LOCUS       NM_011331                536 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 12 (Ccl12), mRNA.
ACCESSION   NM_011331 XM_001480891 XM_001480892 XM_001480893
VERSION     NM_011331.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 536)
  AUTHORS   Ross,J.L., Puigdelloses-Vallcorba,M., Pinero,G., Soni,N.,
            Thomason,W., DeSisto,J., Angione,A., Tsankova,N.M., Castro,M.G.,
            Schniederjan,M., Wadhwani,N.R., Raju,G.P., Morgenstern,P.,
            Becher,O.J., Green,A.L., Tsankov,A.M. and Hambardzumyan,D.
  TITLE     Microglia and monocyte-derived macrophages drive progression of
            pediatric high-grade gliomas and are transcriptionally shaped by
            histone mutations
  JOURNAL   Immunity 57 (11), 2669-2687 (2024)
   PUBMED   39395421
REFERENCE   2  (bases 1 to 536)
  AUTHORS   Cardarelli,S., Biglietto,M., Orsini,T., Fustaino,V., Monaco,L., de
            Oliveira do Rego,A.G., Liccardo,F., Masciarelli,S., Fazi,F.,
            Naro,F., De Angelis,L. and Pellegrini,M.
  TITLE     Modulation of cAMP/cGMP signaling as prevention of congenital heart
            defects in Pde2A deficient embryos: a matter of oxidative stress
  JOURNAL   Cell Death Dis 15 (2), 169 (2024)
   PUBMED   38395995
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 536)
  AUTHORS   Chen,Z., Soni,N., Pinero,G., Giotti,B., Eddins,D.J., Lindblad,K.E.,
            Ross,J.L., Puigdelloses Vallcorba,M., Joshi,T., Angione,A.,
            Thomason,W., Keane,A., Tsankova,N.M., Gutmann,D.H., Lira,S.A.,
            Lujambio,A., Ghosn,E.E.B., Tsankov,A.M. and Hambardzumyan,D.
  TITLE     Monocyte depletion enhances neutrophil influx and proneural to
            mesenchymal transition in glioblastoma
  JOURNAL   Nat Commun 14 (1), 1839 (2023)
   PUBMED   37012245
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 536)
  AUTHORS   Fang,Y., Fan,W., Xu,X., Janoshazi,A.K., Fargo,D.C. and Li,X.
  TITLE     SIRT1 regulates cardiomyocyte alignment during maturation
  JOURNAL   J Cell Sci 135 (7) (2022)
   PUBMED   35260907
REFERENCE   5  (bases 1 to 536)
  AUTHORS   Popiolek-Barczyk,K., Ciechanowska,A., Ciapala,K., Pawlik,K.,
            Oggioni,M., Mercurio,D., De Simoni,M.G. and Mika,J.
  TITLE     The CCL2/CCL7/CCL12/CCR2 pathway is substantially and persistently
            upregulated in mice after traumatic brain injury, and CCL2
            modulates the complement system in microglia
  JOURNAL   Mol Cell Probes 54, 101671 (2020)
   PUBMED   33160071
  REMARK    GeneRIF: The CCL2/CCL7/CCL12/CCR2 pathway is substantially and
            persistently upregulated in mice after traumatic brain injury, and
            CCL2 modulates the complement system in microglia.
REFERENCE   6  (bases 1 to 536)
  AUTHORS   Wagner,K., Dendorfer,U., Chilla,S., Schlondorff,D. and Luckow,B.
  TITLE     Identification of new regulatory sequences far upstream of the
            mouse monocyte chemoattractant protein-1 gene
  JOURNAL   Genomics 78 (3), 113-123 (2001)
   PUBMED   11735217
REFERENCE   7  (bases 1 to 536)
  AUTHORS   Cohen-Tannoudji,M., Vandormael-Pournin,S., Le Bras,S.,
            Coumailleau,F., Babinet,C. and Baldacci,P.
  TITLE     A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus
            region on mouse chromosome 11
  JOURNAL   Genomics 68 (3), 273-282 (2000)
   PUBMED   10995569
REFERENCE   8  (bases 1 to 536)
  AUTHORS   Teuscher,C., Butterfield,R.J., Ma,R.Z., Zachary,J.F., Doerge,R.W.
            and Blankenhorn,E.P.
