LOCUS       NM_001111121            5511 bp    mRNA    linear   ROD 26-SEP-2023
DEFINITION  Mus musculus coiled-coil domain containing 6 (Ccdc6), mRNA.
ACCESSION   NM_001111121 XM_618775
VERSION     NM_001111121.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5511)
  AUTHORS   Butterfield NC, Curry KF, Steinberg J, Dewhurst H, Komla-Ebri D,
            Mannan NS, Adoum AT, Leitch VD, Logan JG, Waung JA, Ghirardello E,
            Southam L, Youlten SE, Wilkinson JM, McAninch EA, Vancollie VE,
            Kussy F, White JK, Lelliott CJ, Adams DJ, Jacques R, Bianco AC,
            Boyde A, Zeggini E, Croucher PI, Williams GR and Bassett JHD.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5511)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5511)
  AUTHORS   Leone V, Langella C, Esposito F, Arra C, Palma G, Rea D, Paciello
            O, Merolla F, De Biase D, Papparella S, Celetti A and Fusco A.
  TITLE     Ccdc6 knock-in mice develop thyroid hyperplasia associated to an
            enhanced CREB1 activity
  JOURNAL   Oncotarget 6 (17), 15628-15638 (2015)
   PUBMED   25970781
  REMARK    GeneRIF: Ccdc6-ex2 knock-in mice developed thyroid hyperplasia
            associated with an enhanced CREB1 activity and an increased
            expression of the CREB-1 regulated genes.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132435.3.
            
            [WARNING] On Jan 19, 2024 this sequence was replaced by
            NM_001111121.2.
            
            On Dec 7, 2007 this sequence version replaced XM_618775.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.77168.1,
                                           SRR10223970.12472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               AC132435.3         107744-108204       c
            462-611             AC132435.3         62597-62746         c
            612-740             AC132435.3         50489-50617         c
            741-844             AC132435.3         38220-38323         c
            845-1005            AC132435.3         36073-36233         c
            1006-1162           AC132435.3         30158-30314         c
            1163-1263           AC132435.3         23065-23165         c
            1264-1388           AC132435.3         17510-17634         c
            1389-5511           AC132435.3         12125-16247         c
FEATURES             Location/Qualifiers
     source          1..5511
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 36.68 cM"
     gene            1..5511
                     /gene="Ccdc6"
                     /gene_synonym="2810012H18Rik"
                     /note="coiled-coil domain containing 6"
                     /db_xref="GeneID:76551"
                     /db_xref="MGI:MGI:1923801"
     exon            1..461
                     /gene="Ccdc6"
                     /gene_synonym="2810012H18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1589
                     /gene="Ccdc6"
                     /gene_synonym="2810012H18Rik"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 6"
                     /protein_id="NP_001104591.1"
                     /db_xref="CCDS:CCDS48591.1"
                     /db_xref="GeneID:76551"
                     /db_xref="MGI:MGI:1923801"
                     /translation="MADSASESDTDAAGGGPAAMQSSCSATSGGSGGGGGGKSGGIVI
                     SPFRLEELTNRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQARAEQEE
                     EFISNTLFKKIQALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQ
                     EFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLE
                     AEKRILQEKLDQPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQH
                     SEKMAQYLEEERHMREENLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMS
                     AQGLRPRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLH
                     VQHMGASHGITRPSPRRSSSPDKFKRPTPPPSPNTQSPVQPPPPPPPPPMQPAVPSAA
                     PTQPAPTQPQHPVHPSSQP"
     exon            462..611
