LOCUS       NM_029115               1938 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus coiled-coil domain containing 181 (Ccdc181), mRNA.
ACCESSION   NM_029115
VERSION     NM_029115.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1938)
  AUTHORS   Zhang,X.J., Hou,X.N., Zhou,J.T., Shi,B.L., Ye,J.W., Yang,M.L.,
            Jiang,X.H., Xu,B., Wu,L.M. and Shi,Q.H.
  TITLE     CCDC181 is required for sperm flagellum biogenesis and male
            fertility in mice
  JOURNAL   Zool Res 45 (5), 1061-1072 (2024)
   PUBMED   39245650
  REMARK    GeneRIF: CCDC181 is required for sperm flagellum biogenesis and
            male fertility in mice.
REFERENCE   2  (bases 1 to 1938)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1938)
  AUTHORS   Schwarz,T., Prieler,B., Schmid,J.A., Grzmil,P. and Neesen,J.
  TITLE     Ccdc181 is a microtubule-binding protein that interacts with Hook1
            in haploid male germ cells and localizes to the sperm tail and
            motile cilia
  JOURNAL   Eur J Cell Biol 96 (3), 276-288 (2017)
   PUBMED   28283191
  REMARK    GeneRIF: Ccdc181 is a binding partner of Hook1.  Ccdc181 localizes
            to the sperm flagella and to the basal half of motile cilia.
REFERENCE   4  (bases 1 to 1938)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1938)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: 4930455F23Rik is most abundantly expressed in tissues rich
            in highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060044.1 and BC048086.1.
            
            On May 7, 2009 this sequence version replaced NM_029115.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060044.1, AK076640.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               BC060044.1         1-108
            109-1938            BC048086.1         1-1830
FEATURES             Location/Qualifiers
     source          1..1938
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.59 cM"
     gene            1..1938
                     /gene="Ccdc181"
                     /gene_synonym="4930455F23Rik"
                     /note="coiled-coil domain containing 181"
                     /db_xref="GeneID:74895"
                     /db_xref="MGI:MGI:1922145"
     exon            1..164
                     /gene="Ccdc181"
                     /gene_synonym="4930455F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            165..305
                     /gene="Ccdc181"
                     /gene_synonym="4930455F23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1718
                     /gene="Ccdc181"
                     /gene_synonym="4930455F23Rik"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 181"
                     /protein_id="NP_083391.2"
                     /db_xref="CCDS:CCDS15434.1"
                     /db_xref="GeneID:74895"
                     /db_xref="MGI:MGI:1922145"
                     /translation="MDEDKDIDSKESGEYEDDFEKDLEWLINDKEKSNGSTIEMACKK
                     EDDLDQVLKENETETELGQQLSDPDNSPKDEALPRRNDFISVPSIQPLDPISDSDSEN
                     SFQDSKPENQKDLEDEEDEEVRRYIMEKIIEANKLLQTQEPVNDKRERKLKFKDKLVD
                     LEVPPLEDSDTCKALLENETNMSGKLSQLCISGDLEQESVLVSVTDGSCEENDRKILV
                     ERDGKFELMNLQDIESQGFLPPISSANSVEHESSQLPLRAPNPSVGGIKKEESEAKGH
                     VLPISPAGEPLAQVPQLLPNPKNRPSSAANPDVTKKARRSNHRIQSAGVSPVTSTYCL
                     SPRQKELQKQLERKREKLKREEEQRKLEEENEKKKENEMVFKAWLQKKREQVIEMRRV
                     QRAKQIEDMSSRQVNRDPQQAFRLWLKKKHEEQMKERKTEELRKQEECLFFLRGTEGR
