LOCUS       NM_001363368            8070 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus coiled coil domain containing 88A (Ccdc88a),
            transcript variant 1, mRNA.
ACCESSION   NM_001363368 XM_006514450
VERSION     NM_001363368.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8070)
  AUTHORS   Wang,H., Yuan,Y.C., Chang,C., Izumi,T., Wang,H.H. and Yang,J.K.
  TITLE     The signaling protein GIV/Girdin mediates the Nephrin-dependent
            insulin secretion of pancreatic islet beta cells in response to
            high glucose
  JOURNAL   J Biol Chem 299 (4), 103045 (2023)
   PUBMED   36822326
REFERENCE   2  (bases 1 to 8070)
  AUTHORS   Reynoso,S., Castillo,V., Katkar,G.D., Lopez-Sanchez,I., Taheri,S.,
            Espinoza,C., Rohena,C., Sahoo,D., Gagneux,P. and Ghosh,P.
  TITLE     GIV/Girdin, a non-receptor modulator for Galphai/s, regulates
            spatiotemporal signaling during sperm capacitation and is required
            for male fertility
  JOURNAL   Elife 10, e69160 (2021)
   PUBMED   34409938
  REMARK    GeneRIF: GIV/Girdin, a non-receptor modulator for Galphai/s,
            regulates spatiotemporal signaling during sperm capacitation and is
            required for male fertility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8070)
  AUTHORS   Swanson,L., Katkar,G.D., Tam,J., Pranadinata,R.F., Chareddy,Y.,
            Coates,J., Anandachar,M.S., Castillo,V., Olson,J., Nizet,V.,
            Kufareva,I., Das,S. and Ghosh,P.
  TITLE     TLR4 signaling and macrophage inflammatory responses are dampened
            by GIV/Girdin
  JOURNAL   Proc Natl Acad Sci U S A 117 (43), 26895-26906 (2020)
   PUBMED   33055214
  REMARK    GeneRIF: TLR4 signaling and macrophage inflammatory responses are
            dampened by GIV/Girdin.
REFERENCE   4  (bases 1 to 8070)
  AUTHORS   Pan,S., Ren,F., Li,L., Liu,D., Li,Y., Wang,A., Li,W., Dong,Y. and
            Guo,W.
  TITLE     MiR-328-3p inhibits cell proliferation and metastasis in colorectal
            cancer by targeting Girdin and inhibiting the PI3K/Akt signaling
            pathway
  JOURNAL   Exp Cell Res 390 (1), 111939 (2020)
   PUBMED   32142853
  REMARK    GeneRIF: MiR-328-3p inhibits cell proliferation and metastasis in
            colorectal cancer by targeting Girdin and inhibiting the PI3K/Akt
            signaling pathway.
REFERENCE   5  (bases 1 to 8070)
  AUTHORS   Weng,L., Han,Y.P., Enomoto,A., Kitaura,Y., Nagamori,S., Kanai,Y.,
            Asai,N., An,J., Takagishi,M., Asai,M., Mii,S., Masuko,T.,
            Shimomura,Y. and Takahashi,M.
  TITLE     Negative regulation of amino acid signaling by MAPK-regulated
            4F2hc/Girdin complex
  JOURNAL   PLoS Biol 16 (3), e2005090 (2018)
   PUBMED   29538402
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8070)
  AUTHORS   Jiang,P., Enomoto,A., Jijiwa,M., Kato,T., Hasegawa,T., Ishida,M.,
            Sato,T., Asai,N., Murakumo,Y. and Takahashi,M.
  TITLE     An actin-binding protein Girdin regulates the motility of breast
            cancer cells
  JOURNAL   Cancer Res 68 (5), 1310-1318 (2008)
   PUBMED   18316593
  REMARK    GeneRIF: Girdin has an important role in tumor progression with
            aberrant activation of the Akt signaling pathway
REFERENCE   7  (bases 1 to 8070)
  AUTHORS   Kitamura,T., Asai,N., Enomoto,A., Maeda,K., Kato,T., Ishida,M.,
            Jiang,P., Watanabe,T., Usukura,J., Kondo,T., Costantini,F.,
            Murohara,T. and Takahashi,M.
