LOCUS       NM_026681               7377 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus coiled-coil domain containing 88C (Ccdc88c),
            transcript variant 1, mRNA.
ACCESSION   NM_026681
VERSION     NM_026681.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7377)
  AUTHORS   Akturk,A., Day,M. and Tarchini,B.
  TITLE     RGS12 polarizes the GPSM2-GNAI complex to organize and elongate
            stereocilia in sensory hair cells
  JOURNAL   Sci Adv 8 (42), eabq2826 (2022)
   PUBMED   36260679
REFERENCE   2  (bases 1 to 7377)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7377)
  AUTHORS   Ozono,Y., Tamura,A., Nakayama,S., Herawati,E., Hanada,Y., Ohata,K.,
            Takagishi,M., Takahashi,M., Imai,T., Ohta,Y., Oshima,K., Sato,T.,
            Inohara,H. and Tsukita,S.
  TITLE     Daple deficiency causes hearing loss in adult mice by inducing
            defects in cochlear stereocilia and apical microtubules
  JOURNAL   Sci Rep 11 (1), 20224 (2021)
   PUBMED   34642354
  REMARK    GeneRIF: Daple deficiency causes hearing loss in adult mice by
            inducing defects in cochlear stereocilia and apical microtubules.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7377)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7377)
  AUTHORS   Kindt,K.S., Akturk,A., Jarysta,A., Day,M., Beirl,A., Flonard,M. and
            Tarchini,B.
  TITLE     EMX2-GPR156-Galphai reverses hair cell orientation in
            mechanosensory epithelia
  JOURNAL   Nat Commun 12 (1), 2861 (2021)
   PUBMED   34001891
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7377)
  AUTHORS   Takagishi,M., Esaki,N., Takahashi,K. and Takahashi,M.
  TITLE     Cytoplasmic Dynein Functions in Planar Polarization of Basal Bodies
            within Ciliated Cells
  JOURNAL   iScience 23 (6), 101213 (2020)
   PUBMED   32535020
REFERENCE   7  (bases 1 to 7377)
  AUTHORS   Siletti,K., Tarchini,B. and Hudspeth,A.J.
  TITLE     Daple coordinates organ-wide and cell-intrinsic polarity to pattern
            inner-ear hair bundles
  JOURNAL   Proc Natl Acad Sci U S A 114 (52), E11170-E11179 (2017)
   PUBMED   29229865
  REMARK    GeneRIF: results suggest that the primary cilium or an associated
            structure influences the domain of cell-intrinsic signals that
            shape the hair bundle. Daple is therefore essential to orient and
            pattern sensory hair bundles.
REFERENCE   8  (bases 1 to 7377)
  AUTHORS   Takagishi,M., Sawada,M., Ohata,S., Asai,N., Enomoto,A.,
            Takahashi,K., Weng,L., Ushida,K., Ara,H., Matsui,S., Kaibuchi,K.,
            Sawamoto,K. and Takahashi,M.
  TITLE     Daple Coordinates Planar Polarized Microtubule Dynamics in
            Ependymal Cells and Contributes to Hydrocephalus
  JOURNAL   Cell Rep 20 (4), 960-972 (2017)
   PUBMED   28746879
REFERENCE   9  (bases 1 to 7377)
  AUTHORS   Ishida-Takagishi,M., Enomoto,A., Asai,N., Ushida,K., Watanabe,T.,
            Hashimoto,T., Kato,T., Weng,L., Matsumoto,S., Asai,M., Murakumo,Y.,
            Kaibuchi,K., Kikuchi,A. and Takahashi,M.
  TITLE     The Dishevelled-associating protein Daple controls the
            non-canonical Wnt/Rac pathway and cell motility
  JOURNAL   Nat Commun 3, 859 (2012)
   PUBMED   22643886
  REMARK    GeneRIF: Findings indicate that Daple interacts with Dishevelled to
            direct the Dishevelled/protein kinase lambda protein complex to
            activate Rac, which in turn mediates the non-canonical Wnt
            signalling pathway required for cell migration.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 7377)
  AUTHORS   Oshita,A., Kishida,S., Kobayashi,H., Michiue,T., Asahara,T.,
            Asashima,M. and Kikuchi,A.