                     /gene="Ccdc6"
                     /gene_synonym="2810012H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            612..740
                     /gene="Ccdc6"
                     /gene_synonym="2810012H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            741..844
                     /gene="Ccdc6"
                     /gene_synonym="2810012H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1005
                     /gene="Ccdc6"
                     /gene_synonym="2810012H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1162
                     /gene="Ccdc6"
                     /gene_synonym="2810012H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1263
                     /gene="Ccdc6"
                     /gene_synonym="2810012H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1388
                     /gene="Ccdc6"
                     /gene_synonym="2810012H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..5511
                     /gene="Ccdc6"
                     /gene_synonym="2810012H18Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccgccgcc gccgccgcgc gtctgcgccc tgccgcccgc ccgcgccgcg ctctgagctc
       61 ccccgctccc cagctccccc gccgccgccg cgcgcccggc cccgcgccca ctcgccgcgc
      121 gcccactcgc cgcgcgcccg gccctcggcg cccggctccc cgcgcccact cgcccagcca
      181 tggcggacag cgcgagcgag agcgacacgg acgcggcggg cggcggcccg gcagccatgc
      241 agtcgtcctg ctcggcgacc tcgggcggca gcggcggggg cggcggcggg aagtcggggg
      301 gcattgtcat ctcgccgttc cgcctggagg agctcaccaa ccgcctggcc tcgctgcagc
      361 aggagaacaa ggtgctcaag atagagctgg agacctacaa actcaagtgc aaggcgctgc
      421 aggaggagaa ccgcgacctg cgcaaagcca gcgtgaccat ccaagccagg gctgagcagg
      481 aagaagaatt catcagtaac actttattca agaaaatcca ggccttgcag aaggagaaag
      541 aaaccctcgc cgtgaattac gagaaggaag aggagtttct caccaatgag ctctcccgga
      601 aactgatgca gctgcagcat gagaaggcgg agctggaaca acacctggag caggaacagg
      661 agtttcaggt caacaagctg atgaagaaga tcaaaaagct ggagaacgac accatctcca
      721 agcaactcac cttagagcag ctgagacggg agaagattga cctggaaaac acactggagc
      781 aagagcagga ggcgctggtg aatcggctgt ggaagaggat ggataagctg gaagctgaga
      841 agagaatcct acaggagaaa ttagaccagc ctgtgtctgc cccaccatcg cctagagaca
      901 tctccatgga gatcgattcc cccgagaaca tgatgaggca tatcaggttt ttaaagaacg
      961 aagtggagcg actgaagaag cagctacgag ccgcccagtt acaacactcg gagaagatgg
     1021 cccagtactt ggaggaggag cggcacatga gggaagagaa cctgcggcta cagcggaagc
     1081 tccagaggga gatggagagg agggaagcgc tgtgtcgcca gctctcggag agcgagtcca
     1141 gcctggagat ggatgatgag aggtatttta atgagatgtc tgcacaagga ttgagacctc
     1201 gcactgtgtc cagcccaatc ccttacacgc cttctcccag ctcaagcaga cctatatcac
     1261 ccggtctttc gtatgcaagt cacacggttg gcttcacacc gccaacgtcg ttgactagag
     1321 ctggaatgtc ctactacaac tctccgggcc tccacgtgca gcacatgggg gcctcccacg
     1381 gcatcacaag gccatcgcca cggagaagca gcagccctga caagtttaaa cggcccacgc
     1441 cgcctccgtc tcccaacaca cagagcccgg tccaaccgcc tccgccgccg ccaccacctc
     1501 ccatgcagcc cgcggtcccc tcggcagccc ccacgcaacc cgcccccacg cagcctcagc
     1561 atccggtgca cccctcctcc cagccttaat gcatgagctt agtcagaatc tccagttggg
     1621 actcgtctga tggagccacc ttctcaacgc caaaggcttc tcctctcccg gcgtacttgg
     1681 atctgacgcg tttgcattga ggttacctat ctacctttcc ctcctcgtcg tgtcgtgaat
     1741 gttcgtcgga aacgcagccg aggttgcggg tccgcaacac taaccagacg actttctcca
     1801 ccagtgtttt acttgaatct ccgcgtctgt cattccctgg ctggaacgtc gctgtctggt
     1861 atctggtaat gagcagcggt gtgcaaaccc taccccaccc cctccaaccc ttccccccca
     1921 ggggggcccc agggctgctt tttttcttgg cttttaggtt tgtaaaataa gaagggagat
     1981 cttttttata acacttctct gtggatttgc aggaaaatta ccgagctgtt tagaaacctt
     2041 ccttctccag gtcagtgacg tttaccgaac ataaccaaga attcagcact acagttcaga
     2101 ccttttgcag acctaactca ctgtaggatt ggaagttaga tgaaccagtg cccacaacat
     2161 gtagtctaga gctttctaca gacacacctt tttacagatt gttttctgat gtaaattgac
     2221 caccatgtcc tttgtaaaac agcctataga aacaaatcac acagccgtat ctcccccacg
     2281 tgcgtgggac gggaactatt gcctattaag atgtgatttt tattttcctt tctcaatgtt
