LOCUS       NM_007627               2310 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus cholecystokinin B receptor (Cckbr), transcript variant
            1, mRNA.
ACCESSION   NM_007627
VERSION     NM_007627.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2310)
  AUTHORS   Gay,M.D., Drda,J.C., Chen,W., Huang,Y., Yassin,A.A., Duka,T.,
            Fang,H., Shivapurkar,N. and Smith,J.P.
  TITLE     Implicating the cholecystokinin B receptor in liver stem cell
            oncogenesis
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 326 (3), G291-G309 (2024)
   PUBMED   38252699
  REMARK    GeneRIF: Implicating the cholecystokinin B receptor in liver stem
            cell oncogenesis.
REFERENCE   2  (bases 1 to 2310)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2310)
  AUTHORS   Su,J., Huang,F., Tian,Y., Tian,R., Qianqian,G., Bello,S.T.,
            Zeng,D., Jendrichovsky,P., Lau,C.G., Xiong,W., Yu,D.,
            Tortorella,M., Chen,X. and He,J.
  TITLE     Entorhinohippocampal cholecystokinin modulates spatial learning by
            facilitating neuroplasticity of hippocampal CA3-CA1 synapses
  JOURNAL   Cell Rep 42 (12), 113467 (2023)
   PUBMED   37979171
REFERENCE   4  (bases 1 to 2310)
  AUTHORS   Mihara,Y., Ishimoto,T., Ozasa,R., Omura,T., Yamato,Y., Yamada,T.,
            Okamoto,A., Matsuyama,Y. and Nakano,T.
  TITLE     Deterioration of apatite orientation in the cholecystokinin B
            receptor gene (Cckbr)-deficient mouse femurs
  JOURNAL   J Bone Miner Metab 41 (6), 752-759 (2023)
   PUBMED   37676507
  REMARK    GeneRIF: Deterioration of apatite orientation in the
            cholecystokinin B receptor gene (Cckbr)-deficient mouse femurs.
REFERENCE   5  (bases 1 to 2310)
  AUTHORS   Zhang,D., Jia,M., Wang,C., Li,Y., Ma,C., Zhu,G., Ma,R., Wen,D.,
            Jia,X., Xu,G., Zhang,X. and Cong,B.
  TITLE     CCK2-receptor deficiency impairs immune balance by influencing CD4+
            T cells development by inhibiting cortical-thymic-epithelial-cells
  JOURNAL   Exp Biol Med (Maywood) 248 (20), 1718-1731 (2023)
   PUBMED   37787155
  REMARK    GeneRIF: CCK2-receptor deficiency impairs immune balance by
            influencing CD4[+] T cells development by inhibiting
            cortical-thymic-epithelial-cells.
REFERENCE   6  (bases 1 to 2310)
  AUTHORS   Kopin,A.S., McBride,E.W., Gordon,M.C., Quinn,S.M. and Beinborn,M.
  TITLE     Inter- and intraspecies polymorphisms in the
            cholecystokinin-B/gastrin receptor alter drug efficacy
  JOURNAL   Proc Natl Acad Sci U S A 94 (20), 11043-11048 (1997)
   PUBMED   9380756
REFERENCE   7  (bases 1 to 2310)
  AUTHORS   Langhans,N., Rindi,G., Chiu,M., Rehfeld,J.F., Ardman,B.,
            Beinborn,M. and Kopin,A.S.
  TITLE     Abnormal gastric histology and decreased acid production in
            cholecystokinin-B/gastrin receptor-deficient mice
  JOURNAL   Gastroenterology 112 (1), 280-286 (1997)
   PUBMED   8978369
REFERENCE   8  (bases 1 to 2310)
  AUTHORS   Nagata,A., Ito,M., Iwata,N., Kuno,J., Takano,H., Minowa,O.,
            Chihara,K., Matsui,T. and Noda,T.
  TITLE     G protein-coupled cholecystokinin-B/gastrin receptors are
            responsible for physiological cell growth of the stomach mucosa in
            vivo
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11825-11830 (1996)
   PUBMED   8876222
REFERENCE   9  (bases 1 to 2310)
  AUTHORS   Samuelson,L.C., Isakoff,M.S. and Lacourse,K.A.
