LOCUS       NM_011333                806 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus C-C motif chemokine ligand 2 (Ccl2), mRNA.
ACCESSION   NM_011333
VERSION     NM_011333.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 806)
  AUTHORS   Pryce,B.R., Oles,A., Talbert,E.E., Romeo,M.J., Vaena,S., Sharma,S.,
            Spadafora,V., Tolliver,L., Mahvi,D.A., Morgan,K.A., Lancaster,W.P.,
            Beal,E., Koren,N., Watts,B., Overstreet,M., Berto,S.,
            Subramanian,S., Calisir,K., Crawford,A., Neelon,B., Ostrowski,M.C.,
            Zimmers,T.A., Tidball,J.G., Wang,D.J. and Guttridge,D.C.
  TITLE     Muscle inflammation is regulated by NF-kappaB from multiple cells
            to control distinct states of wasting in cancer cachexia
  JOURNAL   Cell Rep 43 (11), 114925 (2024)
   PUBMED   39475511
REFERENCE   2  (bases 1 to 806)
  AUTHORS   Ryu,S., Zhang,J., Simoes,R., Liu,X., Guo,Z., Feng,L., Unsinger,J.,
            Hotchkiss,R.S. and Cao,Y.Q.
  TITLE     Regulatory T cells require peripheral CCL2-CCR2 signaling to
            facilitate the resolution of medication overuse headache-related
            behavioral sensitization
  JOURNAL   J Headache Pain 25 (1), 197 (2024)
   PUBMED   39528947
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 806)
  AUTHORS   Hu,S., Tang,Y., Li,X., Li,W., Zeng,Y., Jiang,M., Chen,R., Zheng,P.,
            Yang,L., Song,Z., Xie,D., Chen,Y. and Yuan,Y.
  TITLE     Hsp90aa1/JUN/Ccl2 regulatory axis mediates migration and
            differentiation of NSPCs, promoting the onset and progression of
            early post-ischemic stroke epilepsy
  JOURNAL   Neurobiol Dis 200, 106635 (2024)
   PUBMED   39128813
  REMARK    GeneRIF: Hsp90aa1/JUN/Ccl2 regulatory axis mediates migration and
            differentiation of NSPCs, promoting the onset and progression of
            early post-ischemic stroke epilepsy.
REFERENCE   4  (bases 1 to 806)
  AUTHORS   Liu,Q., Wu,N. and Hou,P.
  TITLE     PRPS2-mediated modulation of the antitumor immune response in lung
            cancer through CCL2-mediated tumor-associated macrophages and
            myeloid-derived suppressor cells
  JOURNAL   Thorac Cancer 15 (23), 1739-1748 (2024)
   PUBMED   38952044
  REMARK    GeneRIF: PRPS2-mediated modulation of the antitumor immune response
            in lung cancer through CCL2-mediated tumor-associated macrophages
            and myeloid-derived suppressor cells.
REFERENCE   5  (bases 1 to 806)
  AUTHORS   Kishinaka,S., Kawashita,E., Nishizaki,T., Ishihara,K. and Akiba,S.
  TITLE     Group IVA Phospholipase A2 in Collagen-Producing Cells Promotes
            High-Fat Diet-Induced Infiltration of Inflammatory Cells into the
            Liver by Upregulating the Expression of MCP-1
  JOURNAL   Biol Pharm Bull 47 (5), 1058-1065 (2024)
   PUBMED   38825533
  REMARK    GeneRIF: Group IVA Phospholipase A2 in Collagen-Producing Cells
            Promotes High-Fat Diet-Induced Infiltration of Inflammatory Cells
            into the Liver by Upregulating the Expression of MCP-1.
REFERENCE   6  (bases 1 to 806)
  AUTHORS   Freter,R.R., Irminger,J.C., Porter,J.A., Jones,S.D. and Stiles,C.D.
  TITLE     A novel 7-nucleotide motif located in 3' untranslated sequences of
            the immediate-early gene set mediates platelet-derived growth
            factor induction of the JE gene
  JOURNAL   Mol Cell Biol 12 (12), 5288-5300 (1992)
   PUBMED   1448065
REFERENCE   7  (bases 1 to 806)
  AUTHORS   Rameh,L.E. and Armelin,M.C.
  TITLE     Downregulation of JE and KC genes by glucocorticoids does not
            prevent the G0----G1 transition in BALB/3T3 cells
  JOURNAL   Mol Cell Biol 12 (10), 4612-4621 (1992)
   PUBMED   1406651
REFERENCE   8  (bases 1 to 806)
  AUTHORS   Baldacci,P.A., Richoux,V., Renard,J.P., Guenet,J.L. and Babinet,C.
  TITLE     The locus Om, responsible for the DDK syndrome, maps close to Sigje
            on mouse chromosome 11
  JOURNAL   Mamm Genome 2 (2), 100-105 (1992)
   PUBMED   1347470
REFERENCE   9  (bases 1 to 806)
  AUTHORS   Aitman,T.J., Hearne,C.M., McAleer,M.A. and Todd,J.A.
  TITLE     Mononucleotide repeats are an abundant source of length variants in
            mouse genomic DNA
  JOURNAL   Mamm Genome 1 (4), 206-210 (1991)
   PUBMED   1794049
  REMARK    Review article
REFERENCE   10 (bases 1 to 806)
  AUTHORS   Wilson,S.D., Billings,P.R., D'Eustachio,P., Fournier,R.E.,
            Geissler,E., Lalley,P.A., Burd,P.R., Housman,D.E., Taylor,B.A. and
            Dorf,M.E.