     2341 aatccaccta agccggcgcc ctctagcgtg agaggagaga cgctttccca ccaagggtct
     2401 cgatggctga ctggaatgta ggcttagatc cctgctgcgg gtgggccgtg agattgtaac
     2461 agccaatgcg gctaaaccca tccattcttt tgtgttgtcc tgagacagag ggtgcaaaca
     2521 ggtactttcc aggtgcaaaa tgctgttagg aaataatgtc tgaggggtag gcgacagaca
     2581 ccctagcatg atggcgcttg gcagatcata gcatagcaag cagtgctctc tggccttgac
     2641 gggcgctcac ttagccagga gagcaccaag aaggttctga actcaatccg ccattccttc
     2701 agcacaaatc cttctgtttg gccgggggtg ggtgtgggtg gggacaccaa gtggctcttt
     2761 tgtagacctt cgtctctgtc tgtccgaggt tactttgtgc tttagtagtc aagtgcttcc
     2821 cctgcccgtg tttgcatatt tatatatgcc gtggatggaa ataacttact agagaatgta
     2881 tattttatga tgagaagcgt gactctgtta gctgtaatca gagaactgaa aaattaattt
     2941 atcagtaatt tttaagagtt catgtttgtg acaaaccatc tcttaacagc acgtcctcat
     3001 ggaacacact cccgaggaca aggaacatac cttggtgata ttgtagataa ttaatattgt
     3061 acagtctaga aacctccatt ttttgccttc gaatgcatat ttaagagtta acagaatgga
     3121 aaagtgttat cagataatag tgtttgacag cgttttaaga acttgagagt aagaacaacc
     3181 ataggacctt tcactcttct ttctcgtcca cccctaaact gagaatgctg tatctccagc
     3241 gaccgggaag aaactgtcag cctataaaag ttttattttc aaggtgtgtg atgtataggc
     3301 catagtgtgg ttagcagaca tgggatggag tctgatatct cctgtcaagg cattaggttt
     3361 tttcagtgtc tgactaaacc ccgggcattt tccaccagct ccccaaccct cttggtacat
     3421 gaccattcca gggaaattct gaggatagac agaggaattc ttccttcatg gtacagtctt
     3481 gatttttttt tttttttttt ttttgtcctt tcgagagaag tacggtatgt gtttacaaaa
     3541 tcttttctgg gattgtagat ttcagtactg ctggctagca gctttatcct ccagcacaca
     3601 ggtccgttct ggaaagttct tccctccact gtctttatca gttaagttac ctcctagaag
     3661 cacaagtgta aaagcaccgg cgtatggcga gcggagcctt tgagacgtag gttcttgaca
     3721 ttgatgcata aagtgtacct gggattcctg tagacccatc agttcacctc aaacccagct
     3781 cttcccacaa gcgctttgca gtccgagtca gtccccggtc cctgcagggg ttaagaacca
     3841 agagaacaaa cactagagga tctgaatgta gggtgtattg tgtcactttt gaagcacata
     3901 gtgataggta agagaaccag atgttgagcc cctagggacg gtagcccctt gactgtgggc
     3961 tgggcgtggc ttctacaggt tcagtcagta gccaccctca gcagttgaga gcaacagtac
     4021 cttcagtggc ttcatttcct gtcttgttga cagagaccct cgggtaccac tgtgctgcta
     4081 atagggccag ggctctgctc cccgacgacc ttgcctttgt acagaaccaa gtccacgcac
     4141 ccagcacccc accagcacct ctgggctcta aactgctttc tctcatcaag catgctggca
     4201 ttcaagacag atttctcgac ctttggcaga catggaagtg ttttaagatt ttatttaaat
     4261 gtctttgttg acccagaagg acttttagat tctgagatcc taaggacccc cccgcccccc
     4321 atgaccatgg ggtgaccgga atgtggcttt gatggctcag gctgctgtgc cttttatcat
     4381 tggcttctga ttcaaaccag aaataattga taatgtgaat ttgtgttgat ccttcagttg
     4441 taggaaaact gtatatctat cccccgttgt taagtagaca tgagcctgtc ccctgcttgt
     4501 agagattgac caggaaaacg ggaggaagca tggccgttgc gtgtttcaga aagtttattg
     4561 tttaaaatac agaaggaagt tttctttgtg acttgatctt ctgtctagta cttgtctaat
     4621 cagttaaccc acgctgagag cttgtagcga tgcctaccaa agacatgcat agtaaacctc
     4681 ctgtttccaa attattaaag agccagccat tgatgctgct cctggttctt tctgggagcc
     4741 attgtgagag actaaaagat tcttagggtg tttgtttgtt tgtttgttcg ttcgtttgtt
     4801 taagttttaa tttctctctt tctaaatttt tgattacaaa tgtgttagcc taatgtgttg
     4861 gggagcattt cccagaatgc tcagcagttg tgattactgg tcacacccag gtcacctctt
     4921 ctggagtgat caacgggatc ctctgtgcgt gctagcatgg gtgctgtgtg tgtgcacgtg
     4981 tgcgtgtgtg cattcatgcc ttaacttggg ttactgctca gctttgccgt ctgacttggt
     5041 cctcaccagc atcagattgt attgtgcatc ctgatctgaa cttcattctg gtaaaaaaaa
     5101 acaacaacaa caacaaaacc acaaggttgc aggtagcaca ggctggaacg cattcctttg
     5161 gaagaacgtc tgctcagatg gaccctgaga tgtctccacg gactttattt gggactttgt
     5221 ttggaaagaa agccgactgt aacttgggca gatgtcgaca aggaagaggg gagagccaga
     5281 tgccaccatg ccctctgcct ctgcatatcc gtgtgctctg tgtgttgtgt aggctcatct
     5341 acagcttacc tggcttggag ttcaggtaat ggtggccatc ctgacattct ctgttggagt
     5401 ttagagagat gtaagacgtc cagttaatgt cttatttact ttatgttgat cagtctttaa
     5461 tacatgtgct gaatcagaaa aacctaaata aagataattt tttaaaatgt a
//
