LOCUS       NM_011332                541 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 17 (Ccl17), mRNA.
ACCESSION   NM_011332
VERSION     NM_011332.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 541)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 541)
  AUTHORS   Heine,A., Lemmermann,N.A.W., Flores,C., Becker-Gotot,J., Garbi,N.,
            Brossart,P. and Kurts,C.
  TITLE     Rapid protection against viral infections by chemokine-accelerated
            post-exposure vaccination
  JOURNAL   Front Immunol 15, 1338499 (2024)
   PUBMED   38348028
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 541)
  AUTHORS   Song,N., Paust,H.J., Asada,N., Peters,A., Kaffke,A., Krebs,C.F.,
            Panzer,U. and Riedel,J.H.
  TITLE     Targeting Monocyte Derived CCL17 Attenuates Murine Crescentic
            Glomerulonephritis by Affecting Renal CCR4+ Regulatory T-Cell
            Recruitment
  JOURNAL   Am J Nephrol 55 (2), 214-224 (2024)
   PUBMED   37742620
  REMARK    GeneRIF: Targeting Monocyte Derived CCL17 Attenuates Murine
            Crescentic Glomerulonephritis by Affecting Renal CCR4+ Regulatory
            T-Cell Recruitment.
REFERENCE   4  (bases 1 to 541)
  AUTHORS   Shin,H., Prasad,V., Lupancu,T., Malik,S., Achuthan,A., Biondo,M.,
            Kingwell,B.A., Thiem,M., Gottschalk,M., Weighardt,H., Forster,I.,
            de Steiger,R., Hamilton,J.A. and Lee,K.M.
  TITLE     The GM-CSF/CCL17 pathway in obesity-associated osteoarthritic pain
            and disease in mice
  JOURNAL   Osteoarthritis Cartilage 31 (10), 1327-1341 (2023)
   PUBMED   37225052
  REMARK    GeneRIF: The GM-CSF/CCL17 pathway in obesity-associated
            osteoarthritic pain and disease in mice.
REFERENCE   5  (bases 1 to 541)
  AUTHORS   Li,Y., Cao,H., Jiang,Z., Yan,K., Shi,J., Wang,S., Wang,F., Wang,W.,
            Li,X., Sun,N., Liu,L., Chen,L., Chen,Y., Guo,R. and Song,Y.
  TITLE     CCL17 acts as an antitumor chemokine in micromilieu-driven immune
            skewing
  JOURNAL   Int Immunopharmacol 118, 110078 (2023)
   PUBMED   37001380
  REMARK    GeneRIF: CCL17 acts as an antitumor chemokine in micromilieu-driven
            immune skewing.
REFERENCE   6  (bases 1 to 541)
  AUTHORS   Bleul,C.C. and Boehm,T.
  TITLE     Chemokines define distinct microenvironments in the developing
            thymus
  JOURNAL   Eur J Immunol 30 (12), 3371-3379 (2000)
   PUBMED   11093154
  REMARK    Erratum:[Eur J Immunol 2001 Feb;31(2):675]
REFERENCE   7  (bases 1 to 541)
  AUTHORS   Ross,R., Ross,X.L., Ghadially,H., Lahr,T., Schwing,J., Knop,J. and
            Reske-Kunz,A.B.
  TITLE     Mouse langerhans cells differentially express an activated T
            cell-attracting CC chemokine
  JOURNAL   J Invest Dermatol 113 (6), 991-998 (1999)
   PUBMED   10594742
REFERENCE   8  (bases 1 to 541)
  AUTHORS   Schaniel,C., Sallusto,F., Ruedl,C., Sideras,P., Melchers,F. and
            Rolink,A.G.
  TITLE     Three chemokines with potential functions in T
            lymphocyte-independent and -dependent B lymphocyte stimulation
  JOURNAL   Eur J Immunol 29 (9), 2934-2947 (1999)
   PUBMED   10508268
REFERENCE   9  (bases 1 to 541)
  AUTHORS   Lieberam,I. and Forster,I.
