LOCUS       NM_001381936            2494 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus coiled-coil domain containing 77 (Ccdc77), transcript
            variant 5, mRNA.
ACCESSION   NM_001381936 XM_006506493
VERSION     NM_001381936.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2494)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2494)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2494)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155720.7.
            
            On Apr 20, 2020 this sequence version replaced XM_006506493.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.846674.1,
                                           SRR7345562.2465400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC155720.7         129242-129282       c
            42-95               AC155720.7         125916-125969       c
            96-279              AC155720.7         122122-122305       c
            280-422             AC155720.7         120303-120445       c
            423-519             AC155720.7         113888-113984       c
            520-583             AC155720.7         111050-111113       c
            584-675             AC155720.7         109984-110075       c
            676-824             AC155720.7         106684-106832       c
            825-1044            AC155720.7         103727-103946       c
            1045-1170           AC155720.7         101249-101374       c
            1171-1323           AC155720.7         101009-101161       c
            1324-2494           AC155720.7         96238-97408         c
FEATURES             Location/Qualifiers
     source          1..2494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 56.95 cM"
     gene            1..2494
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /note="coiled-coil domain containing 77"
                     /db_xref="GeneID:67200"
                     /db_xref="MGI:MGI:1914450"
     exon            1..41
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            42..95
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1473
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /note="isoform 2 is encoded by transcript variant 5;
                     coiled-coil domain-containing protein 77"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 77 isoform
                     2"
                     /protein_id="NP_001368865.1"
                     /db_xref="GeneID:67200"
                     /db_xref="MGI:MGI:1914450"
                     /translation="MNFTPTRTPICRKWKKMADSMESTPLPSVEDRLAVLCPSQELLE
                     YYQKKMANCESENEDLLKKLELYREACEEQHKLEWNLQQREEEIAELQKALSDMQVCL
                     FQEREHVLRLYSENDRLRIRELEDKKKIQNLLALVGPDAGEVTYFHKEPPHRVSILQK
                     TLQAAVACEPSASKADPGVSKRQVRIKDKEGISERHQRDTEMLLLQVEALQAQLGEQT
                     KLSREQVEGLMEDRRIRVEEIQVQHQRNQEKIMELTKSLHHTQELLYESTKDFLQLKF
                     ENQNKEKVWMLEKDHLMSKITQYRAQCKKKEDKLGKVVPILHESHHTQNEYIKSLKDK
                     LIQEKKLSNMYQEQCISLEEELARIREEEGVRREIFKDRSNKMGKRLQIMTKRYQALE
                     HRRALEVEGFKTDIKSLRQKLRDLEQMLYKATMNNTHGDQDLAMLCEVRDSNRRAHKI
                     QGELKNLKSKVFGLENALRLC"
     exon            96..279
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            280..422
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            423..519
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            520..583
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            584..675
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            676..824
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1044
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1170
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1323
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..2494
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2472..2477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2494
                     /gene="Ccdc77"
                     /gene_synonym="2400002C23Rik; 2700091N06Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtttttcggt tgcgttgttg gacgccaggg gttagcactt ggtgtggaga agacagcatg
       61 aacttcactc cgacacggac acccatctgc agaaagtgga agaaaatggc agactcaatg
      121 gagtcaacac ccctgccttc agtcgaggat cgtctggctg tcctttgccc ttctcaggag
      181 cttctggagt attatcagaa gaagatggct aactgtgagt cagagaatga agatctgctg
      241 aagaagctag agctctacag agaagcttgc gaagagcagc ataaacttga gtggaacttg
      301 cagcagaggg aggaagagat tgcagaattg cagaaagctc tgagtgatat gcaggtctgc
      361 ctcttccagg aaagggaaca tgttttacga ctctactcag aaaatgaccg actaagaatc
      421 agagaactgg aagacaagaa aaagattcag aatctgttag ctctggtggg cccagatgct
      481 ggtgaagtga cctattttca taaggagcct ccccacagag tcagcattct ccagaagact
      541 ctgcaggctg cagtcgcatg tgagccttct gcttccaaag cagatcctgg agtaagcaaa
      601 agacaagtaa gaataaagga caaggagggc atttctgagc gccaccagag ggacacagag
      661 atgctgctcc tgcaggtgga agcacttcag gcgcagctgg gagagcagac aaagctttcg
      721 agagagcaag tggaggggct catggaggac agacggatcc gagtcgagga gatccaagtt
      781 cagcaccaga gaaaccaaga gaaaatcatg gagctaacca agagtctcca tcatacccaa
      841 gaactgctct acgagagcac caaggacttt ctacaactaa aatttgaaaa ccaaaataaa
      901 gagaaggtat ggatgcttga gaaagatcac ctgatgtcaa agattacgca gtatagagcg
      961 cagtgtaaga agaaagagga caaacttgga aaagttgttc ccattttaca cgagagtcat
     1021 catactcaaa atgaatatat taagtctctt aaggataagc taatacaaga gaaaaagctg
     1081 tccaacatgt accaagaaca gtgcatttcc ctagaagagg aacttgctcg aattcgggag
     1141 gaagaaggag tgaggagaga gatcttcaag gatcgctcca acaagatggg caagcgctta
     1201 cagataatga caaagcgcta tcaggccttg gagcatcgac gagccctaga agtagaaggc
     1261 ttcaagacgg acattaagtc tctccgacag aagctgcgag acctggagca aatgctctac
     1321 aaggcaacca tgaacaacac ccatggagat caggacctgg ccatgctgtg tgaagtccgt
     1381 gacagcaaca ggagagctca taagatacag ggggaactga agaacctcaa gtctaaagtg
     1441 tttgggctgg agaatgcgct taggctgtgc tgatgactcc tttcagggtt ggcttctgga
     1501 gacctgagac aaggtcacct gtgcccacaa agtggacctg gagttgtcca gagtagtggc
     1561 atcaatttta ataaagatgg tgttaagggc atgatagctc acacctataa tcccagggct
     1621 tgggaatctg aggcaggagg attgccacaa acccatggta caggcaggtg gatctctctg
     1681 attcatggcc agcctgatct acaatagtga cttctaggcc atccaaggct atttaatgaa
     1741 accctgtcta caaacaaaca aacaaacaaa aacaaaaata aaacatcaaa accagagagg
     1801 aaagaaggaa aacagtggca aacctggctc tggcacagct gccctggctg actgcagtct
     1861 caccatcctg ctagccttgt cttttatata ctgataggct tttctgactt taaaaagtca
     1921 gtgatgggga tgtagcttat ctggtgaagt gctgtcgagc atacagaaag ccctggtcct
     1981 gctagctccc ctaaagccag gtttggtggc tcacctgtag tcagcactgg agagagccca
     2041 tgtgggagaa tctaagttca cattcaccct tggctatatg gtgagttcca ggccagcctg
     2101 ggctacacaa gaccacgtct aaaaatgaaa acaagaaaca aacaaacata caaaaaagaa
     2161 aataataact taggaagagc cgttttgctg agcttgctaa gtgtcagtgg gagaatgtgt
     2221 ttcctggaga ccaaagtcat tcactgaagt cattcactca ggaattacat acacatggaa
     2281 agtcacagac ttagctgcgt tccgagttac tgaccaccag ggggcagcat agcccttgct
     2341 ctcaagtaaa attggtcatc aagaaaaggg tgctacttta tgtacagtgg gccaaactgt
     2401 acaaaatgat attttatgtg aaaaagtttg acattttatc catagtttta aatttcaaat
     2461 taagcatttt caataaaatg ggtggtttaa aaca
//
