LOCUS       NM_177111               2951 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus coiled-coil domain containing 66 (Ccdc66), mRNA.
ACCESSION   NM_177111
VERSION     NM_177111.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2951)
  AUTHORS   Chen,X., Tong,P., Jiang,Y., Cheng,Z., Zang,L., Yang,Z., Lan,W.,
            Xia,K., Hu,Z. and Tian,Q.
  TITLE     CCDC66 mutations are associated with high myopia through affected
            cell mitosis
  JOURNAL   J Med Genet 61 (3), 262-269 (2024)
   PUBMED   37852749
  REMARK    GeneRIF: CCDC66 mutations are associated with high myopia through
            affected cell mitosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2951)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2951)
  AUTHORS   Schreiber,S., Petrasch-Parwez,E., Porrmann-Kelterbaum,E.,
            Forster,E., Epplen,J.T. and Gerding,W.M.
  TITLE     Neurodegeneration in the olfactory bulb and olfactory deficits in
            the Ccdc66 -/- mouse model for retinal degeneration
  JOURNAL   IBRO Rep 5, 43-53 (2018)
   PUBMED   30211337
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2951)
  AUTHORS   Gerding,W.M., Schreiber,S., Schulte-Middelmann,T., de Castro
            Marques,A., Atorf,J., Akkad,D.A., Dekomien,G., Kremers,J.,
            Dermietzel,R., Gal,A., Rulicke,T., Ibrahim,S., Epplen,J.T. and
            Petrasch-Parwez,E.
  TITLE     Ccdc66 null mutation causes retinal degeneration and dysfunction
  JOURNAL   Hum Mol Genet 20 (18), 3620-3631 (2011)
   PUBMED   21680557
  REMARK    GeneRIF: Lack of protein CCDC66 causes early, slow progressive
            generalized progressive retinal atrophy in the Ccdc66 mutant mouse
            model.
REFERENCE   5  (bases 1 to 2951)
  AUTHORS   Dekomien,G., Vollrath,C., Petrasch-Parwez,E., Boeve,M.H.,
            Akkad,D.A., Gerding,W.M. and Epplen,J.T.
  TITLE     Progressive retinal atrophy in Schapendoes dogs: mutation of the
            newly identified CCDC66 gene
  JOURNAL   Neurogenetics 11 (2), 163-174 (2010)
   PUBMED   19777273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070471.1.
            
            On Nov 22, 2006 this sequence version replaced NM_177111.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070471.1, SRR7345562.4617317.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2190              BC070471.1         1-2190
            2191-2951           BC070471.1         2192-2952
FEATURES             Location/Qualifiers
     source          1..2951
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 16.51 cM"
     gene            1..2951
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /note="coiled-coil domain containing 66"
                     /db_xref="GeneID:320234"
                     /db_xref="MGI:MGI:2443639"
     exon            1..39
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..2836
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 66"
                     /protein_id="NP_796085.3"
                     /db_xref="CCDS:CCDS36843.1"
                     /db_xref="GeneID:320234"
                     /db_xref="MGI:MGI:2443639"
                     /translation="MNLGDGLKLETELLDGKTKLILSPYEHKSKVSVKMGNKFKIAKC
                     PLRTKQTGHTLKSTQNTYIGNENLSQKKISTLDTSQAKPENSRLTFSPSTDKQYSEKD
                     SVRVQKEISPTTSNIRKIINTTGTCPVAKQKPCKKNPTAETMNSGLVCLTQDQLRQIL
                     MLSVNQGNGSVCLTETGEEEASQDSLHLINIPSQPKDVNDTGFLQNTEAASPVTSEHE
                     HVHRRAQEAFQQCEQKAATENEWKPADIFSTLGERERDKSLLEARRAQWKKELDEQVA
                     LKKKEKEASQKWHNPWKPSDIECEKSQVHDQSKEARLLESPCSAIKQEQQRKWIEELN
                     KQVEDDQQRKAEERMIYSKGEEHDRWAVHFDSLKSHPGSQSRLSSQLTHQHLESLCVS
                     PDTQELADVNGVFTPPPGVQAEPSEKEQRARPVLEMAVSHGPKTNFLRSMTALLDPAQ
                     IEERERRRQKQLEHQKAIMAQVEENRRKKRLEEEQRKKEEQELELRLAREREEMQRQY
                     EEDILKQRQREEIMTLKTNELFHTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIQNL
                     GAQVDYKAFTTISSSHSDPEETADTSTASPKKDTGVQTDDVNLGIFNDALPPCGSVTE
                     KGIRNISSPEISAEFSGQTDIRKENQELSMNKGTNLDKENSWHNGQCNQYRRTEKQTK
                     LMKKCPKKPAWNINKPLKKYVPASAKYPAHLQKEKEEKKVQRQMELLHLVERNNPENL
                     SQNRGISPLATSHRETESESRLHLIKKVEEPLKTPSVSKERFQTSPAVKNRTQQTQSN
                     VLHLPLKNNDYEKETLTLGDGHTKLSDEMSEPSHFIPYVRTNEIYYLDPDAPLSRPST
                     QDNQYQKSHDCAREQELFDSDHIRDPLLNPKLVKNRDRQQAILKGLSELRQGLLQKQK
                     ELETNLIPLTANQEDNFSSSF"
     exon            40..104
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            105..130
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            131..572
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            573..738
