LOCUS       NM_001025576            6329 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus coiled-coil domain containing 141 (Ccdc141), mRNA.
ACCESSION   NM_001025576 XM_619767 XM_886279 XM_896648 XM_896657 XM_896667
            XM_896676 XM_896697 XM_896711 XM_896724 XM_912240 XM_922274
            XM_922277 XM_922280 XM_922286 XM_922295 XM_922299 XM_922303
            XM_922309
VERSION     NM_001025576.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6329)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6329)
  AUTHORS   Okuda,S., Sato,M., Kato,S., Nagashima,S., Inatome,R., Yanagi,S. and
            Fukuda,T.
  TITLE     Oscillation of Cdc20-APC/C-mediated CAMDI stability is critical for
            cortical neuron migration
  JOURNAL   J Biol Chem 297 (2), 100986 (2021)
   PUBMED   34298015
  REMARK    GeneRIF: Oscillation of Cdc20-APC/C-mediated CAMDI stability is
            critical for cortical neuron migration.
REFERENCE   3  (bases 1 to 6329)
  AUTHORS   Fukuda,T., Nagashima,S., Inatome,R. and Yanagi,S.
  TITLE     CAMDI interacts with the human memory-associated protein KIBRA and
            regulates AMPAR cell surface expression and cognition
  JOURNAL   PLoS One 14 (11), e0224967 (2019)
   PUBMED   31730661
  REMARK    GeneRIF: KIBRA inhibited CAMDI-dependent Rab11 activation, thereby
            attenuating AMPAR cell surface expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6329)
  AUTHORS   Fukuda,T., Nagashima,S., Abe,T., Kiyonari,H., Inatome,R. and
            Yanagi,S.
  TITLE     Rescue of CAMDI deletion-induced delayed radial migration and
            psychiatric behaviors by HDAC6 inhibitor
  JOURNAL   EMBO Rep 17 (12), 1785-1798 (2016)
   PUBMED   27737934
  REMARK    GeneRIF: findings showed that CAMDI regulates neuronal migration
            through the modulation of HDAC6 and indicate that HDAC6
            hyperactivation by CAMDI deletion causes psychiatric behaviors, at
            least in part, through delayed radial migration due to impaired
            centrosomes
REFERENCE   5  (bases 1 to 6329)
  AUTHORS   Hutchins,B.I., Kotan,L.D., Taylor-Burds,C., Ozkan,Y., Cheng,P.J.,
            Gurbuz,F., Tiong,J.D., Mengen,E., Yuksel,B., Topaloglu,A.K. and
            Wray,S.
  TITLE     CCDC141 Mutation Identified in Anosmic Hypogonadotropic
            Hypogonadism (Kallmann Syndrome) Alters GnRH Neuronal Migration
  JOURNAL   Endocrinology 157 (5), 1956-1966 (2016)
   PUBMED   27014940
  REMARK    GeneRIF: Ccdc141 is expressed in GnRH neurons and olfactory fibers
            during embryonic development and that knockdown of Ccdc141 reduces
            GnRH neuronal migration.
REFERENCE   6  (bases 1 to 6329)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 6329)
  AUTHORS   Fukuda,T., Sugita,S., Inatome,R. and Yanagi,S.
  TITLE     CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding
            protein, is required for radial migration
  JOURNAL   J Biol Chem 285 (52), 40554-40561 (2010)
   PUBMED   20956536
  REMARK    GeneRIF: CAMDI is required for radial migration probably through
            DISC1 and myosin II-mediated centrosome positioning during neuronal
            development.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB637559.1, AK045498.1, AK053175.1, AK084521.1 and AL928681.5.
