LOCUS       NM_026439               3690 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus coiled-coil domain containing 80 (Ccdc80), mRNA.
ACCESSION   NM_026439
VERSION     NM_026439.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3690)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3690)
  AUTHORS   Li,W., Kuang,Z., Zheng,M., He,G. and Liu,Y.
  TITLE     Multi-omics integrative analysis to access role of coiled-coil
            domain-containing 80 in lipid metabolism
  JOURNAL   Biochem Biophys Res Commun 526 (3), 813-819 (2020)
   PUBMED   32273086
REFERENCE   3  (bases 1 to 3690)
  AUTHORS   Gong,D., Zhang,Q., Chen,L.Y., Yu,X.H., Wang,G., Zou,J., Zheng,X.L.,
            Zhang,D.W., Yin,W.D. and Tang,C.K.
  TITLE     Coiled-coil domain-containing 80 accelerates atherosclerosis
            development through decreasing lipoprotein lipase expression via
            ERK1/2 phosphorylation and TET2 expression
  JOURNAL   Eur J Pharmacol 843, 177-189 (2019)
   PUBMED   30439364
  REMARK    GeneRIF: Here, we showed that CCDC80 inhibited ERK1/2 activation,
            decreased TET2 expression and TET2-mediated DNA demethylation, and
            then promoted DNA methylation of the LPL gene. Consequently, CCDC80
            reduced LPL expression and activity, leading to increased plasma TG
            levels and enhanced atherosclerotic lesions area, which at least
            partially involved FOXO3a.
REFERENCE   4  (bases 1 to 3690)
  AUTHORS   Loo,L., Simon,J.M., Xing,L., McCoy,E.S., Niehaus,J.K., Guo,J.,
            Anton,E.S. and Zylka,M.J.
  TITLE     Single-cell transcriptomic analysis of mouse neocortical
            development
  JOURNAL   Nat Commun 10 (1), 134 (2019)
   PUBMED   30635555
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3690)
  AUTHORS   Grill,J.I., Neumann,J., Ofner,A., Marschall,M.K., Zierahn,H.,
            Herbst,A., Wolf,E. and Kolligs,F.T.
  TITLE     Dro1/Ccdc80 inactivation promotes AOM/DSS-induced colorectal
            carcinogenesis and aggravates colitis by DSS in mice
  JOURNAL   Carcinogenesis 39 (9), 1176-1184 (2018)
   PUBMED   29901779
  REMARK    GeneRIF: The results demonstrate DRO1 to be a strong tumor
            suppressor in the chemically induced colon carcinogenic mouse
            model. Additionally, DRO1 inhibits colitis-associated colon cancer
            formation and plays a putative role for in inflammatory bowel
            disease.
REFERENCE   6  (bases 1 to 3690)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   7  (bases 1 to 3690)
  AUTHORS   Kawaguchi,A., Ikawa,T., Kasukawa,T., Ueda,H.R., Kurimoto,K.,
            Saitou,M. and Matsuzaki,F.
  TITLE     Single-cell gene profiling defines differential progenitor
            subclasses in mammalian neurogenesis
  JOURNAL   Development 135 (18), 3113-3124 (2008)
   PUBMED   18725516
REFERENCE   8  (bases 1 to 3690)
  AUTHORS   Okada,T., Nishizawa,H., Kurata,A., Tamba,S., Sonoda,M., Yasui,A.,
            Kuroda,Y., Hibuse,T., Maeda,N., Kihara,S., Hadama,T., Tobita,K.,
            Akamatsu,S., Maeda,K., Shimomura,I. and Funahashi,T.
  TITLE     URB is abundantly expressed in adipose tissue and dysregulated in
            obesity
  JOURNAL   Biochem Biophys Res Commun 367 (2), 370-376 (2008)
   PUBMED   18178152
  REMARK    GeneRIF: In conclusion, the expression pattern of URB suggests its
            role in obesity and the results suggest that URB is secreted, at
            least in part, from adipocytes.
