LOCUS       NM_011330               1073 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus C-C motif chemokine ligand 11 (Ccl11), mRNA.
ACCESSION   NM_011330
VERSION     NM_011330.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1073)
  AUTHORS   Kong,M., Dong,W., Kang,A., Kuai,Y., Xu,T., Fan,Z., Shi,L., Sun,D.,
            Lu,Y., Li,Z. and Xu,Y.
  TITLE     Regulatory role and translational potential of CCL11 in liver
            fibrosis
  JOURNAL   Hepatology 78 (1), 120-135 (2023)
   PUBMED   36651177
  REMARK    GeneRIF: Regulatory role and translational potential of CCL11 in
            liver fibrosis.
REFERENCE   2  (bases 1 to 1073)
  AUTHORS   Tashiro,R., Ozaki,D., Bautista-Garrido,J., Sun,G., Obertas,L.,
            Mobley,A.S., Kim,G.S., Aronowski,J. and Jung,J.E.
  TITLE     Young Astrocytic Mitochondria Attenuate the Elevated Level of CCL11
            in the Aged Mice, Contributing to Cognitive Function Improvement
  JOURNAL   Int J Mol Sci 24 (6), 5187 (2023)
   PUBMED   36982260
  REMARK    GeneRIF: Young Astrocytic Mitochondria Attenuate the Elevated Level
            of CCL11 in the Aged Mice, Contributing to Cognitive Function
            Improvement.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1073)
  AUTHORS   Fan,Z., Kong,M., Dong,W., Dong,C., Miao,X., Guo,Y., Liu,X.,
            Miao,S., Li,L., Chen,T., Qu,Y., Yu,F., Duan,Y., Lu,Y. and Zou,X.
  TITLE     Trans-activation of eotaxin-1 by Brg1 contributes to liver
            regeneration
  JOURNAL   Cell Death Dis 13 (5), 495 (2022)
   PUBMED   35614068
  REMARK    GeneRIF: Trans-activation of eotaxin-1 by Brg1 contributes to liver
            regeneration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1073)
  AUTHORS   Yang,Y., Paivinen,P., Xie,C., Krup,A.L., Makela,T.P., Mostov,K.E.
            and Reiter,J.F.
  TITLE     Ciliary Hedgehog signaling patterns the digestive system to
            generate mechanical forces driving elongation
  JOURNAL   Nat Commun 12 (1), 7186 (2021)
   PUBMED   34893605
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1073)
  AUTHORS   Dery,L., Charest,G., Guerin,B., Akbari,M. and Fortin,D.
  TITLE     Chemoattraction of Neoplastic Glial Cells with CXCL10, CCL2 and
            CCL11 as a Paradigm for a Promising Therapeutic Approach for
            Primary Brain Tumors
  JOURNAL   Int J Mol Sci 22 (22), 12150 (2021)
   PUBMED   34830041
  REMARK    GeneRIF: Chemoattraction of Neoplastic Glial Cells with CXCL10,
            CCL2 and CCL11 as a Paradigm for a Promising Therapeutic Approach
            for Primary Brain Tumors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1073)
  AUTHORS   Swartz,D.A., Park,E.I., Visek,W.J. and Kaput,J.
  TITLE     The e subunit gene of murine F1F0-ATP synthase. Genomic sequence,
            chromosomal mapping, and diet regulation
  JOURNAL   J Biol Chem 271 (34), 20942-20948 (1996)
   PUBMED   8702853
REFERENCE   7  (bases 1 to 1073)
  AUTHORS   Ganzalo,J.A., Jia,G.Q., Aguirre,V., Friend,D., Coyle,A.J.,
            Jenkins,N.A., Lin,G.S., Katz,H., Lichtman,A., Copeland,N., Kopf,M.
            and Gutierrez-Ramos,J.C.
  TITLE     Mouse Eotaxin expression parallels eosinophil accumulation during
            lung allergic inflammation but it is not restricted to a Th2-type
            response
  JOURNAL   Immunity 4 (1), 1-14 (1996)
   PUBMED   8574847
REFERENCE   8  (bases 1 to 1073)
  AUTHORS   Rothenberg,M.E., Luster,A.D. and Leder,P.
  TITLE     Murine eotaxin: an eosinophil chemoattractant inducible in
            endothelial cells and in interleukin 4-induced tumor suppression
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8960-8964 (1995)
   PUBMED   7568052
REFERENCE   9  (bases 1 to 1073)
  AUTHORS   Rothenberg,M.E., Luster,A.D., Lilly,C.M., Drazen,J.M. and Leder,P.
