LOCUS       NM_029195               3389 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus coiled-coil domain containing 146 (Ccdc146), mRNA.
ACCESSION   NM_029195
VERSION     NM_029195.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Ye,J.W., Abbas,T., Zhou,J.T., Chen,J., Yang,M.L., Huang,X.H.,
            Zhang,H., Ma,H., Ma,A., Xu,B., Murtaza,G., Shi,Q.H. and Shi,B.L.
  TITLE     Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in
            humans and mice
  JOURNAL   Zool Res 45 (5), 1073-1087 (2024)
   PUBMED   39245651
  REMARK    GeneRIF: Homozygous CCDC146 mutation causes
            oligoasthenoteratozoospermia in humans and mice.
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Muronova,J., Kherraf,Z.E., Giordani,E., Lambert,E., Eckert,S.,
            Cazin,C., Amiri-Yekta,A., Court,M., Chevalier,G., Martinez,G.,
            Neirijnck,Y., Kuhne,F., Wehrli,L., Klena,N., Hamel,V., De
            Macedo,L., Escoffier,J., Guichard,P., Coutton,C., Mustapha,S.F.B.,
            Kharouf,M., Bouin,A.P., Zouari,R., Thierry-Mieg,N., Nef,S.,
            Geimer,S., Loeuillet,C., Ray,P.F. and Arnoult,C.
  TITLE     Lack of CCDC146, a ubiquitous centriole and microtubule-associated
            protein, leads to non-syndromic male infertility in human and mouse
  JOURNAL   Elife 12, 86845 (2024)
   PUBMED   38441556
  REMARK    GeneRIF: Lack of CCDC146, a ubiquitous centriole and
            microtubule-associated protein, leads to non-syndromic male
            infertility in human and mouse.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3389)
  AUTHORS   Ma,Y., Wu,B., Chen,Y., Ma,S., Wang,L., Han,T., Lin,X., Yang,F.,
            Liu,C., Zhao,J. and Li,W.
  TITLE     CCDC146 is required for sperm flagellum biogenesis and male
            fertility in mice
  JOURNAL   Cell Mol Life Sci 81 (1), 1 (2023)
   PUBMED   38038747
  REMARK    GeneRIF: CCDC146 is required for sperm flagellum biogenesis and
            male fertility in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3389)
  AUTHORS   Martinez,G., Coutton,C., Loeuillet,C., Cazin,C., Muronova,J.,
            Boguenet,M., Lambert,E., Dhellemmes,M., Chevalier,G.,
            Hograindleur,J.P., Vilpreux,C., Neirijnck,Y., Kherraf,Z.E.,
            Escoffier,J., Nef,S., Ray,P.F. and Arnoult,C.
  TITLE     Oligogenic heterozygous inheritance of sperm abnormalities in mouse
  JOURNAL   Elife 11, e75373 (2022)
   PUBMED   35451961
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3389)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: 4930528G09Rik is most abundantly expressed in tissues rich
            in highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK015926.1, AC113052.10, AK220398.1 and AU018841.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1089              AK015926.1         1-1089
            1090-1176           AC113052.10        165928-166014       c
            1177-1363           AC113052.10        164728-164914       c
            1364-1459           AC113052.10        157535-157630       c
            1460-1630           AC113052.10        156555-156725       c
            1631-1719           AC113052.10        153455-153543       c
            1720-1884           AC113052.10        153195-153359       c
            1885-1913           AC113052.10        151202-151230       c
            1914-3093           AK220398.1         1-1180
            3094-3384           AU018841.2         1-291               c
            3385-3389           AC113052.10        140903-140907       c
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 9.83 cM"
     gene            1..3389
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /note="coiled-coil domain containing 146"
                     /db_xref="GeneID:75172"
