LOCUS       NM_011888                760 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus C-C motif chemokine ligand 19 (Ccl19), mRNA.
ACCESSION   NM_011888 NM_001378465 XM_001472168
VERSION     NM_011888.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 760)
  AUTHORS   Chen,K.Y., De Giovanni,M., Xu,Y., An,J., Kirthivasan,N., Lu,E.,
            Jiang,K., Brooks,S., Ranucci,S., Yang,J., Kanameishi,S.,
            Kabashima,K., Brulois,K., Bscheider,M., Butcher,E.C. and
            Cyster,J.G.
  TITLE     Inflammation switches the chemoattractant requirements for naive
            lymphocyte entry into lymph nodes
  JOURNAL   Cell (2024) In press
   PUBMED   39708807
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 760)
  AUTHORS   Nakano,K., Whitehead,G.S., Lyons-Cohen,M.R., Grimm,S.A.,
            Wilkinson,C.L., Izumi,G., Livraghi-Butrico,A., Cook,D.N. and
            Nakano,H.
  TITLE     Chemokine CCL19 promotes type 2 T-cell differentiation and allergic
            airway inflammation
  JOURNAL   J Allergy Clin Immunol 153 (2), 487-502 (2024)
   PUBMED   37956733
  REMARK    GeneRIF: Chemokine CCL19 promotes type 2 T-cell differentiation and
            allergic airway inflammation.
REFERENCE   3  (bases 1 to 760)
  AUTHORS   Yan,Y., Hu,K., Fu,M., Deng,X., Luo,S., Tong,L., Guan,X., He,S.,
            Li,C., Jin,W., Du,T., Zheng,Z., Zhang,M., Liu,Y. and Hu,Q.
  TITLE     CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein D To
            Induce Protective Systemic Immunity against Genital Viral Challenge
  JOURNAL   mSphere 6 (2), e00058-21 (2021)
   PUBMED   33910988
  REMARK    GeneRIF: CCL19 and CCL28 Assist Herpes Simplex Virus 2 Glycoprotein
            D To Induce Protective Systemic Immunity against Genital Viral
            Challenge.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 760)
  AUTHORS   Shen,Y., Sun,Z., Mao,S., Zhang,Y., Jiang,W. and Wang,H.
  TITLE     IRF-1 contributes to the pathological phenotype of VSMCs during
            atherogenesis by increasing CCL19 transcription
  JOURNAL   Aging (Albany NY) 13 (1), 933-943 (2020)
   PUBMED   33424012
  REMARK    GeneRIF: IRF-1 contributes to the pathological phenotype of VSMCs
            during atherogenesis by increasing CCL19 transcription.
REFERENCE   5  (bases 1 to 760)
  AUTHORS   Choi,S.Y., Bae,H., Jeong,S.H., Park,I., Cho,H., Hong,S.P.,
            Lee,D.H., Lee,C.K., Park,J.S., Suh,S.H., Choi,J., Yang,M.J.,
            Jang,J.Y., Onder,L., Moon,J.H., Jeong,H.S., Adams,R.H., Kim,J.M.,
            Ludewig,B., Song,J.H., Lim,D.S. and Koh,G.Y.
  TITLE     YAP/TAZ direct commitment and maturation of lymph node fibroblastic
            reticular cells
  JOURNAL   Nat Commun 11 (1), 519 (2020)
   PUBMED   31980640
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 760)
  AUTHORS   Bleul,C.C. and Boehm,T.
  TITLE     Chemokines define distinct microenvironments in the developing
            thymus
  JOURNAL   Eur J Immunol 30 (12), 3371-3379 (2000)
   PUBMED   11093154
  REMARK    Erratum:[Eur J Immunol 2001 Feb;31(2):675]
REFERENCE   7  (bases 1 to 760)
  AUTHORS   Luther,S.A., Tang,H.L., Hyman,P.L., Farr,A.G. and Cyster,J.G.
  TITLE     Coexpression of the chemokines ELC and SLC by T zone stromal cells
            and deletion of the ELC gene in the plt/plt mouse
  JOURNAL   Proc Natl Acad Sci U S A 97 (23), 12694-12699 (2000)
   PUBMED   11070085
REFERENCE   8  (bases 1 to 760)
  AUTHORS   Ngo,V.N., Tang,H.L. and Cyster,J.G.
  TITLE     Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed
            by dendritic cells in lymphoid tissues and strongly attracts naive
            T cells and activated B cells
  JOURNAL   J Exp Med 188 (1), 181-191 (1998)
   PUBMED   9653094
REFERENCE   9  (bases 1 to 760)
  AUTHORS   Yoshida,R., Nagira,M., Kitaura,M., Imagawa,N., Imai,T. and
            Yoshie,O.
  TITLE     Secondary lymphoid-tissue chemokine is a functional ligand for the
            CC chemokine receptor CCR7
  JOURNAL   J Biol Chem 273 (12), 7118-7122 (1998)
   PUBMED   9507024
REFERENCE   10 (bases 1 to 760)
  AUTHORS   Ivanova,N.B. and Belyavsky,A.V.