REFERENCE   9  (bases 1 to 3690)
  AUTHORS   Liu,Y., Monticone,M., Tonachini,L., Mastrogiacomo,M., Marigo,V.,
            Cancedda,R. and Castagnola,P.
  TITLE     URB expression in human bone marrow stromal cells and during mouse
            development
  JOURNAL   Biochem Biophys Res Commun 322 (2), 497-507 (2004)
   PUBMED   15325258
  REMARK    GeneRIF: Downregulated during osteoblastic differentiation of bone
            marrow stromal cells.  Suggests role in skeletogenesis.
REFERENCE   10 (bases 1 to 3690)
  AUTHORS   Aoki,K., Sun,Y.J., Aoki,S., Wada,K. and Wada,E.
  TITLE     Cloning, expression, and mapping of a gene that is upregulated in
            adipose tissue of mice deficient in bombesin receptor subtype-3
  JOURNAL   Biochem Biophys Res Commun 290 (4), 1282-1288 (2002)
   PUBMED   11812002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124600.5 and AC129601.4.
            
            On Oct 4, 2017 this sequence version replaced NM_026439.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132178.1, AB075019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               AC124600.5         21631-22045         c
            416-2301            AC124600.5         19299-21184         c
            2302-2458           AC124600.5         11520-11676         c
            2459-2595           AC129601.4         66752-66888
            2596-2744           AC129601.4         68607-68755
            2745-2848           AC129601.4         73353-73456
            2849-2929           AC129601.4         76628-76708
            2930-3690           AC129601.4         77670-78430
FEATURES             Location/Qualifiers
     source          1..3690
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 29.39 cM"
     gene            1..3690
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /note="coiled-coil domain containing 80"
                     /db_xref="GeneID:67896"
                     /db_xref="MGI:MGI:1915146"
     exon            1..415
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /inference="alignment:Splign:2.1.0"
     exon            416..2301
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /inference="alignment:Splign:2.1.0"
     CDS             427..3276
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /note="steroid sensitive gene 1; coiled-coil
                     domain-containing protein 80; up-regulated in BRS-3
                     deficient mouse"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 80
                     precursor"
                     /protein_id="NP_080715.2"
                     /db_xref="CCDS:CCDS28192.1"
                     /db_xref="GeneID:67896"
                     /db_xref="MGI:MGI:1915146"
                     /translation="MMWKMGPHFTTLLAMWLVCGSASHSPALDSDSHTGRKVPLVSPI
                     SSRSARYLRHTGRSGGVEKSTQEEPNPQPFQRRKSVPVLRLAHPTMRPPPSGINGVPV
                     RPEVRPIARSSAREMVRDEGSSARTRMLRFPSGSSSPNILASFAGKNRVWVISAPHAS
                     EGYYRLMMSLLKDDVYCELAERHIQQIVLFHQAGEEGGKVRRITNEGQILEQPLDPNL
                     IPKLMSFLKLEKGKFSMVLLKKTLQVEERYPYPVRLEAMYEVIDQGPIRRIEKIRQKG
                     FVQKCKASGIEGHVVQEGNEGGGGAGGTGLGGDKRKEDPRRTQVHPTREAPRKQATSK
                     AATPQPPPTPRATTLPPAPVTTATRATSRVVTIAARPTTTTAYPATQRPWTSRLHPFS
