LOCUS       NM_009827               2929 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus cholecystokinin A receptor (Cckar), transcript variant
            1, mRNA.
ACCESSION   NM_009827
VERSION     NM_009827.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2929)
  AUTHORS   Chang,H., Perkins,M.H., Novaes,L.S., Qian,F., Zhang,T.,
            Neckel,P.H., Scherer,S., Ley,R.E., Han,W. and de Araujo,I.E.
  TITLE     Stress-sensitive neural circuits change the gut microbiome via
            duodenal glands
  JOURNAL   Cell 187 (19), 5393-5412 (2024)
   PUBMED   39121857
REFERENCE   2  (bases 1 to 2929)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2929)
  AUTHORS   Ruan,H., Mandla,R., Ravi,N., Galang,G., Soe,A.W., Olgin,J.E.,
            Lang,D. and Vedantham,V.
  TITLE     Cholecystokinin-A signaling regulates automaticity of pacemaker
            cardiomyocytes
  JOURNAL   Front Physiol 14, 1284673 (2023)
   PUBMED   38179138
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2929)
  AUTHORS   McCoy,M.E. and Kamitakahara,A.K.
  TITLE     Ontogeny and Trophic Factor Sensitivity of Gastrointestinal
            Projecting Vagal Sensory Cell Types
  JOURNAL   eNeuro 10 (4) (2023)
   PUBMED   36973009
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2929)
  AUTHORS   Li,X., He,L., Hu,X., Huang,F., Wang,X., Chen,M., Yoon,E.G.,
            Bello,S.T., Chen,T., Chen,X., Tang,P., Chen,C., Qu,J. and He,J.
  TITLE     Interhemispheric cortical long-term potentiation in the auditory
            cortex requires heterosynaptic activation of entorhinal projection
  JOURNAL   iScience 26 (4), 106542 (2023)
   PUBMED   37123227
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2929)
  AUTHORS   Takata,Y., Takiguchi,S., Kataoka,K., Funakoshi,A., Miyasaka,K. and
            Kono,A.
  TITLE     Mouse cholecystokinin type-A receptor gene and its structural
            analysis
  JOURNAL   Gene 187 (2), 267-271 (1997)
   PUBMED   9099891
REFERENCE   7  (bases 1 to 2929)
  AUTHORS   Dong,C., Willerford,D., Alt,F.W. and Cooper,M.D.
  TITLE     Genomic organization and chromosomal localization of the mouse Bp3
            gene, a member of the CD38/ADP-ribosyl cyclase family
  JOURNAL   Immunogenetics 45 (1), 35-43 (1996)
   PUBMED   8881035
REFERENCE   8  (bases 1 to 2929)
  AUTHORS   Samuelson,L.C., Isakoff,M.S. and Lacourse,K.A.
  TITLE     Localization of the murine cholecystokinin A and B receptor genes
  JOURNAL   Mamm Genome 6 (4), 242-246 (1995)
   PUBMED   7613026
REFERENCE   9  (bases 1 to 2929)
  AUTHORS   Huppi,K., Siwarski,D., Pisegna,J.R. and Wank,S.
  TITLE     Chromosomal localization of the gastric and brain receptors for
            cholecystokinin (CCKAR and CCKBR) in human and mouse
  JOURNAL   Genomics 25 (3), 727-729 (1995)
   PUBMED   7759110
REFERENCE   10 (bases 1 to 2929)
  AUTHORS   Carmeliet,P., Kieckens,L., Schoonjans,L., Ream,B., van Nuffelen,A.,
            Prendergast,G., Cole,M., Bronson,R., Collen,D. and Mulligan,R.C.
  TITLE     Plasminogen activator inhibitor-1 gene-deficient mice. I.
            Generation by homologous recombination and characterization
  JOURNAL   J Clin Invest 92 (6), 2746-2755 (1993)
   PUBMED   8254028
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147052.1 and AK004730.2.
