LOCUS       NM_001370992            5604 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus coiled-coil domain containing 170 (Ccdc170),
            transcript variant 1, mRNA.
ACCESSION   NM_001370992
VERSION     NM_001370992.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5604)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5604)
  AUTHORS   Liu,X., Li,Y.G., Tan,F., Liu,J., Yi,R. and Zhao,X.
  TITLE     Three functional polymorphisms in CCDC170 were associated with
            osteoporosis phenotype
  JOURNAL   Biol Open 10 (4) (2021)
   PUBMED   33785515
  REMARK    GeneRIF: Three functional polymorphisms in CCDC170 were associated
            with osteoporosis phenotype.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156275.6 and AC158617.9.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849382,
                              SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC156275.6         151194-151307       c
            115-243             AC156275.6         120942-121070       c
            244-500             AC156275.6         119510-119766       c
            501-645             AC156275.6         114772-114916       c
            646-831             AC156275.6         112882-113067       c
            832-1149            AC156275.6         99546-99863         c
            1150-1350           AC156275.6         91940-92140         c
            1351-1524           AC158617.9         236735-236908       c
            1525-1767           AC158617.9         233875-234117       c
            1768-2004           AC158617.9         224941-225177       c
            2005-5604           AC158617.9         219176-222775       c
FEATURES             Location/Qualifiers
     source          1..5604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.06 cM"
     gene            1..5604
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /note="coiled-coil domain containing 170"
                     /db_xref="GeneID:100504234"
                     /db_xref="MGI:MGI:2685067"
     exon            1..114
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2217
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 170
                     isoform 1"
                     /protein_id="NP_001357921.1"
                     /db_xref="CCDS:CCDS87950.1"
                     /db_xref="GeneID:100504234"
                     /db_xref="MGI:MGI:2685067"
                     /translation="MSHSSSLGSGSPECPCNSSPPEGTASHRPEVPDTWEQLNHYRNV
                     TENVQSELAAMLVKFECAQSELRELRSKMLSKEACCQELKVEMESYKESSARKSALLT
                     SLRGRMEELQEESAAVSASKSRAEASVHAMMKENQELMKKVLELDEKLQNCSKENEES
                     KKQGSEHLRRHEEFRAQLHDCLSLDKKHEEASDEDLILKLRELYKEPTFLKGQLATLE
                     ETVTVHEMEAKANRETIRRLAAEVSREQTKAASWAEEKDKLNQDLLSAVEGRTALERE
                     VKLYQERLLASQRAWDASKQELTQLRKRCQELDVSLKASREATTASQSRNSCFREKLT
                     ALLCSRFDTAESTEDAILERIRELGIEEESQRRMASQLEAQISEFVGKLGNESESHQK
                     ALQRAHVAEKKLEALQSQLSHLEGELLSGDVVRDNLFLEKQKYLKFLDQLTEKMKLGH
                     VAADLGFDVCLDVVLARIEQLVRLESNAVIENKTMAHNLQRKLKTQKERLESKEVHMN
                     LLRQKIAQLQQEKEARSALAVERDEAHLAMRKLEKKLERMQKELSACQEHNTELKAKL
                     ADTNELKIKTLEQTKAIEDLNQSRDELEKMKENAEKKLMLVMSELENTEQEARAHQER
                     SRAMIELASLELKTLRKSLDEAERRGMQLADFREVVSSMLGLNMTSHDPPDYEIIKCL
                     ERLLHSHRHHHHHHFVPCACLQDMAAEQGSCSHCRVEIPH"
     exon            115..243
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /inference="alignment:Splign:2.1.0"
     exon            244..500
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /inference="alignment:Splign:2.1.0"
     exon            501..645
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /inference="alignment:Splign:2.1.0"
     exon            646..831
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1149