  TITLE     Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate
            Girdin
  JOURNAL   Nat Cell Biol 10 (3), 329-337 (2008)
   PUBMED   18264090
  REMARK    GeneRIF: the Akt/Girdin signalling pathway is essential in
            VEGF-mediated postneonatal angiogenesis
REFERENCE   8  (bases 1 to 8070)
  AUTHORS   Le-Niculescu,H., Niesman,I., Fischer,T., DeVries,L. and
            Farquhar,M.G.
  TITLE     Identification and characterization of GIV, a novel Galpha
            i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi
            transport vesicles
  JOURNAL   J Biol Chem 280 (23), 22012-22020 (2005)
   PUBMED   15749703
REFERENCE   9  (bases 1 to 8070)
  AUTHORS   Simpson,F., Martin,S., Evans,T.M., Kerr,M., James,D.E.,
            Parton,R.G., Teasdale,R.D. and Wicking,C.
  TITLE     A novel hook-related protein family and the characterization of
            hook-related protein 1
  JOURNAL   Traffic 6 (6), 442-458 (2005)
   PUBMED   15882442
  REMARK    GeneRIF: HkRP1 (A430106J12Rik) is involved in the process of
            tubulation of sorting nexin-1 positive membranes from early
            endosome subdomains.
REFERENCE   10 (bases 1 to 8070)
  AUTHORS   Anai,M., Shojima,N., Katagiri,H., Ogihara,T., Sakoda,H., Onishi,Y.,
            Ono,H., Fujishiro,M., Fukushima,Y., Horike,N., Viana,A.,
            Kikuchi,M., Noguchi,N., Takahashi,S., Takata,K., Oka,Y.,
            Uchijima,Y., Kurihara,H. and Asano,T.
  TITLE     A novel protein kinase B (PKB)/AKT-binding protein enhances PKB
            kinase activity and regulates DNA synthesis
  JOURNAL   J Biol Chem 280 (18), 18525-18535 (2005)
   PUBMED   15753085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935054.11 and BX284634.8.
            
            [WARNING] On Aug 15, 2024 this sequence was replaced by
            NM_001363368.2.
            
            On May 17, 2018 this sequence version replaced XM_006514450.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.199917.1,
                                           SRR14777531.437165.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-753               AL935054.11        52421-53173         c
            754-854             AL935054.11        52224-52324         c
            855-963             AL935054.11        26539-26647         c
            964-1033            AL935054.11        4222-4291           c
            1034-1092           AL935054.11        2001-2059           c
            1093-1176           BX284634.8         4503-4586
            1177-1317           BX284634.8         5282-5422
            1318-1490           BX284634.8         23066-23238
            1491-1572           BX284634.8         26192-26273
            1573-1731           BX284634.8         28289-28447
            1732-1878           BX284634.8         30540-30686
            1879-2023           BX284634.8         31628-31772
            2024-2208           BX284634.8         36019-36203
            2209-2346           BX284634.8         36881-37018
            2347-3417           BX284634.8         38290-39360
            3418-3545           BX284634.8         40781-40908
            3546-3687           BX284634.8         45485-45626
            3688-3852           BX284634.8         52464-52628
            3853-4014           BX284634.8         55660-55821
            4015-4292           BX284634.8         57279-57556
            4293-4436           BX284634.8         57768-57911