            
            On Nov 15, 2007 this sequence version replaced NM_009827.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146738.1, AK004730.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-909               AK147052.1         2-910
            910-2843            AK004730.2         768-2701
            2844-2929           AK147052.1         2844-2929
FEATURES             Location/Qualifiers
     source          1..2929
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 29.52 cM"
     gene            1..2929
                     /gene="Cckar"
                     /note="cholecystokinin A receptor"
                     /db_xref="GeneID:12425"
                     /db_xref="MGI:MGI:99478"
     exon            1..459
                     /gene="Cckar"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..1658
                     /gene="Cckar"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cholecystokinin receptor type A; cholecystokinin-1
                     receptor; CCK-AR; CCK1-R; CCK-A receptor"
                     /codon_start=1
                     /product="cholecystokinin receptor type A isoform 1"
                     /protein_id="NP_033957.1"
                     /db_xref="CCDS:CCDS19293.1"
                     /db_xref="GeneID:12425"
                     /db_xref="MGI:MGI:99478"
                     /translation="MDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSAVQ
                     ILLYSFIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPN
                     LLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALK
                     VIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILF
                     LIPGVVMVVAYGLISLELYQGIKFDASQKKSAKEKRLSSGGGGGGGSSSSRYEDSDGC
                     YLQKSRPPRKLELQQLSTSSSGGRINRIRSSGSAANLIAKKRVIRMLIVIVVLFFLCW
                     MPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMAT
                     FPCCPNPGPTGVRGEVGEEEDGRTIRASLSRYSYSHMSTSAPPH"
     exon            460..711
                     /gene="Cckar"
                     /inference="alignment:Splign:2.1.0"
     exon            712..973
                     /gene="Cckar"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1101
                     /gene="Cckar"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..2929
                     /gene="Cckar"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2760..2765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cckar"
                     /note="hexamer: AACAAG"
     regulatory      2780..2785
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cckar"
                     /note="hexamer: CATAAA"
     polyA_site      2786
                     /gene="Cckar"
                     /note="major polyA site"
     polyA_site      2809
                     /gene="Cckar"
     regulatory      2822..2827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cckar"
                     /note="hexamer: ATTAAA"
     polyA_site      2847
                     /gene="Cckar"
ORIGIN      
        1 gtgtagatgt gtccccattc tgggaagggt taatatgcag ccaggctgcc actgctcagg
       61 gcctcagact ggcccaggag tgggaggggt gggcctggaa ggtggagtgg agcaggcttg
      121 acttgcaccg ctgccttctc cccacaggag tgcaaatgct tgcccagatg gtctgagaat
      181 gctgaactca agttgccttt aggaatggct gcagagccca cacctggatc tctcccctcc
