LOCUS       NM_026202               7017 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus coiled-coil domain containing 50 (Ccdc50), transcript
            variant 1, mRNA.
ACCESSION   NM_026202 XM_489559
VERSION     NM_026202.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7017)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7017)
  AUTHORS   Lachgar-Ruiz,M., Morin,M., Martelletti,E., Ingham,N.J., Preite,L.,
            Lewis,M.A., Serrao de Castro,L.S., Steel,K.P. and
            Moreno-Pelayo,M.A.
  TITLE     Insights into the pathophysiology of DFNA44 hearing loss associated
            with CCDC50 frameshift variants
  JOURNAL   Dis Model Mech 16 (8) (2023)
   PUBMED   37165931
  REMARK    GeneRIF: Insights into the pathophysiology of DFNA44 hearing loss
            associated with CCDC50 frameshift variants.
REFERENCE   3  (bases 1 to 7017)
  AUTHORS   Hou,P., Tian,T., Jia,P., Lin,Y., Li,Z., Wang,Y., Ye,Y., Li,C. and
            Guo,D.
  TITLE     The regulation of NLRP3 inflammasome activation by CCDC50-mediated
            autophagy
  JOURNAL   Autophagy 19 (1), 365-366 (2023)
   PUBMED   35620989
  REMARK    GeneRIF: The regulation of NLRP3 inflammasome activation by
            CCDC50-mediated autophagy.
REFERENCE   4  (bases 1 to 7017)
  AUTHORS   Hou,P., Lin,Y., Li,Z., Lu,R., Wang,Y., Tian,T., Jia,P., Zhang,X.,
            Cao,L., Zhou,Z., Li,C., Gu,J. and Guo,D.
  TITLE     Autophagy receptor CCDC50 tunes the STING-mediated interferon
            response in viral infections and autoimmune diseases
  JOURNAL   Cell Mol Immunol 18 (10), 2358-2371 (2021)
   PUBMED   34453126
  REMARK    GeneRIF: Autophagy receptor CCDC50 tunes the STING-mediated
            interferon response in viral infections and autoimmune diseases.
            Erratum:[Cell Mol Immunol. 2021 Dec;18(12):2682. doi:
            10.1038/s41423-021-00777-7.. PMID: 34654907]
REFERENCE   5  (bases 1 to 7017)
  AUTHORS   Min,J.S., Halder,D., Yoon,J.Y., Jeon,S.J., Jun,S.Y., Lee,J.R.,
            Lee,J.J., Choi,M.H., Jung,C.R., Lee,D., Kim,B.J. and Kim,N.S.
  TITLE     Coiled-coil domain containing 50-V2 protein positively regulates
            neurite outgrowth
  JOURNAL   Sci Rep 10 (1), 21295 (2020)
   PUBMED   33277610
  REMARK    GeneRIF: Coiled-coil domain containing 50-V2 protein positively
            regulates neurite outgrowth.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7017)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 7017)
  AUTHORS   Aubert,J., Dunstan,H., Chambers,I. and Smith,A.
  TITLE     Functional gene screening in embryonic stem cells implicates Wnt
            antagonism in neural differentiation
  JOURNAL   Nat Biotechnol 20 (12), 1240-1245 (2002)
   PUBMED   12447396
REFERENCE   8  (bases 1 to 7017)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 7017)
  AUTHORS   Yang,A., Kaghad,M., Wang,Y., Gillett,E., Fleming,M.D., Dotsch,V.,
            Andrews,N.C., Caput,D. and McKeon,F.
  TITLE     p63, a p53 homolog at 3q27-29, encodes multiple products with
            transactivating, death-inducing, and dominant-negative activities
  JOURNAL   Mol Cell 2 (3), 305-316 (1998)
   PUBMED   9774969
REFERENCE   10 (bases 1 to 7017)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ045424.1, AK151672.1, AK147820.1, CF734428.1, CA319864.1,
            AK162970.1, AK166690.1 and BE948353.1.