            4437-4623           BX284634.8         60995-61181
            4624-4769           BX284634.8         64752-64897
            4770-4862           BX284634.8         68870-68962
            4863-5077           BX284634.8         69049-69263
            5078-5161           BX284634.8         72513-72596
            5162-5365           BX284634.8         73579-73782
            5366-5437           BX284634.8         74505-74576
            5438-5518           BX284634.8         76146-76226
            5519-5787           BX284634.8         78553-78821
            5788-8070           BX284634.8         79022-81304
FEATURES             Location/Qualifiers
     source          1..8070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 16.61 cM"
     gene            1..8070
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /note="coiled coil domain containing 88A"
                     /db_xref="GeneID:108686"
                     /db_xref="MGI:MGI:1925177"
     exon            1..753
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             691..6741
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Hook-related protein 1; Akt-phosphorylation enhancer;
                     girders of actin filament; coiled-coil domain-containing
                     protein 88A; g alpha-interacting vesicle-associated
                     protein"
                     /codon_start=1
                     /product="girdin isoform 1"
                     /protein_id="NP_001350297.1"
                     /db_xref="GeneID:108686"
                     /db_xref="MGI:MGI:1925177"
                     /translation="MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVD
                     GVFLNQVMLQINPKSESQRVNKKVNNDASLRIHNLSILVKQIKFYYQETLQQLIMMPL
                     PDILIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIEKIQGLDFDTKAAVAAHI
                     QEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMVSHLRRLIDERDEHSETIVELSEER
                     DGVHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD
                     CKQELEQIEVELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESELSRYKE
                     RLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLH
                     DMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELAEAPQKSL
                     GHEVNELTSSKLLKLEMENQSLTKTVEELRSTADSAAGSTSKILKVEKENQRLNKKVE
                     ILENEIIQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT
                     VSSLRQRSQISAEARVKDIEKENKILHESIKETCGKLSKIEFEKRQMKKELELYKEKG
                     ERAEELENELNHLGKENELLQKKITNLKITCEKLETLEQENSELERENRKFKKTLDSF
                     KNLTFQLESLEKENSQLDEENLELRRSVESLKCASMRMAQLQLENKELESEKEQLRKG
                     LELMRASFKKTERLEVSYQGLDTENQRLQKALENSNKKIQQLESELQDLEMENQTLQK
                     SLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENN
                     VKIGNLEKENKTLFKEINVYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE
                     KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIK
                     EEKIAALEARLEESTNYNQQLRHELKTVKKNYEALKQRQDEERMVQSSIPVSGEDDKW
                     GRESQEATRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR
                     QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESIMKER
                     EDLKSLYDALIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHKDLEDRYNQ