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            739..842
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            843..955
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1087
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1338
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1423
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1585
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1730
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1841
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2329
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2370
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2624
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2749
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2951
                     /gene="Ccdc66"
                     /gene_synonym="E230015L20Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgagctg cgggtgggcg gcggggccat gaacctggga gatggtttaa agcttgaaac
       61 tgaattactg gatggaaaaa ccaagttaat actgtcccca tatgagcata aatcaaaagt
      121 ttctgtgaag atgggaaata agttcaaaat tgcaaaatgt cctttaagaa caaaacagac
      181 tggacatact ttaaaatcaa cacaaaatac ttacattggg aatgaaaacc tttctcaaaa
      241 gaagatctct actttagaca cttcacaagc aaaacctgaa aatagtagat tgacattttc
      301 acccagtacg gataagcagt attcagaaaa agacagtgtc cgtgttcaaa aggagatttc
      361 acctacaacc tctaatatac ggaagattat aaacactacc ggtacttgtc cagtggctaa
      421 acagaagcct tgcaaaaaaa accccacagc ggagaccatg aacagcggtt tggtgtgtct
      481 cacacaagac cagcttcggc agattttgat gctgagtgtg aaccagggaa atggatctgt
      541 gtgcctcact gagactgggg aggaggaagc aagtcaagat agtttacatt taatcaatat
      601 tcctagtcag ccaaaggatg tgaatgacac aggattcctg caaaacacgg aggccgcttc
      661 ccctgtcacg agtgaacatg agcatgtcca ccggagagct caagaggcat ttcagcagtg
      721 tgagcagaaa gctgccacag agaatgaatg gaaaccagct gacatattca gtactctggg
      781 ggaaagggaa cgtgataaaa gtttgttgga agcaagaaga gcccagtgga aaaaagagct
      841 agatgaacag gttgccttaa agaagaaaga gaaagaagct tcccaaaaat ggcataaccc
      901 ttggaagcca tctgatatag agtgtgagaa gtctcaagtc catgaccagt ctaaggaagc
      961 aagactgctg gagtcccctt gcagcgccat taaacaggag cagcagagaa aatggattga
     1021 agaattgaat aaacaagttg aagatgacca gcaaagaaaa gcagaggaaa gaatgatata
     1081 ttcaaagggt gaggaacatg acagatgggc agtgcatttt gattcattaa agagtcatcc
     1141 tggctcccag tctcgactgt cctctcagtt aacacaccaa cacctggagt cgctttgtgt
     1201 gtctcccgac actcaggagc tggctgatgt caatggtgtt ttcacacctc cacctggagt
     1261 ccaggcggag ccttcagaga aagaacaaag agccagacct gttctggaga tggctgtatc
     1321 acacggtccg aaaacaaact ttctccgttc tatgactgca ctcttggatc cagcccagat
     1381 tgaggagcgg gaacgacgcc gacaaaaaca attagaacat cagaaagcaa tcatggctca
     1441 ggtagaagag aaccgcagga agaagcggct agaggaagaa caaagaaaga aggaggagca
     1501 ggaactggag ctgcgcttgg caagggaacg ggaggagatg cagaggcagt atgaagagga
     1561 cattctgaag cagagacaga gagaagaaat catgactcta aagacaaacg agctattcca
     1621 cacaatgcag cgagctcagg agttggcaca gaggctcaaa caggagcaga ggatcagaga
     1681 actggctcag aagggacatg atacatccag gctgattcaa aatcttggtg cacaagtgga
     1741 ttataaggca ttcactacca tctccagttc ccacagtgac cctgaggaga ctgctgacac
     1801 ttcaacagcc tctcccaaga aggacacagg cgtgcagaca gatgacgtaa acttaggaat
     1861 tttcaatgat gcgctaccac cctgtggatc ggtaacagag aagggtatta gaaacatttc
     1921 ttctccagag atttctgcag aattcagtgg acagactgac attagaaaag agaaccaaga
     1981 actaagtatg aataaaggca ctaatttaga caaagaaaac agctggcata atggccagtg
     2041 taatcagtac agaagaacag agaaacaaac aaaactcatg aagaaatgtc ctaagaagcc
     2101 tgcttggaat ataaacaaac ctctcaaaaa gtatgttcct gcatcagcca agtaccccgc
     2161 acatctccag aaggagaaag aagaaaaaaa ggtacagagg caaatggagc tgcttcactt
     2221 agtggagaga aacaatcccg agaatctctc ccaaaacaga ggcatttcac cacttgctac
     2281 atctcatcga gaaactgagt cagagagcag gttgcacctt atcaaaaagg tagaagaacc
     2341 tctgaaaact ccttcagtta gtaaagaaag gtttcaaaca tcaccagcag taaaaaacag
     2401 aactcaacaa actcaaagta atgtattaca cttaccacta aaaaacaatg actatgaaaa
     2461 ggagactctg actttaggag atggtcatac taaattatca gatgagatgt ctgagccatc
     2521 ccattttatt ccctacgttc gaacaaatga gatctattat cttgatccag acgcaccctt
     2581 gtctaggcct tcaacccagg acaaccaata ccaaaaatct catgattgtg cccgagaaca
     2641 agagctattt gactctgacc atatcaggga tccacttctt aatcctaaat tagtgaaaaa
     2701 cagggaccga cagcaagcta tccttaaggg gctttcagaa ctaagacagg gtcttctcca
     2761 gaaacaaaag gagttggaaa cgaatctcat acccttaact gcaaaccaag aagataattt
     2821 tagttcttcg ttttaaatat gcttaccacg caacagcatt tttcaagcac acaatgacaa
     2881 actttacatt atgtagtgaa atgatgtatt ttctaagtac aataaaaaag tttatagttc
     2941 aaaaaaaaaa a
//