            
            On Jan 18, 2014 this sequence version replaced NM_026202.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147820.1, AK151672.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                CJ045424.1         5-43
            40-2283             AK151672.1         2-2245
            2284-3486           AK147820.1         2233-3435
            3487-4146           CF734428.1         87-746
            4147-4746           CA319864.1         114-713
            4747-5581           AK162970.1         566-1400
            5582-7000           AK166690.1         426-1844
            7001-7017           BE948353.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..7017
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 18.98 cM"
     gene            1..7017
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /note="coiled-coil domain containing 50"
                     /db_xref="GeneID:67501"
                     /db_xref="MGI:MGI:1914751"
     exon            1..182
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1051
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein Ymer"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 50 isoform
                     1"
                     /protein_id="NP_080478.2"
                     /db_xref="CCDS:CCDS37305.1"
                     /db_xref="GeneID:67501"
                     /db_xref="MGI:MGI:1914751"
                     /translation="MADVSVDQSKLPGVKEVCRDFAVLEDHTLAHSLQEQEIEHHLAS
                     NIQRNRLVQHDLQVAKQLQEEDLKAQAQLQKRYKALEQHDCEIAQEIQEKLTIEAERR
                     RIQEKKDEDIARLLQEKELQEEKRRKKHTPEFSGGSVFGDNYYHEDGGMKPRGIKEAV
                     STPARASHRDQEWYDAEIARKLQEEELLATHVDMRAAQVAQDEEIARLLMAEEKKAYK
                     KAKEREKSSLDKRKHDPECKLKAKSAHSKSKEGDEAHRSKIDRPSRPPPPTMMGLEDT
                     DPTHFTNQHSTTWHLPKSESSQKGFHNKQ"
     exon            183..245
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /inference="alignment:Splign:2.1.0"
     exon            246..372
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /inference="alignment:Splign:2.1.0"
     exon            373..463
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /inference="alignment:Splign:2.1.0"
     exon            464..581
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /inference="alignment:Splign:2.1.0"
     exon            582..697
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /inference="alignment:Splign:2.1.0"
     exon            698..742
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /inference="alignment:Splign:2.1.0"
     exon            743..847
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /inference="alignment:Splign:2.1.0"
     exon            848..924
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1031
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..7002
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6976..6981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /note="hexamer: AATAAA"
     polyA_site      7002
