LOCUS       NM_011124                868 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 21 (serine) (Ccl21a), mRNA.
ACCESSION   NM_011124 NM_001193667 XM_001471996 XM_003085426
VERSION     NM_011124.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 868)
  AUTHORS   Wu,Y., Chen,S., Huang,G., Zhang,L., Zhong,L., Feng,Y., Wen,P. and
            Liu,J.
  TITLE     Transcriptome analysis reveals EBF1 ablation-induced injuries in
            cardiac system
  JOURNAL   Theranostics 14 (12), 4894-4915 (2024)
   PUBMED   39239522
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 868)
  AUTHORS   Ushio,A., Matsuda-Lennikov,M., Kalle-Youngoue,F., Shimizu,A.,
            Abdelmaksoud,A., Kelly,M.C., Ishimaru,N. and Takahama,Y.
  TITLE     Functionally diverse thymic medullary epithelial cells interplay to
            direct central tolerance
  JOURNAL   Cell Rep 43 (4), 114072 (2024)
   PUBMED   38581680
REFERENCE   3  (bases 1 to 868)
  AUTHORS   Miyamoto,M., Kawato,Y., Fujie,R., Kurowarabe,K., Fujiwara,K.,
            Nobusawa,R., Hayashi,R., Iida,K., Ohigashi,I. and Hayasaka,H.
  TITLE     CCL21-Ser expression in melanoma cells recruits CCR7+ naive T cells
            to tumor tissues and promotes tumor growth
  JOURNAL   Cancer Sci 114 (9), 3509-3522 (2023)
   PUBMED   37421165
  REMARK    GeneRIF: CCL21-Ser expression in melanoma cells recruits CCR7[+]
            naive T cells to tumor tissues and promotes tumor growth.
REFERENCE   4  (bases 1 to 868)
  AUTHORS   Vallecillo-Garcia,P., Orgeur,M., Comai,G., Poehle-Kronawitter,S.,
            Fischer,C., Gloger,M., Dumas,C.E., Giesecke-Thiel,C., Sauer,S.,
            Tajbakhsh,S., Hopken,U.E. and Stricker,S.
  TITLE     A local subset of mesenchymal cells expressing the transcription
            factor Osr1 orchestrates lymph node initiation
  JOURNAL   Immunity 56 (6), 1204-1219 (2023)
   PUBMED   37160119
REFERENCE   5  (bases 1 to 868)
  AUTHORS   Lucas,B., White,A.J., Klein,F., Veiga-Villauriz,C., Handel,A.,
            Bacon,A., Cosway,E.J., James,K.D., Parnell,S.M., Ohigashi,I.,
            Takahama,Y., Jenkinson,W.E., Hollander,G.A., Lu,W.Y. and
            Anderson,G.
  TITLE     Embryonic keratin19+ progenitors generate multiple functionally
            distinct progeny to maintain epithelial diversity in the adult
            thymus medulla
  JOURNAL   Nat Commun 14 (1), 2066 (2023)
   PUBMED   37045811
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 868)
  AUTHORS   Gunn,M.D., Tangemann,K., Tam,C., Cyster,J.G., Rosen,S.D. and
            Williams,L.T.
  TITLE     A chemokine expressed in lymphoid high endothelial venules promotes
            the adhesion and chemotaxis of naive T lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 95 (1), 258-263 (1998)
   PUBMED   9419363
REFERENCE   7  (bases 1 to 868)
  AUTHORS   Hromas,R., Kim,C.H., Klemsz,M., Krathwohl,M., Fife,K., Cooper,S.,
            Schnizlein-Bick,C. and Broxmeyer,H.E.
  TITLE     Isolation and characterization of Exodus-2, a novel C-C chemokine
            with a unique 37-amino acid carboxyl-terminal extension
  JOURNAL   J Immunol 159 (6), 2554-2558 (1997)
   PUBMED   9300671
REFERENCE   8  (bases 1 to 868)
  AUTHORS   Hedrick,J.A. and Zlotnik,A.
  TITLE     Identification and characterization of a novel beta chemokine
            containing six conserved cysteines
  JOURNAL   J Immunol 159 (4), 1589-1593 (1997)
   PUBMED   9257816
REFERENCE   9  (bases 1 to 868)
  AUTHORS   Nakano,H., Tamura,T., Yoshimoto,T., Yagita,H., Miyasaka,M.,
            Butcher,E.C., Nariuchi,H., Kakiuchi,T. and Matsuzawa,A.
  TITLE     Genetic defect in T lymphocyte-specific homing into peripheral
            lymph nodes
  JOURNAL   Eur J Immunol 27 (1), 215-221 (1997)
   PUBMED   9022021
REFERENCE   10 (bases 1 to 868)
  AUTHORS   Nakano,H., Yoshimoto,T., Kakiuchi,T. and Matsuzawa,A.
