LOCUS       NM_001284508             822 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus cholecystokinin (Cck), transcript variant 2, mRNA.
ACCESSION   NM_001284508
VERSION     NM_001284508.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 822)
  AUTHORS   Wang,H., Lou,R., Wang,Y., Hao,L., Wang,Q., Li,R., Su,J., Liu,S.,
            Zhou,X., Gao,X., Hao,Q., Chen,Z., Xu,Y., Wu,C., Zheng,Y., Guo,Q.
            and Bai,L.
  TITLE     Parallel gut-to-brain pathways orchestrate feeding behaviors
  JOURNAL   Nat Neurosci 28 (2), 320-335 (2025)
   PUBMED   39627537
REFERENCE   2  (bases 1 to 822)
  AUTHORS   Elum,J.E., Szelenyi,E.R., Juarez,B., Murry,A.D., Loginov,G.,
            Zamorano,C.A., Gao,P., Wu,G., Ng-Evans,S., Yee,J.X., Xu,X.,
            Golden,S.A. and Zweifel,L.S.
  TITLE     Distinct dynamics and intrinsic properties in ventral tegmental
            area populations mediate reward association and motivation
  JOURNAL   Cell Rep 43 (9), 114668 (2024)
   PUBMED   39207900
REFERENCE   3  (bases 1 to 822)
  AUTHORS   Godavarthi,S.K., Li,H.Q., Pratelli,M. and Spitzer,N.C.
  TITLE     Embryonic exposure to environmental factors drives transmitter
            switching in the neonatal mouse cortex causing autistic-like adult
            behavior
  JOURNAL   Proc Natl Acad Sci U S A 121 (35), e2406928121 (2024)
   PUBMED   39178233
REFERENCE   4  (bases 1 to 822)
  AUTHORS   Zhang,N., Sui,Y., Jendrichovsky,P., Feng,H., Shi,H., Zhang,X.,
            Xu,S., Sun,W., Zhang,H., Chen,X., Tortorella,M.D. and He,J.
  TITLE     Cholecystokinin B receptor agonists alleviates anterograde amnesia
            in cholecystokinin-deficient and aged Alzheimer's disease mice
  JOURNAL   Alzheimers Res Ther 16 (1), 109 (2024)
   PUBMED   38750512
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 822)
  AUTHORS   Li,H., Feng,J., Chen,M., Xin,M., Chen,X., Liu,W., Wang,L.,
            Wang,K.H. and He,J.
  TITLE     Cholecystokinin facilitates motor skill learning by modulating
            neuroplasticity in the motor cortex
  JOURNAL   Elife 13, e83897 (2024)
   PUBMED   38700136
  REMARK    GeneRIF: Cholecystokinin facilitates motor skill learning by
            modulating neuroplasticity in the motor cortex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 822)
  AUTHORS   Soriano,E., Del Rio,J.A., Martinez,A. and Super,H.
  TITLE     Organization of the embryonic and early postnatal murine
            hippocampus. I. Immunocytochemical characterization of neuronal
            populations in the subplate and marginal zone
  JOURNAL   J Comp Neurol 342 (4), 571-595 (1994)
   PUBMED   7913715
REFERENCE   7  (bases 1 to 822)
  AUTHORS   Boyle,A.L., Feltquite,D.M., Dracopoli,N.C., Housman,D.E. and
            Ward,D.C.
  TITLE     Rapid physical mapping of cloned DNA on banded mouse chromosomes by
            fluorescence in situ hybridization
  JOURNAL   Genomics 12 (1), 106-115 (1992)
   PUBMED   1733847
REFERENCE   8  (bases 1 to 822)
  AUTHORS   Vitale,M., Vashishtha,A., Linzer,E., Powell,D.J. and Friedman,J.M.
  TITLE     Molecular cloning of the mouse CCK gene: expression in different
            brain regions and during cortical development
  JOURNAL   Nucleic Acids Res 19 (1), 169-177 (1991)
   PUBMED   2011497
REFERENCE   9  (bases 1 to 822)
  AUTHORS   Friedman,J.M., Schneider,B.S., Barton,D.E. and Francke,U.
