LOCUS       NM_001101535            3614 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus coiled-coil domain containing 8 (Ccdc8), mRNA.
ACCESSION   NM_001101535 XM_001477278 XM_001480107 XM_001480113 XM_485872
VERSION     NM_001101535.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3614)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3614)
  AUTHORS   Wang,P., Yan,F., Li,Z., Yu,Y., Parnell,S.E. and Xiong,Y.
  TITLE     Impaired plasma membrane localization of ubiquitin ligase complex
            underlies 3-M syndrome development
  JOURNAL   J Clin Invest 129 (10), 4393-4407 (2019)
   PUBMED   31343991
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC148976.3.
            
            On Jun 9, 2018 this sequence version replaced NM_001101535.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR10223970.9207.1,
                                        SRR7345562.1166287.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3614              AC148976.3         55906-59519
FEATURES             Location/Qualifiers
     source          1..3614
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.15 cM"
     gene            1..3614
                     /gene="Ccdc8"
                     /note="coiled-coil domain containing 8"
                     /db_xref="GeneID:434130"
                     /db_xref="MGI:MGI:3612184"
     exon            1..3614
                     /gene="Ccdc8"
                     /inference="alignment:Splign:2.1.0"
     CDS             687..2744
                     /gene="Ccdc8"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 8 homolog"
                     /protein_id="NP_001095005.1"
                     /db_xref="CCDS:CCDS52044.1"
                     /db_xref="GeneID:434130"
                     /db_xref="MGI:MGI:3612184"
                     /translation="MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLIQF
                     LQEEGRTLEDVARIIEKSTPHPPQPRKRTKELRVRRVPQMVTPPLRLVVGTYDSSNGS
                     DSELSDFDTSKVKGNRSSSGRTRKVRKMPVSYLGSKFLGSDVESEDDQELVEAFLRRG
                     EKPSAPPPRRRVNLPVPMFENNLGPQPSKADRWREYVSQVSWGKLKQRVKGWAPRSGS
                     EVGQTQQASTAAERAGEMRHSQASSDDDSSRNTGDRSDQMLGTRRWKPKIKWVSLRRC
                     RKEQVPPFAQGTGMPAEEHPEAAENQGAEAAANQRAEPLASPRAEAAASPRAETAADP
                     RVEAVASPRAEAAASPRAEAVADPRAEAAASPRAEAAASPRTEAAASLRAEAVASPRA
                     EAAASPRAEAAADPRAEAAASPIAEAAANQKAELVDSPRAETAADPRAEAAASPRAEA
                     VADPRVEAAASPIAEAAANQKAELVDSPRAETAADPRAEAAASPRAEAAADPRAEVAA
                     SPRAEAAASPRAEAEASPRAEAAASPKAEAEANLRVEAAAYLRAGVPPDQRAEAIDSQ
                     RAEGPANQRTGATENQRVEVLADQRAGVLHDQREEAGPQGIQEASAGSGSRAQKQVKT
                     VRFQTPGRFSWFRMRRRVFWHTPRLPTLPRRVPRAGEARSLRVLRADIRADVEHREQE
                     EQL"
     regulatory      3594..3599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc8"
                     /note="hexamer: AATAAA"
     polyA_site      3614
                     /gene="Ccdc8"
                     /note="major polyA site"
ORIGIN      
        1 acagactgag cgcaaggtca gtttggagcg ggtggcagac tgcctggggg cgggagaccc
       61 tcctcggggc tgggcggagg cctttaagca cctcgccata ttgaaaggcc acgctgagcc
      121 gtctttgtct gcagagtcct cccaagaact ttcagctata tcctggtgtc tggggcaagg
      181 gagaagcgat cggagctcgt gggaccccaa cttggagccg ggacactggc gattccagtt
      241 tggactgaac tttgagcctc gggaatgagc gtgcttcagt tcatgtaagc atcctggaaa
      301 actgcttgct acaactccga gggggttggg gaagccaact tggacttgtt tcctgaagag
      361 aaaattgtag ggaggagaca ctctgtgcga gcagagttgc taggactgtc caccgccccc
      421 tccccaagac tagcagccaa gtgtctgggc tttttgcccc cactcgagcg tccacgctgg
      481 agatcttaaa gactctcgaa aaaagccacg tagggggatg gttcccctgg ggcttccttc
      541 cgtctcccga ttgcctgatc ctctggagtg tccccgacgt ctgcaaagat gtcgatctgg
