LOCUS       NM_011335               1206 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 21B (leucine) (Ccl21b),
            transcript variant 1, mRNA.
ACCESSION   NM_011335 XM_001478541
VERSION     NM_011335.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1206)
  AUTHORS   Wurm,S., Steege,A., Rom-Jurek,E.M., van Roeyen,C.R., Kurtz,A.,
            Banas,B. and Banas,M.C.
  TITLE     CCR7 Is Important for Mesangial Cell Physiology and Repair
  JOURNAL   J Histochem Cytochem 66 (1), 7-22 (2018)
   PUBMED   29077526
REFERENCE   2  (bases 1 to 1206)
  AUTHORS   Onder,L., Morbe,U., Pikor,N., Novkovic,M., Cheng,H.W., Hehlgans,T.,
            Pfeffer,K., Becher,B., Waisman,A., Rulicke,T., Gommerman,J.,
            Mueller,C.G., Sawa,S., Scandella,E. and Ludewig,B.
  TITLE     Lymphatic Endothelial Cells Control Initiation of Lymph Node
            Organogenesis
  JOURNAL   Immunity 47 (1), 80-92 (2017)
   PUBMED   28709801
REFERENCE   3  (bases 1 to 1206)
  AUTHORS   Nakayama,Y., Masuda,Y., Ohta,H., Tanaka,T., Washida,M.,
            Nabeshima,Y.I., Miyake,A., Itoh,N. and Konishi,M.
  TITLE     Fgf21 regulates T-cell development in the neonatal and juvenile
            thymus
  JOURNAL   Sci Rep 7 (1), 330 (2017)
   PUBMED   28336912
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1206)
  AUTHORS   Mikulski,Z., Johnson,R., Shaked,I., Kim,G., Nowyhed,H., Goodman,W.,
            Chodaczek,G., Pizarro,T.T., Cominelli,F. and Ley,K.
  TITLE     SAMP1/YitFc mice develop ileitis via loss of CCL21 and defects in
            dendritic cell migration
  JOURNAL   Gastroenterology 148 (4), 783-793 (2015)
   PUBMED   25620669
  REMARK    GeneRIF: Loss of CCL21 signaling and dendritic cell migration is
            required for development of ileitis in SAMP mice.
REFERENCE   5  (bases 1 to 1206)
  AUTHORS   Finsen,A.V., Ueland,T., Sjaastad,I., Ranheim,T., Ahmed,M.S.,
            Dahl,C.P., Askevold,E.T., Aakhus,S., Husberg,C., Fiane,A.E.,
            Lipp,M., Gullestad,L., Christensen,G., Aukrust,P. and Yndestad,A.
  TITLE     The homeostatic chemokine CCL21 predicts mortality in aortic
            stenosis patients and modulates left ventricular remodeling
  JOURNAL   PLoS One 9 (11), e112172 (2014)
   PUBMED   25398010
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1206)
  AUTHORS   Nakano,H., Mori,S., Yonekawa,H., Nariuchi,H., Matsuzawa,A. and
            Kakiuchi,T.
  TITLE     A novel mutant gene involved in T-lymphocyte-specific homing into
            peripheral lymphoid organs on mouse chromosome 4
  JOURNAL   Blood 91 (8), 2886-2895 (1998)
   PUBMED   9531599
REFERENCE   7  (bases 1 to 1206)
  AUTHORS   Gunn,M.D., Tangemann,K., Tam,C., Cyster,J.G., Rosen,S.D. and
            Williams,L.T.
  TITLE     A chemokine expressed in lymphoid high endothelial venules promotes
            the adhesion and chemotaxis of naive T lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 258-263 (1998)
   PUBMED   9419363
REFERENCE   8  (bases 1 to 1206)
  AUTHORS   Tanabe,S., Lu,Z., Luo,Y., Quackenbush,E.J., Berman,M.A.,
            Collins-Racie,L.A., Mi,S., Reilly,C., Lo,D., Jacobs,K.A. and
            Dorf,M.E.
  TITLE     Identification of a new mouse beta-chemokine, thymus-derived
            chemotactic agent 4, with activity on T lymphocytes and mesangial
            cells
  JOURNAL   J Immunol 159 (11), 5671-5679 (1997)
   PUBMED   9548511
REFERENCE   9  (bases 1 to 1206)
  AUTHORS   Hromas,R., Kim,C.H., Klemsz,M., Krathwohl,M., Fife,K., Cooper,S.,
            Schnizlein-Bick,C. and Broxmeyer,H.E.
  TITLE     Isolation and characterization of Exodus-2, a novel C-C chemokine
            with a unique 37-amino acid carboxyl-terminal extension
  JOURNAL   J Immunol 159 (6), 2554-2558 (1997)
   PUBMED   9300671
REFERENCE   10 (bases 1 to 1206)
  AUTHORS   Hedrick,J.A. and Zlotnik,A.
  TITLE     Identification and characterization of a novel beta chemokine
            containing six conserved cysteines
  JOURNAL   J Immunol 159 (4), 1589-1593 (1997)
   PUBMED   9257816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL824709.35 and AL844494.42.