  TITLE     Identification and characterization of a novel Dvl-binding protein
            that suppresses Wnt signalling pathway
  JOURNAL   Genes Cells 8 (12), 1005-1017 (2003)
   PUBMED   14750955
  REMARK    GeneRIF: Identification of Daple, a Dvl-binding protein, that
            suppresses Wnt signalling pathway.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131759.3 and AC126262.4.
            
            On Apr 12, 2018 this sequence version replaced NM_026681.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY339881.1, SRR14777534.97192.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC131759.3         70156-70275         c
            121-221             AC131759.3         69620-69720         c
            222-330             AC131759.3         63678-63786         c
            331-400             AC126262.4         20578-20647
            401-459             AC126262.4         33268-33326
            460-543             AC126262.4         34072-34155
            544-684             AC126262.4         36153-36293
            685-869             AC126262.4         36555-36739
            870-951             AC126262.4         38086-38167
            952-1110            AC126262.4         38450-38608
            1111-1257           AC126262.4         50237-50383
            1258-1402           AC126262.4         51116-51260
            1403-1587           AC126262.4         55916-56100
            1588-1725           AC126262.4         57310-57447
            1726-2787           AC126262.4         58639-59700
            2788-2915           AC126262.4         62423-62550
            2916-3042           AC126262.4         63312-63438
            3043-3228           AC126262.4         64277-64462
            3229-3390           AC126262.4         65389-65550
            3391-3668           AC126262.4         66440-66717
            3669-3812           AC126262.4         68778-68921
            3813-3999           AC126262.4         71202-71388
            4000-4145           AC126262.4         72634-72779
            4146-4235           AC126262.4         73943-74032
            4236-4474           AC126262.4         75482-75720
            4475-4663           AC126262.4         81179-81367
            4664-4732           AC126262.4         82952-83020
            4733-4801           AC126262.4         86150-86218
            4802-5094           AC126262.4         87677-87969
            5095-7377           AC126262.4         90742-93024
FEATURES             Location/Qualifiers
     source          1..7377
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 51.11 cM"
     gene            1..7377
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /note="coiled-coil domain containing 88C"
                     /db_xref="GeneID:68339"
                     /db_xref="MGI:MGI:1915589"
     exon            1..120
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..6090
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein Daple; DVL-binding protein DAPLE; coiled-coil
                     domain-containing protein 88C; dvl-associating protein
                     with a high frequency of leucine residues"
                     /codon_start=1
                     /product="protein Daple isoform 1"
                     /protein_id="NP_080957.2"
                     /db_xref="CCDS:CCDS26110.1"
                     /db_xref="GeneID:68339"
                     /db_xref="MGI:MGI:1915589"
                     /translation="MDVTVSQLVELFLQSPLVTWVKTFGSFGSGHQDNLTLYMDLVDG
                     IFLNQIMLQIDPRPSNQRINKHVNNDVNLRIQNLSILVRNIKTYYQEVLQQLIVMNLP