  TITLE     Constitutive and allergen-induced expression of eotaxin mRNA in the
            guinea pig lung
  JOURNAL   J Exp Med 181 (3), 1211-1216 (1995)
   PUBMED   7869037
REFERENCE   10 (bases 1 to 1073)
  AUTHORS   Jose,P.J., Griffiths-Johnson,D.A., Collins,P.D., Walsh,D.T.,
            Moqbel,R., Totty,N.F., Truong,O., Hsuan,J.J. and Williams,T.J.
  TITLE     Eotaxin: a potent eosinophil chemoattractant cytokine detected in a
            guinea pig model of allergic airways inflammation
  JOURNAL   J Exp Med 179 (3), 881-887 (1994)
   PUBMED   7509365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW986913.1, AK010146.1 and BE200119.1.
            
            On Oct 5, 2007 this sequence version replaced NM_011330.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW986913.1, AK009307.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AW986913.1         1-90
            91-1062             AK010146.1         2-973
            1063-1073           BE200119.1         1-11                c
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 49.84 cM"
     gene            1..1073
                     /gene="Ccl11"
                     /gene_synonym="eotaxin; Scya11"
                     /note="C-C motif chemokine ligand 11"
                     /db_xref="GeneID:20292"
                     /db_xref="MGI:MGI:103576"
     exon            1..211
                     /gene="Ccl11"
                     /gene_synonym="eotaxin; Scya11"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..429
                     /gene="Ccl11"
                     /gene_synonym="eotaxin; Scya11"
                     /note="small chemokine (C-C motif) ligand 11; C-C motif
                     chemokine 11; small-inducible cytokine A11; eosinophil
                     chemotactic protein"
                     /codon_start=1
                     /product="eotaxin precursor"
                     /protein_id="NP_035460.1"
                     /db_xref="CCDS:CCDS36246.1"
                     /db_xref="GeneID:20292"
                     /db_xref="MGI:MGI:103576"
                     /translation="MQSSTALLFLLLTVTSFTSQVLAHPGSIPTSCCFIMTSKKIPNT
                     LLKSYKRITNNRCTLKAIVFKTRLGKEICADPKKKWVQDATKHLDQKLQTPKP"
     exon            212..323
                     /gene="Ccl11"
                     /gene_synonym="eotaxin; Scya11"
                     /inference="alignment:Splign:2.1.0"
     exon            324..1073
                     /gene="Ccl11"
                     /gene_synonym="eotaxin; Scya11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1052..1057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccl11"
                     /gene_synonym="eotaxin; Scya11"
                     /note="hexamer: AATAAA"
     polyA_site      1073
                     /gene="Ccl11"
                     /gene_synonym="eotaxin; Scya11"
                     /note="major polyA site"
ORIGIN      
        1 ctccttcatg accttgtgca ggcagttttc tctggaagct tccacccact ctgctcccta
       61 taaagctagt cgggagagcc tacagagccc agaggctgag atccaagcag taacttccat
      121 ctgtctccct ccaccatgca gagctccaca gcgcttctat tcctgctgct cacggtcact
      181 tccttcacct cccaggtgct ggctcaccca ggctccatcc caacttcctg ctgctttatc
      241 atgaccagta agaagatccc caacacacta ctgaagagct acaaaagaat caccaacaac
      301 agatgcaccc tgaaagccat agtcttcaag accaggttgg gcaaagagat ctgtgctgac
      361 cccaagaaga agtgggtcca ggatgccaca aagcacctgg accaaaaact ccaaactcca
      421 aaaccataaa caacctcctc tcttgacact aacccagagc ctaagaactg cttgattcct
      481 tctctttcct aagacgtgct ctgagggaat atcagcacca gtcgcccaag gacttggctt
      541 catgtagttc cagatgggac tggaagtcat tatgtttgct gaaataagtc agactcaaaa
      601 gattgtgtaa tttcttgcat atgcaacatc ttaaaagggg ggcatgaaag gagatgtggg
      661 attattgagg aacacaatgg gacgagttag gagtaactga ggataatagc agcttataca
      721 catatatgaa aatgtctatt gttttgcaca attaatatac actaattaaa attaatttac
      781 actaactaaa atgttaatat ttaaagacat gttacattta agaaattgga gttttaaagc
      841 ataatttaat ggatatcagt cctttttgtt attgtgttgt ttgtttgctt gcttgtttga
      901 aacagggact cactgtatca ccctgactga cctgtaactc actgtgtaga ccaggctgac
      961 ctcaaactca cagaaattta cctgcctctg cctttaaagt gctaccatgc caagccagaa
     1021 tgttttttat tagaatatac caattatata taataaaata ttttactaca aca
//