                     /db_xref="MGI:MGI:1922422"
     exon            1..113
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            114..346
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..3058
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /codon_start=1
                     /product="coiled-coil domain-containing protein 146"
                     /protein_id="NP_083471.1"
                     /db_xref="CCDS:CCDS51427.1"
                     /db_xref="GeneID:75172"
                     /db_xref="MGI:MGI:1922422"
                     /translation="MEYNSKDAEEETEDEEEGLKEAEGEEQEKEEVTATSETDDDQED
                     LPSVLVPTVNIREERLINLAETPAFLCLHELHSKGKLPGTRMAELKAKYTLLHDTVVS
                     TQESEVQLLENAKRFTEQIQQQQVCLQQAEDFPNVFTTEVCKLREQLLKYQNEYTAAQ
                     EREYNIQYRLTSLTEEKSIILKEFEKIPKPGEIEKKTRLLKESTEELRKEVIQRRLEI
                     KNLREDVVLKQKQLVREQKELEELMEYQVGLKDDVVHHQSVPVQITKEIEKMTRKKVE
                     TEKKNIVLESELKELSDSLKKLENKVNTLAEERDDIMKEVEGKRTLLEVKEREYGQLL
                     KLLELTKENEASSLAERGILDINLRNCLIDKQNYHDELSRKQREKERDFRNLKKTELL
                     LKVSLDALTQAQAMNQRLLLEMEAIPKEYLTLPERRKELHKEVDLARRNLAQQKSLSE
                     AEAKLVEQQIAQENKLLKEQESLRELVFNLGRMTQIKIDEKEQKAKDFLKAQRRYSEI
                     VKEIKSKDLEIRLYKKRKHEIHRRLREFASLYDTIRNERNKFVNLLHKAHQKVNEIKE
                     RLKMSLNELEILRNSAVSQERKLQNAMLKHSNNVTIKESIQNDVCKITAKLQEMKEKK
                     EAQLTSMDRLASMITVIEEEMVQLRKKYEKAVQRRNESGVQLIEREEEVCIFYEKVNV
                     QEKIKLHQDVEIHILEEKIRFLKLRIAEKQRQISVTRKLVPIKKSLDADLAVIQIQFS
                     QCTDRIKDLEKLFVNPDSKGRVRFIKGKDLTEEEMIKKLDMLELQIAKKEEKLLEKDF
                     IYEQVSQLTNRLKGKTQACKKDTLLLAKKMNSYQQKIKVVTQEMMALVAELSMKQALT
                     IELQKEVREKEEFIFSCSARIEKGLPLNREIEKDWLKVLRDEEMYAFATAEMSREYME
                     TDYRQLPNGVYTTAEQRPNAYMPEADTELPLPKPYGAMAPFKPSEPGANRRHIRKPVV
                     KPIEI"
     exon            347..429
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            430..639
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            640..697
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            698..874
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            875..948
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1176
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1363
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1459
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1630
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1719
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1884
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2109
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2338
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2467
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2605
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2854
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3389
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3366..3371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /note="hexamer: AATAAA"
     polyA_site      3386
                     /gene="Ccdc146"
                     /gene_synonym="4930528G09Rik; mKIAA1505"
                     /note="major polyA site"
ORIGIN      
        1 gataccaagg acgcgactct taggagaggg tgaagttttg aagtgagacc ccagggacca
       61 aaacacacgg agaaaaataa gagtttaaac aaggatcagg accaaaagaa aggaactgtg
      121 aaaaatggaa tacaatagca aagatgcaga agaagaaact gaagatgaag aggagggact
      181 gaaggaggcg gagggggagg aacaggagaa ggaggaggta acagcaacct cagaaacaga
      241 cgatgaccaa gaagacctcc cttctgtctt agtgcctaca gttaacattc gggaggagcg
      301 gctcatcaat ttagctgaaa caccagcttt cctctgtctg catgagctgc actccaaggg
      361 aaaacttcct ggaaccagaa tggcagagtt gaaagccaag tacaccttgc tacacgatac