      601 acgtgttagt ggaggcctta aggcctgtgg gcacctttaa gaaaatcgga aaggtgttcc
      661 gcaaagaaga ggactccacg gtggggatgc tgcagattgg ggaggatgtt gactatctgc
      721 tcatcccccg ggaggtccgc ctggctgggg gcgtgtggag agtcatctcc aagcctgcaa
      781 cgaaggaagc tgagtttcgg gagcggctaa tccagttttt gcaggaggag ggccgcaccc
      841 tggaagatgt ggcccgtatc atcgaaaaga gcactccaca cccaccccaa ccccgcaaaa
      901 gaaccaagga gctgagagtg aggagagtcc cgcagatggt cactcctcca cttcggctgg
      961 ttgtaggtac ctatgacagc agcaatggca gcgacagtga gttgagtgac ttcgatacct
     1021 ccaaagtcaa aggcaacagg agctcctccg ggaggaccag gaaggtgcgc aaaatgccgg
     1081 tcagttactt gggcagcaaa ttcctgggca gcgatgtgga gagtgaggat gatcaggagc
     1141 tggtggaggc cttcctccgc cgtggggaga agcccagcgc gcctcctcca cgacgccgag
     1201 tcaatcttcc agtgcccatg tttgagaaca acctggggcc ccagccatcc aaggccgaca
     1261 gatggaggga gtatgttagc caggtgtcct gggggaagct gaaacagagg gtgaagggct
     1321 gggcacccag atcaggctcc gaggtgggcc agacccagca ggcctccaca gcagctgaga
     1381 gggctggaga aatgagacac agccaagcca gctcggacga tgatagctcc agaaacacag
     1441 gagaccggag tgaccagatg ctgggtacta gacgctggaa gcccaagatc aagtgggttt
     1501 ccctgagacg atgcaggaag gagcaggtgc cacccttcgc tcagggaaca ggcatgccag
     1561 ctgaggagca cccagaggct gcagagaacc agggggcaga ggctgcagct aaccagaggg
     1621 cagagcctct agctagtcca agggcagagg ctgcagctag tccaagggca gagactgcag
     1681 ctgatccaag agtagaggct gttgctagtc caagagcaga ggctgcagct agtccaaggg
     1741 cagaggctgt agctgatcca agagcagagg ctgcagctag tccaagggca gaggctgcag
     1801 ctagtccaag gactgaggct gcagctagtc tcagggcaga ggctgttgct agtcccaggg
     1861 cagaggctgc agctagtcca agggcagagg ctgcagctga tccaagagca gaggctgcag
     1921 ctagtccaat agcagaggct gctgctaacc agaaggcaga gcttgtagat agtccaaggg
     1981 cagagactgc agctgatcca agagcagagg ctgcagctag tccaagggca gaggctgtag
     2041 ctgatccaag agtagaggct gcagctagtc caatagcaga ggctgctgct aaccagaagg
     2101 cagagcttgt agatagtcca agggcagaga ctgcagctga tccaagagca gaggctgcag
     2161 ctagtccaag ggcagaggct gcagctgatc caagagcaga ggttgcagct agtccaaggg
     2221 cagaggctgc agctagtcca agggcagagg ctgaagctag tccaagggca gaggctgcag
     2281 ctagtccaaa ggcagaggct gaagctaatc tgagggtaga ggctgcagct tatctcaggg
     2341 caggagtccc acctgaccag agggcagaag ccatagatag tcagagggca gagggcccag
     2401 ctaaccaaag aactggtgct acagaaaatc agagggtgga ggtcctagct gaccaaaggg
     2461 caggggtcct ccatgaccag agggaggagg caggacctca gggtatacag gaagcctcag
     2521 ctggttcggg atctagggcc cagaaacagg taaagacagt gaggttccag accccaggac
     2581 gcttctcatg gtttcgcatg cgcaggagag tcttctggca cactcccagg ttgccaaccc
     2641 tgcccaggag agtccccagg gcaggtgagg ccaggagcct ccgggtacta agggctgaca
     2701 tcagagcaga tgtggaacac agagagcaag aagaacagct gtaagggaag cccagtgccc
     2761 ctgccccctg cctgcctttg ttagctactg ggatgcctct ctccttttca ggttccttct
     2821 ctctccatgt ttgaaaatgg ggggggggca ggggtgaggg gtcaggcagc accgcccaca
     2881 cctttcctcc cctttccacc ctcattctct aacctttcct cttcttccct ctccctttct
     2941 tctctctctt tttctttcct tctgtctcta ttttttattt aagacagagt cttgctatgc
     3001 agccccgatg gcctggtgct ccatatataa ttggcctcaa actcacagta gtcgtctacc
     3061 ttagggccca gagtactagg gttacaggtg tgtgcctcta catctggccc caatgaccct
     3121 cttttgtttt gtgttgtttg agacagggtc tctctatcta gccccagctg gcctggaact
     3181 cgcagtgtag accaggctgg ccttgaactc acagatctgg atggctgcct ctgctaggac
     3241 tacaggcatg tgccaccatg cccatctttc agtggcctac tatatcatct tgcttttatg
     3301 tgatgagatt gtgtgttcag ggtggtgtgg ctatagaaac acttaaattt ttttttatat
     3361 gttgattttt taaaatacta agtatagcat cttaaagaat gaaagacata agcccgtgga
     3421 gcctggcggc ctgggtggta ttttaacttc ttatgtattt taagtgctca cagcctggca
     3481 aagggaaatg ggtagagggg ggggggaatc agtctgtcct ttttcttctg tctgtaacta
     3541 attttgattg atggcctttt tgcacttaaa gagaaaactc aagttgatat gcaaataaaa
     3601 atgtgtacaa ggtg
//