                     ERAFRQWLRRKQIEKIAEQQAVKERARQLRLEARRSKQLQSSLYSIPEAKAFRFTDHY
                     N"
     exon            306..1253
                     /gene="Ccdc181"
                     /gene_synonym="4930455F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1400
                     /gene="Ccdc181"
                     /gene_synonym="4930455F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1555
                     /gene="Ccdc181"
                     /gene_synonym="4930455F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1896
                     /gene="Ccdc181"
                     /gene_synonym="4930455F23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1872..1877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc181"
                     /gene_synonym="4930455F23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1896
                     /gene="Ccdc181"
                     /gene_synonym="4930455F23Rik"
                     /note="major polyA site"
ORIGIN      
        1 ccggaagaag gcctcagagg cgcgctgttg ccatggcacc cgggtgctgg gtgcttcagg
       61 agcaggcccc ggggtgtcac cgttgcctcg ttgtcagagc ttagaaaagg agaagagagc
      121 tcctgcggcc atctctgtga ccccagccgc tgcatcttcc acagcattat tcattgataa
      181 gtggaaaaat ggatgaagat aaagatattg attcaaaaga gagtggagaa tatgaagatg
      241 actttgaaaa ggacttggag tggttgatca atgataaaga aaaaagtaat ggcagcacaa
      301 tagagatggc ttgcaagaag gaagatgatc ttgaccaggt attaaaagag aatgaaacag
      361 aaacagaact tggccaacag ctctctgatc cagataactc tccaaaggat gaggccttgc
      421 ccagaaggaa tgatttcatt tctgtcccaa gtattcagcc gttggatccc atatcagact
      481 cagacagtga gaactccttc caggattcca aaccagaaaa ccagaaagac ctggaggatg
      541 aagaggatga ggaagtaagg agatacatta tggagaaaat tatagaggct aacaagcttc
      601 ttcagactca agagcctgtg aatgataaga gggagcgaaa actgaagttc aaagacaaat
      661 tggttgatct ggaagtccca ccattagaag acagtgatac ttgtaaagct ctcttagaaa
      721 acgagaccaa tatgtctggg aaactgtccc agttatgtat ttctggtgac ttagaacaag
      781 agagtgttct cgtgtcagtt accgatggca gctgtgaaga aaacgatagg aagatactgg
      841 tggagagaga tggaaagttt gaacttatga atctgcagga cattgagagt cagggctttc
      901 tgccccccat tagcagcgct aatagtgtgg aacatgaatc ctcccagttg ccgctcaggg
      961 ctcccaaccc gtctgttggt gggatcaaga aagaagagtc tgaagcaaag ggtcatgtct
     1021 tgcctatctc tccagcagga gagccattgg ctcaggtccc tcagctactc cccaacccca
     1081 agaatcgtcc aagctctgct gccaacccag atgtaactaa aaaagccagg aggtccaatc
     1141 acaggataca gtcagcagga gtctctccag tgacctcaac atactgtctt tcaccacgac
     1201 agaaggaact ccaaaaacag ctggaacgaa agcgtgaaaa gctcaagagg gaggaagaac
     1261 agcgcaaact ggaggaagag aatgagaaga aaaaggagaa tgagatggtg tttaaagcat
     1321 ggctgcagaa gaaaagagag caggtcatag aaatgcggag agttcagcgg gcaaagcaga
     1381 tcgaagacat gagcagcaga caagtgaaca gagacccaca gcaagctttt cggttatggc
     1441 ttaagaaaaa gcatgaggag cagatgaaag aaaggaagac agaagaactc agaaagcaag
     1501 aggagtgttt gttcttcctg aggggaacag agggccgcga gagagccttt cgacaatggc
     1561 tcagaaggaa acagatcgag aagatagccg agcagcaggc tgtcaaagag agagccaggc
     1621 agctccggct cgaagcccgc cgctccaaac agctacagag cagcctgtac agcatacccg
     1681 aagccaaggc tttccgcttc accgaccact acaactgaag ccacccggga aagactacat
     1741 gtgaagccgc tggcaccagg atgttgtgtg ttgttcccca ggggccccat gtctcggcgt
     1801 cactacagat tgtgggagta ggatttgcct tttggtgatg ctggatttat gttgttttcg
     1861 cacaaacaca aaataaatgt ctctcacagt gttgaaaaaa aaaaaaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa aaaaaaaa
//