      241 ctgctcctcc acggcaggtt gcatttggga gactctatga tcattagagg aaagagacag
      301 gagtgagcca ttcaccagct cgccagcact tggtaggaag cggcaggatg gatgtggtcg
      361 acagccttct tatgaatggg agcaacatca ctcccccctg tgaactcggg ctggaaaatg
      421 agacgctttt ctgcctggat caacctcagc cttcaaaaga atggcagtct gcagtgcaga
      481 ttctcctgta ctccttcata ttccttctca gtgtgctggg gaacacgctg gttatcacgg
      541 tgctgattcg aaacaagagg atgcggactg tcaccaacat cttcctgctg tccctggctg
      601 tcagtgacct catgctttgc ctcttctgca tgccgttcaa cctcatcccc aacctgctca
      661 aggatttcat cttcggaagt gccgtgtgca agactaccac ctacttcatg ggcacttccg
      721 tgagtgtttc caccttcaac ctggtagcca tctctctgga gagatacggt gccatctgca
      781 gacccctaca atcccgcgtc tggcaaacaa agtcccatgc tttgaaggtc atcgctgcca
      841 cctggtgcct ctcctttacc atcatgactc cgtaccccat ttacagcaac ttggtgcctt
      901 ttactaaaaa caataaccag acggcgaaca tgtgccgctt cctgttgcca agtgacgcta
      961 tgcagcagtc ctggcaaaca ttcctgctac tcatcctctt ccttatccct ggggttgtga
     1021 tggtggtggc ttacggactc atctctctgg aactctacca aggaatcaaa tttgatgcca
     1081 gccagaagaa atctgctaaa gagaagaggc taagcagcgg cggcggcggc ggcggcggta
     1141 gcagcagcag ccgatatgag gatagcgatg gctgttactt gcagaaatcc aggcctccaa
     1201 ggaagctaga gctgcagcag ctgtcaacca gcagcagtgg tggcagaatc aaccggatca
     1261 ggagcagtgg ttctgctgcc aacctgatcg ccaagaagcg cgtgatccgc atgctcattg
     1321 tcattgtggt cctcttcttc ctgtgctgga tgcccatctt cagtgccaat gcctggcggg
     1381 catatgacac ggtttctgcc gagaaacacc tctcagggac ccccatctcc ttcatcctcc
     1441 tcctctccta cacctcctcc tgtgtcaacc ccattatcta ctgcttcatg aacaaacgct
     1501 ttcgcctggg cttcatggcc accttcccct gttgcccgaa tcctggtccc accggggtga
     1561 gaggagaagt gggagaggag gaagatggaa ggaccataag ggcatccctg tcccggtatt
     1621 cctacagcca catgagcacc tctgccccac cccactgagc tgtacctggt tcgctgcggg
     1681 cagcagaaag gaggggactg ggagcaagga ggaagaggaa gtgggaggga aggagaagga
     1741 agacccattt ctaacgagga ctcttccgat gtctgctttt cacccttcac aaagttccag
     1801 aaggaactta aggcggggtc atgaaaacgc taagacattt tccataatgt ttaccatggg
     1861 agaaacctca gcaggccagc gatagggacc ccactgggct cgtgctacaa atgtcactgc
     1921 caagtccacg ttcaaaatgg gggtgtagac cttgatgagc gttagaattt tttggaacgc
     1981 cccagatgac gtctctccat actaacacac tgctctgctc tgttttcttc tgctcctgaa
     2041 gaattctggt cctccccatg cctacttctc acacatacta cagctacaca ccttctcatg
     2101 gccaccaatg acatgtgacc acgcacgcgc acacacctcc tctggcctct tctgaataag
     2161 ggagaagtct gacaaatttt aaaagcttga ggttgtacaa gtatactcag gggtgaaagg
     2221 ttgaggttgt catcagaaat acatgaagaa tgtgtctaaa agacaggtgt taggattttt
     2281 atttctacaa aggacagggt atgcgaggcc agtagctaga actgttttct gtcagcaatg
     2341 tcaagctgca gaaggatgat ctctacagta taatctctcc tctgaagcta atccccacaa
     2401 cctttttttt tctttaacct caactcactt tcttctgttc acctgtattt cctcctttcc
     2461 agaaatgcct ccgggtaaga agggagaggt ccttacctgg gcaagggtgg taacatatgt
     2521 aatcagtccc caaggaaaac tagcatgtgg gactcactta ataagtagct ttgaatgcca
     2581 aaactatgta tgcttttaaa taccatcgat gtagctcttg atagttggct cgttgtgtgt
     2641 gtgagtgtgt gtgtgtgtgt gtgtgtgtgt gtctgtgtgt ctgtgtgtac gtgtgcgtaa
     2701 actaaacata tggctacatt atctgtgtgt taacaacttg caaatggata ttggaactca
     2761 acaagtgtta tcattcttcc ataaaagttg gagtattgtg tgagcttcat ttctttgcaa
     2821 aattaaagtg ttacagctct tttagaattt ctttgcaaaa ttagtgttga aaacacttaa
     2881 ctctaagaat tctgcttaaa aatagaaata aattatacag tgaaagacc
//