                     LLKQKGQLEDLEKMIKTEQEKMLLESKNHEVVASEYKKLCGENDRLNYTYSQLLKETE
                     ILQMDHKNLKSVLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
                     EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIM
                     DQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPH
                     QDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMND
                     LVQSMVLAGGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAAFRSK
                     QLVNNKDTTSFEDISPQGISDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKA
                     GAVNIQSRPQSHSSGDFSLLHDHETWSSSGSSPIQYLKRQTRSSPMLQHKISETIESR
                     AHHKMKAGSPGSEVVTLQQFLEESNKLTSIQLKSSSQENLLDEVMKSLSVSSDFLGKD
                     KPVSCTLARSVSGKTPGDFYDRRTTKPEFLRTGPQKTEDAYTISSAGKPTPSTQGKIK
                     LVKETSVSRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLSKDSRLPVSVDSSPP
                     TAGSSSTTASSEYHLQQWSSDMPTHSEDTSESVYTQARNSSSGRPCFLNQTFATVKMS
                     NDTFGISGNDSHETFSVVHSSQPFLSLNTELVSNISGLPPKSPLTRITGQTFASLDKT
                     AQKDNKHFSDSQNPSHSKTQFSEDSDLIIPACLYPDDTDVALSVSEDSQIVWYEYGCI
                     "
     exon            754..854
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..963
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1033
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1092
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1176
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1317
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1490
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1572
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1731
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1878
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2023
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2208
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2346
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..3417
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..3545
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3687
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..3852
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3853..4014
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..4292
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4293..4436
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4437..4623
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4624..4769
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4770..4862
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            4863..5077
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5078..5161
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5162..5365
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5366..5437
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5438..5518
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5519..5787
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            5788..8070
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7474..7479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /note="hexamer: AATAAA"
     polyA_site      7494
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /note="major polyA site"
     regulatory      7708..7713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
                     /note="hexamer: ATTAAA"
     polyA_site      7730
                     /gene="Ccdc88a"