                     /gene="Ccdc50"
                     /gene_synonym="C3orf6"
                     /note="major polyA site"
ORIGIN      
        1 tttctggcac ctctctccct ccgtactgga ctccggtgca tttccggccc gggagagtcc
       61 ggcgtccacc cgggccagcc cgcggggtgg gcgtgcgccg tgatctccgc gcgcccgagg
      121 cccagcggcc gccatggccg acgtgagtgt agatcagtcc aagttgccgg gcgtgaagga
      181 agtgtgtaga gattttgccg tcctggagga ccacaccctg gcccatagcc tgcaggaaca
      241 agagattgag catcatttgg catccaacat tcagcggaac cgtctggtac aacatgatct
      301 gcaggttgct aagcagctcc aagaggaaga cctcaaagcc caagctcagc tccagaagcg
      361 ctacaaagcc cttgaacaac atgattgtga aattgctcag gaaatccagg agaagctaac
      421 cattgaggct gagagacgac gcattcagga aaagaaggat gaggacatag cacgtctttt
      481 gcaagagaag gagctacagg aggagaaaag gaggaagaaa cacactccag agttttctgg
      541 gggcagtgtt tttggagata actactatca tgaggatgga ggaatgaaac caagaggaat
      601 aaaagaagct gtctctactc cagcacgagc aagccacagg gaccaggagt ggtatgatgc
      661 tgaaattgcc aggaaattgc aagaagaaga acttttggct actcatgtgg acatgagagc
      721 agctcaggtt gcccaggatg aggaaattgc tcgacttcta atggctgaag aaaaaaaagc
      781 ttacaagaaa gccaaagagc gagaaaagtc atctttggac aaaaggaaac atgaccctga
      841 atgcaagtta aaagcaaagt cagcccactc aaagtcaaaa gagggtgatg aagcacaccg
      901 ctccaagatt gacaggccat caagaccacc accacctacc atgatgggcc ttgaggacac
      961 agatcccacc cattttacaa accagcacag tacaacatgg catcttccaa agtcagagtc
     1021 ctcacagaaa ggcttccata acaagcagta aaataataca aacaaaaagg gatcggcctc
     1081 gaaaatggac ttcgtatagc acatattact tcttatagca catattactg aaagatacaa
     1141 catgcattcc acgttggctg ttgtccttct gtgtgccatt ctgggagttg ctctcaagtg
     1201 ttttcttaac taaaaaagta cttcacttca ttttaaactt ttggtaattt tggtcacttt
     1261 ggccgtgtaa gaaatgtagc atctgaacat tggccgtctc ttctgtggat atgtttcctg
     1321 ggatgtagta attctataaa attattacac agttgctagt cataggatat tggcgtctag
     1381 ggaactgagt ttctttagca attagaagtg cacagggatt cattatgaag tcaagcatag
     1441 cgtttggatg gatgaggtgt aggaaagctg tggagcagct gctttgctgt ttattatgat
     1501 agtttgaaag atacagcctt tgctttttta tccttttcag aaaaagaaaa gccacaacaa
     1561 taaagtacag gaaaacacac agagcagtga agtgtgttcc tctgaataaa tggatgggta
     1621 gaggctctag atggccttgt aaccctcact cgttatcgtg tactgctgtt tcctcaggac
     1681 caggtctttt tgatgccctt aggcaatgaa tcatgtgtta atattaattt gtatagactt
     1741 taattgtctg atactttctc tcaggtccat gaggcgtcaa ctcaaaatta aagaacaaac
     1801 agccttccat tgccttgctt ttctaagtta attatagagc caaaggaata gaacagtttc
     1861 cataggactt ggtaccatcc gcccaactag ctgtgcacat ccagcctcct gctcccagga
     1921 tatagcagtt tttgttggca accttgcagt gatgttttat gcacctgcaa tattagatta
     1981 gttcagtgtg aagttgaacg tgatgaagtg agtcactatc caggtgtata catctaagct
     2041 gatggtcatt gtattcctct ctgtaagacc tttaagctcc tctataaaac tttgtgtatt
     2101 catccatacc acttactcaa tatcaatggc agctatgctg aacctatata tgattgccat
     2161 tttcccagct tgacttcctg ttcttttcaa tgtgtgggtc tgacattttc tgtcatgtca
     2221 gtatgctgtt tatttagaaa agaagaaaac aaggttgctg aaagaaataa tttaaggact
