LOCUS       NM_028804               2769 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus coiled-coil domain containing 3 (Ccdc3), mRNA.
ACCESSION   NM_028804 XM_129987
VERSION     NM_028804.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2769)
  AUTHORS   Iskusnykh,I.Y., Fattakhov,N., Li,Y., Bihannic,L., Kirchner,M.K.,
            Steshina,E.Y., Northcott,P.A. and Chizhikov,V.V.
  TITLE     Lmx1a is a master regulator of the cortical hem
  JOURNAL   Elife 12, e84095 (2023)
   PUBMED   37725078
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2769)
  AUTHORS   Kobayashi,S., Kita,S., Okuzaki,D., Fujishima,Y., Otsuki,M.,
            Kato,H., Nishizawa,Y., Miyashita,K., Yokoyama,C., Fukuhara,A.,
            Morii,E. and Shimomura,I.
  TITLE     Favine/CCDC3 deficiency accelerated atherosclerosis and thrombus
            formation is associated with decreased MEF2C-KLF2 pathway
  JOURNAL   iScience 25 (11), 105252 (2022)
   PUBMED   36281455
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2769)
  AUTHORS   Hoffmann,S., Schmitteckert,S., Raedecke,K., Rheinert,D.,
            Diebold,S., Roeth,R., Weiss,B., Granzow,M., Niesler,B.,
            Griesbeck,A., Eckstein,V., Zimmermann,W.H., Just,S. and
            Rappold,G.A.
  TITLE     Network-driven discovery yields new insight into Shox2-dependent
            cardiac rhythm control
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (4-5), 194702 (2021)
   PUBMED   33706013
REFERENCE   4  (bases 1 to 2769)
  AUTHORS   Liao,W., Liu,H., Zhang,Y., Jung,J.H., Chen,J., Su,X., Kim,Y.C.,
            Flores,E.R., Wang,S.M., Czarny-Ratajczak,M., Li,W., Zeng,S.X. and
            Lu,H.
  TITLE     Ccdc3: A New P63 Target Involved in Regulation Of Liver Lipid
            Metabolism
  JOURNAL   Sci Rep 7 (1), 9020 (2017)
   PUBMED   28827783
  REMARK    GeneRIF: Altogether, these results demonstrate that CCDC3 modulates
            liver lipid metabolism by inhibiting liver de novo lipogenesis as a
            downstream player of the p63 network.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2769)
  AUTHORS   Kobayashi,S., Fukuhara,A., Otsuki,M., Suganami,T., Ogawa,Y.,
            Morii,E. and Shimomura,I.
  TITLE     Fat/vessel-derived secretory protein (Favine)/CCDC3 is involved in
            lipid accumulation
  JOURNAL   J Biol Chem 290 (12), 7443-7451 (2015)
   PUBMED   25605713
  REMARK    GeneRIF: deficiency of Favine attenuated differentiation of primary
            adipocytes. Taken together, these data demonstrate that Favine has
            adipogenic and lipogenic effects on adipocytes
REFERENCE   6  (bases 1 to 2769)
  AUTHORS   Kobayashi,S., Fukuhara,A., Taguchi,T., Matsuda,M., Tochino,Y.,
            Otsuki,M. and Shimomura,I.
  TITLE     Identification of a new secretory factor, CCDC3/Favine, in
            adipocytes and endothelial cells
  JOURNAL   Biochem Biophys Res Commun 392 (1), 29-35 (2010)
   PUBMED   20043878
  REMARK    GeneRIF: These results indicate that CCDC3 is a protein secreted by
            adipocytes and endothelial cells, and that its level is regulated
            both hormonally and nutritionally.
REFERENCE   7  (bases 1 to 2769)
  AUTHORS   Horie,K., Yusa,K., Yae,K., Odajima,J., Fischer,S.E., Keng,V.W.,
            Hayakawa,T., Mizuno,S., Kondoh,G., Ijiri,T., Matsuda,Y.,
            Plasterk,R.H. and Takeda,J.
  TITLE     Characterization of Sleeping Beauty transposition and its
            application to genetic screening in mice
  JOURNAL   Mol Cell Biol 23 (24), 9189-9207 (2003)
   PUBMED   14645530
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC058616.1.
