LOCUS       NM_001372297            3232 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus coiled-coil alpha-helical rod protein 1 (Cchcr1),
            transcript variant 1, mRNA.
ACCESSION   NM_001372297 XM_011246447
VERSION     NM_001372297.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3232)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3232)
  AUTHORS   Oka,A., Takagi,A., Komiyama,E., Yoshihara,N., Mano,S.,
            Hosomichi,K., Suzuki,S., Haida,Y., Motosugi,N., Hatanaka,T.,
            Kimura,M., Ueda,M.T., Nakagawa,S., Miura,H., Ohtsuka,M., Tanaka,M.,
            Komiyama,T., Otomo,A., Hadano,S., Mabuchi,T., Beck,S., Inoko,H. and
            Ikeda,S.
  TITLE     Alopecia areata susceptibility variant in MHC region impacts
            expressions of genes contributing to hair keratinization and is
            involved in hair loss
  JOURNAL   EBioMedicine 57, 102810 (2020)
   PUBMED   32580135
  REMARK    GeneRIF: Alopecia areata susceptibility variant in MHC region
            impacts expressions of genes contributing to hair keratinization
            and is involved in hair loss.
REFERENCE   3  (bases 1 to 3232)
  AUTHORS   Ling,Y.H., Wong,C.C., Li,K.W., Chan,K.M., Boukamp,P. and Liu,W.K.
  TITLE     CCHCR1 interacts with EDC4, suggesting its localization in P-bodies
  JOURNAL   Exp Cell Res 327 (1), 12-23 (2014)
   PUBMED   24858563
REFERENCE   4  (bases 1 to 3232)
  AUTHORS   Tiala,I., Wakkinen,J., Suomela,S., Puolakkainen,P., Tammi,R.,
            Forsberg,S., Rollman,O., Kainu,K., Rozell,B., Kere,J.,
            Saarialho-Kere,U. and Elomaa,O.
  TITLE     The PSORS1 locus gene CCHCR1 affects keratinocyte proliferation in
            transgenic mice
  JOURNAL   Hum Mol Genet 17 (7), 1043-1051 (2008)
   PUBMED   18174193
REFERENCE   5  (bases 1 to 3232)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   6  (bases 1 to 3232)
  AUTHORS   Corbi,N., Bruno,T., De Angelis,R., Di Padova,M., Libri,V., Di
            Certo,M.G., Spinardi,L., Floridi,A., Fanciulli,M. and Passananti,C.
  TITLE     RNA polymerase II subunit 3 is retained in the cytoplasm by its
            interaction with HCR, the psoriasis vulgaris candidate gene product
  JOURNAL   J Cell Sci 118 (Pt 18), 4253-4260 (2005)
   PUBMED   16141233
REFERENCE   7  (bases 1 to 3232)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CU467494.10.
            
            On Aug 29, 2019 this sequence version replaced XM_011246447.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-687               CU467494.10        96322-97008
            688-754             CU467494.10        97286-97352
            755-968             CU467494.10        97448-97661
            969-1272            CU467494.10        99944-100247
            1273-1436           CU467494.10        103515-103678
            1437-1572           CU467494.10        103768-103903
            1573-1683           CU467494.10        104046-104156
            1684-1833           CU467494.10        104329-104478
            1834-1944           CU467494.10        105449-105559
            1945-2051           CU467494.10        105678-105784
            2052-2164           CU467494.10        107138-107250
            2165-2210           CU467494.10        107411-107456
            2211-2359           CU467494.10        107609-107757
            2360-2548           CU467494.10        107847-108035
            2549-2650           CU467494.10        108114-108215
            2651-2802           CU467494.10        109217-109368
            2803-2917           CU467494.10        109513-109627
            2918-3232           CU467494.10        109770-110084
FEATURES             Location/Qualifiers
     source          1..3232