  TITLE     Localization of the murine cholecystokinin A and B receptor genes
  JOURNAL   Mamm Genome 6 (4), 242-246 (1995)
   PUBMED   7613026
REFERENCE   10 (bases 1 to 2310)
  AUTHORS   Huppi,K., Siwarski,D., Pisegna,J.R. and Wank,S.
  TITLE     Chromosomal localization of the gastric and brain receptors for
            cholecystokinin (CCKAR and CCKBR) in human and mouse
  JOURNAL   Genomics 25 (3), 727-729 (1995)
   PUBMED   7759110
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC125055.3.
            
            On Sep 26, 2022 this sequence version replaced NM_007627.5.
            
            Summary: This gene encodes a multipass transmembrane receptor
            protein expressed in the central nervous system and
            gastrointestinal tract. Cholecystokinin and gastrin bind to the
            encoded protein to stimulate gastric acid secretion and mucosal
            growth in the gastrointestinal tract, and anxiety, pain sensation
            and memory in the brain. Mice lacking the encoded protein exhibit
            an increase in the basal gastric pH and gastrin levels in the
            bloodstream as well as mild hypocalcemia, secondary
            hyperparathyroidism and increased bone resorption. [provided by
            RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028325.1, AK053307.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC125055.3         103515-103696       c
            183-434             AC125055.3         95856-96107         c
            435-684             AC125055.3         95446-95695         c
            685-860             AC125055.3         94995-95170         c
            861-2310            AC125055.3         93351-94800         c
FEATURES             Location/Qualifiers
     source          1..2310
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.86 cM"
     gene            1..2310
                     /gene="Cckbr"
                     /gene_synonym="CCK-BR; CCK2-R; CCK2R; CCKR-2"
                     /note="cholecystokinin B receptor"
                     /db_xref="GeneID:12426"
                     /db_xref="MGI:MGI:99479"
     exon            1..182
                     /gene="Cckbr"
                     /gene_synonym="CCK-BR; CCK2-R; CCK2R; CCKR-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1393
                     /gene="Cckbr"
                     /gene_synonym="CCK-BR; CCK2-R; CCK2R; CCKR-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gastrin/cholecystokinin type B receptor; CCK2/gastrin
                     receptor; cholecystokinin-2 receptor; CCK-B/gastrin
                     receptor; CCK-B receptor"
                     /codon_start=1
                     /product="gastrin/cholecystokinin type B receptor isoform
                     1"
                     /protein_id="NP_031653.1"
                     /db_xref="CCDS:CCDS21651.1"
                     /db_xref="GeneID:12426"
                     /db_xref="MGI:MGI:99479"
                     /translation="MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRI
                     RGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLL
                     LAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPL
                     QARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMW
                     SVLLLILLFFIPGVVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAP
                     GPVHQNGGCRHVTSLTGEDSDGCYVQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAK
                     KRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGARRALAGAPISFIHLLSYTSACAN
                     PLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTL
                     GPG"
     exon            183..434
                     /gene="Cckbr"
                     /gene_synonym="CCK-BR; CCK2-R; CCK2R; CCKR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..684