            
            On Jan 24, 2005 this sequence version replaced XM_129987.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058616.1, AK009833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2769
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 3.25 cM"
     gene            1..2769
                     /gene="Ccdc3"
                     /gene_synonym="2310045O21Rik"
                     /note="coiled-coil domain containing 3"
                     /db_xref="GeneID:74186"
                     /db_xref="MGI:MGI:1921436"
     exon            1..532
                     /gene="Ccdc3"
                     /gene_synonym="2310045O21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..980
                     /gene="Ccdc3"
                     /gene_synonym="2310045O21Rik"
                     /note="coiled-coil domain-containing protein 3; favine;
                     fat/vessel-derived secretory protein"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 3
                     precursor"
                     /protein_id="NP_083080.1"
                     /db_xref="CCDS:CCDS15664.1"
                     /db_xref="GeneID:74186"
                     /db_xref="MGI:MGI:1921436"
                     /translation="MPLPLLLAALCLAASPAPARACQLPSEWRPLSEGCRAELAETIV
                     YAKVLALHPEVPGLYNYLPWQYQAGEGGLFYSAEVEMLCDQAWGSMLEVPAGSRLNLT
                     GLGYFSCHSHTVVQDYSYFFFVRMDENYNLLPHGVNFQDAIFPDTQENRRMFSSLFQF
                     ANCSQGQQLTTFSSDWEVQEDNRLMCSSVQKALFEEEDHVKKLQQKVATLEKRNRQLR
                     ERVKKVKRSLRQARKNSRHLELVNQKLNEKLGASSAQQHINALGREPVRAPYLHG"
     exon            533..707
                     /gene="Ccdc3"
                     /gene_synonym="2310045O21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            708..2663
                     /gene="Ccdc3"
                     /gene_synonym="2310045O21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1066..1071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc3"
                     /gene_synonym="2310045O21Rik"
                     /note="hexamer: ATTATA"
     polyA_site      1089
                     /gene="Ccdc3"
                     /gene_synonym="2310045O21Rik"
                     /note="major polyA site"
ORIGIN      
        1 gccgaagagc tagccgtgca cccagctctc cggagcgcgt gcaggcgagc cgagcgcccc
       61 gtccgcggtt ctcgggcagg cgctgcgggc tccccggctc cccgccgtcc cgggcacccg
      121 ggcgggccat gcgcccgggc tagagcgtag ccgccggcat gccgctcccg ctgctgctcg
      181 ccgcgctctg cctcgccgcc tccccggcgc ccgcgcgcgc ctgccagctg ccgtcggagt
      241 ggagaccctt gagcgaaggc tgccgcgccg agctagccga gaccatcgtg tatgccaagg
      301 tgctggcgct gcaccccgag gtgcctggcc tctacaacta cctgccgtgg cagtaccaag
      361 ctggagaggg agggctcttc tactccgccg aggtggagat gctgtgtgac caggcgtggg
      421 gcagtatgtt ggaggtgccc gccggctccc ggctcaacct tactggtctg ggctacttct
      481 cctgccactc ccacacggtg gtccaggact actcttattt cttctttgta aggatggatg
      541 agaattacaa tctcttgcca cacggagtca atttccaaga tgccatcttt ccagacaccc
      601 aggagaacag aaggatgttt tccagccttt tccagtttgc taactgttcc caagggcagc
      661 agctgacgac tttctcgagt gactgggagg tccaggaaga caacaggctc atgtgctcct
      721 cggtgcagaa ggccctgttt gaggaagagg accatgtcaa gaagctgcag cagaaggtgg
      781 ccaccctgga gaagcggaac aggcagctcc gagagcgggt caagaaggtc aagaggtctc
      841 tgaggcaggc acggaagaac agccgccacc tggagctggt gaaccaaaaa ctcaatgaga
      901 agctaggggc ctccagtgct cagcagcaca ttaacgctct gggccgggag cccgtgcgtg
      961 ccccctatct gcatgggtag caggggcagg tggatgctgg cctgccttgc ctgtgccggc
     1021 tgactgagaa caaccgcaag ctctatatat gcacttactt caaacattat agtagctatc
     1081 catttggcat ttggtagagt ctaactgggt aaattgtcag gttttgcttt ctttcccatt
     1141 gggtcctggc cttactggcc atttgacttc agatcccatg tgccacatgt cctctttctg
     1201 tcctggtgcc acacaagagc cttaaaaccg gaaggcaata gtatcttgag tctggccctc
     1261 agcctctaga gagttccttc gctgggggga gaacattcta gaacctcggt atacatgaag
     1321 atatcacagg actctcttgt ttcagaaggg agtcggtgtt gaggctcagc aaccagggtt
     1381 ggcacacgca tgcgtgttct aaaatgttct ggaatgttct gccttttctc gtgtttttag
     1441 aaatggtgtc tacgtgtaaa tgtgcagggc acccacccgt gcttcagtca ccatttctcc
     1501 caaagctgaa agatgttaag acttaatgag ttcattacag gtaagggaac tgggcgagga
     1561 gctgaggcag ctagtaattg gtaaagataa attatatctg ttttccaacc ccagctcctt
     1621 ggggctgaca tgattcccta caggatgttt taatctaaag cgtaattgct tttatagaca
     1681 taccatattt catcactcat gtttccaaac tggaattaag ctcaacctaa ctttgtggag
     1741 tcttaacttt gtgttagcgc agcttgccat ggctccgagt ttaaggtcac tgacttgcac
     1801 acactgagac tttctactct gcagaaacag ctccctgcct gaaggggttc aataagctct
     1861 atgctagggt cccaaagggc tttgtccagg gattctaacc caagcttcta tgcaacctcc
     1921 aagcctctga cccaacacac acacacacac acacacacac acacacacac acactgctca
     1981 ggttctcata aaaggtctac gtgtacccca tagaagtatt tgcataacaa acactttctt
     2041 ttaataagag tgctttcact atccttccca tggccatgtt tgatcatgtc ccatttgtgt
     2101 tactaagaag tcaatggagt ggctgctggt tcatcgcctc taatggtggc cctccagatc
     2161 taatgccgtg ccacactgtt ccaccaatag aaagaatcct tcagctctac accattgacc
     2221 acctagaacc cattccagac acatgatact gataaaagtg gtcattactg tcacactgcc
     2281 gcctttctgc ttgcaggaag tccaggcctc tgtgagaagt ccctcctgtc acatgagtat
     2341 tggtaggggt ggggataagt ttgtgccctt ggctggtcag ggcatgatgg gaaggaactt
     2401 ctattctggg accaatcttc atccactctc ccccactcag cctctttaag cagtgctatt
     2461 cataatatgc tacagaggtg tgccttctca ttaattctcc ctgggagcat taagttaaag
     2521 cgcttttgtt acctcccaag ggaatgaatg gcaagcttag gggtgatgga gtcaggactc
     2581 ggagaactgt ggaagccgaa gatgtcttat gttctgcttt tccaataaac atgagcagtg
     2641 cttccaatgg ctgtggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2701 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2761 aaaaaaaaa
//