            
            On Jun 30, 2010 this sequence version replaced NM_001025576.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The genomic coordinates used for
            the transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.2580.1,
                                           SRR9219382.33157.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BB637559.1         1-26
            27-873              AK045498.1         2-848
            874-2543            AK053175.1         860-2529
            2544-2544           AK084521.1         1639-1639
            2545-3023           AK053175.1         2531-3009
            3024-3209           AL928681.5         62830-63015         c
            3210-3393           AL928681.5         61186-61369         c
            3394-3506           AL928681.5         57040-57152         c
            3507-3623           AL928681.5         53507-53623         c
            3624-4477           AL928681.5         47988-48841         c
            4478-6329           AL928681.5         43500-45351         c
FEATURES             Location/Qualifiers
     source          1..6329
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 45.38 cM"
     gene            1..6329
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /note="coiled-coil domain containing 141"
                     /db_xref="GeneID:545428"
                     /db_xref="MGI:MGI:1919735"
     exon            1..251
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            252..374
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            375..566
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            567..675
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            676..929
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1046
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1241
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1414
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1556
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1676
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1868
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2048
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2228
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2354
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2543
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2723
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2873
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3014
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3209
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3393
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3506
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            3507..3623
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..4477
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
     exon            4478..6329
                     /gene="Ccdc141"
                     /gene_synonym="2610301F02Rik; CAMDI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgttctttcc ttttggccgg gcaatcagtg tgaacagagg cgcgttccct gaaagagtcc
       61 cggtagcctc gtggaagcct tctgacatga ccagcagaca gcatcactac caaggctgct
      121 cggggtttaa gccctgcttc taaagtgcca tgtcctgcaa agaaagtccc catgtgggtg
      181 cttccaccac cactgtcagc tctgtagccg tgcacgctgg ggactccaag atcgtgatcg
      241 ccgttgtcaa gtgtggcaaa tgggtacgac tccaactggc tgaatcgcag cccaatctcc
      301 tcgaaattgg gagcagtcaa gatgaaacca aaaaactcct tcacgatcat gagctgcttc
      361 tggccaagct taaggccttg gaagatcgtg tgtgggaact cttacgggaa gcagaccgga
      421 cagctgaagc aaacaaggct caaagtcagg tgtatgacgc catggcccag acgctgggtg
      481 aggcatgggc aaccctggtc tccatgcttg aaagaagaag ggagctcctt gggctgacgt
