LOCUS       NM_138603               2274 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus coiled-coil domain containing 22 (Ccdc22), mRNA.
ACCESSION   NM_138603
VERSION     NM_138603.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2274)
  AUTHORS   Bartuzi,P., Billadeau,D.D., Favier,R., Rong,S., Dekker,D.,
            Fedoseienko,A., Fieten,H., Wijers,M., Levels,J.H., Huijkman,N.,
            Kloosterhuis,N., van der Molen,H., Brufau,G., Groen,A.K.,
            Elliott,A.M., Kuivenhoven,J.A., Plecko,B., Grangl,G.,
            McGaughran,J., Horton,J.D., Burstein,E., Hofker,M.H. and van de
            Sluis,B.
  TITLE     CCC- and WASH-mediated endosomal sorting of LDLR is required for
            normal clearance of circulating LDL
  JOURNAL   Nat Commun 7, 10961 (2016)
   PUBMED   26965651
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2274)
  AUTHORS   Tomsig,J.L., Snyder,S.L. and Creutz,C.E.
  TITLE     Identification of targets for calcium signaling through the copine
            family of proteins. Characterization of a coiled-coil
            copine-binding motif
  JOURNAL   J Biol Chem 278 (12), 10048-10054 (2003)
   PUBMED   12522145
  REMARK    GeneRIF: Identifies this protein as a copine-binding protein.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY136942.1, AF229637.1 and BM936498.1.
            
            On Mar 22, 2007 this sequence version replaced NM_138603.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011195.1, AF229637.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                BY136942.1         1-62
            63-2238             AF229637.1         4-2179
            2239-2274           BM936498.1         546-581
FEATURES             Location/Qualifiers
     source          1..2274
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.42 cM"
     gene            1..2274
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /note="coiled-coil domain containing 22"
                     /db_xref="GeneID:54638"
                     /db_xref="MGI:MGI:1859608"
     exon            1..177
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            178..355
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            356..488
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            489..595
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            596..662
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            663..841
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1036
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1099
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1219
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1339
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1456
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1558
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1666
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1762
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1822
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1897
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2256
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2233..2238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /note="hexamer: AATAAA"
     polyA_site      2256
                     /gene="Ccdc22"
                     /gene_synonym="DXImx40e; Ppp1r3f; Sfc22"
                     /note="major polyA site"
ORIGIN      
        1 tacatttccc aatgttcctc gcgcggcacg tgactctctg tcctcgccgc gccgagagca
       61 gcgcggagag ctccaatttc tctgatctgg tcctagaccc agccccggag ttagaattaa
      121 ctccaccatg gaggaggctg accgaatcct catccattcc ttgcgccagg cgggcacggc
      181 agttcctcca gaagtgcaga ctctgcgagc tttcaccact gagctggtcg tagaggctgt
      241 ggtccgatgc cttcgagtga ttaatcctga tgtgggctct ggcctcagtc acttgctacc
      301 accagccatg tctgcccgct tccgcctggc catgagtctg gcccaggcct gcatggacct
      361 gggctatccc ttggagcttg gctatcagaa cttcctctat cccagtgagc ctgaccttcg
      421 agatctgctt cttttcttgg ctgagcgact acccagcgat gcctctgagg acgcagacca
      481 gcctgcaggt gactcggcta ttttccttcg ggccattggg agccaaatcc gggaccagct
      541 ggccctgccc tgggtcccac ctctccttcg aactcccaag gtgcagcgcc tccagggctc
      601 agccctccag cagccgttcc actccagcag gttggttcta cctgagttga attccagcgg
      661 agagctatgg gagttccagg ccagtcccct gctgctacca gcccccacac aggtgcccca
      721 gcttcagggg agggcagcct cactccttga acaccatgcc agccagctct gccagcatgt
      781 gaacagggat tgcccaggag atgaagaccg ggtgcgctgg gcatcccgcg tcccatccca
      841 ggaggattcc cgggctccac agcagagact gcacaagcag ctgattgaac atctgcgtca
      901 aagctggggc ccacttggag ccccgacaca agtccgagac ctaggagaga tgctgcagac
      961 ctggggtgct agggctatga ctggtgtgcc caaaggctcc cgcttcaccc attcagagaa
     1021 gtttaccttc catctggagc cccaggtcca ggcagctcag gtggcagatg taccagctac
     1081 ctctcaaagg cttgaacagg acacacgggc agctcaagag caggagttag agtcccttcg
     1141 tgagcagctg gcgagtgtga accacaacat tgaagaggtt gaagctgaca tgaagaccct
     1201 gggaatcaac cttgtgcagg tggaaaccga gtgccgacaa agtgaactca gtgtggccga
     1261 gcaggagcag gccctgcgcc tgaagagcag gacggtggaa ttgctgcctg atggggctgc
     1321 caacctcgcc aaactgcagc ttgtggtgga gagcagcgct cagaggctca tccatctagc
     1381 aagccagtgg gagaaacacc gggtcccact tcttgctgag taccgccacc tcagaagact
     1441 ccaggactgt agggagctgg aatcgtctcg acggctggca gaaatccagg agctgcacca
     1501 cagtgttcga gcagctgcag aggaggctcg ccggaaggag gaggtctata agcagctggt
     1561 gtcagagctg gagactctgc caaaagatgt gtcccggctg gcctatactc agcgcatcct
     1621 ggagattgtg ggcaacatcc ggaagcagaa ggaagagatc actaagatct tgtcggacac
     1681 aaaggaactg cagaaggaaa tcaactctct ctctgggaag ctcgaccgga catttgcagt
     1741 gactgatgag cttgtgttca aggatgctaa gaaggatgat gctgttcgga aagcctacaa
     1801 gtacctagct gccctgcatg agaattgcag tcagctcatc cagaccattg aggacacagg
     1861 cactatcatg agggaagttc gagatcttga ggagcagatt gagacagaga tgggcaagaa
     1921 gactttgagc aacctggaga agatctgtga ggactaccga gcccttcgcc aggagaatgc
     1981 tggcctcttg ggccgggtcc gagaggccta gagccctgat ggatgtctcc taaccacagg
     2041 caggaatttg gggtgctgga gacagtgctg aggcacctgt tctagcactc tctttcattt
     2101 ggtatccgct ttctcctgct gggatcttaa acccagctgt ctgcttatat gttcccatat
     2161 ctgatcaggg tgattgtcca gctgaccaca gtttattgga tgggcactgg gggccagggg
     2221 ccttggatcc caaataaaag agaagttctt ctgtggaaaa aaaaaaaaaa aaaa
//