                     NVLMIGKDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQ
                     EVTHNQENVFDLQWLDLPDVAPEELEALSRNMVFHLRRLIDERDECTELIVDLTQERD
                     YLQTQQPPSPGKFSSPDSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEEKTEQ
                     LADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLREKANRVERLEMDLVR
                     CKEKLHDVDFYKARMEELREDNIILIETKAMLEEQLTASRARSDKVHELEKENLQLKS
                     KLHDLELDRDADKKQIEKLLEEYMVLEMAQKQSMKESAHLGWELEQLSKNADLSDASR
                     KSFVFELNECASSRILKLEKENQSLQSTIQGLRDTSLALEESSLKYGELEKENQQLSK
                     KIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSGMEALKADRARQIKDLEQEKGHL
                     HQAVWSLRERPQVNSTKDVEKENRALHQAVTEAGSKLSQLELEKQQLHRDLEEAKEKG
                     EQAEALEKELHRLEKENEQLTKEVTSLKAATEKVEALEHQSQGLELENRSLRKSLDTL
                     QNVSVQLEGLERDKQQLGQENLELRKMVEAMRFTSAKMAQIETENRQLEREKEELRRD
                     VELLKTLSKKSERLELSYQSVSAENLQLQHSLESSTHKSQALQRELSQLEAERQALRR
                     DLETLQLTHKQLEGAEEDRKALEQEVAQLEKDKKLLEKEARRLWQQVELKDAILDDSA
                     AKLSAAEKESRALDKELARCRDVGSKLKELEKDNRDLTKQVTMHTRTLTTLREDLVLE
                     KLKSQQLSSELDKLSQELEKVGLSKDLLLQEDDGHGDGKGKTESALKTTLAMKEEKIV
                     FLEAQVEEKESLSRQLQIELQMIKKEHEQLRQTQEGGDKAQNALKRPPGKVTSHQEKE
                     AWEPSHKEATMELLRVKDRAIELERSNAALQAERQLLKEQLQHLETQNVSFSSQILTL
                     QKQSAFLQEHTTTLQTQTAKLQVENSTLSSQNAALSAQYTVLQSQQAAKEAEHEGLQQ
                     QQEQLAAVYEALLQDHKHLGTLYECQSSEYEALIRQHSCLKTLHRNLELEHKELGERH
                     GDLQQRKAELEELEKVLSTEREALEREQKTNAIATSENQRLRGELDRISFLHQQLKGE
                     YEELHAHTKELKTSLNNSQLELSRWQVRFDELKEQHQSMDISLTKMDNHCELLSRLKG
                     NLEEENHHLLSQIQLLSQQNQMLLEQNMESKEQYHEEQKQYIDKLNALRRHKEKLEEK
                     IMDQYKFYDPAPKKKNHWIGAKALVKLIKPKKEGSRERLKSTTDSPPWQLEPSDPASP
                     SPSQALRSQTENPDNPPSGPNCVEERDTHNGPVGKGPGDLKPKRGSPRGGSVDRTDTS
                     TDPAVKSWPSEPGSRTFSTSATTAALSSSTPIPKHLGRTKGCNSDDNLCEPSSEPDGP
                     YHRQQASRPNSLESSRNASSNSSPLSLKGSSDHLHSRCESFSSADLIPSRDPATLSRD
                     GNTSGRGLLGRHEYPPPRNGPVSQETIQKKGAASTHTGVRPHSASPSSEMVTLEEFLE
                     ESNRGGSPTHDTPSCRDDLLSDYFRKAHDPPALGGQPGPPARKDGAKMPTSFVAPTIK
                     MSINTSEGQQLKPGHYVKPNLRPSEAEALAGMPSRQVQPPQSLSLGRPRQTTMTQNCH
                     MPVSRSASLSRAFSLASADLLRASGPEACRPESPQKPGGHEAAGARETSTHSLQGSHI
                     LARERTPIVGKADSPSPGQGTRGRPLDTRRFSLAPPKEERLAPLQQSATAPALATGCS
                     SGSNPQIQHFSPTVAPAVRTKSKVPQHSGEVATVAPVRPGLGTSEGDGGPGHGYSEGL
                     LTKSPGRSSDLPPHVKRGPDDFSQGSSSKSTPASPEPGGDPQTVWYEYGCV"
     exon            121..221
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            222..330
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            331..400
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            401..459
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            460..543
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            544..684
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            685..869
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            870..951
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1110
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1257
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1402
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1587
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1725