  TITLE     Nonspecific augmentation of lymph node T cells and I-E-independent
            selective deletion of V beta 14+ T cells by Mtv-2 in the DDD mouse
  JOURNAL   Eur J Immunol 23 (10), 2434-2439 (1993)
   PUBMED   8405042
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL772334.17.
            
            On or before Oct 26, 2020 this sequence version replaced
            NM_001193667.1, NM_011124.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028747.1, AF001980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               AL772334.17        59561-59700         c
            141-261             AL772334.17        59352-59472         c
            262-444             AL772334.17        59075-59257         c
            445-868             AL772334.17        58569-58992         c
FEATURES             Location/Qualifiers
     source          1..868
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 22.43 cM"
     gene            1..868
                     /gene="Ccl21a"
                     /gene_synonym="6CKBAC2; 6Ckine; ALP; CKb9; Gm1987; plt;
                     Scya21; SCYA21a; Scya21b; SLC; Tca4"
                     /note="C-C motif chemokine ligand 21 (serine)"
                     /db_xref="GeneID:18829"
                     /db_xref="MGI:MGI:1349183"
     exon            1..140
                     /gene="Ccl21a"
                     /gene_synonym="6CKBAC2; 6Ckine; ALP; CKb9; Gm1987; plt;
                     Scya21; SCYA21a; Scya21b; SLC; Tca4"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..475
                     /gene="Ccl21a"
                     /gene_synonym="6CKBAC2; 6Ckine; ALP; CKb9; Gm1987; plt;
                     Scya21; SCYA21a; Scya21b; SLC; Tca4"
                     /note="CCL21-Ser; CC chemokine 6Ckine-ser; C-C motif
                     chemokine 21a; small inducible cytokine A21a; chemokine
                     (C-C motif) ligand 21A (serine); exodus-2; thymus-derived
                     chemotactic agent 4; beta-chemokine exodus-2"
                     /codon_start=1
                     /product="C-C motif chemokine 21a precursor"
                     /protein_id="NP_035254.1"
                     /db_xref="CCDS:CCDS18081.1"
                     /db_xref="GeneID:18829"
                     /db_xref="MGI:MGI:1349183"
                     /translation="MAQMMTLSLLSLVLALCIPWTQGSDGGGQDCCLKYSQKKIPYSI
                     VRGYRKQEPSLGCPIPAILFSPRKHSKPELCANPEEGWVQNLMRRLDQPPAPGKQSPG
                     CRKNRGTSKSGKKGKGSKGCKRTEQTQPSRG"
     exon            141..261
                     /gene="Ccl21a"
                     /gene_synonym="6CKBAC2; 6Ckine; ALP; CKb9; Gm1987; plt;
                     Scya21; SCYA21a; Scya21b; SLC; Tca4"
                     /inference="alignment:Splign:2.1.0"
     exon            262..444
                     /gene="Ccl21a"
                     /gene_synonym="6CKBAC2; 6Ckine; ALP; CKb9; Gm1987; plt;
                     Scya21; SCYA21a; Scya21b; SLC; Tca4"
                     /inference="alignment:Splign:2.1.0"
     exon            445..868
                     /gene="Ccl21a"
                     /gene_synonym="6CKBAC2; 6Ckine; ALP; CKb9; Gm1987; plt;
                     Scya21; SCYA21a; Scya21b; SLC; Tca4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacacacaga ccccaacttg cggctgtcca tctcacctac agctctggtc tcatcctcaa
       61 ctcaaccaca atcatggctc agatgatgac tctgagcctc cttagcctgg tcctggctct
      121 ctgcatcccc tggacccaag gcagtgatgg agggggtcag gactgctgcc ttaagtacag
      181 ccagaagaaa attccctaca gtattgtccg aggctatagg aagcaagaac caagtttagg
      241 ctgtcccatc ccggcaatcc tgttctcacc ccggaagcac tctaagcctg agctatgtgc
      301 aaaccctgag gaaggctggg tgcagaacct gatgcgccgc ctggaccagc ctccagcccc
      361 agggaaacaa agccccggct gcaggaagaa ccggggaacc tctaagtctg gaaagaaagg
      421 aaagggctcc aagggctgca agagaactga acagacacag ccctcaagag gatagcccag
      481 tagcccgcct ggagcccagg agatccccca cgaacttcaa gctgggtggt tcacggtcca
      541 actcacaggc aaagagggag ctagaaaaca gactcaggag cccaaagcag ccacctcatg
      601 ctggcctccg tccacaccct tgccctgctt caaccatcac atctgcacgg ccatcccttt
      661 cttacctggc ggagctgcct tccctggggt agacctagag agtcagaaga aagagtgtct
      721 cccagggaat gaggaaggag acagcaggac tgtcccctct aggaggtcac tcaggtccca
      781 agacctgaac ctgctctcca tggcgccctt cccttgtcct tgcacctatg atttatacct
      841 aactgaataa aaaggtgatc cagcctca
//