  TITLE     Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2
            (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are
            candidates for eae7, a locus controlling susceptibility to
            monophasic remitting/nonrelapsing experimental allergic
            encephalomyelitis
  JOURNAL   J Immunol 163 (4), 2262-2266 (1999)
   PUBMED   10438970
REFERENCE   9  (bases 1 to 536)
  AUTHORS   Sarafi,M.N., Garcia-Zepeda,E.A., MacLean,J.A., Charo,I.F. and
            Luster,A.D.
  TITLE     Murine monocyte chemoattractant protein (MCP)-5: a novel CC
            chemokine that is a structural and functional homologue of human
            MCP-1
  JOURNAL   J Exp Med 185 (1), 99-109 (1997)
   PUBMED   8996246
REFERENCE   10 (bases 1 to 536)
  AUTHORS   Jia,G.Q., Gonzalo,J.A., Lloyd,C., Kremer,L., Lu,L., Martinez-A,C.,
            Wershil,B.K. and Gutierrez-Ramos,J.C.
  TITLE     Distinct expression and function of the novel mouse chemokine
            monocyte chemotactic protein-5 in lung allergic inflammation
  JOURNAL   J Exp Med 184 (5), 1939-1951 (1996)
   PUBMED   8920881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645596.7.
            
            On Aug 17, 2018 this sequence version replaced NM_011331.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012356.1, U50712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AL645596.7         56491-56618
            129-246             AL645596.7         57257-57374
            247-536             AL645596.7         57756-58045
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 49.9 cM"
     gene            1..536
                     /gene="Ccl12"
                     /gene_synonym="MCP-5; Scya12"
                     /note="C-C motif chemokine ligand 12"
                     /db_xref="GeneID:20293"
                     /db_xref="MGI:MGI:108224"
     exon            1..128
                     /gene="Ccl12"
                     /gene_synonym="MCP-5; Scya12"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..370
                     /gene="Ccl12"
                     /gene_synonym="MCP-5; Scya12"
                     /note="C-C motif chemokine 12; chemokine (C-C motif)
                     ligand 12; MCP-1-related chemokine; small-inducible
                     cytokine A12; monocyte chemotactic protein 5; monocyte
                     chemoattractant protein 5"
                     /codon_start=1
                     /product="C-C motif chemokine 12 precursor"
                     /protein_id="NP_035461.2"
                     /db_xref="CCDS:CCDS36247.1"
                     /db_xref="GeneID:20293"
                     /db_xref="MGI:MGI:108224"
                     /translation="MKISTLLCLLLIATTISPQVLAGPDAVSTPVTCCYNVVKQKIHV
                     RKLKSYRRITSSQCPREAVIFRTILDKEICADPKEKWVKNSINHLDKTSQTFILEPSC
                     LG"
     exon            129..246
                     /gene="Ccl12"
                     /gene_synonym="MCP-5; Scya12"
                     /inference="alignment:Splign:2.1.0"
     exon            247..536
                     /gene="Ccl12"
                     /gene_synonym="MCP-5; Scya12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagacactg gttcctgact cctctagctt tcatttcgaa gtctttgacc tcaacatgaa
       61 gatttccaca cttctatgcc tcctgctcat agctaccacc atcagtcctc aggtattggc
      121 tggaccagat gcggtgagca ccccagtcac gtgctgttat aatgttgtta agcagaagat
      181 tcacgtccgg aagctgaaga gctacaggag aatcacaagc agccagtgtc cccgggaagc
      241 tgtgatcttc aggaccatac tggataagga gatctgtgct gaccccaagg agaagtgggt
      301 taagaattcc ataaaccact tggataagac gtctcaaacc ttcatccttg aaccttcatg
      361 tctaggctga gagttccaaa aactcttacg tatttccccc tgaagttccc cacgggcagt
      421 gtgatattta ttatgatatc taaaaagaga tgtttttaat aatttaaaca aacttgctta
      481 aataatattt aatggtattt aagtaatatt tgggccaatt aaaccgaatc taattt
//