  TITLE     Identification of differentially expressed genes by restriction
            endonuclease-based gene expression fingerprinting
  JOURNAL   Nucleic Acids Res 23 (15), 2954-2958 (1995)
   PUBMED   7659517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772334.17.
            
            On or before Oct 27, 2020 this sequence version replaced
            NM_001378465.1, NM_011888.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF059208.2, AK144337.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AL772334.17        41979-42267         c
            290-422             AL772334.17        40877-41009         c
            423-516             AL772334.17        40566-40659         c
            517-760             AL772334.17        40234-40477         c
FEATURES             Location/Qualifiers
     source          1..760
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 22.44 cM"
     gene            1..760
                     /gene="Ccl19"
                     /gene_synonym="CKb11; ELC; exodus-3; Gm2023; MIP3B;
                     Scya19"
                     /note="C-C motif chemokine ligand 19"
                     /db_xref="GeneID:24047"
                     /db_xref="MGI:MGI:1346316"
     exon            1..289
                     /gene="Ccl19"
                     /gene_synonym="CKb11; ELC; exodus-3; Gm2023; MIP3B;
                     Scya19"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..555
                     /gene="Ccl19"
                     /gene_synonym="CKb11; ELC; exodus-3; Gm2023; MIP3B;
                     Scya19"
                     /function="strongly attracts lymphocytes"
                     /note="C-C motif chemokine 19; chemokine CCL19;
                     small-inducible cytokine A19; epstein-Barr virus-induced
                     molecule 1 ligand chemokine; EBI1 ligand chemokine;
                     EBV-induced molecule 1 ligand chemokine; EBI-1 ligand
                     chemokine; chemokine (C-C motif) ligand 19"
                     /codon_start=1
                     /product="C-C motif chemokine 19 precursor"
                     /protein_id="NP_036018.1"
                     /db_xref="CCDS:CCDS18080.1"
                     /db_xref="GeneID:24047"
                     /db_xref="MGI:MGI:1346316"
                     /translation="MAPRVTPLLAFSLLVLWTFPAPTLGGANDAEDCCLSVTQRPIPG
                     NIVKAFRYLLNEDGCRVPAVVFTTLRGYQLCAPPDQPWVDRIIRRLKKSSAKNKGNST
                     RRSPVS"
     exon            290..422
                     /gene="Ccl19"
                     /gene_synonym="CKb11; ELC; exodus-3; Gm2023; MIP3B;
                     Scya19"
                     /inference="alignment:Splign:2.1.0"
     exon            423..516
                     /gene="Ccl19"
                     /gene_synonym="CKb11; ELC; exodus-3; Gm2023; MIP3B;
                     Scya19"
                     /inference="alignment:Splign:2.1.0"
     exon            517..760
                     /gene="Ccl19"
                     /gene_synonym="CKb11; ELC; exodus-3; Gm2023; MIP3B;
                     Scya19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      739..744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl19"
                     /gene_synonym="CKb11; ELC; exodus-3; Gm2023; MIP3B;
                     Scya19"
                     /note="hexamer: AATAAA"
     polyA_site      760
                     /gene="Ccl19"
                     /gene_synonym="CKb11; ELC; exodus-3; Gm2023; MIP3B;
                     Scya19"
                     /note="major polyA site"
ORIGIN      
        1 aggcataaat tggagctggt ggcagcctca gcaggctcaa gcgggctcac tggggcacac
       61 acaagctcac ttgcacttgg ctcctgaacc ccttcacgcc acaggaggac atctgagcga
      121 ttccagtcac tcccctgtga acccgtcgga gcctcggcct ctcagattct tgcgcacaca
      181 gtctctcagg ctcactcact ctctgtggcc tgcctcagat tatctgccat ggccccccgt
      241 gtgaccccac tcctggcctt cagcctgctg gttctctgga ccttcccagc cccaactctg
      301 gggggtgcta atgatgcgga agactgctgc ctgtctgtga cccagcgccc catccctggg
      361 aacatcgtga aagccttccg ctaccttctt aatgaagatg gctgcagggt gcctgctgtt
      421 gtgttcacca cactaagggg ctatcagctc tgtgcacctc cagaccagcc ctgggtggat
      481 cgcatcatcc gaagactgaa gaagtcttct gccaagaaca aaggcaacag caccagaagg
      541 agccctgtgt cttgagtaaa gagatgtgaa tcactctggc ccaggaaacc aaggaccaga
      601 agagaggacc aggcctcctg atgctctgtc ccagacctaa cccagccaag tctgtgccta
      661 gagagtcgat gtgagtgtgg acaagagagt ttgtgtggct agaacaccat ctctctgtgg
      721 ctagactgca gagcttccaa taaagccgct tggtaccgtg
//