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..2787
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2915
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3042
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3228
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..3390
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            3391..3668
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..3812
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            3813..3999
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            4000..4145
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4235
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            4236..4474
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            4475..4663
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            4664..4732
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            4733..4801
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            4802..5094
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     exon            5095..7377
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7356..7361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /note="hexamer: AATAAA"
     polyA_site      7377
                     /gene="Ccdc88c"
                     /gene_synonym="0610010D24Rik; Daple; mKIAA1509"
                     /note="major polyA site"
ORIGIN      
        1 gtctcccgcg cccgccgccg gctgccggag ccgctttgtg cggcgcggcc gcggctcagc
       61 atggacgtga cggtgtcgca gctcgttgag ctgtttctgc agagccctct ggtgacctgg
      121 gtgaaaactt ttggatcgtt tggaagcggc caccaggaca acttgactct gtacatggat
      181 ttagtggacg gcatcttttt gaatcaaatc atgctgcaaa tagaccccag gcccagcaat
      241 cagcgcatca acaagcatgt caacaatgat gtcaacctgc gcatccaaaa cctgagtatc
      301 ctggtgagaa acatcaagac ctactaccag gaagttctcc agcagctgat cgtaatgaat
      361 ttgcccaatg tcttgatgat tggcaaagac ccgctgtctg ggaagagcat ggaggagatt
      421 aagaaggtcc tgctgctggt gctgggctgt gccgttcagt gtgagaggaa ggaggagttc
      481 attgagagaa tcaaacagct ggacatcgag acccaggctg gcattgtggc tcatatccag
      541 gaggtgaccc acaaccagga gaatgtgttt gacctgcagt ggctggactt gccagatgtg
      601 gccccagagg agctggaggc cctctccaga aacatggtgt tccacctccg cagactcatt
      661 gacgagcgtg acgagtgtac cgagctgatc gtggacctga cacaagagag ggactacctc
      721 cagacacagc agcctcccag ccccggcaag ttctccagcc cagactccac accaagcccc
      781 accagcagcc tgtccagtga agacaagcag cacctagccg tggagctggc tgacaccaag
      841 gccaggctgc ggcgtgtcag gcaggagctg gaggagaaga cggagcagct tgcagacacc
      901 aggcacgagg tggatcagct ggtcctggag cttcagaagg ccaagcaaga taatattcag
      961 cttgcagctg atgcgcggtc agcccgggcc tatcgggatg agctggactc gctgagggaa
     1021 aaggcgaacc gtgtagagag gctggagatg gatctggtac gctgcaagga gaagctgcac
     1081 gacgtggact tctacaaggc tcgcatggag gagctgaggg aagacaatat catcttaatc
     1141 gagaccaaag ccatgttgga ggaacaactg actgcctccc gggctcgcag tgataaagtc
     1201 cacgagctgg agaaagagaa cctacagcta aaatctaaac tccatgactt ggaactggat
     1261 cgggatgcag acaagaaaca aattgagaag ctgctggaag aatacatggt tctggagatg
     1321 gctcagaagc agagcatgaa agagtcggcc caccttggct gggaactgga gcagctgtcc
     1381 aagaacgcag acttgtccga cgcctccagg aaatccttcg tctttgagct gaatgagtgc
     1441 gcctccagcc gcatcctgaa gctggagaag gagaaccaaa gcctacagag caccatccag
     1501 ggtctgcggg acacgtcgct ggcgctggag gagagcagcc tcaagtatgg ggagctggag
     1561 aaggagaacc agcagcttag caagaagatt gaaaagttac aaacgcagct ggagagagaa
     1621 aagcagagta accaagacct ggagacgctg agtgaggagc tgatccgaga gaaggaacag
     1681 ctacagagtg gcatggaggc cctgaaggcg gacagggcca ggcagataaa ggatctggaa