  TITLE     The murine beta-chemokine TARC is expressed by subsets of dendritic
            cells and attracts primed CD4+ T cells
  JOURNAL   Eur J Immunol 29 (9), 2684-2694 (1999)
   PUBMED   10508243
REFERENCE   10 (bases 1 to 541)
  AUTHORS   Yoneyama,H., Harada,A., Imai,T., Baba,M., Yoshie,O., Zhang,Y.,
            Higashi,H., Murai,M., Asakura,H. and Matsushima,K.
  TITLE     Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant
            hepatic failure in mice
  JOURNAL   J Clin Invest 102 (11), 1933-1941 (1998)
   PUBMED   9835618
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007663.1 and BC028505.1.
            
            On Mar 28, 2009 this sequence version replaced NM_011332.2.
            
            Sequence Note: This RefSeq is annotated with the 5'-most in-frame
            translation start codon, which appears to be rodent-specific and
            has a weak Kozak signal. Due to leaky scanning by ribosomes, it is
            possible that an alternative downstream start codon may sometimes
            be used, thus producing a protein that is 10 aa shorter at the
            N-terminus.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028505.1, AF125570.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AK007663.1         2-514
            514-541             BC028505.1         498-525
FEATURES             Location/Qualifiers
     source          1..541
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.85 cM"
     gene            1..541
                     /gene="Ccl17"
                     /gene_synonym="Abcd-2; Scya17; Scya17l; Tarc"
                     /note="C-C motif chemokine ligand 17"
                     /db_xref="GeneID:20295"
                     /db_xref="MGI:MGI:1329039"
     exon            1..119
                     /gene="Ccl17"
                     /gene_synonym="Abcd-2; Scya17; Scya17l; Tarc"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..331
                     /gene="Ccl17"
                     /gene_synonym="Abcd-2; Scya17; Scya17l; Tarc"
                     /note="small inducible cytokine subfamily A17; CC
                     chemokine TARC; small-inducible cytokine A17; thymus and
                     activation-regulated chemokine; C-C motif chemokine 17;
                     chemokine (C-C motif) ligand 17"
                     /codon_start=1
                     /product="C-C motif chemokine 17 precursor"
                     /protein_id="NP_035462.2"
                     /db_xref="CCDS:CCDS57633.1"
                     /db_xref="GeneID:20295"
                     /db_xref="MGI:MGI:1329039"
                     /translation="MKTFTSAFGTMRSLQMLLLAALLLGTFLQHARAARATNVGRECC
                     LDYFKGAIPIRKLVSWYKTSVECSRDAIVFLTVQGKLICADPKDKHVKKAIRLVKNPR
                     P"
     exon            120..237
                     /gene="Ccl17"
                     /gene_synonym="Abcd-2; Scya17; Scya17l; Tarc"
                     /inference="alignment:Splign:2.1.0"
     exon            238..514
                     /gene="Ccl17"
                     /gene_synonym="Abcd-2; Scya17; Scya17l; Tarc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      495..500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl17"
                     /gene_synonym="Abcd-2; Scya17; Scya17l; Tarc"
                     /note="hexamer: AATAAA"
     polyA_site      514
                     /gene="Ccl17"
                     /gene_synonym="Abcd-2; Scya17; Scya17l; Tarc"
                     /note="major polyA site"
ORIGIN      
        1 aagacaggca gaaggaccca tgaagacctt cacctcagct tttggtacca tgaggtcact
       61 tcagatgctg ctcctggctg ctctgcttct ggggactttt ctgcagcatg ccagagctgc
      121 tcgagccacc aatgtaggcc gagagtgctg cctggattac ttcaaagggg ccattcctat
      181 caggaagttg gtgagctggt ataagacctc agtggagtgt tccagggatg ccatcgtgtt
      241 tctgactgtc cagggcaagc tcatctgtgc agaccccaaa gacaaacatg tgaagaaggc
      301 catcagattg gtgaaaaacc caaggccatg accttcccgc tgaggcattt ggagacgcca
      361 gggctgctgt ccatggtttc aacataaaac ggcctgtgac cagcagagcc caagagcagc
      421 cacagagcag aagtccctgt tccctttttt atggactctt atgcactaca ggcgaacaca
      481 aaaaaaagca acggaataaa gccttcctcc ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa
      541 a
//