                     /gene_synonym="A430106J12Rik; Ape; C130096N06Rik;
                     C330012F17Rik; D130005J21Rik; Girdin; Giv; Grdn; Hkrp1"
ORIGIN      
        1 gttaccctag ctcctccaga gggcggcgga ggaggctgga gcgcggcagc ggagcgtccg
       61 ggcgtcgctg aggcacacgg aggctggcgg ggctcctgca gccggacggt cagggacacg
      121 cctcggtgct ccggaccccg gccaaggcca gggcgctgaa gcgagcgcga ggccgcggag
      181 ggatgctgag cgcctggaga ggggcgagcc gcgcctgagg ctgtgaggtt gcgggcagac
      241 gctcccagct ctcggcgccc gtgcccactg gcggccggaa cgcccagaac cgctcgccca
      301 ggtccagccc ggccccctcg gcccccacgt tgggcttgag ttcttggcgg ccgctgcgct
      361 ggccggctcc ccccgggagc ggggcaacct tgacgggctt tttgtctcgt gccccggccg
      421 ctctccgcgt cctcctcctc cagatgcctt ttttctgccc ctcctcaccg ggtgcagact
      481 gccagcatcg gctgcggctc agcgcgggat tcgggctcgt ttccccgggg gggctaagga
      541 gggacagctc ttccccttct tcgatgggat tttcctctcc tgccggaatg aactttcatt
      601 gattccgtct tctacattta ctgaccaatt ccctgggcgt atttgtggta cttcctcccc
      661 ccgccccctc ctgaatatat aatctgtaaa atggagaacg aaatcttcac tccccttctg
      721 gagcagttca tgaccagccc cttggtcact tgggttaaaa cgtttggacc tctggctgca
      781 ggaaatggga ctaacctgga tgagtatgtg gctttagtgg atggggtatt cttgaaccag
      841 gtcatgctcc aaattaatcc taagtcggag agtcaacgag taaataaaaa agtcaacaat
      901 gatgcttccc ttagaattca caatctgtcc attttggtga aacagataaa attttattat
      961 caggagactt tgcagcagtt gattatgatg ccattgccag atatcttaat cattggcaaa
     1021 aatccctttt ctgaacaagg tacagaagaa gttaaaaagt tgcttttgct cttacttggt
     1081 tgtgcagttc agtgtcagaa aaaggaagaa tttattgaaa aaattcaagg tttagatttt
     1141 gatacgaaag cagcagttgc tgcacacatt caagaggtaa ctcataatca agaaaatgta
     1201 tttgatctgc aatggatgga agtgacagat atgtctcagg aagacataga accactctta
     1261 aagaatatgg tgtcacatct aagaagactg atagatgaga gagatgaaca ttcagagact
     1321 attgtagaac tctcagaaga gcgagatggt gttcatttcc taccccatgc ctcttcatct
     1381 gcacagtcac cctgtggttc tccaggcatg aagcgaacag aaagtcgaca gcatctctca
     1441 gtggaattgg ctgatgctaa agccaagatc cgaagactta ggcaggaatt ggaagaaaag
     1501 actgagcagt tactggactg taaacaagaa cttgagcaaa tagaagtgga attgaagagg
     1561 ctgcaacaag agaacatgaa tttgctttcg gatgctcgat ctgctagaat gtaccgagat
     1621 gaattggatg ccctccgaga gaaagcagtc agagttgata agcttgaaag tgaactcagt
     1681 agatataaag agagactaca tgatattgaa ttttataagg caagagttga ggaattaaaa
     1741 gaagataatc aagttttatt agaaacaaaa actatgctgg aagaccaact agaaggaact
     1801 cgggctcgtt ctgacaaact acatgaatta gaaaaagaga atttacaact aaaggctaaa
     1861 ttgcatgata tggagatgga acgagatatg gatagaaaga agattgaaga attaatggaa
     1921 gaaaatatga ctctggaaat ggcacagaaa caaagtatgg atgagtcatt acaccttggc
     1981 tgggagctgg aacagatatc cagaactagt gaacttgctg aagcaccaca gaagtccttg
     2041 ggccatgagg taaatgaatt aacatcaagt aagttattaa agttggaaat ggaaaaccag
     2101 agtctgacga aaaccgtaga agagctccgg agcactgcgg actccgcagc aggcagcact
     2161 tccaaaatcc taaaagttga aaaggaaaac cagagactga ataaaaaggt tgaaattctt
     2221 gaaaatgaaa ttattcaaga aaagcaaagt cttcagaatt gtcaaaattt aagcaaggat
     2281 ctaatgaaag agaaagctca gcttgaaaaa acaatagaga cgctcagaga gaattcagag
     2341 aggcagatta aaatattgga gcaggaaaat gaacatctga atcaaacagt gtcttcctta
     2401 cggcagcgct cccagattag tgctgaggcg agagtgaaag acattgaaaa agaaaataaa
     2461 attctccatg aatctatcaa agaaacatgt ggaaaactaa gcaagattga atttgaaaaa
     2521 agacaaatga aaaaggaatt agagctttat aaagagaaag gagagcgagc agaagaactt
     2581 gaaaacgagt tgaatcatct tggaaaggag aatgaattgt tgcagaaaaa gataacgaat