  TITLE     Clustering of cytokine genes on mouse chromosome 11
  JOURNAL   J Exp Med 171 (4), 1301-1314 (1990)
   PUBMED   1969921
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK150937.1.
            
            On Apr 5, 2007 this sequence version replaced NM_011333.2.
            
            Summary: This gene is one of several cytokine genes clustered on
            chromosome 11. Chemokines are a superfamily of secreted proteins
            involved in immunoregulatory and inflammatory processes. The
            superfamily is divided into four subfamilies based on the
            arrangement of N-terminal cysteine residues of the mature peptide.
            This chemokine is a member of the CC subfamily which is
            characterized by two adjacent cysteine residues. This cytokine
            displays chemotactic activity for monocytes and memory T cells but
            not for neutrophils. The human ortholog has been implicated in the
            pathogenesis of diseases characterized by monocytic infiltrates,
            such as psoriasis, rheumatoid arthritis, and atherosclerosis.
            [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150937.1, AK153520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-806               AK150937.1         2-807
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 49.82 cM"
     gene            1..806
                     /gene="Ccl2"
                     /gene_synonym="HC11; JE; MCAF; MCP-1; MCP1; Scya2; Sigje;
                     SMC-CF"
                     /note="C-C motif chemokine ligand 2"
                     /db_xref="GeneID:20296"
                     /db_xref="MGI:MGI:98259"
     exon            1..161
                     /gene="Ccl2"
                     /gene_synonym="HC11; JE; MCAF; MCP-1; MCP1; Scya2; Sigje;
                     SMC-CF"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..532
                     /gene="Ccl2"
                     /gene_synonym="HC11; JE; MCAF; MCP-1; MCP1; Scya2; Sigje;
                     SMC-CF"
                     /note="C-C motif chemokine 2; small-inducible cytokine A2;
                     monocyte chemotactic protein 1; monocyte chemoattractant
                     protein 1; chemokine (C-C motif) ligand 2;
                     platelet-derived growth factor-inducible protein JE"
                     /codon_start=1
                     /product="C-C motif chemokine 2 precursor"
                     /protein_id="NP_035463.1"
                     /db_xref="CCDS:CCDS25139.1"
                     /db_xref="GeneID:20296"
                     /db_xref="MGI:MGI:98259"
                     /translation="MQVPVMLLGLLFTVAGWSIHVLAQPDAVNAPLTCCYSFTSKMIP
                     MSRLESYKRITSSRCPKEAVVFVTKLKREVCADPKKEWVQTYIKNLDRNQMRSEPTTL
                     FKTASALRSSAPLNVKLTRKSEANASTTFSTTTSSTSVGVTSVTVN"
     exon            162..279
                     /gene="Ccl2"
                     /gene_synonym="HC11; JE; MCAF; MCP-1; MCP1; Scya2; Sigje;
                     SMC-CF"
                     /inference="alignment:Splign:2.1.0"
     exon            280..806
                     /gene="Ccl2"
                     /gene_synonym="HC11; JE; MCAF; MCP-1; MCP1; Scya2; Sigje;
                     SMC-CF"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      631
                     /gene="Ccl2"
                     /gene_synonym="HC11; JE; MCAF; MCP-1; MCP1; Scya2; Sigje;
                     SMC-CF"
     regulatory      777..782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl2"
                     /gene_synonym="HC11; JE; MCAF; MCP-1; MCP1; Scya2; Sigje;
                     SMC-CF"
     polyA_site      806
                     /gene="Ccl2"
                     /gene_synonym="HC11; JE; MCAF; MCP-1; MCP1; Scya2; Sigje;
                     SMC-CF"
ORIGIN      
        1 gcagagagcc agacgggagg aaggccagcc cagcaccagc accagccaac tctcactgaa
       61 gccagctctc tcttcctcca ccaccatgca ggtccctgtc atgcttctgg gcctgctgtt
      121 cacagttgcc ggctggagca tccacgtgtt ggctcagcca gatgcagtta acgccccact
      181 cacctgctgc tactcattca ccagcaagat gatcccaatg agtaggctgg agagctacaa
      241 gaggatcacc agcagcaggt gtcccaaaga agctgtagtt tttgtcacca agctcaagag
      301 agaggtctgt gctgacccca agaaggaatg ggtccagaca tacattaaaa acctggatcg
      361 gaaccaaatg agatcagaac ctacaacttt atttaaaact gcatctgccc taaggtcttc
      421 agcacctttg aatgtgaagt tgacccgtaa atctgaagct aatgcatcca ctaccttttc
      481 cacaaccacc tcaagcactt ctgtaggagt gaccagtgtg acagtgaact agtgtgactc
      541 ggactgtgat gccttaatta atattaaact tatttaactt attgatgtta tggtattccc
      601 tttcatgaat actaaaattt cttaaatgca aggtgtggat ccatttttcc ctctctgtga
      661 atccagattc aacactttca atgtatgaga gatgaatttt gtaaagatga atgggtaaac
      721 tttgtgtttg agattccaag gtattgttta aaatattatt atggatattc cttattatta
      781 aaagaaatat attatttttg tacacc
//
