LOCUS       NM_025977               1531 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus coiled-coil domain containing 159 (Ccdc159),
            transcript variant 2, mRNA.
ACCESSION   NM_025977
VERSION     NM_025977.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1531)
  AUTHORS   Ge,T., Yuan,L., Xu,L., Yang,F., Xu,W., Niu,C., Li,G., Zhou,H. and
            Zheng,Y.
  TITLE     Coiled-coil domain containing 159 is required for spermatid head
            and tail assembly in micedagger
  JOURNAL   Biol Reprod 110 (5), 877-894 (2024)
   PUBMED   38236177
REFERENCE   2  (bases 1 to 1531)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1531)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011114.1 and BC120702.1.
            
            On Sep 3, 2009 this sequence version replaced NM_025977.2.
            
            Transcript Variant: This variant (2) uses a different splice site
            at the 5' end which results in the use of a downstream start codon,
            compared to variant 1. The resulting protein (isoform 2) has a
            shorter and distinct N-terminus when compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011114.1, BC120702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               AK011114.1         2-388
            388-1494            BC120702.1         363-1469
            1495-1531           AK011114.1         1496-1532
FEATURES             Location/Qualifiers
     source          1..1531
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.92 cM"
     gene            1..1531
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /note="coiled-coil domain containing 159"
                     /db_xref="GeneID:67119"
                     /db_xref="MGI:MGI:1914369"
     exon            1..258
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1459
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /note="isoform 2 is encoded by transcript variant 2;
                     coiled-coil domain-containing protein 159"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 159
                     isoform 2"
                     /protein_id="NP_080253.2"
                     /db_xref="CCDS:CCDS40557.1"
                     /db_xref="GeneID:67119"
                     /db_xref="MGI:MGI:1914369"
                     /translation="MNGCDSLLAGLSRDSDDCVSHLCTPPLLAITSWAAKERSQYSPP
                     PGEPGPSSDKALDCMTHWSRVLEPEIVNTASEQAGKSGAWEKEWDSEPQPHEGTPCSS
                     SDVNKDHYHDQDLVKRNHCVAKKSLEPSSAKVKVKNTMIIPDSQKLLRCELESLRSQL
                     QAQSKAFEFLNHSVTMLEKESCLQQIKIQQLEEVLSPTSRQGEKYGRKWSTEQELYGA
                     LAQGLQGLQKTLKEGEELQRARTTRCLQLLAREIRDSKKFLWEELELVREEVTFIYQK
                     LQDQEDEISENLLNIQKMQKTQVKCRKVLTKMKQQAYDSWPEAEGVPTEGNGCCKDDL
                     QKELGDIWSAVHSLQSSIDCLALSMGTRPRASSLRGQKGHQCKSSQCPSWDSDSDWER
                     PFSKSGSYPPA"
     exon            259..392
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            393..619
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            620..653
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            654..742
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            743..824
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1011
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1079
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1156
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1272
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1355
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1454
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1531
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1501..1506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1526
                     /gene="Ccdc159"
                     /gene_synonym="2510048L02Rik"
                     /note="major polyA site"
ORIGIN      
        1 agttggcttg cgggaatcaa ctggccatct cgcctctccg gacttcatcc agtctcaccg
       61 aagatgcgca ggcgccaatg agctccgcgc ctgagcggag tgaacgggcg tggcttatgg
      121 gaggaccacg cccttctctg tgactccacc tttggcctcc cctcgttttc caacgatggt
      181 gtcctcaggg gatcaaaact tcagcgtcac agctggggac tggcttcgtg gtccctgatg
      241 ggagagcatg aacgggtgtg actctctttt ggctggccta tcccgggact ctgacgactg
      301 tgtttctcat ctctgcacac ctccgttact cgccatcaca tcttgggctg ctaaggagag
      361 gagccagtac tcaccacctc ctggagagcc tgggccctcc tcagacaagg ctttggactg
      421 tatgacccac tggtccaggg ttttggagcc tgagatcgtg aacactgctt ctgaacaagc
      481 agggaagtct ggggcctggg agaaggagtg ggactcagaa ccacagcctc atgagggtac
      541 accctgttcc agctcagacg tgaacaagga ccattatcat gaccaggacc ttgtgaagag
      601 gaaccactgt gtagccaaga agtccctgga gcccagctca gccaaagtaa aagttaagaa
      661 caccatgata attcctgact ctcagaagct cttgcgatgc gaactggagt ctctcaggag
      721 ccagctgcag gctcagagca aggctttcga gttcctgaat cactctgtga ccatgctgga
      781 gaaggagagc tgcctacagc agatcaagat tcagcagctt gaagaagtgc tgagccccac
      841 gagccgccaa ggagagaagt atggccgtaa gtggagcaca gagcaggagc tgtatggggc
      901 cctggctcaa ggcctgcagg ggttgcagaa gacactgaag gaaggcgagg agctgcaacg
      961 ggcccgtacc actcgctgcc tgcagctgtt ggcccgggag atccgggaca gcaagaagtt
     1021 cctgtgggag gaactggagc tggtgcggga agaggtgact ttcatctatc agaaactcca
     1081 ggaccaggag gatgagatct cagagaatct cctgaatatc cagaagatgc agaaaactca
     1141 ggtgaagtgc cgcaaggttc ttaccaagat gaagcagcag gcatacgatt catggccaga
     1201 agccgagggg gtgcccacag aaggcaacgg ttgctgtaag gatgacctcc agaaggagct
     1261 gggtgacata tggtctgccg ttcacagtct gcagagctcc attgactgtc ttgctttgtc
     1321 aatgggcacc agacccaggg cctccagcct cagaggccag aaaggacacc agtgcaagag
     1381 ctctcagtgc ccctcctggg actccgattc agactgggag agacctttca gcaagagtgg
     1441 atcctaccct cccgcttgag cagctgggac tgcttgccct gaagatccct ccagagagaa
     1501 aataaactag ctgagacctt tctccaccct g
//