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.69 cM"
     gene            1..3232
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /note="coiled-coil alpha-helical rod protein 1"
                     /db_xref="GeneID:240084"
                     /db_xref="MGI:MGI:2385321"
     exon            1..687
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     CDS             490..3051
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /note="isoform 1 is encoded by transcript variant 1; HCR
                     (a-helix coiled-coil rod homolog); alpha-helical
                     coiled-coil rod protein"
                     /codon_start=1
                     /product="coiled-coil alpha-helical rod protein 1 isoform
                     1"
                     /protein_id="NP_001359226.1"
                     /db_xref="GeneID:240084"
                     /db_xref="MGI:MGI:2385321"
                     /translation="MWPHSSRTRPWANSLIGNDSEILARWCLDGLPNGPTIPWQGLWR
                     VGSLYCVQRVLSCRDRRHLRRKGNIGDWRQELQDSYNRKMLPPSGFAGLVPPSHFQAR
                     PLPTLPRMAPTWASDVPLVQSPASQDVLERRLDAQRSTVTTWGQDFCGDGQGLGRRGR
                     SLELGFSSALSQQAELISRQLQELRRLEEEVRSLRETSLQQKMRLETQAVELDALAVA
                     EKAGQAEAEGLRTALAGAEMVRKNLEEAKHKELEEIQSLHQEQLSSLTQAHQKALDSL
                     ASKAEGLEKSLNSLETKRAGEAKQLAMAQKEADMLRNQLSKTQEELEAQVTLVESLRK
                     YVGEQVLPEFPSQEWELERKELLDTLKHLKEDRADLQATVELLQVRVQSLTHMLALQE
                     EELTRKIQPLDPLEPEFPKKCRSLLRNWREKVFALMVQLKAQDLQHRDSTSQLRIQVA
                     ELQEQVTSQSQEQAILQRALQDKTAQVEVERMSTKSLQMELDQAQEARRRQEQQIASA
                     EEQLKFVVGAMNSTQAKLQSTMTRMDQAVARIPSLSNRLSYAVRKVHTIKGLMARKVA
                     LAQLRVESSPPSEAAPPLDTDLSVELEQLREERNRLDAELQLSAHLIQQEVGRAREQG
                     EVERRRLIEVAQQLEQELQRAQESLASVGQQLEAARRGQQESTEEAASLRQELTQQQE
                     IYGQALQEKVAEVETRLREQLSDTKRRLNEARREQAKAVVSLRQIQHKATQEKERNQE
                     LRRLQDEARKEEGQRLTRRVQELERDKNLMLQRLLAVLPSGVNKKCSPRSVESSSSES
                     PAAASCKESVKGSLTVLLDNLQGLSEAISRDEDICVEDNQNTKKTKNPPSDPLLS"
     exon            688..754
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            755..968
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1272
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1436
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1572
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1683
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1833
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1944
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2051
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2164
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2210
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2359
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2548
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2650
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2802
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2917
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3232
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3196..3201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /note="hexamer: AATAAA"
     polyA_site      3223
                     /gene="Cchcr1"
                     /gene_synonym="Hcr"
                     /note="major polyA site"
ORIGIN      
        1 agttgggggc gggaagagtc tgagaggggg cgcaaggggg gcggagggga tccacagggc
       61 aagaggggtg caggagctgg gtcaaaggat agatgaggag gtcaagacag cctcagagtt
      121 cagggtcctg acggggatta gcccggggtg tgtgcgggag agaagtgggg gagacaggac
      181 agggagcgac caagataatt ccatcgaaaa agactcatac taggtctagg aagagaaacg
      241 ggtaggaatc gcgggggttg agtgaaaaaa aaaaaaaccc aaaaacttga attctgatgg