      541 ccgagttctt tcaaagtgct ttggagtttg ctataaaaat agaccaagct gaagcttttc
      601 tgcagaatcc tcatgagttt gagagcactg aagccttaca gtcacttctt ctgcttcatg
      661 accgacatgc caaagaactc ttagaaagat ccctagacct tttaaacaaa agtcaacaac
      721 tgactgactt catagaaaaa ttcaagtgtg aaggatctac tatgaattct gagctgatcc
      781 agggagctca gagcagctgt ctgaagatcg acagcctcct tgaacttctg caagacagga
      841 gaaggcagct cgacaagtac ttgcagcaac agcggcagga attgtctcag gttctgcagt
      901 tgtgtctgtg ggaccaacaa gaaaaccagg tttcttcttg gtttcagaaa gcaataagag
      961 atctgcagga acagagtctg ggcgcatcac tttcagacaa cagagagcta atctgcaagc
     1021 acgaggacct gatagtcaaa gcaaaggaat gggattcggc cgtagagaag ctgaaaagcc
     1081 aggctttggg gattctattg tccaaggact tggcaggaaa ggaacatcta cagctctcta
     1141 accagaaact gaatcggctt caagaagaat ttggaagact catggtggaa aggaaagcct
     1201 ggttatcgat ggcaaatgac ttttttacca gtgctaacaa gtcatttgat gtacttggga
     1261 aagttgaagc ttaccttaag ctccttaaat cagagggttt aagcctgcct gtcttggcag
     1321 cgaagcatga ggaattacac agagaaatta aagactctac agccactgct ctgcaaaagg
     1381 gacgaacctt aatcagccaa gtagactcct gccgctctcg ggtgacagga atccacgaga
     1441 tgatgggata cattcagaac cgagtggatt gtctcactga acagtgtaca gcgcatgagg
     1501 aatttgcccg caagagacag caattagcaa catcagtgga cgactaccta aggaaggtgg
     1561 aaatgtcaat tcaggaaatc aggcccattc ttgctaccac attggatgtt gcttccagcc
     1621 cttctgaatc agagaagatt ttaaataaat atctggaatt ggatatccaa gtcaaggaga
     1681 cagcacatgc attagaagca gctgcaaaaa tcatgacaga gaaaaatgaa cttgaactca
     1741 atgaagtggc attgcttcct cttaaagtga aatggctaga ggaagaatta agcacgcttg
     1801 gtcgaagcat cagctgcagg tcacggatcc tgcagacgta cgtggcattt cgaaagtcat
     1861 ccgaggaggc agaggagcag cttcagagcc taaaggaatt ttatctgact gaaattcctt
     1921 ggaaagatga agacgatgct gtggtcaagt gccagtctaa ctccgctgag aggaaatggc
     1981 agctgttttt aaagaagagt tttttgaccc aggacttgag cctcgagttt ctgaacttaa
     2041 taaacatggc aaaagagaat gagatattaa atgttaaaaa tgaaatgcac attatggaga
     2101 acattatgga aaagcaaaca aatggaaggg aagagctcag ccatctccga gtggcgtggt
     2161 acctcaaagc tatcgaaggc aagcctgcga gagagcagtg ggaaatgttc aaagagaaac
     2221 ttacaaagac tactcacagt gtaaaacttc tccacgaagt tctcatgcct gtctctgcgc
     2281 ttgaccttgg ggggagcctc cagagcacgt cagatctgcg gaggaggtgg atcgcaatga
     2341 agcctcagct ccagcaactg catgaggatg ttcagcaaat cacgaaagag tgggaagtgt
     2401 taagcagtca gggagctcct ctgaaggaga aggctgaaca gctgaaggac cttgtccatc
     2461 tccaccggag gcagcgagag cgaatccagg aatatgagga aatcctatac aagacagtcc
     2521 agttccacca ggtcaaggaa gagctggtcc atctcatcaa accaagagaa ctggaacttc
     2581 tagcacagcc catggaactg gcaagttctg aggaggtcca gatgcaactg ggccgttcgc
     2641 aagaaaggcg ggcacatgta gaccatctcc atcagctggc cctgacctta ggagtggaca
     2701 tcatttcatc cgtgcaacaa cctaattgct ctaatatttc tgcaaagaac ctgcagcagc
     2761 agctggaggc ccttgaactg gagagcagga gttggagtgc ccaagccaaa gaacatgagc
     2821 gcgtcctgtc ctgcagcttg gagtactgca ctgcacgtga tgagatcagt gagctcaaag
     2881 agtcattcaa agacataaaa aagaaattca acaatctgaa gtttaattac tccaagaaaa
     2941 atgagaaatc tcgaaattta aagactcttc agtatcaaat ccaacaagtg gatacatatg
     3001 ctgaaaaaat tcaggctcta aggaagaaaa tggaaaaagt taataataag acatctgatt
     3061 cattcttaag ttatccaagt aataaagcta acatgctttc ggaagccatg gaggatttga
     3121 aaaagaacgt ggatgacttt gacaaagttg tgacagatta caaaatgaat ttggacctga
     3181 ctgagcatct tcaggaagta atagaagagt gtaacttttg gtatgaagat gcaagtgcca
     3241 ccgttgtgag agttgggaag tattccatgg agtgccaaac aagggaagct gtggacatcc
     3301 tccacaggca gttcaataag tttattactc cctcggtgcc ccagcaagaa gaaaggattc
     3361 aggaggtcat tgaccttgct cagcgcttat atggtttgga agaggggcag aaatatgcag