            
            On Feb 24, 2020 this sequence version replaced NM_011335.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660819.216225.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN02415122 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AL824709.35        144528-144704
            178-267             AL824709.35        153196-153285
            268-478             AL844494.42        130331-130541       c
            479-599             AL844494.42        130122-130242       c
            600-782             AL844494.42        129845-130027       c
            783-1206            AL844494.42        129339-129762       c
FEATURES             Location/Qualifiers
     source          1..1206
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 22.12 cM"
     gene            1..1206
                     /gene="Ccl21b"
                     /gene_synonym="6CKBAC1; 6Ckine; CKb9; exodus-2; Scya21;
                     Scya21a; Scya21b; Scya21c; SLC; TCA4"
                     /note="C-C motif chemokine ligand 21B (leucine)"
                     /db_xref="GeneID:100042493"
                     /db_xref="MGI:MGI:1349182"
     exon            1..177
                     /gene="Ccl21b"
                     /gene_synonym="6CKBAC1; 6Ckine; CKb9; exodus-2; Scya21;
                     Scya21a; Scya21b; Scya21c; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            178..267
                     /gene="Ccl21b"
                     /gene_synonym="6CKBAC1; 6Ckine; CKb9; exodus-2; Scya21;
                     Scya21a; Scya21b; Scya21c; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            268..478
                     /gene="Ccl21b"
                     /gene_synonym="6CKBAC1; 6Ckine; CKb9; exodus-2; Scya21;
                     Scya21a; Scya21b; Scya21c; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..813
                     /gene="Ccl21b"
                     /gene_synonym="6CKBAC1; 6Ckine; CKb9; exodus-2; Scya21;
                     Scya21a; Scya21b; Scya21c; SLC; TCA4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; small inducible cytokine A21; C-C motif
                     chemokine 21b; thymus-derived chemotactic agent 4;
                     small-inducible cytokine A21a; beta-chemokine exodus-2;
                     small-inducible cytokine A21b; secondary lymphoid organ
                     chemokine; C-C motif chemokine 21c; Small-inducible
                     cytokine A21c; chemokine (C-C motif) ligand 21C (leucine);
                     Ccl21-leu; chemokine (C-C motif) ligand 21B (leucine)"
                     /codon_start=1
                     /product="C-C motif chemokine 21b isoform 1 precursor"
                     /protein_id="NP_035465.2"
                     /db_xref="CCDS:CCDS51145.1"
                     /db_xref="GeneID:100042493"
                     /db_xref="MGI:MGI:1349182"
                     /translation="MAQMMTLSLLSLVLALCIPWTQGSDGGGQDCCLKYSQKKIPYSI
                     VRGYRKQEPSLGCPIPAILFLPRKHSKPELCANPEEGWVQNLMRRLDQPPAPGKQSPG
                     CRKNRGTSKSGKKGKGSKGCKRTEQTQPSRG"
     exon            479..599
                     /gene="Ccl21b"
                     /gene_synonym="6CKBAC1; 6Ckine; CKb9; exodus-2; Scya21;
                     Scya21a; Scya21b; Scya21c; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            600..782
                     /gene="Ccl21b"
                     /gene_synonym="6CKBAC1; 6Ckine; CKb9; exodus-2; Scya21;
                     Scya21a; Scya21b; Scya21c; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1206
                     /gene="Ccl21b"
                     /gene_synonym="6CKBAC1; 6Ckine; CKb9; exodus-2; Scya21;
                     Scya21a; Scya21b; Scya21c; SLC; TCA4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggagccg gtgcagagcg ggcggcggcg gcggcagtgg aggcggcggc tccagccggc
       61 gcggcgcggg gttcggcagt gggatccggc cgcagtgctc gctccgcgct cctgcctcgc
      121 tccccgcctg cagcggccga agggcgcggc gcggagcccg ggtggcccga gggcgcgaac
      181 cctgccctgt cacatcatcc caggaagact ttggtctgga gaggaggata atattgatgt
      241 gtgtggagaa cagctggtgg taacgaggaa aaggaggggg agcgagggaa gcgaaagtct
      301 cagactgcat aaataggcag caagccagtc gcagcccaca cacacagacc ccaacttgca
      361 gctgtccatc tcacctacag ctctggtctc atcctcaact caaccacaat catggctcag
      421 atgatgactc tgagcctcct tagcctggtc ctggctctct gcatcccctg gacccaaggc
      481 agtgatggag ggggacagga ctgctgcctt aagtacagcc agaagaaaat tccctacagt
      541 attgtccgag gctataggaa gcaagaacca agtttaggct gtcccatccc ggcaatcctg
      601 ttcttacccc ggaagcactc taagcctgag ctatgtgcaa accctgagga aggctgggtg
      661 cagaacctga tgcgccgcct ggaccagcct ccagccccag ggaaacaaag ccccggctgc
      721 aggaagaacc ggggaacctc taagtctgga aagaaaggaa agggctccaa gggctgcaag
      781 agaactgaac agacacagcc ctcaagagga tagcccagta gcccgcctgg agcccaggag
      841 atcccccacg aacttcaagc tgggtggttc acggtccaac tcacaggcaa agagggagct
      901 agaaaacaga ctcaggagcc caaagcagcc acctcatgct ggcctccgtc cacacccttg
      961 ccctgcttca accattacat ctgcacggcc atccctttct tacctggcgg agctgccttc
     1021 cctggggtag acctagagag tcagaagaaa gagtgtctcc cagggaatga ggaaggagac
     1081 agcaggactg tcccctctag gaggtcactc aggtcccaag acctgaacct gctctccatg
     1141 gcgccctccc cttgtccttg cacctatgat ttatacctaa ctgaataaaa aagtgatcca
     1201 gcctca
//
