LOCUS       NM_027616               3335 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus coiled coil domain containing 178 (Ccdc178), mRNA.
ACCESSION   NM_027616
VERSION     NM_027616.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3335)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3335)
  AUTHORS   Miyata,H., Castaneda,J.M., Fujihara,Y., Yu,Z., Archambeault,D.R.,
            Isotani,A., Kiyozumi,D., Kriseman,M.L., Mashiko,D., Matsumura,T.,
            Matzuk,R.M., Mori,M., Noda,T., Oji,A., Okabe,M.,
            Prunskaite-Hyyrylainen,R., Ramirez-Solis,R., Satouh,Y., Zhang,Q.,
            Ikawa,M. and Matzuk,M.M.
  TITLE     Genome engineering uncovers 54 evolutionarily conserved and
            testis-enriched genes that are not required for male fertility in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7704-7710 (2016)
   PUBMED   27357688
REFERENCE   3  (bases 1 to 3335)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029534.1 and BC145066.1.
            
            On Nov 19, 2009 this sequence version replaced NM_027616.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029534.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849384
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1030              AK029534.1         2-1031
            1031-2357           BC145066.1         1069-2395
            2358-2621           AK029534.1         2359-2622
            2622-2934           BC145066.1         2660-2972
            2935-3335           AK029534.1         2936-3336
FEATURES             Location/Qualifiers
     source          1..3335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 11.96 cM"
     gene            1..3335
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /note="coiled coil domain containing 178"
                     /db_xref="GeneID:70950"
                     /db_xref="MGI:MGI:1918200"
     exon            1..25
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            26..108
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            109..192
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..2732
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 178"
                     /protein_id="NP_081892.2"
                     /db_xref="CCDS:CCDS29092.1"
                     /db_xref="GeneID:70950"
                     /db_xref="MGI:MGI:1918200"
                     /translation="MPENEKEPAQPTTNEDALDTGKTCLQIKELKDKERALMLAENAR
                     MQGLSEFFFSRHEDKRLYESKSTNTEDVNKAIYFSYPSRRHSCTLVNIPKPCVNKMIS
                     HIEDVESKIQEHLTQFEASFEEWTSVTKDKEAGLDVSAPEKQVHPEKGKDEKCPELKK
                     RMETLLSEAIHLIKSLETDRAEAEQALKQHKSRKKKISMKIDSWSIWKLQELPLAVQK
                     EHENFSKINAELRSYLEDIALKVEQLQERKEKLEKANAKLQVDIDYMASHSVLLEKKR
                     KQELGCLKERYHKKFEVMEKFRAIHEELKESVDKCEGAKARLKNMKVENEREIQEELI
                     NATSYEKELDKLSVLDAHYTTSIETVNLDIEGDEEAMNEVLRETQSTTNELENLKKTV
                     DDLKRLFDQYCWRQRKYENEYLEAFSNFYSLKKTWDIELSNVSKDAKDLTIVYEAQSE
                     ENKRIQSEIQSITDDIEESIKKTAEMEEEVHTFVEMKMKNNNYLKQLYKQAYQVGAVY
                     HLSRHKTEELEDKLADLKRIFKGREELLKKLTRGDIATGIEIQKRLYAIEETQFIEMQ
                     EFIRRQVLYNMALLEVEEQLKELEAEAVRIRYLHRQHSKMLHNIRKRKERVKKNVDAT
                     KKKLLKKSKKSRMELTRTEGKRSIIHEEIEIARGQTVALHEKCIELSKEIRIMNLERT
                     NYEERLKKLQEEFFKLQFDREHVHGVYDHLMREKQYCEERIFEEERRFRRLIDMRKNT
                     LKNIRKCQDDLLEENLRLAKEYQSAQLIFLKEKESYFNGYDRLLSLNFSLSDKKKLCQ
                     LQKRLDQKWQEYFRLMILFNKTKLAKFQGDSQNSIQKILAVQEESSSLMQHILDFFKS
                     FPNSSCGEDD"
     exon            193..252
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            253..342
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            343..482
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            483..505
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            506..585
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            586..786
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            787..1007
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1150
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1304
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1400
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1537
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1721
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1784
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1946
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2060
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2206
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2366