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1350
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1524
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1767
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..2004
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..5604
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5580..5585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /note="hexamer: AATAAA"
     polyA_site      5604
                     /gene="Ccdc170"
                     /gene_synonym="Gm221"
                     /note="major polyA site"
ORIGIN      
        1 agtgctcctg catcttgggt cccagcagca tctcccgacc cagccagcat gagccacagc
       61 agctccttgg gctccgggag tccggaatgt ccctgcaact cctcacctcc agagggaact
      121 gccagtcatc gcccagaagt ccctgatacc tgggaacagc tgaaccacta ccggaatgtg
      181 actgaaaatg ttcaaagtga gcttgcagca atgctggtca aatttgaatg tgctcagtcc
      241 gagcttcgag aactccgctc caagatgctt tctaaagaag cttgctgtca ggagctgaag
      301 gtggaaatgg agagctataa agaaagcagt gccagaaagt cagctctcct cacgtctctg
      361 aggggcagga tggaggagct ccaggaggaa tcagcagcgg tttcagcttc taaaagcaga
      421 gcagaggcct ctgttcacgc catgatgaag gagaaccagg aactaatgaa gaaagttcta
      481 gaactggatg agaaattaca aaactgttca aaggaaaatg aggagtctaa gaaacaaggc
      541 tcagagcacc tccggaggca cgaggaattt cgggctcagc ttcatgattg cttgagtcta
      601 gacaagaagc atgaagaggc atcggatgaa gatttaattt taaagcttag agagctgtac
      661 aaggagccca cattcctgaa aggacagctc gctactcttg aagagactgt aactgtccat
      721 gagatggagg caaaggctaa cagagaaact atcaggaggc tggcagccga agtcagcagg
      781 gagcagacaa aagctgcctc ctgggcagag gagaaagaca agctgaatca ggacttgctc
      841 agtgctgtgg aggggagaac agctctagaa agggaagtga agctctacca agaacggctg
      901 cttgcatctc agcgagcctg ggatgcctcg aagcaggagc tgacccagct gaggaaacgc
      961 tgccaggagc tggatgtgag cttgaaggcc agcagggagg ccaccacagc ctcgcagagc
     1021 cggaactcct gcttcaggga gaaactcaca gctcttcttt gcagcagatt cgacacagct
     1081 gaatccacag aggatgccat attggagagg attcgagagc taggcattga ggaggagagc
     1141 cagagaagga tggcctctca gcttgaagcc cagatctctg agtttgttgg gaagttggga
     1201 aatgaatctg agtctcacca gaaagcccta cagagggccc atgtggcaga aaagaagttg
     1261 gaggctcttc agagtcagct gagtcacctg gagggagagc tgctttctgg agacgtcgtg
     1321 agagacaact tgtttctaga gaagcaaaaa tatctgaagt ttctggacca gctgacagag
     1381 aaaatgaagt tgggccacgt agctgctgac cttggctttg acgtgtgtct ggatgtagtt
     1441 ctagctcgca tagagcagtt agttcgcctt gaaagcaatg ctgtcattga aaacaagacc
     1501 atggctcaca acttacagag gaagctaaag actcagaaag aaagactgga gagcaaagaa
     1561 gttcatatga acctccttcg gcagaaaatt gcccagctgc agcaggagaa agaggcgcgc
     1621 tcagccttgg ctgtggagag ggacgaagcc catcttgcca tgaggaagct ggagaagaag
     1681 ctggagagga tgcagaagga gttgagtgcg tgtcaggagc acaacactga gctcaaagcc
     1741 aaactggcag acaccaatga actcaagatt aaaaccttgg aacagaccaa agccattgaa
     1801 gatttaaatc aatcccgaga cgagctggag aagatgaagg agaatgcaga gaaaaagctc
     1861 atgttggtca tgtctgagct ggaaaacaca gagcaggagg ctcgagcaca ccaggaaaga
     1921 agcagagcca tgatagagtt ggccagcctt gaactgaaga ccctgaggaa gtctttggat
     1981 gaagcggaga ggagaggaat gcagctggca gacttcagag aggtggtttc cagtatgctg
     2041 ggcttgaaca tgacctctca cgatcctccc gactatgaga tcatcaagtg tctggaaaga
     2101 ctgctccatt cacaccgcca ccaccaccac caccactttg ttccctgtgc ctgcctccaa
     2161 gacatggctg ctgagcaagg cagctgctca cactgccgtg tggaaattcc gcattgatca
     2221 cttgcctccc tgagggagga actaagggag ggggtacgat tctccagttg tgcagttcat
     2281 acattcctca tatttttgaa attcagccat agtgtgtgac taatatattc tctgatgact
     2341 tactaagaat atatcacctg tgaaaagatc tcccaaagtg ccatccctag ggccagagaa
     2401 agtaaaggca cttgctgcca agcctggcaa cccgagttct gtccttggga cacacatggt
     2461 agaaggaaga gaagtgactt ttgcaagctg tcctctgacc tatacacatg ctttgtaact
     2521 taagtgttta cacacacaca cacacacaca cacacacaca cacacacaca cacacacaga