     2281 gcctgccttc catttgcctt gtctttccaa actgtcttaa acttgtggag ggttctggaa
     2341 ggctgctccc aacagatttt gatctctgat tttgagaaca gtcttttgtt tcataaaatg
     2401 acacccgata gaaatttgaa tgaaaagtgg ctaagagtga tgctgtggga gcaaatgcaa
     2461 gggagtgaac tgcaggcctg cgtgtcagcc agcagatcca tgcaggagat cctccttctg
     2521 cgaaggaggc aaagggaaag ccccgcctta agccagagtc tacacagtgc tttcctccca
     2581 gcttagtgta atgctatatc tttcattatc tgccctgtga tcttacttca tgtttttaaa
     2641 agatattttg aaagggtaac tttaaagaaa aaaaatatag ttgcattttt atttgctaat
     2701 taggcaaagc aggcaacatc ttctgccata tttttgtttt tataaatatt tatttttcta
     2761 tctcatgaaa tgatcacttt taactttaaa aactgtattt cttttgtttt gcatgaactt
     2821 cacttaatca tatttattac tgtaaaatgt acatgtttta gtttaaaaaa tgccaagcca
     2881 cttaaccaga atgctgcagt cttacctgtc gccgtggatg gccagaggca gtgcaacctg
     2941 tgtgatggct agctcaacat cagtattgga aattttgtta cattttaagt tctttttaaa
     3001 gtctacagtt ttaaaatatt ttgtttgtct tattttactt ttgtaaagtg aacagttttt
     3061 ttaagagtac cagtaattat tatgagtaag aagatagaaa aatattctta tttattctta
     3121 cttagaattt tttctatcag tcaaataata tatctttgag atgattgaaa caactaacag
     3181 ctcttactga actgccagtc ttcactgtgg tctctgcttt ttaattttta tattgaaatg
     3241 aaagcattta ttttgttcct gttattgagc acatgcaatt taacttatga ggtccacaca
     3301 gtgttatgtc ttgctgtcaa cataagagta atccttctag ctttgggaaa tctttttgtt
     3361 tctcaactgt ttttctctgc aggccatgtg ctgttaacag cagcattcct ggatgagcac
     3421 actatgttaa ggagcctcat tatgagactg gtgtgtcact ctctcatttc catcctagaa
     3481 aaggggctag ataaaagtca gattaaatat gctgacctga aagaaaatta attccagtat
     3541 tcaagctact gttagtcata attgccttat tgggagaata gaaaaatgct tcttttgtgc
     3601 tcaaagaata ttgagatttt ttgcaaatgg ctttgcatgc cattgaaatg ctatggggtc
     3661 aagtgacttt atgacaaatg gcagttggta atgaactcaa aaccaaacta tgtatttctg
     3721 atcttgagaa acatctaaat taggaagaga ggtatgcata aaaatgtgcc caaagaaaac
     3781 tcttcacagt ggcctgggtc actacaccta ggcagcagtc taaagtatgt gacctgtggt
     3841 ccactggatg ctttaatact atcagagctt ctcttaagtc actttgtgcc aaatttaaaa
     3901 caaaaacaaa gacaaaaaac atattgtaat atggtgcatt ctgtttacca cataagtggt
     3961 taacatttta cagccttgac ttataatatg agtaatgcct ttgtataaat ctcactttgg
     4021 gaaacatgaa aatgttactc tcctttaaaa ggtaacttct aattggctga gagcatcagc
     4081 ctattgaaga gatgaggccc atgtagaaat aactcgaagg cctgagatag aatagagcgt
     4141 gcagtaaatg gctacttcca tttggggagg gtggtgtttg tggaaggagc gctgacattg
     4201 aagtcacact gacaaggaga cattgttccc tttgatttca ctgtgaactc cgtgccatgt
     4261 tctcatagga cacttgtaca aaacagtccc tacaacattg aaaacccgac ctttgattta
     4321 tagaagtctg taatgtgtct gtcatatgct gtttatgact cggtcactca ttctctcttc
     4381 ctatctcaca atcagagaag tgacccagga gagtcagctc ctctctctct ctctctctct
     4441 ctctctctct ctctctctct ctctctctgt ctctgtctct gtctctgtct gtctgtctgt
     4501 ctatcggtgc ctgtatgctg tagagccata tctgtatctg actggtgact gatgcttcct
     4561 tcttcccacc ctgtaacaag gcagtgcagg cagacagaag cctcctgtgg agtaccctgt