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2516
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2651
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..3335
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3091..3096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3113
                     /gene="Ccdc178"
                     /gene_synonym="4921528I01Rik"
                     /note="major polyA site"
ORIGIN      
        1 agacaagtga aagctggcat agaggattct cacataacga ggggagtgta gctctcaaga
       61 tggcacacaa ggataggaac tgtttctgat ccccctgtgt ttccccaggt tttaaaatac
      121 tgtcaaaaat catgccagaa aacgagaaag agccagctca acctactacc aatgaggatg
      181 cacttgatac aggtaaaaca tgtcttcaaa taaaggagct caaagacaaa gaaagggcat
      241 taatgcttgc agaaaatgcc agaatgcaag gcttgtcaga attcttcttc tccagacatg
      301 aggataaaag gctttatgaa agtaaatcaa caaatacaga agacgtgaat aaagccatct
      361 acttcagcta cccaagtcgg cgacatagtt gtactttggt aaatatccct aaaccatgtg
      421 taaacaaaat gatttcccac attgaagatg tggaatctaa aatacaggag catttgacac
      481 aatttgaagc ttcttttgaa gaatggactt ctgtcacaaa agataaagag gcaggtttgg
      541 acgtctctgc tccagagaaa caagtccacc cagaaaaagg aaaggatgag aagtgtcccg
      601 agttgaagaa gaggatggag acattgctat cagaggccat ccacctcatt aaaagtctgg
      661 aaactgacag agcagaagca gaacaagctt taaaacaaca caaatcacga aagaaaaaga
      721 ttagcatgaa aattgactct tggtccattt ggaagctcca agaactccca ttagctgtac
      781 agaaagaaca tgagaacttc tccaaaatta atgcagagct gcgtagctat cttgaagaca
      841 ttgcccttaa ggtggagcaa ctgcaggagc ggaaggagaa gctggaaaaa gccaatgcga
      901 agctccaggt ggacatagac tacatggctt ctcatagtgt tctgctggag aaaaagcgca
      961 agcaggagct aggatgtctg aaagagcgtt accataaaaa gtttgaggta atggaaaaat
     1021 ttagagcaat tcatgaagag cttaaagagt ctgtggataa atgtgaaggt gcaaaagcaa
     1081 ggcttaagaa tatgaaagta gagaatgaaa gagaaattca agaagaatta ataaatgcaa
     1141 cgtcctatga gaaagaacta gataagctta gcgtcctgga tgcccactac acaacttcaa
     1201 ttgagactgt taacttggac attgaaggtg atgaagaagc catgaatgag gtgctgagag
     1261 aaacacagag cacaacaaat gaactggaga atttaaagaa aacagtagat gacttgaaaa
     1321 gactgtttga tcaatattgc tggagacaaa gaaaatatga aaatgagtac ctggaagcat
     1381 tttctaattt ttattcctta aaaaaaacat gggatattga gctttctaat gtttcaaaag
     1441 acgccaaaga tcttacaatc gtatatgagg cacagtcaga agaaaacaaa aggattcaat
     1501 ctgaaattca atccatcaca gatgacattg aagaaagtat aaagaaaaca gcagagatgg
     1561 aagaagaagt ccacacattt gtggaaatga agatgaagaa taacaactac ctaaaacagc
     1621 tctacaagca ggcctaccag gttggggctg tctaccacct ctctagacac aaaacggaag
     1681 agttggaaga taaactagca gatctgaaaa gaatattcaa gggtagagaa gaacttctga
     1741 agaagctcac aagaggggac atcgccacag ggattgagat tcagaaaagg ctgtatgcca
     1801 ttgaagaaac tcagtttatt gagatgcagg agtttatacg aagacaagta ctctataata
     1861 tggctttgtt agaagtagag gagcaactga aagagttaga agccgaggct gtgagaatca
     1921 ggtaccttca cagacagcac tctaagatgc tgcataatat acggaagagg aaagaaagag
     1981 ttaaaaaaaa tgtagatgca acaaagaaaa aattactaaa aaagagcaag aaaagccgca
     2041 tggaactcac aagaactgag ggaaaaagat ccataattca tgaagaaata gagatagcga
     2101 gaggccaaac agttgctctc cacgagaagt gcattgagct gagtaaggaa ataaggataa
     2161 tgaacctaga aaggacgaac tatgaagaaa gactgaaaaa gttgcaggaa gagttcttca
     2221 agctgcaatt tgacagggag cacgtgcacg gtgtgtacga ccatctcatg agagagaagc
     2281 agtactgtga agagaggatc tttgaagagg agaggaggtt ccgaaggctt atagacatga
     2341 ggaagaacac cctgaagaat atcaggaaat gtcaagatga tttactggaa gaaaacctgc
     2401 gtttagccaa agaatatcaa agcgcacagc ttattttctt aaaggagaaa gaatcttact
     2461 tcaatggata tgacagactg ctatcactca atttttctct ttctgataag aaaaagctct
     2521 gtcagctgca aaaaaggctg gaccagaaat ggcaagaata cttccgactg atgatccttt
     2581 ttaacaagac caagctggcc aagttccagg gagactccca gaacagcatt cagaaaatat
     2641 tagctgtgca ggaggaatcc tcaagcctaa tgcaacacat cttagatttc ttcaagagtt
     2701 tcccaaatag ttcatgtgga gaagatgact aaccaaacaa ccaatgtatc tcggaagctg
     2761 aaataaaaga caggaaaagt cgcacagttc agataacagt gtaattggac attcacctgt
     2821 ttgccatttc acacttccat ggacgaaaaa ctctcacctc ccagcatgct ttgccactct
     2881 cttacttaca gcaaatccat aacaatgaaa caggtgactt tcatgccgct gtcaggaacg
     2941 atctaatttc agctctgggt gactgattgc aattggcttt gcctcatctg ataattaatc
     3001 tatgtcacca ttaattggaa gagagaataa ttactggcgg tgttgacagt gactgctggc
     3061 ttccccagat ttccccaccg tgttggccca aataaaggct ttgtgagtca gtacttaaag
     3121 tttgtgtaaa ctgtaacagt gcctataccc atgtgacacc cttagatgct ctgtctaata
     3181 cacttttgtt tttgtgttta ccaatctttt ttagctcccc gagagctgtc tctctcaatc
     3241 actcctcaat gttctatctt aattttgtgg aagtttaaag ttttcaatga gctggagatg
     3301 aatgattaat gaataaattt aaatgcttca ttttg
//
