LOCUS       NM_016960                852 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 20 (Ccl20), transcript
            variant 1, mRNA.
ACCESSION   NM_016960 XM_484888
VERSION     NM_016960.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 852)
  AUTHORS   Zhu,Y., Tan,J., Wang,Y., Gong,Y., Zhang,X., Yuan,Z., Lu,X.,
            Tang,H., Zhang,Z., Jiang,X., Zhu,W. and Gong,L.
  TITLE     Atg5 deficiency in macrophages protects against kidney fibrosis via
            the CCR6-CCL20 axis
  JOURNAL   Cell Commun Signal 22 (1), 223 (2024)
   PUBMED   38594728
  REMARK    GeneRIF: Atg5 deficiency in macrophages protects against kidney
            fibrosis via the CCR6-CCL20 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 852)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 852)
  AUTHORS   Won,E.J., Kim,H.J., Lee,Y.J., Kim,M.J., Lee,H.I., Jang,H.H.,
            Kim,S.H., Kang,J.H., Park,K.J., Shim,S.C., Jo,S., Kim,T.H. and
            Kim,T.J.
  TITLE     CCL20 inhibition for treating inflammation in ankylosing
            spondylitis
  JOURNAL   Rheumatology (Oxford) 62 (12), 4000-4005 (2023)
   PUBMED   37279731
  REMARK    GeneRIF: CCL20 inhibition for treating inflammation in ankylosing
            spondylitis.
REFERENCE   4  (bases 1 to 852)
  AUTHORS   Liu,Y., Wei,D., Deguchi,Y., Xu,W., Tian,R., Liu,F., Xu,M., Mao,F.,
            Li,D., Chen,W., Valentin,L.A., Deguchi,E., Yao,J.C., Shureiqi,I.
            and Zuo,X.
  TITLE     PPARdelta dysregulation of CCL20/CCR6 axis promotes gastric
            adenocarcinoma carcinogenesis by remodeling gastric tumor
            microenvironment
  JOURNAL   Gastric Cancer 26 (6), 904-917 (2023)
   PUBMED   37572185
  REMARK    GeneRIF: PPARdelta dysregulation of CCL20/CCR6 axis promotes
            gastric adenocarcinoma carcinogenesis by remodeling gastric tumor
            microenvironment.
REFERENCE   5  (bases 1 to 852)
  AUTHORS   Lorchner,H., Canes Esteve,L., Goes,M.E., Harzenetter,R.,
            Brachmann,N., Gajawada,P., Gunther,S., Doll,N., Poling,J. and
            Braun,T.
  TITLE     Neutrophils for Revascularization Require Activation of CCR6 and
            CCL20 by TNFalpha
  JOURNAL   Circ Res 133 (7), 592-610 (2023)
   PUBMED   37641931
  REMARK    GeneRIF: Neutrophils for Revascularization Require Activation of
            CCR6 and CCL20 by TNFalpha.
REFERENCE   6  (bases 1 to 852)
  CONSRTM   IUIS/WHO Subcommittee on Chemokine Nomenclature
  TITLE     Chemokine/chemokine receptor nomenclature
  JOURNAL   J Immunol Methods 262 (1-2), 1-3 (2002)
   PUBMED   12080938
REFERENCE   7  (bases 1 to 852)
  AUTHORS   Scheerens,H., Hessel,E., de Waal-Malefyt,R., Leach,M.W. and
            Rennick,D.
  TITLE     Characterization of chemokines and chemokine receptors in two
            murine models of inflammatory bowel disease: IL-10-/- mice and
            Rag-2-/- mice reconstituted with CD4+CD45RBhigh T cells
  JOURNAL   Eur J Immunol 31 (5), 1465-1474 (2001)
   PUBMED   11465103
REFERENCE   8  (bases 1 to 852)
  AUTHORS   Tanaka,Y., Imai,T., Baba,M., Ishikawa,I., Uehira,M., Nomiyama,H.
            and Yoshie,O.
  TITLE     Selective expression of liver and activation-regulated chemokine
            (LARC) in intestinal epithelium in mice and humans
  JOURNAL   Eur J Immunol 29 (2), 633-642 (1999)
   PUBMED   10064080
REFERENCE   9  (bases 1 to 852)
  AUTHORS   Utans-Schneitz,U., Lorez,H., Klinkert,W.E., da Silva,J. and
            Lesslauer,W.
