LOCUS       NM_026613               2097 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus coiled-coil domain containing 34 (Ccdc34), transcript
            variant 1, mRNA.
ACCESSION   NM_026613
VERSION     NM_026613.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2097)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2097)
  AUTHORS   Cong,J., Wang,X., Amiri-Yekta,A., Wang,L., Kherraf,Z.E., Liu,C.,
            Cazin,C., Tang,S., Hosseini,S.H., Tian,S., Daneshipour,A., Wang,J.,
            Zhou,Y., Zeng,Y., Yang,S., He,X., Li,J., Cao,Y., Jin,L., Ray,P.F.
            and Zhang,F.
  TITLE     Homozygous mutations in CCDC34 cause male infertility with
            oligoasthenoteratozoospermia in humans and mice
  JOURNAL   J Med Genet 59 (7), 710-718 (2022)
   PUBMED   34348960
REFERENCE   3  (bases 1 to 2097)
  AUTHORS   Srivastava,U., Paigen,B.J. and Korstanje,R.
  TITLE     Differences in health status affect susceptibility and mapping of
            genetic loci for atherosclerosis (fatty streak) in inbred mice
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (10), 2380-2386 (2012)
   PUBMED   22837474
REFERENCE   4  (bases 1 to 2097)
  AUTHORS   Aubert,J., Dunstan,H., Chambers,I. and Smith,A.
  TITLE     Functional gene screening in embryonic stem cells implicates Wnt
            antagonism in neural differentiation
  JOURNAL   Nat Biotechnol 20 (12), 1240-1245 (2002)
   PUBMED   12447396
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147056.1, AK033555.1 and BQ748443.1.
            
            On Sep 21, 2008 this sequence version replaced NM_026613.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147056.1, AK033555.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164131,
                                           SAMN01164132 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-713               AK147056.1         2-714
            714-1402            AK033555.1         693-1381
            1403-2070           AK147056.1         1404-2071
            2071-2097           BQ748443.1         508-534
FEATURES             Location/Qualifiers
     source          1..2097
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 56.66 cM"
     gene            1..2097
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
                     /note="coiled-coil domain containing 34"
                     /db_xref="GeneID:68201"
                     /db_xref="MGI:MGI:1915451"
     exon            1..398
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1155
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 34"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 34 isoform
                     a"
                     /protein_id="NP_080889.3"
                     /db_xref="CCDS:CCDS50655.1"
                     /db_xref="GeneID:68201"
                     /db_xref="MGI:MGI:1915451"
                     /translation="MRAAGPWRAASPAPCTRYLARCKPGFRPSSSFVVDLLVDSGDPG
                     LEDVALTECLSPPSLSCSNSTLSLLSPLGHQSFPFGADDSEGEDEEALDEDARESESK
                     VESLEGIEFQQRSSCEVESQDKQEKLVLLQHGSLTPWEMWFVGKEKEERGRLQQKFLE
                     ELNQQIEKRKEMEEREKRKIIAEVKHKEWVQKKNKQERKEREQKINKEMEEKEAKKRE
                     KEHLQEKAKEKYQEWLKKKKAEEYEKKKKEKEKEKQRQAELQEKKEIAEKKFKEWLEN
                     AKNKPRPAAKSYGYSSGKLTGFYSGNSYPEPTFYNPIPWKPIHMPPPKEAKSGPGKKS
                     KRHAASQPLPSSSLAVHNAKSSLCLGALCRGQR"
     exon            399..531
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            532..639
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            640..798
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            799..940