     2641 ttaaagatta cgtgtgaaaa acttgagaca ttagaacagg aaaattcaga gctagaaaga
     2701 gaaaatagga aatttaaaaa aactttggac agctttaaaa accttacttt tcagttagaa
     2761 tctctagaaa aagagaattc ccaactcgat gaagaaaact tagaactgcg aaggagcgtg
     2821 gagtctctga agtgtgcgag catgagaatg gcccagctcc agctagagaa caaggagctg
     2881 gagagtgaga aggagcagct gaggaagggc ttggagctca tgagagcctc tttcaagaag
     2941 acagaacgct tggaagttag ctaccagggg ctagacacag aaaatcaaag actacaaaaa
     3001 gctctagaaa atagcaataa aaaaatccaa cagttagaga gtgagctaca agacttagag
     3061 atggaaaatc aaacattaca aaaaagccta gaggaactga aaatatctag caaaagactg
     3121 gaacaactag aaaaagaaaa caagtcatta gagcaagaga catctcaact tgaaaaggac
     3181 aaaaaacaat tggagaagga aaataaacga ctccgacaac aagcagaaat aaaagatacc
     3241 acattagaag aaaataatgt gaaaattggg aatttggaaa aagaaaacaa aactttattc
     3301 aaagaaatta atgtatataa agagtcctgt gttcgtctaa aagaattaga aaaagaaaat
     3361 aaagagcttg taaaaagagc aactattgat attaaaacct tggttacatt acgtgaggat
     3421 ttagtcagtg agaaattgaa gacacaacaa atgaacaatg atcttgagaa attaactcat
     3481 gagcttgaga agataggttt aaataaagag cggctcctac acgatgagca gagcactgat
     3541 gacagtaggt acaaactttt ggaatcaaaa ttagaatcca ctcttaagaa gtcccttgaa
     3601 ataaaagaag aaaaaattgc tgctttagaa gctcggttag aagaatctac aaattacaat
     3661 cagcaattgc gccacgaact taaaacagtg aaaaaaaatt atgaagctct caaacagaga
     3721 caagatgaag aaaggatggt acagagttcc attccagtct ctggagaaga tgacaagtgg
     3781 ggccgagaaa gtcaagaagc gactagagag ctcctgaaag ttaaagacag gttaattgaa
     3841 gtagaaagaa acaatgctac gctgcaagca gagaagcaag cactgaaaac tcaactgaag
     3901 caacttgaaa cacaaaataa taatttgcag gctcagattc ttgcactgca gaggcagacc
     3961 gtgtcattgc aggagcagaa taccacgctt cagacacaga atgccaagct tcaggttgaa
     4021 aattctaccc ttaattcaca aagtacttca cttatgaacc agaatgcaca gcttctaatc
     4081 cagcagtctt ccttagaaaa tgaaaatgaa tctataatga aagaacgaga agacttgaaa
     4141 tctctgtatg atgctctgat aaaagatcac gaaaagctgg aacttcttca tgagcggcaa
     4201 gcttcagagt atgagtctct gatctctaaa catggcaccc tgaagtctgc tcacaaaaat
     4261 cttgaagtgg aacataaaga ccttgaagac cgttacaatc agttattaaa acagaaagga
     4321 caattggaag atttggaaaa aatgatcaaa acggaacagg aaaaaatgct gcttgaaagc
     4381 aaaaaccatg aagtggtagc ttcagagtac aagaagcttt gtggtgaaaa tgataggtta
     4441 aattatacat atagtcagct tttaaaagag actgaaattt tacaaatgga tcataaaaat
     4501 ttgaaaagtg ttctaaataa ttctaaattg gaacaaacaa gattagaagc tgaattttca
     4561 aagctaaagg agcagtatca gcaactagat atcacatcta ccaagctaaa taaccagtgt
     4621 gagttgctca gccaacttaa aggaaattta gaagaagaaa atcgacatct acttgatcag
     4681 atccagacac taatgctaca gaacagaaca ctgctggagc aaaatatgga aagcaaggat
     4741 ctctttcatg ttgaacaaag acagtacatt gataaattaa atgaattgag acgacaaaaa
     4801 gaaaaattag aagagaaaat tatggatcaa tacaaatttt atgacccatc tcctcctaga
     4861 aggagaggca actggattac tctaaaaatg agaaaattga taaagtcaaa aaaagatatt
     4921 aatcgggaac gtcagaaatc tctaacacta acacccaccc gctcagactc cagtgaagga
     4981 tttcttcagc tgccccatca agacagccaa gacagctctt cagtaggatc aaactcttta
     5041 gaagatggcc aaaccctggg gaccaagaag agcagcatgg ttgcactgaa aagactgccc
     5101 tttttgagga acagaccgaa ggataaagac aaaatgaagg cctgctaccg tcgttccatg
     5161 tccatgaatg acctggtgca gtccatggtc ctagcaggag gacagtggac aggtagtact
     5221 gaaaatttgg aggtccctga tgatatttca acgggtaaaa ggagaaaaga attgggagct
     5281 atggccttct ctactacagc catcaacttt tcaactgtca actcttctgc agccttccga