     1741 caggagaagg gccacctcca ccaggctgtg tggtccctgc gggagaggcc gcaggtcaac
     1801 agcacgaagg atgtggagaa ggagaacaga gccctccacc aggctgtgac agaggcgggc
     1861 agcaagctca gccagctgga gttggagaag cagcagctgc acagagactt ggaggaggcc
     1921 aaggagaagg gagagcaggc ggaggcgctg gagaaggagc tgcaccggct ggagaaggag
     1981 aatgagcagc tgaccaagga ggtgacctcc ctgaaggcag ccactgagaa ggtcgaggcc
     2041 ctggagcatc agagccaggg tctggagctg gagaaccgct cgctgagaaa gtccctggac
     2101 accctgcaga acgtgtctgt gcagctcgag ggcctggaga gggacaagca gcagctgggt
     2161 caggagaacc tagagctgcg caagatggtg gaggccatgc gcttcaccag cgccaagatg
     2221 gcgcagattg agacggagaa ccggcagctg gagagggaga aggaggagct gcgcagggac
     2281 gtggagctgc tcaagacctt gagcaagaag tcggagcggc tggagctcag ctaccagagc
     2341 gtgagcgccg agaacctgca gctgcagcac agcttggaga gcagcaccca caagtctcag
     2401 gcgctgcaga gggagctgag ccagctggag gccgagcgcc aggccctgag gcgagaccta
     2461 gagactctcc agctcaccca caagcagctg gagggggccg aggaggacag gaaggccctg
     2521 gagcaggagg tggcccagct ggagaaggac aagaaactgc tagagaagga ggccagacgc
     2581 ctgtggcagc aggtggagct taaggacgcc atcctggatg acagcgctgc caagctgtcg
     2641 gcggccgaga aggagagccg tgcgctggac aaggagctgg cccgctgccg ggacgtgggc
     2701 agcaagctga aggagctgga gaaggacaac agggacctca ccaagcaagt caccatgcac
     2761 acgaggacgc tgaccaccct gagagaggac ctggtgctgg agaagttgaa gagccagcag
     2821 ctaagcagcg agctggacaa gctgagccag gagctggaga aggtcggcct cagcaaggac
     2881 ctgttgctgc aggaggatga cggtcacggt gacggaaaag gcaaaaccga atcagccttg
     2941 aaaacaacac tggctatgaa agaagaaaag attgtgtttt tggaggcaca ggtggaagag
     3001 aaagagagct tgagtcgcca actccagatt gagctgcaga tgataaagaa agaacatgag
     3061 cagctgaggc agacccaaga gggtggagac aaggcacaga acgcactgaa gcgccctccg
     3121 ggcaaggtca ccagtcacca agagaaggag gcctgggagc ccagccataa agaggccacc
     3181 atggagctac tccgtgtgaa ggaccgggcc atcgagctgg agcgcagtaa cgcagctctt
     3241 caggccgaga ggcagctgct gaaggagcaa ctacagcact tggagactca gaacgtgtcc
     3301 ttcagcagcc agatcctgac cctacagaag cagagcgcct tcctgcaaga gcacaccacc
     3361 acgctgcaga cccagactgc gaagctgcag gtggagaatt ccacactgag ttcccagaac
     3421 gcagcgctca gtgcacagta cacggtgttg cagagccagc aggctgccaa ggaggccgag
     3481 cacgagggtc tgcagcagca gcaggagcag ctggcagccg tctatgaagc cctgctgcag
     3541 gaccacaagc acctgggcac cctgtacgag tgccagtcct cagagtatga ggccctcatc
     3601 cgccagcaca gctgcctgaa gacgctgcac aggaacctgg agctggagca caaggagctg
     3661 ggggagaggc acggagactt acagcagcgt aaggcagagc tggaggagct ggagaaagta
     3721 ctgagcaccg agcgggaggc acttgagcgg gagcagaaga ccaacgccat tgccacgagc
     3781 gagaaccaga ggcttcgagg agagctggac aggatcagct tcctgcacca gcagctgaaa
     3841 ggggagtatg aagagctgca cgcccacacc aaggagttga aaacctcgct caacaactct
     3901 cagctggagc tgagccgctg gcaggtgcgc ttcgacgagc ttaaggagca gcaccagagc
     3961 atggacatct ctctgaccaa gatggacaac cactgtgagc tgctctcccg gctcaagggg
     4021 aacttagagg aggagaatca tcacctgctg agccagatcc agctgctgag tcagcagaac
     4081 cagatgctcc tggaacagaa catggagagc aaggagcagt accacgagga gcagaagcag
     4141 tacatagaca agttaaacgc cttacggaga cacaaggaga agctggaaga aaaaatcatg
     4201 gatcagtaca agttctatga ccctgctcca aagaagaaga accactggat tggagccaaa
     4261 gccctagtca aacttatcaa gccaaagaaa gaaggttcca gagaacggtt aaaatccacc
     4321 acagatagcc ccccctggca gctggagccc tcagaccctg cctcgccatc tccctctcag
     4381 gctctcagat cgcagacgga gaaccccgac aaccccccat cgggtccaaa ctgtgtggaa
     4441 gaacgagaca cccacaacgg gcctgtgggg aaaggcccag gggatctaaa accaaaacga
     4501 gggtccccgc gtggaggcag tgttgaccgc acagacacct ccactgaccc agctgtgaag