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            941..2079
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1395..1400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1400
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
                     /note="major polyA site"
     regulatory      1571..1576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
                     /note="hexamer: AGTAAA"
     regulatory      1583..1588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
                     /note="hexamer: CATAAA"
     polyA_site      1592
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
     polyA_site      1603
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
     regulatory      2050..2055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2076
                     /gene="Ccdc34"
                     /gene_synonym="2810027O19Rik; 4930522P10Rik"
ORIGIN      
        1 gggagaacgc gccttcggcc ttgctcgggc cgtttgaact tggcgggcct gatgcgggcc
       61 gctgggccgt ggcgggctgc ctctccggct ccgtgcaccc gttacctcgc ccgctgcaag
      121 ccgggcttcc ggccctcctc gagttttgtc gtcgacctct tagtggattc cggggatcca
      181 gggctggagg atgtggcgct gaccgagtgc ttgtcgccgc cgtctctgag ctgcagcaac
      241 tccaccctgt ccctgttgtc tccccttggc caccagagct ttccgtttgg cgcggacgac
      301 agtgaggggg aggatgaaga ggccctggac gaagatgccc gtgagtccga gagcaaggtg
      361 gagagcttgg aaggaataga gttccagcag cgctccagct gtgaagttga gtcgcaagac
      421 aaacaagaga agctggtgct gttacagcac ggcagtctga cgccatggga gatgtggttt
      481 gttggcaagg agaaagaaga gcgaggccgg ctacaacaga aatttctgga ggaattaaat
      541 cagcaaatag aaaaaagaaa agaaatggaa gaacgtgaaa aaaggaagat aattgctgaa
      601 gtaaagcaca aggaatgggt tcaaaagaaa aataagcagg aaaggaaaga aagggaacaa
      661 aaaattaata aggaaatgga agaaaaagaa gcaaaaaaac gggagaaaga acatttgcaa
      721 gaaaaagcaa aagaaaaata tcaagaatgg ttgaagaaaa aaaaagctga agagtatgag
      781 aagaagaaaa aagagaagga aaaagaaaag caacggcaag cagaattaca ggagaaaaag
      841 gaaatcgcag aaaaaaagtt taaagaatgg ttggaaaatg caaaaaataa acctcgtccg
      901 gctgcaaaga gctatggtta ctccagtgga aagcttacag gtttttacag tggaaattcc
      961 tacccagaac caacttttta taacccaatt ccttggaagc caattcatat gccccctcct
     1021 aaggaagcta agagtggacc cggaaagaag agtaaacgac atgcagcgag ccagcccctc
     1081 ccatcgtcat ccctggcagt tcataatgcc aagagcagtc tttgccttgg agctctgtgc
     1141 cgaggacaga gatagagtgt gtgcacagag catacctagc tacccggagc ttacatttaa
     1201 aatcagaata tttttcttaa cacttcctaa tcagtaaatc aacatttgat gtggtaatta
     1261 acaggtacca aaattttaaa tttgtatgtg gaatccttag agttaaagat agtttttata
     1321 ttttggtttt tataaaccgt taaggttgat ctaatgattg tgttttagtt tttattaaaa
     1381 ctcactacag tatcaataaa ccaacagtct ttcttgtgtt cttttgtact ctgttatttg
     1441 cttgtgtttt atgcttagaa acataccatt aattttttca aacaggcact tctaaacctt
     1501 acctaaatta aatgggttag aaaccaagga aaataaattt caatgtttac actgtttgtt
     1561 aatggttttt agtaaagttt tccataaagg aattttaaag ttttcctttt tgcatttatt
     1621 tattttgtgt gagtgtgtat gtgtgtgggc atgcatatac tataacatga ctgtggagag
     1681 cagaggctag cttgcagtga gtcagatctc cacttctact gtgtgcattc taaggattga
     1741 gctcacgtcg ccagacttgt gcagcaagca cctgtaccag aaaagttgtc ccattggttc
     1801 cctgtggagg tgctttaaaa aactaaccaa aagactgctc tgcagcaccg aaataagagt
     1861 tggagttgtt aagacaaaat tttaaaatac tattttgtgt tgtagatctg atgtttttat
     1921 aatgttgaga cactaataat atgttgttac acttcataaa atccttttta tatgcttata
     1981 attggattgc tggctttgaa attagggtca ccatttgctc ctttgtaata cttgctacct
     2041 taaatgttaa ataaaactgg gaacattctg ataaaatcaa aaaaaaaaaa aaaaaaa
//