     5341 tccaagcagt tggttaataa taaagatact acatcctttg aagacataag tccacaaggt
     5401 attagtgatg attctagtac gggatcaaga gttcatgctt caagaccagc cagccttgat
     5461 agtggcagaa catccactag caatagcaat aataatgctt cactccatga agtcaaagca
     5521 ggtgcagtta atatccaaag caggccacaa agccacagca gtggagattt cagtctgctt
     5581 catgatcatg agacttggtc tagcagtggt agcagtccaa ttcagtattt gaaaagacag
     5641 accaggtcaa gccctatgct ccagcacaaa atatctgaaa caatagagag tcgagcccat
     5701 cacaagatga aagctggctc cccaggaagt gaagttgtta ctctacaaca gtttttggaa
     5761 gaaagcaaca agcttacctc aatacagttg aagtcctcga gtcaagagaa tcttttagat
     5821 gaagtaatga aaagtttgtc tgtgtcttcc gactttctgg ggaaagacaa gccagttagc
     5881 tgtaccctgg ccaggtcagt aagtggaaag actccagggg acttctatga tagacggaca
     5941 actaagcctg aatttttgag aactggtcct caaaagactg aagatgccta caccatcagc
     6001 tctgcaggga aacctacacc aagcactcaa ggaaagataa aactagtaaa agaaacctct
     6061 gtgtcaagac aatcaaaaga tagcaatcct tatgccactt tacctcgtgc aagcagtgtg
     6121 atctctactg ctgaaggaac aactcgaagg acgagcatcc atgatttttt gagcaaagac
     6181 agtagactgc ccgtgtcagt cgattcatca ccacctactg ctggtagcag cagcactaca
     6241 gcatctagtg agtaccattt acagcagtgg tcctctgaca tgccaacaca ttctgaagac
     6301 acatctgagt ccgtttatac ccaggctaga aattcaagtt caggaaggcc atgttttcta
     6361 aaccaaactt ttgccactgt taaaatgtct aatgatacat ttggaatatc aggtaatgat
     6421 agccatgaga catttagtgt tgttcattca tctcagccat ttctatccct gaacacagaa
     6481 ctagttagta acataagtgg gttacctccc aagtcaccac tcactagaat aactggccag
     6541 acctttgcct ctttggataa aactgcacag aaagataaca aacatttttc tgatagtcag
     6601 aaccccagtc acagtaagac acagttctct gaagatagcg atcttatcat tcctgcatgc
     6661 ctctaccctg atgacacaga cgttgcatta tcggtttcag aggacagcca aattgtttgg
     6721 tatgaatatg gttgtatttg atcaaaactg catagtatgt taatattact cattaggctt
     6781 atattaagat tgttacagag ttcagctata taaaaaggca tgtatataaa caccacacca
     6841 aagtctgcat gaaatagtaa ttgcattgtg catttttgca tgccttttaa accccaccca
     6901 catttctttt acatcttttt aatgcttgat aaagatgata aagacacttc atgtcatgga
     6961 tcatgtccaa gtagctgcat gttctgttat caagaaaaca tatccaagtc attgtttggc
     7021 tgcttctaaa aagcatgttc atcgctcttc ctgctgcctg ctccccagcc ctctcctttg
     7081 cttcctgaat gtgcacttca tgctgcacat gcacagcatt cataagaaaa tgtttttgaa
     7141 atggtatttt tttgtcactt aatcatgtta tctttcctgt tctcttttca aagaaatagt
     7201 taatagttca tctttatttg aactaatgct tgcacttata aaacattgtt caaatttaaa
     7261 atactgttta ttcataaatg tgttattcct ggagttttct atcaaattta aatgtaactt
     7321 acacagtgag taggcatgtt tgtattacag ttcccttctt ggtgctgttc ctttcccgat
     7381 aaatgcaata gcttaactac ttccccttta tttttttggt atccttaaca caaatttttc
     7441 cagttttttt tttaaacata tgagtcaaag agaaataaac caagttactt attaccttgg
     7501 gaatttgtat ttttacttca attcagaaga atagcaaggt ttttaaatga tgaaaaaaat
     7561 taacttctgt cattaattta ttactaaatg taaatcctta atgcaaactt tttaaaaatt
     7621 aatacattgc gctagagtat aaaattagaa cttgtgagca taaaaatgaa aaatacacta
     7681 tgtagtcttt attctaaaat ctgttgtatt aaaaacatag tcttgcctgg tgtatgcctt
     7741 taaccctggc agtttgggag gcagaggtga gtggttctct gagttccagg ccagccagcg
     7801 ctgtgaactg ggaccccgtc tcaaaaagtt caaacaaaaa gaaaacaaaa caagcaaaaa
     7861 tagaaaaata gtctttagct ccccacgctc tcaaacagta cacacacaca aacgcacaca
     7921 cacacacaca cacacacaca cacacgacaa agatactatc cataaacatg gactccaatg
     7981 tcatatagtt ttcaattatc tttctgtgtt catgtcaatc tacaccaaat cagctttaat
     8041 tcctcagcat taaaaaaatc tataatctta
//