                     VSHRPPATAEVTTARGPSVSEQLYPLPRKEQQREKPQATRRPSKATNYGSFTATPPPT
                     LWEVSARVVGTSRFRDNRTDKREHGHQDPNAVPGPHKPVKGKLPKKKDRILSNEYEDK
                     YDLSQPTSSQGEEERQVDSVPSQNAKESKKLEKLEKPEKEKKKKGKSAKQDKLLKSEK
                     QAKKAEKKTKQEKDKNKKKKAGKTEQDDNQKPTAKHLAPSPKKSVADLLGSFEGKRRL
                     LLITTPKAENNMYVQQRDEYLESFCKMATRRISVVTIFGPVNNSSMKIDHFQLDNEKP
                     MRVVDDDDLVDQHLISELRKEYGMTYDDFFMVLTDVDLRVKQYYEVPIAMKSVFDLID
                     TFQSRIKDMEKQKKEGIACKEDKRQSLENFLSRFRWRRRLLVISAPNDEDWAYSQQLS
                     ALNGQACNFGLRHITILKLLGVGEEVGGVLELFPINGSSIVEREDVPAHLVKDIRNYF
                     QVSPEYFSMLLVGKDGNVKSWYPSPMWSMVIVYDLIDSMQLRRQEMAIQQSLGMRCPE
                     DEYAGYGYHSYHQGYQDGYQDDYRHHESYHHGYPY"
     exon            2302..2458
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2595
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2744
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2848
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..2929
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3690
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3405..3410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /note="hexamer: ATTAAA"
     polyA_site      3431
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /note="major polyA site"
     regulatory      3615..3620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /note="hexamer: AGTAAA"
     regulatory      3638..3643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
                     /note="hexamer: ATTAAA"
     polyA_site      3638
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
     polyA_site      3657
                     /gene="Ccdc80"
                     /gene_synonym="2610001E17Rik; DRO1; Ssg1; Urb"
ORIGIN      
        1 ttacgctcgg aaacaaaggg actcggccag actgcaggag gggaagggtg ataagaagtt
       61 ctgggaaaac tccacagaag ggaagagcga gattcagaaa tcactaggac ttcactttca
      121 ggaagatccc tgtggcaacc aaggaccggc acacacagac ccaggagaaa ctgcagacaa
      181 atggagatac aaacggtccc aaggacagca gcgttcacct cctcccactg gaccagaagg
      241 taaaagacac agccagcaaa aggaatcggc ccaggctggg ctccctgggg ctgctttgca
      301 gacagacaag gagacagaga gcaggaagga accgatctca cctaggaaac tgtcctgggg
      361 accaaccttc acgtttctct ggaaagcctc tgcaagcatc tccatgaacc actgttggat
      421 aatacaatga tgtggaaaat gggaccccac ttcaccacgc tcttggccat gtggctggtg
      481 tgtggctcag catctcattc tcctgccttg gatagcgaca gccacactgg acggaaagta
      541 cctttggttt ctccaatcag cagtaggtca gctcggtatc tgaggcacac cgggaggtct
      601 ggtggagttg agaaatccac ccaggaagaa ccaaatcctc agcctttcca aaggaggaag
      661 agtgtaccag tgttgagatt agctcacccg accatgagac cacccccctc aggtatcaat
      721 ggagttccag tcagacctga ggtgagaccc atagctagga gctcggcgcg tgagatggtc
      781 cgagatgagg ggtcttctgc tcggacaaga atgttgcgat tcccctctgg atctagctct
      841 cccaatatcc tggccagctt tgcaggaaag aacagggtat gggtcatctc agcccctcac
      901 gcctcagagg gctactaccg cctcatgatg agcctcctga aggacgacgt gtattgtgag
      961 ctggcagaaa ggcacatcca acagattgtg ctcttccacc aggcaggcga ggaagggggc
     1021 aaggtacgga ggatcaccaa tgaagggcag atcctggagc agcctctgga ccccaatctc
     1081 atcccaaagc tgatgagctt cttgaaactg gagaagggca agtttagcat ggtgctgtta