      301 aagtggggga aagaagatgc tgtaggactc cgaagagaga tgcatcggga atggaagccg
      361 aggggataga gagcaactga ggcccgttac agagaggccc agatgagttg ccaggaagct
      421 ggcttcccag caacgggctc ccggctgctc cgattcctca gggatcctag ggaagacgct
      481 taaccccaca tgtggcctca ttcttcccgg accaggcctt gggctaactc tttaatagga
      541 aatgactcag aaatcctggc tcgatggtgc ctagatgggc ttcccaacgg ccctaccatt
      601 ccatggcaag gactgtggag agtgggctcc ttatactgtg tccagagagt cctgagctgc
      661 agggaccgta gacacttaag gaggaagggg aacataggtg actggagaca agagctacag
      721 gattcatata acaggaagat gttgccaccg tcaggttttg ctgggctggt tcctccctcc
      781 cacttccaag ctcggcccct tccaactctg ccaagaatgg ccccgacctg ggcttcagac
      841 gttcccttgg tccaatctcc ggccagccaa gatgtcttag agagacggct agatgctcag
      901 aggtcgacag tgaccacgtg gggacaggat ttctgtggag atgggcaggg gctagggcgg
      961 agaggcaggt ctctggagct ggggttctcc agtgccctga gccagcaggc cgagctgatc
     1021 tcacggcagc tccaagagtt gcggcggctg gaggaggaag tccggtccct acgggagacc
     1081 tcgctgcagc agaagatgag gttggagact caggccgtgg agctggatgc tctggcagtg
     1141 gcagagaagg ccggccaagc tgaggccgag ggcctgcgca ccgccttggc cggagctgaa
     1201 atggttcgga agaacctgga agaggcgaag cacaaggagc tggaggagat tcagagcctg
     1261 caccaagagc agctgtcctc cctgacacag gctcaccaga aggctctcga cagtctggcc
     1321 agcaaggccg agggcttgga gaagtctctg aatagcctgg aaacgaaacg ggcaggggaa
     1381 gccaagcagc tggctatggc ccagaaggag gcggacatgc tcaggaacca gctgagcaag
     1441 acccaagaag agctggaagc tcaggtgacc ttggtggaga gtctgaggaa gtatgtgggg
     1501 gaacaagttc ttcctgagtt tcctagccag gaatgggagc tggaacgaaa ggagcttcta
     1561 gacaccttga agcacttgaa ggaggatcgg gctgaccttc aggccaccgt ggagttactg
     1621 caggtacgag tacagagcct cacacacatg ctcgccctgc aggaagagga gctgaccagg
     1681 aagattcagc ctttagatcc cttggaaccc gagtttccta agaagtgccg ctcgctgctg
     1741 cgcaactggc gggagaaggt atttgccctc atggtgcagc tcaaagccca ggacctgcag
     1801 cacagggact ccacgtcgca gctgaggatc caggtagcag agctccagga gcaagtgacc
     1861 tcccaaagcc aggagcaggc catcttgcag cgtgccctgc aagacaaaac tgcacaggtg
     1921 gaggtggagc ggatgagcac caagagcctg cagatggagc tggatcaggc tcaggaggcc
     1981 aggcggaggc aggaacagca gatagcctct gctgaagagc agttgaagtt cgtggtcggt
     2041 gctatgaaca gcactcaggc caaactccaa agcaccatga ccaggatgga tcaggctgta
     2101 gcccggattc ccagcctcag caaccgactc agctatgctg tccggaaggt ccacaccatt
     2161 aagggtttga tggctcgaaa ggtggctctt gctcagttgc gcgtggagag ctctccccca
     2221 tcggaagccg cacccccact ggacacagac ctgagcgttg agctggaaca gctacgggaa
     2281 gaacggaacc gcctggatgc agagctgcag ctgagtgccc acctgatcca gcaggaggtg
     2341 ggccgggcac gggagcaagg ggaggtcgag cgccgacggt tgatagaggt ggcccagcag
     2401 ctggagcagg agctgcagcg tgcccaggaa tccctggcca gcgttgggca gcagttggag
     2461 gcagcacgtc ggggccagca ggagagcacg gaggaagctg ccagcctccg tcaggagctg
     2521 acacagcagc aggaaatcta cgggcaagcc ctgcaagaga aggtggccga ggtggaaact
     2581 cggcttcggg aacagctctc agacacaaag aggaggctga acgaggcccg aagggagcag
     2641 gccaaggctg tggtttcctt gcgccagatc cagcacaaag ccactcagga aaaggagcgc
     2701 aaccaggagc tcaggcgcct gcaggatgaa gcccggaagg aagagggtca gcggctgacg
     2761 aggcgtgtgc aggagctgga gagggacaag aacctgatgc tgcagcgcct gttagcagtg
     2821 cttccctcgg gagtgaataa gaagtgcagc ccccggtctg tggagtcctc atcctctgag
     2881 tctccggcag ctgcttcgtg caaggaatct gtgaaaggct ccctgaccgt cctgcttgat
     2941 aacctgcaag gcctgagcga ggccatttcc agagatgaag atatttgtgt ggaagataac
     3001 cagaacacca agaaaaccaa gaaccctcct tcagatccac tgctgagcta gagctgccag
     3061 ggggaagaat gaagccagcc tgaagctgga cccccaggag ggttgggtcg gaggaaatgg
     3121 ggtgggggcc agcctagccc tgccccccag caagccttgg aaccccagct tctaccaaat
     3181 tcaaactctg caatgaataa agatggcaat agtgttgcct ggagatgttt ga
//
