
            Constantin,G. and Laudanna,C.
  TITLE     JAK tyrosine kinases promote hierarchical activation of Rho and Rap
            modules of integrin activation
  JOURNAL   J Cell Biol 203 (6), 1003-1019 (2013)
   PUBMED   24368807
REFERENCE   5  (bases 1 to 887)
  AUTHORS   Bryson,J.L., Griffith,A.V., Hughes,B. 3rd, Saito,F., Takahama,Y.,
            Richie,E.R. and Manley,N.R.
  TITLE     Cell-autonomous defects in thymic epithelial cells disrupt
            endothelial-perivascular cell interactions in the mouse thymus
  JOURNAL   PLoS One 8 (6), e65196 (2013)
   PUBMED   23750244
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 887)
  AUTHORS   Brennan,J., Karl,J. and Capel,B.
  TITLE     Divergent vascular mechanisms downstream of Sry establish the
            arterial system in the XY gonad
  JOURNAL   Dev Biol 244 (2), 418-428 (2002)
   PUBMED   11944948
REFERENCE   7  (bases 1 to 887)
  AUTHORS   Nakano,H. and Gunn,M.D.
  TITLE     Gene duplications at the chemokine locus on mouse chromosome 4:
            multiple strain-specific haplotypes and the deletion of secondary
            lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the
            plt mutation
  JOURNAL   J Immunol 166 (1), 361-369 (2001)
   PUBMED   11123313
REFERENCE   8  (bases 1 to 887)
  AUTHORS   Vassileva,G., Soto,H., Zlotnik,A., Nakano,H., Kakiuchi,T.,
            Hedrick,J.A. and Lira,S.A.
  TITLE     The reduced expression of 6Ckine in the plt mouse results from the
            deletion of one of two 6Ckine genes
  JOURNAL   J Exp Med 190 (8), 1183-1188 (1999)
   PUBMED   10523616
REFERENCE   9  (bases 1 to 887)
  AUTHORS   Gunn,M.D., Tangemann,K., Tam,C., Cyster,J.G., Rosen,S.D. and
            Williams,L.T.
  TITLE     A chemokine expressed in lymphoid high endothelial venules promotes
            the adhesion and chemotaxis of naive T lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 258-263 (1998)
   PUBMED   9419363
REFERENCE   10 (bases 1 to 887)
  AUTHORS   Hromas,R., Kim,C.H., Klemsz,M., Krathwohl,M., Fife,K., Cooper,S.,
            Schnizlein-Bick,C. and Broxmeyer,H.E.
  TITLE     Isolation and characterization of Exodus-2, a novel C-C chemokine
            with a unique 37-amino acid carboxyl-terminal extension
  JOURNAL   J Immunol 159 (6), 2554-2558 (1997)
   PUBMED   9300671
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT868690.24, BX522471.1 and AA123440.1.
            
            On or before Oct 29, 2020 this sequence version replaced
            NM_023052.2, NM_001374239.1, NM_001378661.1, XM_003688791.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX522471.1, SRR1660821.112782.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 CT868690.24        209494-209496       c
            4-536               BX522471.1         25-557
            537-674             CT868690.24        208559-208696       c
            675-887             AA123440.1         209-421
FEATURES             Location/Qualifiers
     source          1..887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..887
                     /gene="Ccl21d"
                     /gene_synonym="6Ckine; Ccl21b; Ccl21c; CKb9; exodus-2;
                     Gm21541; Scya21; Scya21b; Scya21c; SLC; TCA4"
                     /note="C-C motif chemokine ligand 21D"
                     /db_xref="GeneID:100862177"
                     /db_xref="MGI:MGI:5434896"
     exon            1..139
                     /gene="Ccl21d"
                     /gene_synonym="6Ckine; Ccl21b; Ccl21c; CKb9; exodus-2;
                     Gm21541; Scya21; Scya21b; Scya21c; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..474
                     /gene="Ccl21d"
                     /gene_synonym="6Ckine; Ccl21b; Ccl21c; CKb9; exodus-2;
                     Gm21541; Scya21; Scya21b; Scya21c; SLC; TCA4"
                     /note="C-C motif chemokine 21b; Beta-chemokine exodus-2;
                     Small-inducible cytokine A21b; Thymus-derived chemotactic
                     agent 4; C-C motif chemokine 21c; Small-inducible cytokine
                     A21c; chemokine (C-C motif) ligand 21C (leucine); c-C
                     motif chemokine 21c-like; Ccl21-leu; chemokine (C-C motif)
                     ligand 21D"
                     /codon_start=1
                     /product="C-C motif chemokine 21b precursor"
                     /protein_id="NP_001257289.1"
                     /db_xref="CCDS:CCDS57267.1"
                     /db_xref="GeneID:100862177"
                     /db_xref="MGI:MGI:5434896"
                     /translation="MAQMMTLSLLSLVLALCIPWTQGSDGGGQDCCLKYSQKKIPYSI
                     VRGYRKQEPSLGCPIPAILFLPRKHSKPELCANPEEGWVQNLMRRLDQPPAPGKQSPG
                     CRKNRGTSKSGKKGKGSKGCKRTEQTQPSRG"
     exon            140..260
                     /gene="Ccl21d"
                     /gene_synonym="6Ckine; Ccl21b; Ccl21c; CKb9; exodus-2;
                     Gm21541; Scya21; Scya21b; Scya21c; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            261..443
                     /gene="Ccl21d"
                     /gene_synonym="6Ckine; Ccl21b; Ccl21c; CKb9; exodus-2;
                     Gm21541; Scya21; Scya21b; Scya21c; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            444..867
                     /gene="Ccl21d"
                     /gene_synonym="6Ckine; Ccl21b; Ccl21c; CKb9; exodus-2;
                     Gm21541; Scya21; Scya21b; Scya21c; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacacagac cccaacttgc agctgtccat ctcacctaca gctctggtct catcctcaac
       61 tcaaccacaa tcatggctca gatgatgact ctgagcctcc ttagcctggt cctggctctc
      121 tgcatcccct ggacccaagg cagtgatgga gggggacagg actgctgcct taagtacagc
      181 cagaagaaaa ttccctacag tattgtccga ggctatagga agcaagaacc aagtttaggc
      241 tgtcccatcc cggcaatcct gttcttaccc cggaagcact ctaagcctga gctatgtgca
      301 aaccctgagg aaggctgggt gcagaacctg atgcgccgcc tggaccagcc tccagcccca
      361 gggaaacaaa gccccggctg caggaagaac cggggaacct ctaagtctgg aaagaaagga
      421 aagggctcca agggctgcaa gagaactgaa cagacacagc cctcaagagg atagcccagt
      481 agcccgcctg gagcccagga gatcccccac gaacttcaag ctgggtggtt cacggtccaa
      541 ctcacaggca aagagggagc tagaaaacag actcaggagc ccaaagcagc cacctcatgc
      601 tggcctccgt ccacaccctt gccctgcttc aaccattaca tctgcacggc catccctttc
      661 ttacctggcg gagctgcctt ccctggggta gacctagaga gtcagaagaa agagtgtctc
      721 ccagggaatg aggaaggaga cagcaggact gtcccctcta ggaggtcact caggtcccaa
      781 gacctgaacc tgctctccat ggcgccctcc ccttgtcctt gcacctatga tttataccta
      841 actgaataaa aaagtgatcc agcctcaaaa aaaaaaaaaa aaaaaaa
//