     2581 gtaagtgaat gtaaaaaaaa aaaaggccag tcctagataa atattcagca ctaaaaccac
     2641 ctattactta attagttagc acattgagac ctacaggaat ccctagattc atgcctacat
     2701 tgggacatat gtgcacagag ttcagaaaag cagagcatct tagctagagt attactgatg
     2761 agtttaaatc ttaagatacc atgcgcagaa gttttctgaa aatattactt aaaattattt
     2821 tatatttagg tgtgtgtgtg cgcgtacgcg caggggccag cagacaccat agagagagtg
     2881 agattctttg gcattagagt tacaggcact tgatgtgctt gctgggaacg gaacttaggt
     2941 cccctgaaag agtagcaagt gcagttaacc atctctccag ccccacaaaa cctgtctgtc
     3001 tgtctgtctg tctgtctgtc tacatacaat ttgatacata gtatctggac ctgtttatag
     3061 atttctgagt ggccttccaa tccacacata caaggtgtaa ctatgagatc acggtaacat
     3121 ggtagagtct taaaacattt atttacatgc tttccagagc ccagaaacaa ttgaactaac
     3181 tcaatgcatg agttgtgcat ggttagtagt ggagccagga tgtacaagat agaggctgta
     3241 ccacttgtaa cccacagttt cagattcaac ttggttttga ggctgatagg acttgctgga
     3301 atgaaggaag gaaggaaggc aactctacga tcaggaggag acttctaaag gcagcagagt
     3361 ttaaaaagtg actcatttga atagccctca cataggactg aggcacggta agaaatgtgt
     3421 atgcatttat ttatttatta ttattttttt tgttcttcga gacagggttt ctctgtgtag
     3481 tcctggctgt cctggaactc actgtgtagg cctcaggctg gcctcagaaa tctacctgcc
     3541 tctgtctccc aagtgctggg attaaaggca tgcgccacca ctgcctggcg tgtatgcttt
     3601 tattactgct ccaaatggca gctttgaaag tgtgaacagg gctaaccgca gttctttaaa
     3661 atcaaaatct ctcacccaag cctaggttga taggatggat aaatcctctt aagtttcatt
     3721 cactatatta gtcagggttt tactgctgtg aacagatacc atgaccaagg caaatcttat
     3781 aaaaacaaca tttaattggg gctggcttac aggttcagag gttcagtcct ttatcatcaa
     3841 ggtgggagca tggcagcatc caggcaggca tggcactggt gcaggcagag ctgagagttg
     3901 tacctcttca tccaaaggct gctagtggaa gactgacttc caggcaccta gggtgagagt
     3961 attatgccca catccacagg aatacaccta ctccaaccag gtcacaccta ttccaacaag
     4021 gccatacctc caaatggtgc cacgccctgg tccaagaata tacaaaccat cacattcacc
     4081 aatgtataaa atactcttaa cagtgaagga acattttcat ggtcttgatt ctatcataaa
     4141 taaattcctc tcatctttca aaacttccgt tggataaata tatcgtaaaa aaccatattc
     4201 ttagcattac tgacaatgtt ttctattgga tagtttatct tcttttaaat atatgaaata
     4261 taaacctata aattgtctct gattgttgtg tatacgtgtg tgagagagca agagctacaa
     4321 ctgtagagtg gggtatgcac acgtttgtgc aggtgctgtg cctttgtatg tgtataaaag
     4381 gccaccaaag gacatcaggt tcaccctcta tccctttcca ccttatttcc ttggggtaga
     4441 gtctgccatt gaacctggag ataggctggc agctactgaa ctctgccatc ctcctgtctc
     4501 ccggggcgga gtgactgatc cagctggaat ctgaattcag gtctttatgc aagagtcatc
     4561 tctccagtcc cagcttgtat ctttatgtgt ccgattaacc aaccaaccaa acaaacaaac
     4621 aaaaccacaa acagctctag tgccttacaa cattaagaga aaatgagaaa ttatacagct
     4681 aactcttgtc tcacagccat gaacaaggca caagctgatt caagactaca cacgataaag
     4741 gagccatagc aacccattgc aaagcttgga aagatatact agtttgtgac aaaaggcata
     4801 agaatattct tgcaataact tgagtaaatg gctcatccaa tatattttta aagttatact
     4861 gcttccttca gtcacggggg tgtacacatg gaatctcagc cctcagggca ctgagccaag
     4921 aggattgagt ttgaagtcac ttggggccac atcgtgagtt tcgggcaagc ctagactaca
     4981 gagtgaaact caatctcaaa ccatgctaac aaccaaacaa ccaacttgtt aacttattag
     5041 ccattcctcc tgcaaccctt aacaaaacaa ataaccatat taggttagct tttacctcct
     5101 tttgccggac tgtatgtgtc taaaggaata agtgtattgt gtttttttcc ttttgattgg
     5161 tcatgaatta cctattaggg ttcatgtaag agactaataa taactcatag tagttatctc
     5221 tgtgcttaat catgtgaaat ttcattttgt ttatccacat atatggctcg tgtttaaata
     5281 acaattcttg atacatatat taatattcca aatatgtaac ctagagatgt ccagtgaaag
     5341 gatatgtggc atgagcgtaa ataaattctg tgcctgcaga tagttcacgc acactgtaac
     5401 agtttgttat ttgggcaaac tgaaaatgtg ttagcataaa gccctgtcct tcatgtcaaa
     5461 atgccagttg gttgctggcc tttcctttgt gcacaaattc cagagttggc agggctagct
     5521 tcacatttct gtactatgtt ttgtttttct ataatatcca tgtatatttt atatcatgca
     5581 ataaaatgca tttgatgaac gtga
//