     4561 tcctggccct cggagcctgg ctcccggacc ttttcaacct cagccaccac agcagccctt
     4621 tccagctcca ctcctatccc caagcaccta ggccgcacca aaggttgtaa ttcagatgac
     4681 aatctctgtg agccatcctc ggagcccgac ggcccctacc acaggcagca ggcatcgcgg
     4741 ccaaacagct tggagagcag taggaacgca tccagcaaca gctcgccttt gagcctaaag
     4801 ggctcctctg accatctgca cagccggtgt gagagcttca gcagcgcaga cctgatcccc
     4861 agcagggacc ctgccacgct gtctcgggat ggcaacacct cgggacgtgg tcttctcggc
     4921 cgccatgagt accctccacc ccggaatggg cctgtctccc aggagactat ccagaagaag
     4981 ggcgcagctt caacccacac gggagtgcga ccccactcag cctctcccag cagtgagatg
     5041 gtcaccttgg aggaattttt agaggagagt aaccgaggag gctctcctac ccatgatact
     5101 cccagctgcc gtgatgacct gcttagtgac tacttccgaa aggcccatga tcccccagcc
     5161 ctgggaggcc agccaggacc accagctagg aaagatggag ccaagatgcc caccagcttc
     5221 gtggctccca ccatcaagat gtcaatcaac acctctgagg ggcagcagct gaagccaggg
     5281 cattatgtaa agcccaacct gagaccatct gaggccgagg ccctggctgg gatgccttca
     5341 agacaggtcc agcctcccca gagcctgtct ctgggtagac ccaggcaaac cacgatgacc
     5401 cagaattgtc acatgcctgt cagccgaagt gcgtctctga gcagagcctt cagcctggct
     5461 tcagctgacc tcctccgggc cagtgggcca gaagcctgtc ggccagagtc tcctcagaag
     5521 ccagggggtc atgaggctgc aggagccaga gagacaagca cccacagcct gcaaggctcc
     5581 cacatcctag cccgggagag aacgccaatc gtaggaaaag ctgacagtcc ctctccaggc
     5641 cagggtaccc gaggccggcc actggacaca agacgcttct ctctggcccc cccaaaggaa
     5701 gagaggctgg cccccctaca gcagtctgcc acagccccag cccttgctac tggatgtagc
     5761 agtggtagca acccccagat ccagcacttt tctcctacag tggctcctgc agtcaggaca
     5821 aaatccaaag tgccacaaca ctcaggggag gtagccaccg tagctcctgt gcgtccaggg
     5881 ctcggcacct cagagggaga tgggggccca gggcatggtt acagcgaagg gcttctgacc
     5941 aaaagccctg gcaggtcttc tgacttgcct ccccatgtca aaaggggccc cgatgacttc
     6001 agtcaaggga gcagttcaaa gagcacaccg gcgtccccag agccaggtgg ggacccgcag
     6061 acagtgtggt atgagtacgg ctgcgtgtga ctcgcatcgt ggatctgcag cttgcaaatg
     6121 ctaaactact ggtgcgcctt ctgattacaa tggcctttcc ccctgtttgc ctgtggtggt
     6181 ggtgggggga agggtgaaaa atgaggagtg gagttcccac ggtcatcctg ttggctgaag
     6241 ggaaacactg tgccaagccc taagaggatt accctccagg gtctgtaact tattttctgt
     6301 agctgcggct tccagcagct ggcatcttat ggacaaggcc gtttagcatg ggagccagtt
     6361 aggagtcagt ggcaaagcga ctttacccag aaacagacac tacttgagta ggaatgctcg
     6421 tttgcaacct gtcaacctcc actaaatagc atgtgcacgt gtgagtacat gcacggacgc
     6481 caggttcaca aagctacgtc ctgatgggtc tcgaaactcc actcctgcct aaaagccatt
     6541 ggtcctggga aaggcttaga ctgggcaaac cacaaagatt tgcagggttt tggggaaagc
     6601 ccagagcagg gctggctgct aaacccagga cccttgccat cctatttctg aggtccaagc
     6661 acttcccttt aaaacaggac caagtttcag gatcagccac gggtcttagc tctcgtagct
     6721 ggctgttggg ccctgcctag tgggctttaa gactacctag gaaccagcct tttgggactt
     6781 cccaggcttg ctttactaca aacactggat ctgccaggcc tagggtgtga ggcaaagaga
     6841 tgccctacga gtatcccagt ctggcaggca tagttactac acagaaggaa ggccaaagcc
     6901 acacttgctt tgtaatgtgg ctgttgcacc cagcccttct tggctcaaac aatttttttt
     6961 atttctgaat aactttttgg gggtagaaac caaatttcta tatacacata catacacaca
     7021 catgaatatg tgtgtgtgtg tatacatata tatgtatatg tacacacaca cacacacaca
     7081 cacttacttt tgagggccta tttatgttct gaaagtcatt ctttcagtag tctgacctgc
     7141 tgtttgttcg tttgtctggt ctacttcctg acatgttttg tttcctattg taatggtgct
     7201 tttcctggga tggactaaac gatttatttt ctgttttgat gtaatgtgct gaagaagaaa
     7261 cgggggagac cttgaatgtt aacaggatcc atggtgaggg tgttggggtt gtgtgttaaa
     7321 tagccattcg ttctggaaga ccaggacagg gctgtaataa agtggaaagg aatgtga
//