     1141 aaaaagactc tgcaggtgga ggagcgctac ccttacccgg tcaggctgga agccatgtat
     1201 gaggtcattg atcaaggtcc catccgcagg atcgagaaaa tcaggcagaa gggttttgtc
     1261 caaaagtgta aggcctcggg catagagggc catgtagtcc aggaaggaaa cgagggcggt
     1321 ggaggagcag gaggtacagg cctgggcggt gataagagga aagaggaccc aaggagaaca
     1381 caagtccacc ccaccagaga ggctccgaga aagcaggcca ccagcaaggc agccactcct
     1441 cagcctcccc caactccaag ggccaccacc cttcctcctg ctccagtcac gacagccact
     1501 cgggccacat cccgggtagt gacaatagcc gcaagaccta caaccaccac tgcctatcca
     1561 gctacccaga ggccctggac atcccggttg catcccttct cagtctccca caggccccct
     1621 gcaacagcag aggtgaccac tgccaggggc ccctccgtct cagagcagct ataccctcta
     1681 cctcggaagg agcaacagag agagaagcca caggccacca ggaggcccag caaagccacc
     1741 aactatggaa gcttcacagc caccccacct cccaccctct gggaggtcag cgcaagagtt
     1801 gtgggcacaa gccgtttccg ggacaaccgg acagacaaac gggaacatgg ccatcaggac
     1861 ccaaatgcgg tgccaggtcc tcacaagcca gtaaagggga agctgcccaa aaagaaggac
     1921 agaattctca gcaacgaata tgaagacaag tatgacctca gccagcccac ctcctctcag
     1981 ggggaggagg agcggcaggt ggatagcgtt ccctcgcaga atgccaagga gtcgaaaaag
     2041 cttgaaaagc tcgagaaacc tgagaaggag aagaagaaaa aagggaagag tgcaaaacaa
     2101 gacaagttac tcaagagtga aaagcaagcg aagaaagctg agaaaaagac caaacaggag
     2161 aaagacaaga ataagaagaa aaaggcgggt aagacagagc aggatgacaa tcagaagccc
     2221 accgcaaaac atctcgctcc aagtcccaag aagtcagtgg ccgacctgtt ggggtctttc
     2281 gaaggcaaac gaagactcct cctgatcacc actcccaagg ctgagaacaa tatgtatgtg
     2341 cagcagcggg atgaatatct ggagagcttc tgcaagatgg ccaccaggag gatctctgtg
     2401 gtcaccatct ttggtcctgt caacaacagc tccatgaaaa ttgatcactt ccagctagat
     2461 aatgagaaac ccatgcgtgt ggtggatgat gatgacttgg tggaccaaca tctcatcagc
     2521 gagctgagga aggagtatgg aatgacctac gatgacttct tcatggtgct gacagacgtg
     2581 gatctgagag tcaagcaata ctacgaagtg ccaatagcaa tgaagtccgt gtttgatctt
     2641 attgacactt tccaatcccg aatcaaagat atggagaagc agaagaagga gggcattgcc
     2701 tgcaaggagg acaagaggca gtccctggag aacttcctat ccaggttccg atggaggagg
     2761 aggttgctgg tgatctctgc tcctaatgat gaagactggg cctattcaca acagctctct
     2821 gccctcaacg gtcaggcatg caattttggt ctgcgacata taaccattct gaagcttttg
     2881 ggtgttggag aggaagttgg aggagtttta gaactgttcc caattaatgg gagctccatc
     2941 gttgagcggg aagatgtgcc agcccacttg gtcaaagata tccgcaacta ttttcaagtg
     3001 agcccagagt acttctccat gcttctagtt ggaaaagatg gcaatgttaa atcttggtat
     3061 ccttctccta tgtggtcgat ggtcatcgtg tatgacttaa ttgattccat gcaacttcgg
     3121 agacaggaaa tggccattca gcagtctctg gggatgcgct gcccagaaga tgagtatgca
     3181 ggatatggtt accatagtta tcaccaagga taccaggatg gctaccagga tgactaccgt
     3241 catcatgaaa gttaccacca tggataccct tactgaacag aaatatgtaa ccttattccc
     3301 atccagtttc cccttcatct gctaaagctg tgtgctggca gcttcataag ggaatttctc
     3361 catactctac ataccccgac tttttctttc agtgttcttc caagattaaa gaaatagtaa
     3421 actttcccct actcatgact tgttattaag acatttaaaa gaactctcta actggagaga
     3481 gaaaagtgtg gtgctaaata atttttactg aaaaacaaaa ggtagtatct cttttcttat
     3541 ctaatggcta ttatttgata tgcaaatgta tataaaatgt ttatacatct ttccttcatt
     3601 tctatcaatt tgtaagtaaa aattgtgtta aggaaaaatt aaaactcaca gtacaaatgt
     3661 tttcgtagaa catctggata gacacaaaag
//