      421 agtggtgagc acgcaggagt ctgaggtgca gctactggag aacgccaagc gcttcacgga
      481 gcagatccag cagcagcagg tctgtctgca gcaggccgaa gacttcccca acgtcttcac
      541 cactgaggtc tgcaaacttc gggagcagct gctcaagtac caaaatgaat acacggcagc
      601 gcaagaaagg gagtacaata ttcagtacag gctgactagc ttaacagaag aaaagagtat
      661 catattaaag gaatttgaga agatacctaa gccaggagaa atagagaaga agacgaggct
      721 cctgaaagaa agcactgagg aactgcgcaa ggaggtgatt cagaggagac tggagatcaa
      781 aaacctgcgg gaagatgtgg tgctcaagca gaagcagcta gtgagggagc agaaggagct
      841 ggaggagctg atggagtatc aggttggctt gaaggatgac gtggtccacc atcaaagtgt
      901 tcctgtacaa attacaaagg agatagaaaa aatgacacgc aaaaaagtag aaacagagaa
      961 gaaaaatatt gtcttggaat ctgagttgaa agagctaagt gactctttaa agaagcttga
     1021 aaacaaagtc aacactcttg cggaagaaag ggatgacata atgaaggaag ttgagggcaa
     1081 gcgaacctta ctagaagtca aagaacgaga gtatggccaa ctgcttaaac tattggaact
     1141 aaccaaagag aacgaagcct cctcgctagc tgaaagaggg atcttggata tcaatctacg
     1201 gaactgtctc atcgacaagc agaactacca tgatgaactt tctcgtaagc aaagagagaa
     1261 agaacgagat tttcggaatc tgaagaagac agagctgctc ctgaaagtgt ctttggatgc
     1321 gctcactcag gcacaagcca tgaatcaaag gcttctacta gagatggaag ctatcccaaa
     1381 agaatacctt acattgcctg aacgaaggaa agagctccac aaagaggttg atctagctag
     1441 gagaaatctg gctcaacaga aatctctgtc agaagctgag gccaagttag tggagcagca
     1501 gattgcacag gagaacaaac ttctaaagga gcaagaaagt ttgcgggagc tggtgttcaa
     1561 cctcgggcga atgactcaga tcaaaataga tgagaaagaa caaaaggcta aggatttcct
     1621 gaaagcccag cgaagatata gtgagattgt taaggaaatc aaatcaaagg accttgaaat
     1681 caggctatac aagaagagaa agcatgaaat tcataggaga ctcagagaat ttgccagctt
     1741 gtatgataca attagaaatg aaagaaacaa atttgtaaac ctacttcaca aagctcatca
     1801 gaaagtaaat gagataaaag aaagactcaa aatgtcatta aatgagctgg aaatcttaag
     1861 gaacagcgct gtctctcaag aacgaaagct acaaaacgcc atgctaaagc attccaacaa
     1921 tgtgaccatc aaggagagca tacagaacga tgtgtgcaaa atcactgcta aactccagga
     1981 aatgaaggag aagaaggagg cccagctgac cagcatggac aggctggcca gcatgatcac
     2041 cgtgatcgaa gaggagatgg tgcagctgcg caagaagtat gagaaggccg tacagcggcg
     2101 gaatgaaagt ggtgttcagc tgatcgagcg ggaagaagaa gtgtgcattt tttacgaaaa
     2161 agtgaatgtc caagagaaga taaaacttca tcaggatgtt gaaatccaca ttctggaaga
     2221 aaaaatccga ttcctaaaac tgaggattgc cgaaaagcaa aggcagattt ctgtgacacg
     2281 gaaactagtg ccaatcaaga agtccctgga tgccgacctg gctgtgatcc agattcagtt
     2341 ttcacagtgc acagacagga taaaagacct ggagaaactc tttgtgaacc ctgacagcaa
     2401 gggcagggtc cgcttcatta aagggaaaga tctgactgaa gaagaaatga tcaagaaatt
     2461 agatatgctg gaacttcaga tagccaagaa ggaggagaag ctcctggaga aggatttcat
     2521 ctatgagcag gtgtcccagc tcacaaacag gctcaaaggc aaaactcagg cttgcaagaa
     2581 ggacacactg ctcttagcca agaagatgaa tagctaccaa caaaagatca aagttgttac
     2641 ccaggaaatg atggctcttg ttgctgagct gtccatgaaa caagccctga ccattgaact
     2701 ccaaaaggag gtgagagaga aagaagaatt catcttctcc tgcagtgcca ggatagaaaa
     2761 gggcctcccg ctcaacagag agattgagaa ggactggctg aaggtgcttc gagatgaaga
     2821 aatgtatgcc tttgcgactg ctgagatgtc tcgggagtac atggaaacgg attatcggca
     2881 gctgcccaat ggtgtttata caactgcaga gcagcgtcca aacgcctaca tgcctgaagc
     2941 agataccgag cttcctctgc ccaaaccgta tggcgcgatg gctccattta agccctctga
     3001 acccggagcc aacaggaggc acattaggaa acctgttgta aagcccattg aaatctaaac
     3061 atgtgaacca acccagcagt cctctcacag agagggcctg agccaagcct cagaccttct
     3121 atggagaatg agcaccaggg ttctagggct gctgatgagc caggcacggt caacaacaat
     3181 gggttgtttc caaagcagtg gcttccttgt acattcacca actattacct ggtaagtgac
     3241 actgaatggg acatagacta cagctgtgtc aaagggcatt ttgattgttc atgtgtttct
     3301 ttttcactgc ttatagttac tacacctcag gaatgtacag tagacaagat gctgtaaaag
     3361 tacaaaataa ataacttttc agtgaagta
//