     3421 agaagattgt cacaagacac aaggagattc ttgaatctat tactgaatta tgtgggtctc
     3481 tcgtggaact taaagaaaaa ctgatgcagg gagaggttcc aaagatgaat tcagatttgg
     3541 aagatttcca tgacaattgc attgatctgc taaaggggcc agggaaggat gaccagaaaa
     3601 cattcagtga agaaaggaat gaggggcagg tgcagggagc agatgtattg gccgtcaatg
     3661 gaacaagaga agatgggctt cccatggact tgaggcggac ctcctctgac aaagaggaca
     3721 gcgcccaggg tctgatcctt ccagaagaca cactatctgg agaagaatct gagtgtatct
     3781 catccgatga catctctttg cctccactgc cagtgagccc cgagtcccct ctggcaccat
     3841 cagacatgga ggtagaagaa cttaccagct cctctgccct cgccctgcac atcagcggct
     3901 acaggatgca tccagggaca ggtggtctag gaaaggccca ggagtctgct cttccctcac
     3961 ccattgcctt tgcggatggg ggccatagta agaaagacac atttacaagt cattttgaga
     4021 ggccctatcc acagttgaaa gctgaatcct cattagcctc cagaggatca gcagagatga
     4081 gtaccaagtt gcacatcaat gtgaaatgtc cagcgagcat gccccatgaa gtgcacgaca
     4141 aagctttaca gcaatgctcc caggctcggg agagcacact agaaatgcag gaaaaagtgc
     4201 atgctgattc taacgtcact aaaacccaag acaggctgca tgctgccctt gatgtgtccc
     4261 ctggcctcgg ctctcaacca gacaccagcg agagccatca gaggcgagtg ggtccccaag
     4321 gaaacaagaa aaactcatcc gcagaaaaca gcgtggtcag cctagctggc caggcacctc
     4381 atttctccag gctgctgtcc aatgtaactg tcatggaagg ttccccagtg actttggaag
     4441 tcgaagtaac aggattccca gagcctacac tgacatggtt caagaagggc cagaaactgt
     4501 gtgcagatgg acacttacag gtcttgcaca aggacacaaa gcattcggtg ttcattccga
     4561 aggtatgtga ggcagatgct ggcctctatg tggctcaagc ccaaaactct agtggcaccc
     4621 tgtcttccaa agccatcctc catgtgacag gtaaccatgg gccaccaatt acaagactaa
     4681 actggattat gctgtgtatc atctatgtca gtgtatcagt aatatactgg ctacttacac
     4741 gatagtgaca tgttgccatc aatggacatt gttatgagcc taaaagacaa tatgattgtt
     4801 gattttctca tacatcacac aaagcactcc cccaacatac acacaccaat ttatctccac
     4861 tttgactaat cccactgcta ggtgaaatag ttgtattttc tctacgattt aacatacttg
     4921 ggaaacacgg gaaattatgt acagcgggta atgatacatt tcatactcta ggaagagaaa
     4981 gattctgtct aataagctga tctcttgttt aaaggcatat caatgcgcac atagttcaca
     5041 aggatcatag ggttttgtcc taattttcaa atccaaatgt ttttcatttc tccttcactg
     5101 tgctcataac tatctctttg tagggcattg catcaaactg aggttgtgat tctcaatgtt
     5161 gtattagctt ccattaactg tgcttttcac attttgatct tgtttaccaa acaaacttga
     5221 cctatgctgt ctcaacctac tctacattcc tacgtcggag gatgtcacta tcaataacca
     5281 ttcctcatga tggtctcttg ggcttgatgt tggagaacag acgtgccatc agcttcaaaa
     5341 tggagtcaac ctttctatta gctctgaatg tcatatgtca aaatgacata caggctgcag
     5401 gaggggacca gttttccccc tgtccttcca ctgctgtgca ttgaccatct gtgcataact
     5461 ataggcaggt cctactgcat ctgctgctgc tgctgttgct gctgaacact gtgtagccct
     5521 ttacaaggca tctcagtgcc ccccctttcc catctggaag aggggctcat ctacctcttg
     5581 acaactgagt ttttatttta tgtcctgtgg tgatctggcc aatggaaaaa tactcagaga
     5641 agactcatta caatgcttgg tgtgatttgc catcatgcta ctcattaccc attaattccc
     5701 tttcagattc tgatctttta gaatattaaa tgaaaagagt gctgttaata tgtaatttct
     5761 aactactccc ttgggggagg gtaagactga tgttctatga attagagttt aaattccttt
     5821 ctaacttctt acaactacat ccttttcaaa ggctctggac ggtaacctct ggaggatata
     5881 gttagcgtgt tttagaggga gtctgggtaa gatagaagaa gacaattcta gctttctttt
     5941 gtgcaattat ctctgtaata ttgaagaatg ttgtatggct tcctaatacg aattattaaa
     6001 aaaaataaga gaggtgtttg ttttcatatt ttaaactttg tcatgctagg gtaaaatcaa
     6061 gttgaaagaa taatttatta cagatttttg atgaagggaa gaaattaatt atgttgctga
     6121 aagactgtct acaaataatc aaaatattta aatagaatat atttgatgtg atattaaaaa
     6181 gctactgaat gttgtggaag ataagaaatg tctagtctag taaaaaattg gcctattttt
     6241 tcttgtcctg tgtatacaat ttaattgaaa aattgtaact gttttctttc aagttttgac
     6301 agaaagctat taaaatctta tatatacac
//