  TITLE     Level of expression and chromosome mapping of the mouse
            cholecystokinin gene: implications for murine models of genetic
            obesity
  JOURNAL   Genomics 5 (3), 463-469 (1989)
   PUBMED   2575582
REFERENCE   10 (bases 1 to 822)
  AUTHORS   Friedman,J., Schneider,B.S. and Powell,D.
  TITLE     Differential expression of the mouse cholecystokinin gene during
            brain and gut development
  JOURNAL   Proc Natl Acad Sci U S A 82 (17), 5593-5597 (1985)
   PUBMED   3862083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131660.4.
            
            On Aug 1, 2022 this sequence version replaced NM_001284508.2.
            
            Summary: This gene encodes a member of the gastrin/cholecystokinin
            family of proteins. The encoded preproprotein is proteolytically
            processed to generate multiple protein products, including the
            peptide hormones cholecystokinin-8, -12, -33, and others. The
            encoded peptides have been shown to regulate gastric acid secretion
            and food intake. A sulfated form of cholecystokinin-8 may modulate
            neuronal activity in the brain. Homozygous knockout mice for this
            gene exhibit impaired insulin secretion, enhanced insulin
            sensitivity, and resistance to obesity. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Nov
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028487.1, ERR3835353.20137.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC131660.4         101785-101849
            66-281              AC131660.4         102915-103130
            282-444             AC131660.4         103916-104078
            445-822             AC131660.4         107246-107623
FEATURES             Location/Qualifiers
     source          1..822
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.43 cM"
     gene            1..822
                     /gene="Cck"
                     /note="cholecystokinin"
                     /db_xref="GeneID:12424"
                     /db_xref="MGI:MGI:88297"
     exon            1..65
                     /gene="Cck"
                     /inference="alignment:Splign:2.1.0"
     exon            66..281
                     /gene="Cck"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..472
                     /gene="Cck"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="cholecystokinin isoform 2 precursor"
                     /protein_id="NP_001271437.1"
                     /db_xref="CCDS:CCDS90686.1"
                     /db_xref="GeneID:12424"
                     /db_xref="MGI:MGI:88297"
                     /translation="MKSGVCLCVVMAVLAAGALAQPVVPAEATDPVEQRAQEAPRRQL
                     RAVLRTDGEPRARLGALLARYIQQVRKVAWMVTSGWVLTWTSRAGLKHRRWASFLWSS
                     RTQFFLPAFEQPMACRPVCIWLDCSFWPHVRS"
     exon            282..444
                     /gene="Cck"
                     /inference="alignment:Splign:2.1.0"
     exon            445..822
                     /gene="Cck"
                     /inference="alignment:Splign:2.1.0"
     regulatory      796..801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cck"
                     /note="hexamer: ATTAAA"
     polyA_site      822
                     /gene="Cck"
                     /note="major polyA site"
ORIGIN      
        1 aacttagctg gactgcagcc ttctccgctg gaactcgcca agccagctga tttccccatc
       61 caaagccatg aagagcggcg tatgtctgtg cgtggtgatg gcagtcctag ctgctggcgc
      121 cctggcgcag ccggtagtcc ctgcagaagc tacggacccc gtggagcagc gggcgcaaga
      181 ggcgccccga aggcagctgc gggctgtgct ccggacggac ggcgagcccc gagcgcgcct
      241 gggcgcactg ctagcgcgat acatccagca ggtccgcaaa gtggcatgga tggtgacctc
      301 tggttgggtg ttaacctgga ccagtagagc tggattaaaa cacaggaggt gggcatcctt
      361 tctgtggagc tcacgaaccc aatttttcct gcccgcattt gaacagccca tggcttgtcg
      421 acctgtctgc atttggcttg actgctcctt ctggccgcat gtccgttctt aagaacctgc
      481 agagcctgga ccccagccat agaataagtg accgggacta catgggctgg atggattttg
      541 gccggcgcag tgccgaggac tacgaatacc catcgtagtg ggccagcgtc ttggccctgc
      601 ttggaggagg tggaatgagg aaacaaccac acatacgacc cctcgcctct aatgtctgac
      661 gttttgagta tctatttatt aagtccccaa tgtgaaatct gtccagagtg tgcaatgcag
      721 ccacatctca gcctagctgt gtggtcggaa ggcagtgttt ccttcagtga ctcccagacc
      781 taatgttgct atgctattaa agagatttcc ttctgcccct ca
//