                     /gene="Cckbr"
                     /gene_synonym="CCK-BR; CCK2-R; CCK2R; CCKR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..860
                     /gene="Cckbr"
                     /gene_synonym="CCK-BR; CCK2-R; CCK2R; CCKR-2"
                     /inference="alignment:Splign:2.1.0"
     exon            861..2310
                     /gene="Cckbr"
                     /gene_synonym="CCK-BR; CCK2-R; CCK2R; CCKR-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2291..2296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cckbr"
                     /gene_synonym="CCK-BR; CCK2-R; CCK2R; CCKR-2"
                     /note="hexamer: GATAAA"
     polyA_site      2310
                     /gene="Cckbr"
                     /gene_synonym="CCK-BR; CCK2-R; CCK2R; CCKR-2"
                     /note="major polyA site"
ORIGIN      
        1 agttggagct gagtgggact tcacaggagc catggatctg ctcaagctga accgcagctt
       61 gcagggacca ggacccgggt cagggtcttc tttgtgccgc ccgggtgtct ccctcctcaa
      121 cagcagtagc gccggcaacc tcagctgcga gacccctcgt atccgcggaa ccgggaccag
      181 agaattggag ttgaccattc gaatcaccct ttatgcggtg atctttctga tgagtgttgg
      241 cggaaacgtg ctcatcattg tggtcctggg actgagccga cgcctaagaa cggtcaccaa
      301 cgccttccta ctctccctgg cagtcagcga cctcctgctg gctgtcgctt gcatgccctt
      361 cacactcctg cccaacctca tgggcacatt catcttcggc acagtcatct gcaaggccgt
      421 ttcctacctc atgggggtat cagtgagtgt gtccactcta aatctcgcgg ccatcgccct
      481 ggagcgatac agcgccatct gccgaccact gcaagcacga gtgtggcaga cacgctccca
      541 cgcagctcgg gtgatcttag ccacgtggct gctgtctgga ttgcttatgg tcccctaccc
      601 cgtgtacacc gtggtgcagc cagtggggcc tcgaatactg cagtgcatgc atctctggcc
      661 cagtgaacgt gtccaacaaa tgtggtccgt gcttctgcta atactgctgt tcttcatccc
      721 gggcgtggtt atggcggtgg cctatggact catctcccgc gaactctacc tagggctccg
      781 ctttgatggt gataatgaca gcgagaccca aagccgggtc cgaaaccaag ggggtctgcc
      841 gggtggggca gcagcaccag ggcctgtcca ccagaacggg ggttgccggc atgtgaccag
      901 cctgactggg gaagacagtg atggctgcta cgtgcaactt ccgcgttccc gactggagat
      961 gacaacgctg accacgccca ctactgggcc aggccctggc cctcggccca accaggccaa
     1021 gctgctggct aagaagcggg tggtgcgaat gctgctggtg attgttttgc tttttttcgt
     1081 gtgttggctg ccagtgtaca gcgccaacac gtggcgtgcc ttcgatggcc caggcgcgcg
     1141 ccgagcactc gcaggggccc ctatctcttt catccacttg ctgagctaca cctctgcttg
     1201 tgccaacccc ctggtctact gtttcatgca ccgccgattc cgccaggcct gcctggacac
     1261 atgtgcccgc tgttgcccac gccctccacg agctcgccca cggcctcttc cggatgagga
     1321 tcctcctacc ccctccatcg cttctctgtc caggctaagc tataccacca tcagcacgct
     1381 gggacctggc tgagggattg ggagagtgga gagtgagatg agatacataa ctactataaa
     1441 atgacccatc caaacacata acaaaatccg ggattaattc aggtggtacc caacatcatg
     1501 gacagacccc tacacacaga aagcagtatc tttgctgccc cacctgaaac agacaggagt
     1561 cttacatagg aaaagaggct cacttctgat atgggactga gtccttccct agacatctgg
     1621 cactgacccc attacataga cagacatacg gtccatagca gtaaactttc cctatacaag
     1681 gggaactctg acaagggctg attggcttct cacatgagta cactaatggc actattctat
     1741 agtgcccata gcctagtgcg gtagtgactt aggacattgc agctgtcccc agtttgacct
     1801 catcattgcc ttccttatcc agcactgaaa ttatcaacag gcctaaaatc acatgccttt
     1861 cggagccgca gatctcttag cactgaaaaa gtcccgtcat ccctttccat tagggactgt
     1921 ggaaaatcct cttccctcct gcctctcccc cctcaccaga ccacatcata aaagtataag
     1981 tgacttagcg tcctcctgga cttcctgggc tttggtgggc aggtgagcag gtgtggttta
     2041 tgggaaacat ctttatctgt ttgctcccat gactattcaa ccccatgtcc gaccttgtgc
     2101 aaaaagagat gagcgtatcc tcccttgatt gtcatctggg acctaaccct actccggtga
     2161 tgtagtagct gggacacact gtggcaggtg ggatatccat gacacttcat gactcctgag
     2221 tacaccctct catttggtgc catcgttaaa gtactatact aatggcttcc tgttaatttt
     2281 ttgatgaaaa gataaaaaga tgaaagacta
//