     4621 ccacgctgca tgcaacagta ttagctgaat atgtgctggg aggtttgttt gtttggttag
     4681 tttttatcat ggtgatatgt aagataatta aagggaagag ttaaaggctt tgttgcgtct
     4741 gctataactc atcagaaatg ctcaaatttc atcgtagcgt ctccaagaag gtagagagct
     4801 tggaaaacat tagttatagt cacctttctg atgagccctg cactttatgt cagcaatgtc
     4861 tgtggagatc agttttgcct taaattagtt tgagtccacc caaggccatt gtgcttagta
     4921 tcatgagcac ttgtcagctc tccattagca tgcagttcat aacagagctt caagcagcag
     4981 cagcacccag agctttgaac ctcgcccact gtgctctggg tgacttgtaa cattaatagg
     5041 aatatcttct cagttccctg atagcagcgg catggccaga gcactgctgt gagacagttc
     5101 cctggctgga gtattcaccc agtgttaact ttctgaacag ttggggggtt cttatccttt
     5161 tttttttttt ttaatggtga ctacaaaaga ttagaacaaa ggttctttgg ttcagtgaca
     5221 atactcagat tatttctaag aattttagcg atgacctttg tgtattgaaa agcttattta
     5281 ccattaacaa atacaggaga aacctctccc cctcccccaa atggatgtat tacttggaat
     5341 cgtgatctga aaagtgctct agtttatttc ttttaacaga attaagcagt taaatgtggc
     5401 tatggttgaa aagatagaag aacagctttt ctaggctgca cacagaagag tacagttatg
     5461 caggtaacca cactgattta catacgtgtt tgccactaaa atccattttc tgcccttata
     5521 aattcgaaca ctgctactaa tatggtcata taggtttcat atgcctctgt gtattacaag
     5581 taaaaaaaaa agttttttct cctcatttta aaaagttact tttcataata tgctgactta
     5641 agcattttag atcagggcaa gcttaattat gtaactgtgt tgcccaggtt tttattggtg
     5701 aaattcaaat atgaagatga gaaaaaattc aaaaggtttg agtaacaaat tagcaagaat
     5761 tgcctacagt aaagagtagg cattgagagg ctatgcagta atgggtggca gtctttggat
     5821 atattgctac actgatttca cactatgctg aaattgattc tagctaaaaa tttgataaga
     5881 gtttgggtgt gagaagtttt atacttatgt atgaatcgtt tctaaattcc tttagattgt
     5941 agaccttgat gtaacccgaa aggcagatgt cctatcccaa ggatagctgt atttttcatg
     6001 gttttaaatg agcaaccaga tattcatttc atgaaataat gtaaatatta gaaagtaata
     6061 tggataaatg acatataaaa gtgacatttc caaatgacaa ttctctgtaa tgcctgttgt
     6121 ctgctaagaa gaatctatcc ctgtgaaaca tttgaaaggt gctggatttg aaagtactag
     6181 agtttgttac ataaatcaag tttctcagga tatttgaggt gatactgcca tttatttctg
     6241 ttataatttg gaaaaaaatc atttcttttg ttacactatg aggaaactgc acactttatt
     6301 tggtaagagt cctttaagtt cagtaaccta gagatgagta taaaacaagt gtgggatccc
     6361 agcgctggtc agtttacggt cagcccaccc ctcagtgggg aggtgtgaag gagatcccag
     6421 tgctggtcag tttatggtca gcccacccct cagtgggggg ttgtgcagta catattttat
     6481 ggagctgaat ggaacttcaa tagaatatcg tcccttgtct gaggaaagac cacctcaacc
     6541 acatgcctat ctagagattg aataaaactg tgaggagaca ctgtgtggat gccttaagat
     6601 ggctggcgct ggctgcaggg aacaatctat ttcagctcat cttcataaag cccaagatgc
     6661 tcccgtgcat aaccttgttg aagaaatgag aaatgcggtg ctggctactt tgatgtgtct
     6721 ggggaggctg gcgtcattgg ttaccatcat taagtcactg tccagtgccc aagccttcct
     6781 tcactaccac tcatatgtct acatccattc attcatctat gcaagcttgt gtttttgtgg
     6841 tttgtatttt acacctggac atcaggttta acattggtgt tttaaataat ttttaaacca
     6901 aagtatttta tgagtaagtc tatgtgctct gtttttgtga atgttttgag ataaatacct
     6961 atcttgtttt ctcttaataa agtcatccat ttattaagtc aaaaaaaaaa aaaaaaa
//