  TITLE     A novel rat CC chemokine, identified by targeted differential
            display, is upregulated in brain inflammation
  JOURNAL   J Neuroimmunol 92 (1-2), 179-190 (1998)
   PUBMED   9916893
  REMARK    Erratum:[J Neuroimmunol 1999 Feb 1;94(1-2):222]
REFERENCE   10 (bases 1 to 852)
  AUTHORS   Varona,R., Zaballos,A., Gutierrez,J., Martin,P., Roncal,F.,
            Albar,J.P., Ardavin,C. and Marquez,G.
  TITLE     Molecular cloning, functional characterization and mRNA expression
            analysis of the murine chemokine receptor CCR6 and its specific
            ligand MIP-3alpha
  JOURNAL   FEBS Lett 440 (1-2), 188-194 (1998)
   PUBMED   9862452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY026108.1, BX525886.1 and BC028504.1.
            
            On May 1, 2009 this sequence version replaced NM_016960.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY025309.1, AB015136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BY026108.1         1-28
            29-539              BX525886.1         7-517
            540-852             BC028504.1         510-822
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 42.69 cM"
     gene            1..852
                     /gene="Ccl20"
                     /gene_synonym="CKb4; exodus-1; LARC; MIP-3A; MIP-3[a];
                     MIP3A; Scya20; ST38"
                     /note="C-C motif chemokine ligand 20"
                     /db_xref="GeneID:20297"
                     /db_xref="MGI:MGI:1329031"
     exon            1..137
                     /gene="Ccl20"
                     /gene_synonym="CKb4; exodus-1; LARC; MIP-3A; MIP-3[a];
                     MIP3A; Scya20; ST38"
                     /inference="alignment:Splign:2.1.0"
     exon            138..252
                     /gene="Ccl20"
                     /gene_synonym="CKb4; exodus-1; LARC; MIP-3A; MIP-3[a];
                     MIP3A; Scya20; ST38"
                     /inference="alignment:Splign:2.1.0"
     exon            253..330
                     /gene="Ccl20"
                     /gene_synonym="CKb4; exodus-1; LARC; MIP-3A; MIP-3[a];
                     MIP3A; Scya20; ST38"
                     /inference="alignment:Splign:2.1.0"
     exon            331..802
                     /gene="Ccl20"
                     /gene_synonym="CKb4; exodus-1; LARC; MIP-3A; MIP-3[a];
                     MIP3A; Scya20; ST38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      783..788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl20"
                     /gene_synonym="CKb4; exodus-1; LARC; MIP-3A; MIP-3[a];
                     MIP3A; Scya20; ST38"
                     /note="hexamer: AATAAA"
     polyA_site      802
                     /gene="Ccl20"
                     /gene_synonym="CKb4; exodus-1; LARC; MIP-3A; MIP-3[a];
                     MIP3A; Scya20; ST38"
                     /note="major polyA site"
ORIGIN      
        1 gagcactcgc agggcactgg gtacccagca ctgagtacat caactcctgg agctgagaat
       61 ggcctgcggt ggcaagcgtc tgctcttcct tgctttggca tgggtactgc tggctcacct
      121 ctgcagccag gcagaagcag caagcaacta cgactgttgc ctctcgtaca tacagacgcc
      181 tcttccttcc agagctattg tgggtttcac aagacagatg gccgatgaag cttgtgacat
      241 taatgctatc atctttcaca cgaagaaaag aaaatctgtg tgcgctgatc caaagcagaa
      301 ctgggtgaaa agggctgtga acctcctcag cctaagagtc aagaagatgt aaaaaactga
      361 tgcttttttg ggatggaatt ggacacagcc caaggaggaa atgatcacag ctggggttga
      421 aggcttcacc tgcacatcac tgcacagacc tgatttgtgt cccagtggac ttgtccaatg
      481 gatgaagttg attcatattg catcatagtg tgtcatattt aagctcacat tagagttaag
      541 ttgtatttta tgttatttat agatctgaat tttctatgtt tagctattta atgttaattt
      601 cccacaatcc atgggggcgc ttagtggaag gattaatatt atgtttaagg gaatagttta
      661 tatggacctt tttgtcaaca ataagctatt gtaaagatat ttaatgttct gtttatttaa
      721 ttgcttctta aattgatatg attttcttat aaaacagaaa agaattataa gaatatattg
      781 aaaataaaag aattgaaagg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      841 aaaaaaaaaa aa
//
